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1. 发明申请

US20050072904A1 Detector array using a continuous light guide 有权
标题翻译：检测器阵列使用连续光导
公开(公告)号：US20050072904A1
公开(公告)日：2005-04-07
申请号：US10680015
申请日：2003-10-07
申请人： Mehmet Aykac , Matthias Schmand , Niraj Doshi , Mark Andreaco , Lars Eriksson , Charles Williams , Ronald Nutt
发明人： Mehmet Aykac , Matthias Schmand , Niraj Doshi , Mark Andreaco , Lars Eriksson , Charles Williams , Ronald Nutt
IPC分类号： G01T1/164 , G01T1/29 , H01L27/00
CPC分类号： G01T1/1644 , A61B6/037 , G01T1/2928
摘要： A detector for use in imaging applications includes at least one detector array, an array of photodetectors, and a continuous light guide disposed between the detectors and the photodetectors. The light guide is continuous over the entire area of the photodetectors and detectors. The thickness of the light guide is optimized based on the shape of the photodetector array. Each detector array includes a plurality of scintillator elements disposed in an M×N array, where “M” and “N” are independently selectable and are each at least one. A mechanism for maintaining the relative positions of the individual scintillator elements with respect to each other is provided. The retainer is further provided to enhance the separation between the individual detector arrays to define distinct boundaries between the position profiles of the scintillator arrays.
摘要翻译：用于成像应用的检测器包括至少一个检测器阵列，光电检测器阵列，以及设置在检测器和光电探测器之间的连续光导。导光体在光电检测器和检测器的整个区域上是连续的。基于光电检测器阵列的形状优化光导的厚度。每个检测器阵列包括设置在MxN阵列中的多个闪烁体元件，其中“M”和“N”可独立选择并且各自至少一个。提供了用于保持各个闪烁体元件相对于彼此的相对位置的机构。进一步提供保持器以增强各个检测器阵列之间的间隔，以限定闪烁体阵列的位置分布之间的不同边界。

2. 发明申请

US20070221856A1 Photo sensor panel for high resolution PET 有权
标题翻译：用于高分辨率PET的照片传感器面板
公开(公告)号：US20070221856A1
公开(公告)日：2007-09-27
申请号：US11387377
申请日：2006-03-23
申请人： Lars Eriksson , Matthias Schmand , Michael Casey , Niraj Doshi , Mehmet Aykac , Ronald Nutt
发明人： Lars Eriksson , Matthias Schmand , Michael Casey , Niraj Doshi , Mehmet Aykac , Ronald Nutt
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , A61B6/037 , G01T1/2008 , G01T1/2985
摘要： Apparatus and method for providing nuclear medical imaging, in particular positron emission tomography, wherein a panel detector including scintillation blocks with a light guide is attached thereto. The scintillation block is arranged to cover a plurality of photosensors in an N by N configuration where there are outer photosensors which share light information from adjacent scintillation blocks and at least one center photosensor which does not share light information from adjacent scintillation blocks.
摘要翻译：用于提供核医学成像，特别是正电子发射断层摄影的装置和方法，其中附接有包括具有光导的闪烁块的面板检测器。闪烁块被布置成以N×N构造覆盖多个光电传感器，其中存在共享来自相邻闪烁块的光信息的外部光电传感器和不共享来自相邻闪烁块的光信息的至少一个中心光电传感器。

3. 发明授权

US07164136B2 Detector array using a continuous light guide 有权
标题翻译：检测器阵列使用连续光导
公开(公告)号：US07164136B2
公开(公告)日：2007-01-16
申请号：US10680015
申请日：2003-10-07
申请人： Mehmet Aykac , Matthias J. Schmand , Niraj K. Doshi , Mark S. Andreaco , Lars A. Eriksson , Charles W. Williams , Ronald Nutt
发明人： Mehmet Aykac , Matthias J. Schmand , Niraj K. Doshi , Mark S. Andreaco , Lars A. Eriksson , Charles W. Williams , Ronald Nutt
IPC分类号： G01T3/06
CPC分类号： G01T1/1644 , A61B6/037 , G01T1/2928
摘要： A detector for use in imaging applications includes at least one detector array, an array of photodetectors, and a continuous light guide disposed between the detectors and the photodetectors. The light guide is continuous over the entire area of the photodetectors and detectors. The thickness of the light guide is optimized based on the shape of the photodetector array. Each detector array includes a plurality of scintillator elements disposed in an M×N array, where “M” and “N” are independently selectable and are each at least one. A mechanism for maintaining the relative positions of the individual scintillator elements with respect to each other is provided. The retainer is further provided to enhance the separation between the individual detector arrays to define distinct boundaries between the position profiles of the scintillator arrays.
摘要翻译：用于成像应用的检测器包括至少一个检测器阵列，光电检测器阵列，以及设置在检测器和光电探测器之间的连续光导。导光体在光电检测器和检测器的整个区域上是连续的。基于光电检测器阵列的形状优化光导的厚度。每个检测器阵列包括设置在MxN阵列中的多个闪烁体元件，其中“M”和“N”可独立选择并且各自至少一个。提供了用于保持各个闪烁体元件相对于彼此的相对位置的机构。进一步提供保持器以增强各个检测器阵列之间的间隔，以限定闪烁体阵列的位置分布之间的不同边界。

4. 发明授权

US07408164B2 Detector array utilizing air gaps as a reflector between array elements 有权
标题翻译：检测器阵列利用气隙作为阵列元件之间的反射器
公开(公告)号：US07408164B2
公开(公告)日：2008-08-05
申请号：US10441682
申请日：2003-05-20
申请人： Matthias J. Schmand , Lars A. Eriksson , Niraj K. Doshi , Mehmet Aykac , Ronald Nutt
发明人： Matthias J. Schmand , Lars A. Eriksson , Niraj K. Doshi , Mehmet Aykac , Ronald Nutt
IPC分类号： G01T1/20
CPC分类号： G01T1/2002 , G01T1/202
摘要： A detector array including a plurality of scintillators for use in association with an imaging device. The detector array is provided for accurate determination of the location of the impingement of radiation upon an individual scintillator detector. An air gap is disposed between the scintillator elements, thereby increasing the packing fraction and overall sensitivity of the array. The amount of light transmitted down the scintillator element and the amount of light transmitted to adjacent elements is modified to optimize the identification of each element in a position profile map by adjusting the surface finish of the detector elements.
摘要翻译：一种检测器阵列，包括用于与成像装置相关联的多个闪烁体。检测器阵列被提供用于准确地确定辐射冲击位置在单独的闪烁体检测器上。在闪烁器元件之间设置气隙，从而增加阵列的封装分数和整体灵敏度。通过调整检测器元件的表面光洁度来修改向下闪烁体元件传输的光量和透射到相邻元件的光量，以优化位置分布图中每个元素的识别。

5. 发明授权

US07019297B2 Detector array using internalized light sharing and air coupling 有权
标题翻译：使用内部光共享和空气耦合的检测器阵列
公开(公告)号：US07019297B2
公开(公告)日：2006-03-28
申请号：US10441681
申请日：2003-05-20
申请人： Mehmet Aykac , Matthias J. Schmand , Niraj K. Doshi , Charles W. Williams , Ronald Nutt
发明人： Mehmet Aykac , Matthias J. Schmand , Niraj K. Doshi , Charles W. Williams , Ronald Nutt
IPC分类号： G01T1/202
CPC分类号： G01T1/202 , B33Y70/00 , B33Y80/00 , G01T1/2002
摘要： A method for fabricating an array adapted to receive a plurality of scintillators for use in association with an imaging device. The method allows the creation of a detector array such that location of the impingement of radiation upon an individual scintillator detector is accurately determinable. The array incorporates an air gap between all the scintillator elements. Certain scintillators may have varying height reflective light partitions to control the amount of light sharing which occurs between elements. Light transmission is additionally optimized by varying the optical transmission properties of the reflective light partition, such as by varying the thickness and optical density of the light partitions. In certain locations, no light partitions exist, thereby defining an air gap between those elements. The air gap allows a large increase in the packing fraction and therefore the overall sensitivity of the array.
摘要翻译：一种用于制造适于接收与成像装置相关联使用的多个闪烁体的阵列的方法。该方法允许创建检测器阵列，使得能够精确地确定单个闪烁体检测器上的辐射冲击位置。该阵列包括所有闪烁体元件之间的气隙。某些闪烁体可以具有变化的高度反射光分区，以控制在元件之间发生的光共享的量。通过改变反射光分区的光传输特性，例如通过改变光分区的厚度和光密度来另外优化透光。在某些位置，不存在光分区，从而在这些元件之间限定气隙。空气间隙允许包装分数大幅度增加，因此阵列的整体灵敏度增加。

6. 发明授权

US07301153B2 Photo sensor panel for high resolution PET 有权
公开(公告)号：US07301153B2
公开(公告)日：2007-11-27
申请号：US11387377
申请日：2006-03-23
申请人： Lars A. Eriksson , Matthias J. Schmand , Michael E. Casey , Niraj K. Doshi , Mehmet Aykac , Ronald Nutt
发明人： Lars A. Eriksson , Matthias J. Schmand , Michael E. Casey , Niraj K. Doshi , Mehmet Aykac , Ronald Nutt
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , A61B6/037 , G01T1/2008 , G01T1/2985
摘要： Apparatus and method for providing nuclear medical imaging, in particular positron emission tomography, wherein a panel detector including scintillation blocks with a light guide is attached thereto. The scintillation block is arranged to cover a plurality of photosensors in an N by N configuration where there are outer photosensors which share light information from adjacent scintillation blocks and at least one center photosensor which does not share light information from adjacent scintillation blocks.

7. 发明申请

US20070102641A1 Combined PET/MR Imaging System and APD-Based PET Detector For Use In Simultaneous PET/MR Imaging 有权
标题翻译：组合PET / MR成像系统和基于APD的PET检测器，用于同时PET / MR成像
公开(公告)号：US20070102641A1
公开(公告)日：2007-05-10
申请号：US11532665
申请日：2006-09-18
申请人： Matthias Schmand , Ron Grazioso , Ronald Nutt , Robert Nutt , Nan Zhang , James Corbeil , Ralf Ladebeck , Markus Vester , Gunter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd Pichler
发明人： Matthias Schmand , Ron Grazioso , Ronald Nutt , Robert Nutt , Nan Zhang , James Corbeil , Ralf Ladebeck , Markus Vester , Gunter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd Pichler
IPC分类号： G01T1/164 , G01T1/166 , A61B5/05
CPC分类号： G01R33/481 , A61B6/037 , A61B8/5261 , G01R33/26 , G01R33/28 , G01R33/307 , G01R33/381 , G01T1/1603 , G01T1/2018 , G01T1/2985
摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.
摘要翻译：提供基于APD的PET模块，用于组合PET / MR成像。每个模块包括多个独立的光隔离探测器。每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。模块位于MR扫描仪的通道中。基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。

8. 发明申请

US20130130309A1 Radiopharmaceutical Production System and Quality Control System Utilizing High Performance Liquid Chromatography 审中-公开
标题翻译：使用高效液相色谱的放射性药物生产系统和质量控制系统
公开(公告)号：US20130130309A1
公开(公告)日：2013-05-23
申请号：US13446334
申请日：2012-04-13
申请人： Ronald Nutt , Antony M. Giamis , Aaron McFarland
发明人： Ronald Nutt , Antony M. Giamis , Aaron McFarland
IPC分类号： G01N30/74 , G01N33/60
CPC分类号： G01N30/74 , A61K51/0491 , B01J19/0093 , B01J2219/00788 , B01J2219/00873 , B01J2219/00891 , B01J2219/00905 , G01N30/88 , G01N33/60 , G01N2030/77 , G01N2030/8872
摘要： HPLC-based quality control systems to perform quality control testing on a radiopharmaceutical solution shortly after synthesis. An HPLC-based quality control system makes efficient use of sample volume and is compatible with a variety of radioisotopes and radiopharmaceutical compounds. In several embodiments, the automated nature of an HPLC-based quality control system allows for quality control tests to be conducted quickly and with minimal impact on user workflow. When used as part of an integrated PET biomarker radiopharmaceutical production system, the present general inventive concept permits a manufacturer to produce product and conduct quality control tests with lower per dose costs.
摘要翻译：基于HPLC的质量控制系统，在合成后不久就对放射性药物溶液进行质量控制测试。基于HPLC的质量控制系统有效利用样品体积，并与各种放射性同位素和放射性药物化合物相容。在几个实施例中，基于HPLC的质量控制系统的自动化性质允许快速进行质量控制测试并且对用户工作流程的影响最小。当作为PET生物标志物整合放射性药物生产系统的一部分使用时，本发明总体上允许制造商生产产品并以较低的每剂量成本进行质量控制测试。

9. 发明授权

US07476883B2 Biomarker generator system 有权
标题翻译：生物标记发生器系统
公开(公告)号：US07476883B2
公开(公告)日：2009-01-13
申请号：US11441999
申请日：2006-05-26
申请人： Ronald Nutt
发明人： Ronald Nutt
IPC分类号： H05H9/00 , G21G1/10
CPC分类号： G21G4/08 , G21G1/0005 , G21G1/10 , G21H5/02 , H05H13/005
摘要： A biomarker generator system for producing approximately one (1) unit dose of a biomarker. The biomarker generator system includes a small, low-power particle accelerator (“micro-accelerator”) and a radiochemical synthesis subsystem having at least one microreactor and/or microfluidic chip. The micro-accelerator is provided for producing approximately one (1) unit dose of a radioactive substance, such as a substance that emits positrons. The radiochemical synthesis subsystem is provided for receiving the radioactive substance, for receiving at least one reagent, and for synthesizing the approximately one (1) unit dose of a biomarker.
摘要翻译：生物标志物发生器系统，用于生产大约一（1）个单位剂量的生物标志物。生物标志物发生器系统包括具有至少一个微反应器和/或微流体芯片的小型低功率粒子加速器（“微加速器”）和放射化学合成子系统。提供微促进剂用于产生大约一（1）单位剂量的放射性物质，例如发射正电子的物质。提供放射化学合成子系统用于接收放射性物质，用于接收至少一种试剂，并用于合成大约一（1）单位剂量的生物标志物。

10. 发明授权

US06362479B1 Scintillation detector array for encoding the energy, position, and time coordinates of gamma ray interactions 有权
标题翻译：闪烁探测器阵列，用于编码伽马射线相互作用的能量，位置和时间坐标
公开(公告)号：US06362479B1
公开(公告)日：2002-03-26
申请号：US09272228
申请日：1999-03-18
申请人： Mark S. Andreaco , Charles W. Williams , Ronald Nutt , Michael E. Casey
发明人： Mark S. Andreaco , Charles W. Williams , Ronald Nutt , Michael E. Casey
IPC分类号： G01T120
CPC分类号： G01T1/1644 , A61B6/037 , G01T1/1648
摘要： A scintillation detector which includes a plurality of discrete scintillators composed of one or more scintillator materials. The discrete scintillators interact with incident radiation to produce a quantifiable number of photons with characteristic emission wavelength and decay time. A light guide is operatively associated with the scintillation crystals and may be either active or non-active and segmented or non-segmented depending upon the embodiment of the design. Photodetectors are provided to sense and quantify the scintillation light emissions. The process and system embodying various features of the present invention can be utilized in various applications such as SPECT, PET imaging and simultaneous PET systems. In accordance with the present invention, the detector array of the present invention incorporates either a single scintillator layer of discrete scintillators or discrete scintillators composed of two stacked different layers that can be the same scintillator material or of two different scintillator materials. In either case the different layers are composed of materials that have distinctly different decay times. The variants in these figures are the types of optical detectors which are used, i.e. photomultipliers and/or photodiodes, whether or not a segmented optical light guide is used, and whether the light guide is active or non-active. If a segmented optical light guide is used then the variant is whether the configuration is inverted or non-inverted.
摘要翻译：闪烁检测器，其包括由一个或多个闪烁体材料组成的多个分立的闪烁体。离散的闪烁体与入射辐射相互作用以产生具有特征发射波长和衰减时间的可量化数量的光子。光引导件与闪烁晶体可操作地相关联，并且可以是有源的或非有效的，并且根据设计的实施例是分段的或非分段的。提供光电检测器来感测和量化闪烁光发射。体现本发明各种特征的方法和系统可以用于诸如SPECT，PET成像和同时PET系统的各种应用中。根据本发明，本发明的检测器阵列包括单个闪烁体层的离散闪烁体或由两层不同层组成的分立闪烁体，其可以是相同的闪烁体材料或两种不同的闪烁体材料。在任一情况下，不同的层由具有截然不同的衰变时间的材料组成。这些图中的变型是使用的光学检测器的类型，即光电倍增管和/或光电二极管，是否使用分段的光学光导，以及光导是活动的还是非活动的。如果使用分段光学光导，则该变体是配置是倒置还是非反转。

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