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1. 发明授权

US07503902B2 Blood flow reversal valves and related systems and methods 有权
标题翻译：血流逆转阀及相关系统及方法
公开(公告)号：US07503902B2
公开(公告)日：2009-03-17
申请号：US11246724
申请日：2005-10-06
申请人： Mel Jensen , Lynn E. Jensen , Thomas I. Folden , John Oliver , Olli Tuominen
发明人： Mel Jensen , Lynn E. Jensen , Thomas I. Folden , John Oliver , Olli Tuominen
IPC分类号： A61M37/00 , A61M1/00 , F16K51/00
CPC分类号： A61M39/223 , A61M1/3658 , A61M2205/581 , A61M2205/582 , A61M2205/583 , F16K11/074 , F16K35/04
摘要： A blood flow reversal valve useful in hemodialysis having rotational detent features enabling audible and tactile feedback to a clinician and alignment features such as visible indicators associated with the blood lines on either side of the valve to confirm normal or reverse flow.
摘要翻译：可用于血液透析的血流逆转阀，其具有旋转止动特征，使得能够向临床医师发出声音和触觉反馈以及对准特征，例如与瓣膜两侧的血管相关联的可见指示器，以确认正常或反向流动。

2. 发明授权

US07935074B2 Cassette system for peritoneal dialysis machine 有权
标题翻译：腹膜透析机盒系统
公开(公告)号：US07935074B2
公开(公告)日：2011-05-03
申请号：US11515359
申请日：2006-08-31
申请人： Kulwinder S. Plahey , Frank L. Hedmann , Stephan Klatte , Thomas I. Folden
发明人： Kulwinder S. Plahey , Frank L. Hedmann , Stephan Klatte , Thomas I. Folden
IPC分类号： A61M1/00
CPC分类号： A61M1/28 , A61M1/16 , A61M1/281 , A61M1/288 , A61M2205/122 , A61M2205/128 , A61M2205/505
摘要： A portable peritoneal dialysis apparatus having a side-hinged, inclined door for enclosing a disposable cassette that seals tightly shut using air pressure which imposes a safety interlock, a cassette with its inlet/outlet tube exclusively along the lower edge so that the connected lines can hang straight, a circumferential channel defined in the cassette, and a pneumatic system for sealing the membranes of both the pump chamber diaphragms and the pressure sensor diaphragms in the cassette to the respective mating pistons and pressure sensors in the cycler. In addition a system for draining patient line fluid to an empty solution bag is disclosed.
摘要翻译：一种便携式腹膜透析装置，具有侧面铰接的倾斜门，用于封闭一次性盒，其密封使用施加安全联锁的空气压力密封，盒的入口/出口管仅沿着下边缘排列，使得连接的线可以垂直地悬挂，限定在盒中的圆周通道，以及用于将盒室中的两个泵室隔膜和压力传感器膜片的膜密封到循环仪中的相应配合活塞和压力传感器的气动系统。此外，公开了一种用于将患者线液体排出到空溶液袋的系统。

3. 发明授权

US5711883A Method for testing dialyzer integrity prior to use 失效
标题翻译：在使用前测试透析器完整性的方法
公开(公告)号：US5711883A
公开(公告)日：1998-01-27
申请号：US534375
申请日：1995-09-27
申请人： Thomas I. Folden , Hans D. Polaschegg , Harald Peter
发明人： Thomas I. Folden , Hans D. Polaschegg , Harald Peter
IPC分类号： A61M1/16 , B01D65/10 , B01D61/24
CPC分类号： B01D65/102 , A61M1/16 , A61M2205/705
摘要： The present invention includes a method and apparatus for the testing the integrity of a dialyzer prior to use. The dialyzer is tested on the same hardware used for the treatment of dialysis. The dialysate and blood sides of the dialyzer are primed in the normal manner. The blood and saline lines are clamped while the venous line is vented to the atmosphere. The ultrafiltrate flow rate is increased until the blood side fluid is ultrafiltered. The dialysate side is monitored for pressure increases. If the pressure does not increase, the test fails.
摘要翻译：本发明包括用于在使用前测试透析器的完整性的方法和装置。透析器在用于治疗透析的相同硬件上进行测试。透析液的透析液和血液两侧均以正常方式灌注。血液和盐水线被夹紧，而静脉线通向大气。超滤液流速增加直到血液侧流体超滤。监测透析液侧的压力增加。如果压力不增加，测试失败。

4. 发明申请

US20110196289A1 CASSETTE SYSTEM FOR PERITONEAL DIALYSIS MACHINE 有权
标题翻译：用于石膏脱水机的CASSETTE系统
公开(公告)号：US20110196289A1
公开(公告)日：2011-08-11
申请号：US13092560
申请日：2011-04-22
申请人： Kulwinder S. Plahey , Frank L. Hedmann , Stephan Klatte , Thomas I. Folden
发明人： Kulwinder S. Plahey , Frank L. Hedmann , Stephan Klatte , Thomas I. Folden
IPC分类号： A61M1/28
CPC分类号： A61M1/28 , A61M1/16 , A61M1/281 , A61M1/288 , A61M2205/122 , A61M2205/128 , A61M2205/505
摘要： A peritoneal dialysis (PD) system that includes a disposable PD cassette including a base having a substantially planar portion and a dome-shaped protrusion extending from the substantially planar portion and a flexible membrane attached to the base and covering a recessed region of the dome-shaped protrusion to form a pumping chamber between the flexible membrane and the recessed region of the dome-shaped protrusion. The system also includes a PD machine including a deck and a door hinged from one side to the deck. The door and the deck can cooperate to form a cassette compartment, and the door has a cylindrical recess positioned to receive the dome-shaped protrusion of the base of the disposable PD cassette when the disposable PD cassette is disposed in the cassette compartment and the door is closed.
摘要翻译：一种腹膜透析（PD）系统，其包括一个一次性PD盒，所述一次性PD盒包括具有基本平坦部分的底座和从所述基本上平坦的部分延伸的圆顶形突起，以及附接到所述基部并且覆盖所述圆顶状凹部的凹陷区域的柔性膜，在柔性膜与圆顶状突起的凹陷区域之间形成泵送室。该系统还包括一台PD机，包括一个甲板和一个从一侧铰接到甲板的门。门和甲板可以协作以形成盒式隔间，并且门具有圆柱形凹部，该圆柱形凹槽定位成当一次性PD盒设置在盒室和门中时接收一次性PD盒的底部的圆顶状突出部关闭了。

5. 发明授权

US06648845B1 Method and apparatus for determining hemodialysis parameters 失效
标题翻译：用于确定血液透析参数的方法和装置
公开(公告)号：US06648845B1
公开(公告)日：2003-11-18
申请号：US09003798
申请日：1998-01-07
申请人： Frank A. Gotch , Thomas I. Folden
发明人： Frank A. Gotch , Thomas I. Folden
IPC分类号： A61M3700
CPC分类号： A61M1/3653 , A61M1/16 , A61M1/1605 , A61M1/1607 , A61M1/1609 , A61M1/361 , A61M1/3612 , A61M1/3655 , A61M1/3656 , A61M1/3658 , A61M1/3661 , A61M2202/0498 , A61M2205/15 , A61M2205/3317 , A61M2205/3324 , A61M2205/3368 , A61M2205/50
摘要： This invention provides a method and apparatus for calculating a hemodialysis parameter, especially blood access flow rate, using multiple dialysance values. The dialysance values may be calculated based upon either sodium or urea concentrations. One dialysance value can be determined for conditions in which a patient's arterial line withdraws blood from an upstream location in a patient's fistula and treated blood is returned by a venous line to a downstream location in a patient's fistula. The second dialysance value can be determined when the lines have been reconfigured so that the arterial line withdraws blood from a downstream portion of a patient's fistula and the venous line returns treated blood to an upstream portion of a patient's fistula. Since it is possible to determine the dialysance values solely from concentration measurements made on the dialysate side of the dialysis apparatus, the present method and apparatus provide a non-invasive means for determining hemodialysis parameters such as blood access flow rate and recirculation.
摘要翻译：本发明提供一种使用多个透析值计算血液透析参数，特别是血液存取流量的方法和装置。透析值可以基于钠或尿素浓度来计算。可以确定患者的动脉线从患者瘘管中的上游位置抽出血液的情况下的一个透析值，并且将经处理的血液通过静脉管线返回到患者瘘管的下游位置。当线重新配置时，可以确定第二透析值，使得动脉线从患者瘘的下游部分抽出血液，并且静脉线将经处理的血液返回到患者瘘的上游部分。由于可以仅通过在透析装置的透析液侧进行的浓度测定来确定透析值，因此本方法和装置提供用于确定血液透析参数如血液存取流量和再循环的非侵入性手段。

6. 发明授权

US5423768A Tubing administration set for use in peritoneal dialysis 失效
标题翻译：用于腹膜透析的管道管理
公开(公告)号：US5423768A
公开(公告)日：1995-06-13
申请号：US84731
申请日：1993-06-25
申请人： Thomas I. Folden , Arnold Gross
发明人： Thomas I. Folden , Arnold Gross
IPC分类号： A61M1/28 , A61M39/00 , A61M39/10 , A61M39/22 , A61M5/24
CPC分类号： A61M1/28 , A61M39/00 , A61M39/221 , A61M2039/1061 , Y10S137/91 , Y10S604/905 , Y10T137/1654
摘要： Apparatus for administering dialysis, including a separable tubing coupling (32). The tubing coupling (32) consists of a hollow cylindrical element (42, 44) insertable into the lumens of the distal and proximal regions of the fluid delivery tube (16), and has a scored circumference at which the coupling can be broken-off by application of an adequate bending force. The device allows rapid and reliable disconnecting of the patient from the dialysis apparatus, without the need for scissors or a knife to be employed.
摘要翻译：用于透析的装置，包括可分离的管接头（32）。管接头（32）由可插入流体输送管（16）的远端和近端区域的腔内的中空圆柱形元件（42,44）组成，并且具有刻痕圆周，联接器可以在该刻痕圆周处被断开通过施加足够的弯曲力。该装置允许患者从透析装置快速可靠地断开，而不需要使用剪刀或刀。

7. 发明授权

US07892197B2 Automatic prime of an extracorporeal blood circuit 有权
标题翻译：自动提取体外血液回路
公开(公告)号：US07892197B2
公开(公告)日：2011-02-22
申请号：US11858104
申请日：2007-09-19
申请人： Thomas I. Folden , Martin Joseph Crnkovich
发明人： Thomas I. Folden , Martin Joseph Crnkovich
IPC分类号： A61M37/00 , C02F1/44
CPC分类号： A61M1/3643 , A61M1/3644 , A61M1/3647 , A61M1/3649
摘要： A system for priming an extracorporeal blood circuit is described. The system includes a fluid circuit with an air venting mechanism, a reversible pump, arterial and venous lines, a prime waste bag and a switchable coupler selectively connecting the arterial and venous lines to the waste bag or alternatively interconnecting the arterial and venous lines. A priming fluid is connected to the circuit and circulated in the circuit under different configurations of the arterial and venous line connections.
摘要翻译：描述了用于引发体外血液回路的系统。该系统包括具有通气机构的流体回路，可逆泵，动脉和静脉线，主废物袋和可切换的联接器，其选择性地将动脉和静脉线连接到废物袋，或者交替地连接动脉和静脉线。启动流体连接到电路，并在电路中在动脉和静脉线连接的不同配置下循环。

8. 发明申请

US20080125693A1 Peritoneal dialysis systems and related methods 有权
标题翻译：腹膜透析系统及相关方法
公开(公告)号：US20080125693A1
公开(公告)日：2008-05-29
申请号：US11513629
申请日：2006-08-31
申请人： David A. Gavin , Thomas I. Folden
发明人： David A. Gavin , Thomas I. Folden
IPC分类号： A61M1/28
CPC分类号： A61M1/28 , A61M1/281 , A61M1/287 , A61M1/288 , A61M2205/12
摘要： Peritoneal dialysis systems and related methods are disclosed. The methods can include combining a first solution having a first concentration of a solute with a second solution having a second concentration of the solute to form a custom dialysate, e.g., according to a specific prescription for a patient.
摘要翻译：公开了腹膜透析系统及相关方法。所述方法可以包括将具有第一浓度溶质的第一溶液与具有第二浓度溶质的第二溶液组合以形成定制的透析液，例如根据患者的具体处方。

9. 发明授权

US5722944A Method of peritoneal dialysis 失效
标题翻译：腹膜透析法
公开(公告)号：US5722944A
公开(公告)日：1998-03-03
申请号：US534452
申请日：1995-09-27
申请人： Thomas I. Folden
发明人： Thomas I. Folden
IPC分类号： A61J1/00 , A61J1/05 , A61J1/10 , A61L2/18 , A61M1/00 , A61M1/28 , A61M37/00
CPC分类号： A61L2/18 , A61J1/10 , A61M1/0019 , A61M1/0096 , A61M1/28 , Y10S128/24
摘要： A method for manufacturing and using a dialysis collection bag for peritoneal dialysis treatment, and the dialysis collection bag itself. A collection bag is fabricated with a sterilization tablet therein, having a soluble coating over a sterilization agent. When the collection bag is filled with used dialysis solution at the completion of the dialysis therapy, the soluble coating dissolves over a known period of time such as about 30 minutes. The delayed dissolution allows time to take a specimen sample of the unadulterated used dialysis solution. When the dissolution of the coating is completed, the tablet releases the sterilization agent to sterilize the used dialysis solution, so that pathogens are destroyed to prevent the transmission of disease in the event the collection bag is disposed of improperly.
摘要翻译：用于制造和使用用于腹膜透析治疗的透析收集袋的方法和透析收集袋本身。收集袋用其中的杀菌片制成，在消毒剂上具有可溶性涂层。当在透析治疗完成时收集袋装有用过的透析溶液时，可溶性涂层在已知的时间段内溶解，例如约30分钟。延迟溶解允许时间取出未掺杂的用过的透析溶液的样品样品。当涂层的溶解完成时，片剂释放灭菌剂以对所使用的透析溶液进行灭菌，从而在收集袋被不适当地处理的情况下破坏病原体以防止疾病传播。

10. 发明授权

US08870811B2 Peritoneal dialysis systems and related methods 有权
标题翻译：腹膜透析系统及相关方法
公开(公告)号：US08870811B2
公开(公告)日：2014-10-28
申请号：US11513629
申请日：2006-08-31
申请人： David A. Gavin , Thomas I. Folden
发明人： David A. Gavin , Thomas I. Folden
IPC分类号： A61M1/00 , A61M1/28
CPC分类号： A61M1/28 , A61M1/281 , A61M1/287 , A61M1/288 , A61M2205/12
摘要： Peritoneal dialysis systems and related methods are disclosed. The methods can include combining a first solution having a first concentration of a solute with a second solution having a second concentration of the solute to form a custom dialysate, e.g., according to a specific prescription for a patient.
摘要翻译：公开了腹膜透析系统及相关方法。所述方法可以包括将具有第一浓度溶质的第一溶液与具有第二浓度溶质的第二溶液组合以形成定制的透析液，例如根据患者的具体处方。

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