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1. 发明申请

US20070102641A1 Combined PET/MR Imaging System and APD-Based PET Detector For Use In Simultaneous PET/MR Imaging 有权
标题翻译：组合PET / MR成像系统和基于APD的PET检测器，用于同时PET / MR成像
公开(公告)号：US20070102641A1
公开(公告)日：2007-05-10
申请号：US11532665
申请日：2006-09-18
申请人： Matthias Schmand , Ron Grazioso , Ronald Nutt , Robert Nutt , Nan Zhang , James Corbeil , Ralf Ladebeck , Markus Vester , Gunter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd Pichler
发明人： Matthias Schmand , Ron Grazioso , Ronald Nutt , Robert Nutt , Nan Zhang , James Corbeil , Ralf Ladebeck , Markus Vester , Gunter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd Pichler
IPC分类号： G01T1/164 , G01T1/166 , A61B5/05
CPC分类号： G01R33/481 , A61B6/037 , A61B8/5261 , G01R33/26 , G01R33/28 , G01R33/307 , G01R33/381 , G01T1/1603 , G01T1/2018 , G01T1/2985
摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.
摘要翻译：提供基于APD的PET模块，用于组合PET / MR成像。每个模块包括多个独立的光隔离探测器。每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。模块位于MR扫描仪的通道中。基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。

2. 发明授权

US09121893B2 Combined PET/MR imaging system and APD-based pet detector for use in simultaneous PET/MR imaging 有权
标题翻译：组合PET / MR成像系统和基于APD的宠物检测器，用于同时PET / MR成像
公开(公告)号：US09121893B2
公开(公告)日：2015-09-01
申请号：US11532665
申请日：2006-09-18
申请人： Matthias J. Schmand , Ron Grazioso , Ronald Nutt , Robert E. Nutt , Nan Zhang , James Luke Corbeil , Ralf Ladebeck , Markus Vester , Günter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd J. Pichler
发明人： Matthias J. Schmand , Ron Grazioso , Ronald Nutt , Robert E. Nutt , Nan Zhang , James Luke Corbeil , Ralf Ladebeck , Markus Vester , Günter Schnur , Wolfgang Renz , Hubertus Fischer , Bernd J. Pichler
IPC分类号： G01T1/164 , G01T1/166 , G01R33/28 , G01R33/26 , G01R33/381 , G01R33/48 , G01T1/16 , G01T1/29 , A61B6/03 , A61B8/08
CPC分类号： G01R33/481 , A61B6/037 , A61B8/5261 , G01R33/26 , G01R33/28 , G01R33/307 , G01R33/381 , G01T1/1603 , G01T1/2018 , G01T1/2985
摘要： APD-based PET modules are provided for use in combined PET/MR imaging. Each module includes a number of independent, optically isolated detectors. Each detector includes an array of scintillator (e.g. LSO) crystals read out by an array of APDs. The modules are positioned in the tunnel of a MR scanner. Simultaneous, artifact-free images can be acquired with the APD-based PET and MR system resulting in a high-resolution and cost-effective integrated PET/MR system.
摘要翻译：提供基于APD的PET模块，用于组合PET / MR成像。每个模块包括多个独立的光隔离探测器。每个检测器包括由APD阵列读出的闪烁体阵列（例如LSO）晶体。模块位于MR扫描仪的通道中。基于APD的PET和MR系统可以获得同时，无伪影的图像，从而产生高分辨率和成本效益的集成PET / MR系统。

3. 发明申请

US20080017803A1 Signal Polarity Inverting Multiplexing Circuits For Nuclear Medical Detectors 有权
标题翻译：用于核医学检测器的信号极性反相多路复用电路
公开(公告)号：US20080017803A1
公开(公告)日：2008-01-24
申请号：US11751372
申请日：2007-05-21
申请人： Nan Zhang , Matthias Schmand , Niraj Doshi
发明人： Nan Zhang , Matthias Schmand , Niraj Doshi
IPC分类号： G01T1/20
CPC分类号： G01T1/1642 , G01T1/1647
摘要： A system for multiplexing photodetector signals from a scintillation detector. The system includes a detector module having a number of scintillator blocks, each scintillator block having a number of photosensors, and a number of multiplexing circuits. Each multiplexing circuit includes a number of inputs, a signal polarity inverter and at least one differential output attached to the signal polarity inverter. The multiplexing system inverts the polarity of preselected signals from the photosensors and selectively combines signals of different polarities to calculate event positioning and total energy.
摘要翻译：一种用于复用来自闪烁检测器的光检测器信号的系统。该系统包括具有多个闪烁体块的检测器模块，每个闪烁体块具有多个光电传感器，以及多个复用电路。每个多路复用电路包括多个输入端，信号极性反相器和附加到信号极性反相器的至少一个差分输出。复用系统将来自光电传感器的预选信号的极性反转，并且选择性地组合不同极性的信号以计算事件定位和总能量。

4. 发明授权

US08410776B2 Detector module for an emission tomography scanner 有权
标题翻译：用于发射断层扫描仪的检测器模块
公开(公告)号：US08410776B2
公开(公告)日：2013-04-02
申请号：US12585867
申请日：2009-09-28
申请人： Matthias J. Schmand , Markus Vester , Nan Zhang
发明人： Matthias J. Schmand , Markus Vester , Nan Zhang
IPC分类号： G01V3/00
CPC分类号： A61B6/4411 , A61B5/0035 , A61B5/055 , A61B6/037 , A61B6/4417 , G01R33/481 , G01T1/1603 , G01T1/1644
摘要： An emission tomography detector module and an emission tomography scanner are disclosed. In at least one embodiment, the emission tomography detector modules includes a scintillator to capture an photon, the scintillator emitting a scintillating light on capturing the photon; a first type of solid-state photodetector to detect the scintillating light; and a second type of solid-state photodetector to detect the scintillating light, wherein the first type of solid-state photodetector and the second type of solid-state photodetector are different with respect to a detecting property.
摘要翻译：公开了一种发射断层摄影检测器模块和发射断层扫描仪。在至少一个实施例中，发射断层摄影检测器模块包括闪光体以捕获光子，闪烁体在捕获光子时发射闪烁光; 用于检测闪烁光的第一种类型的固态光电检测器; 以及用于检测闪烁光的第二类型的固态光电检测器，其中所述第一类型的固态光电检测器和所述第二类型的固态光电检测器相对于检测特性是不同的。

5. 发明申请

US20110074426A1 Detector module for an emission tomography scanner 有权
标题翻译：用于发射断层扫描仪的检测器模块
公开(公告)号：US20110074426A1
公开(公告)日：2011-03-31
申请号：US12585867
申请日：2009-09-28
申请人： Matthias J. Schmand , Markus Vester , Nan Zhang
发明人： Matthias J. Schmand , Markus Vester , Nan Zhang
IPC分类号： G01T1/164 , G01T1/20 , G01V3/00
CPC分类号： A61B6/4411 , A61B5/0035 , A61B5/055 , A61B6/037 , A61B6/4417 , G01R33/481 , G01T1/1603 , G01T1/1644
摘要： An emission tomography detector module and an emission tomography scanner are disclosed. In at least one embodiment, the emission tomography detector modules includes a scintillator to capture an photon, the scintillator emitting a scintillating light on capturing the photon; a first type of solid-state photodetector to detect the scintillating light; and a second type of solid-state photodetector to detect the scintillating light, wherein the first type of solid-state photodetector and the second type of solid-state photodetector are different with respect to a detecting property.
摘要翻译：公开了一种发射断层摄影检测器模块和发射断层扫描仪。在至少一个实施例中，发射断层摄影检测器模块包括闪光体以捕获光子，闪烁体在捕获光子时发射闪烁光; 用于检测闪烁光的第一种类型的固态光电检测器; 以及用于检测闪烁光的第二类型的固态光电检测器，其中所述第一类型的固态光电检测器和所述第二类型的固态光电检测器相对于检测特性是不同的。

6. 发明申请

US20090108206A1 MR-Compatible Blood Sampling System For PET Imaging Applications in Combined PET/MR Imaging System 有权
标题翻译： MR兼容血液采样系统用于PET / MR成像系统的PET成像应用
公开(公告)号：US20090108206A1
公开(公告)日：2009-04-30
申请号：US12260966
申请日：2008-10-29
申请人： Johannes Breuer , Ronald Grazioso , James Corbeil , Nan Zhang , Matthias J. Schmand
发明人： Johannes Breuer , Ronald Grazioso , James Corbeil , Nan Zhang , Matthias J. Schmand
IPC分类号： G01T1/164 , G01V3/00
CPC分类号： G01R33/28 , A61B5/150992 , G01R33/481 , G01T1/1603
摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.
摘要翻译：用于PET成像应用的自动采血系统，其可以在MR扫描器的视野（FOV）中或非常接近的范围内操作，例如在组合的MR / PET成像系统中。辐射检测器使用APD（雪崩光电二极管）从正电子 - 电子湮灭光子被吸收的晶体中收集闪烁光。必要的伽马屏蔽由合适的屏蔽材料制成，优选钨聚合物复合材料。由于APD相当小并且磁性不敏感，所以它们可以在无扰动的MR设备的强磁场中操作。

7. 发明授权

US09606199B2 MR-compatible blood sampling system for PET imaging applications in combined PET/MR imaging system 有权
公开(公告)号：US09606199B2
公开(公告)日：2017-03-28
申请号：US12260966
申请日：2008-10-29
申请人： Johannes Breuer , Ronald Grazioso , James Corbeil , Nan Zhang , Matthias J. Schmand
发明人： Johannes Breuer , Ronald Grazioso , James Corbeil , Nan Zhang , Matthias J. Schmand
IPC分类号： G01R33/28 , A61B5/15 , G01R33/48 , G01T1/16
CPC分类号： G01R33/28 , A61B5/150992 , G01R33/481 , G01T1/1603
摘要： An automated blood sampling system for PET imaging applications that can be operated in or very near to the field of view (FOV) of an MR scanner, such as in a combined MR/PET imaging system. A radiation detector uses APDs (avalanche photo-diodes) to collect scintillation light from crystals in which the positron-electron annihilation photons are absorbed. The necessary gamma shielding is made from a suitable shielding material, preferably tungsten polymer composite. Because the APDs are quite small and are magnetically insensitive, they can be operated in the strong magnetic field of an MR apparatus without disturbance.

8. 发明授权

US09588230B2 Systems and methods for calibrating a silicon photomultiplier-based positron emission tomography system 有权
标题翻译：用于校准基于硅光电倍增管的正电子发射断层扫描系统的系统和方法
公开(公告)号：US09588230B2
公开(公告)日：2017-03-07
申请号：US12560054
申请日：2009-09-15
申请人： Ronald Grazioso , Debora Henseler , Nan Zhang
发明人： Ronald Grazioso , Debora Henseler , Nan Zhang
IPC分类号： G01D18/00 , G12B13/00 , G01T1/164 , A61B6/03
CPC分类号： G01T1/1644 , A61B6/037 , G01T1/1648
摘要： A representative positron emission tomography (PET) system includes a positron emission tomography detector having one or more silicon photomultipliers that output silicon photomultipliers signals. The PET system further includes a calibration system that is electrically coupled to the silicon photomultipliers. The calibration system determines a single photoelectron response of the silicon photomultipliers signals and adjusts a gain of the silicon photomultipliers based on the single photoelectron response.
摘要翻译：代表性的正电子发射断层摄影（PET）系统包括正电子发射断层摄影检测器，其具有输出硅光电倍增管信号的一个或多个硅光电倍增管。 PET系统还包括电耦合到硅光电倍增管的校准系统。校准系统确定硅光电倍增管信号的单个光电子响应，并且基于单个光电子响应调整硅光电倍增管的增益。

9. 发明授权

US09244975B2 Just-in-time analytics on large file systems 有权
标题翻译：大型文件系统的即时分析
公开(公告)号：US09244975B2
公开(公告)日：2016-01-26
申请号：US13328810
申请日：2011-12-16
申请人： Gautam Das , Hao H. Huang , Sandor Szalay , Nan Zhang
发明人： Gautam Das , Hao H. Huang , Sandor Szalay , Nan Zhang
IPC分类号： G06F17/30
CPC分类号： G06F17/30442
摘要： As file systems reach the petabytes scale, users and administrators are increasingly interested in acquiring high-level analytical information for file management and analysis. Two particularly important tasks are the processing of aggregate and top-k queries which, unfortunately, cannot be quickly answered by hierarchical file systems such as ext3 and NTFS. Existing pre-processing based solutions, e.g., file system crawling and index building, consume a significant amount of time and space (for generating and maintaining the indexes) which in many cases cannot be justified by the infrequent usage of such solutions. User interests can often be sufficiently satisfied by approximate (i.e., statistically accurate) answers. A just-in-time sampling-based system can, after consuming a small number of disk accesses, produce extremely accurate answers for a broad class of aggregate and top-k queries over a file system without the requirement of any prior knowledge. The system is efficient, accurate and scalable.
摘要翻译：随着文件系统达到PB级，用户和管理员越来越有兴趣获取用于文件管理和分析的高级分析信息。两个特别重要的任务是处理聚合和top-k查询，不幸的是不能通过分层文件系统（如ext3和NTFS）快速回答。现有的基于预处理的解决方案，例如文件系统爬行和索引构建，消耗了大量的时间和空间（用于生成和维护索引），这在许多情况下不能被这种解决方案的频繁使用所证明。用户兴趣通常可以通过近似（即统计准确的）答案来充分满足。基于时间抽样的系统可以在消耗少量磁盘访问后，通过文件系统为广泛的聚合和顶级查询提供非常准确的答案，而无需任何先前的知识。该系统是高效，准确和可扩展的。

10. 发明授权

US09086492B2 Concurrent DC-coupled anode and dynode readout scheme for PET block detectors 有权
标题翻译：并联DC耦合阳极和用于PET块检测器的倍增电极读出方案
公开(公告)号：US09086492B2
公开(公告)日：2015-07-21
申请号：US11753067
申请日：2007-05-24
申请人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi , Michael D. Loope
发明人： Nan Zhang , Matthias J. Schmand , Niraj K. Doshi , Michael D. Loope
IPC分类号： G01T1/00 , G01T1/164
CPC分类号： G01T1/1642 , G01T1/208
摘要： A scintillation detector including one or more photomultiplier tubes, a scintillation block optically attached to the photomultiplier tubes, and a DC-coupled bleeder circuit combining outputs of dynodes of the photomultipliers to provide a DC-coupled dynode output together with a DC-coupled anode output of the photomultiplier tubes. The DC-coupled bleeder circuit includes a RF transformer. A positive high voltage supply also can be used together with a DC-coupled bleeder circuit for the anode outputs.
摘要翻译：闪烁检测器，包括一个或多个光电倍增管，与光电倍增管光学连接的闪烁块，以及组合光电倍增管的倍增电极输出的DC耦合泄放电路，以提供DC耦合的倍增电极输出以及直流耦合的阳极输出的光电倍增管。直流耦合放电电路包括RF变压器。阳极高压电源也可以与阳极输出的直流耦合泄放电路一起使用。

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