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1. 发明授权

US07069069B2 Implantable cardiac device for and method of monitoring progression or regression of heart disease by quantifying morphological features 失效
标题翻译：通过量化形态学特征可植入心脏装置和监测心脏病进展或消退的方法
公开(公告)号：US07069069B2
公开(公告)日：2006-06-27
申请号：US10094929
申请日：2001-12-06
申请人： Matthew G. Fishler , Eric Falkenberg , Drew Hoffmann
发明人： Matthew G. Fishler , Eric Falkenberg , Drew Hoffmann
IPC分类号： A61B5/0472
CPC分类号： A61B5/0031 , A61B5/0006 , A61B5/0452
摘要： An implantable cardiac device and method provides for monitoring a progression or regression in heart disease during an extended time period. A sensor generates an electrogram signal representing electrical activity of a patient's heart. From the generated electrogram signal, a processor determines morphology measurements wherein the morphology measurements indicate a progression or regression in the heart disease. The morphology measurements are stored in a memory during the extended period of time. A telemetry circuit transmits the stored morphology measurements to an external receiver for retrieval or display. The morphology measurements may be of electrogram intrinsic activity or evoked response activity characteristics.
摘要翻译：可植入心脏装置和方法提供在延长的时间段内监测心脏病的进展或消退。传感器产生表示患者心脏的电活动的电描记图信号。根据生成的电描记图信号，处理器确定形态学测量，其中形态学测量指示心脏病的进展或消退。形态测量在长时间内存储在存储器中。遥测电路将存储的形态测量值传输到外部接收器以进行检索或显示。形态学测量可以是电描记图内在活性或诱发反应活性特征。

2. 发明授权

US08630692B2 Method and implantable system for blood-glucose concentration monitoring using parallel methodologies 有权
标题翻译：使用并行方法进行血糖浓度监测的方法和植入式系统
公开(公告)号：US08630692B2
公开(公告)日：2014-01-14
申请号：US12433414
申请日：2009-04-30
申请人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
发明人： Brian Jeffrey Wenzel , Taraneh Ghaffari Farazi , Euljoon Park , Eric Falkenberg , Michael E. Benser
IPC分类号： A61B5/0205 , A61B5/0402 , A61B5/042 , A61B5/0452 , A61B5/145
CPC分类号： A61B5/0006 , A61B5/0205 , A61B5/04012 , A61B5/0428 , A61B5/0452 , A61B5/14532 , A61B5/14542 , A61B5/14551 , A61B5/1459 , A61B5/4836 , A61B5/4866 , A61B5/6846 , A61B5/686 , A61B5/7285 , A61B5/746
摘要： In an implantable medical device for monitoring glucose concentration in the blood, a blood-glucose concentration analysis is performed using correlations of blood-glucose concentration with measures of metabolic oxygen consumption including oxymetric, and/or temperature. Analysis of electrocardiographic data is used in a parallel method to detect and/or confirm the onset and/or existence and/or extent of hypoglycemia and/or hyperglycemia. Blood-glucose concentration calculation is enhanced by using the combination of the oxygen metabolism analysis and electrocardiographic analysis.
摘要翻译：在用于监测血液中葡萄糖浓度的可植入医疗装置中，使用血糖浓度与包括氧测量和/或温度在内的代谢氧消耗量的相关性进行血糖浓度分析。使用并行方法来分析心电图数据以检测和/或确认低血糖和/或高血糖症的发作和/或存在和/或程度。通过使用氧代谢分析和心电图分析的组合，提高血糖浓度计算。

3. 发明授权

US07519425B2 Tiered therapy for respiratory oscillations characteristic of Cheyne-Stokes respiration 有权
标题翻译： Cheyne-Stokes呼吸特征的分层治疗呼吸振荡
公开(公告)号：US07519425B2
公开(公告)日：2009-04-14
申请号：US10968730
申请日：2004-10-18
申请人： Michael Benser , Eric Falkenberg
发明人： Michael Benser , Eric Falkenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/36514 , A61N1/3601
摘要： An exemplary method includes delivering a maintenance therapy that aims to prevent occurrence of apnea, sensing information, based at least in part on the information, determining if apnea exists and, if apnea exists, delivering a termination therapy that aims to terminate the apnea. An exemplary implantable device includes an input for information pertaining to respiration and control logic to call for overdrive pacing at a first rate that aims to minimize occurrence of a respiratory condition, to analyze the information for occurrence of the respiratory condition and, upon occurrence of the respiratory condition, to call for overdrive pacing at a higher rate. Other exemplary methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括：至少部分地基于信息来确定是否存在呼吸暂停，并且如果存在呼吸暂停，则提供旨在防止呼吸暂停发生的感测信息，感测信息，传递旨在终止呼吸暂停的终止疗法。示例性可植入装置包括用于与呼吸和控制逻辑相关的信息的输入，以以旨在最小化呼吸状况发生的第一速率来呼叫超速起搏，分析呼吸状况发生的信息，并且在出现呼吸状况，以更高的速度呼叫超速起搏。还公开了其它示例性方法，装置，系统等。

4. 发明授权

US07386342B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
标题翻译：皮下心脏刺激装置提供抗心动过速起搏治疗和方法
公开(公告)号：US07386342B1
公开(公告)日：2008-06-10
申请号：US10937756
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

5. 发明授权

US07363081B1 System and method for providing preventive overdrive pacing and antitachycardia pacing using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置提供预防性超速起搏和抗心动过速起搏的系统和方法
公开(公告)号：US07363081B1
公开(公告)日：2008-04-22
申请号：US10657840
申请日：2003-09-08
申请人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
发明人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
IPC分类号： A61N1/362
CPC分类号： A61N1/3712 , A61N1/3624 , A61N1/3688 , A61N1/3714 , A61N1/395
摘要： Techniques for enabling both preventive overdrive pacing and antitachycardia pacing (ATP) within an implantable device are provided. The device gains the benefits of overdrive pacing for preventing the onset of a tachycardia and, if one nevertheless occurs, ATP is employed to terminate the tachycardia. In particular, a technique is provided for promptly detecting the onset of atrial tachycardia during preventive overdrive pacing based on loss of capture of atrial pacing pulses. A technique is also provided for using detection of loss of capture of atrial or ventricular pacing pulses to trigger automatic switching from overdrive pacing to ATP. A setup technique determines whether to enable the automatic switching from overdrive pacing to ATP within a particular patient. Also, techniques are provided for verifying loss of capture of atrial or ventricular backup pacing pulses and for detecting low amplitude ventricular fibrillation based on loss of capture of ventricular backup pacing pulses.
摘要翻译：提供了在植入式装置内实现预防性超速起搏和抗心动过速起搏（ATP）的技术。该装置获得超速起搏的好处，以防止心动过速的发作，并且如果仍然发生，则使用ATP来终止心动过速。特别地，提供了一种技术，用于基于心房起搏脉冲的捕获损失，在预防性超速起搏中及时检测心房心动过速的发生。还提供了一种技术，用于检测心房或心室起搏脉冲的捕获损失，以触发从过速起搏到ATP的自动切换。设置技术确定是否启用在特定患者内从过速起搏到ATP的自动切换。此外，提供了用于验证心房或心室起搏脉冲的捕获损失的技术，并且用于基于心室起搏脉冲的捕获损失来检测低振幅心室颤动。

6. 发明授权

US07340302B1 Treating sleep apnea in patients using phrenic nerve stimulation 有权
标题翻译：使用膈神经刺激治疗患者的睡眠呼吸暂停
公开(公告)号：US07340302B1
公开(公告)日：2008-03-04
申请号：US10951839
申请日：2004-09-27
申请人： Eric Falkenberg , Mark W. Kroll
发明人： Eric Falkenberg , Mark W. Kroll
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/3601 , A61N1/3627
摘要： An exemplary implantable cardiac device is programmed to administer pacing therapy that treats both congestive heart failure (CHF) and sleep apnea. To treat CHF, the exemplary device delivers pacing pulses of a first voltage level via a lead in the left-sided veins of the heart. During periods of apnea, the device occasionally increases the pulse voltage and delivers one or more phrenic nerve stimulation pulses via the same lead to stimulate the phrenic nerve. This awakens the respiratory system to minimize or prevent episodes of sleep apnea. In an exemplary method, one or more phrenic nerve stimulation pulses are applied in synchronization with the pacing frequency so that the sleep apnea therapy does not disturb the normal cardiac rhythm. Other exemplary devices and methods are also disclosed.
摘要翻译：将示例性可植入心脏装置编程为施用治疗充血性心力衰竭（CHF）和睡眠呼吸暂停的起搏疗法。为了治疗CHF，示例性装置通过心脏的左侧静脉中的引线提供第一电压电平的起搏脉冲。在呼吸暂停期间，该装置偶尔会增加脉搏电压，并通过相同的导线传送一个或多个膈神经刺激脉冲，以刺激膈神经。这唤醒呼吸系统以最小化或预防睡眠呼吸暂停发作。在示例性方法中，与起搏频率同步地施加一个或多个膈神经刺激脉冲，使得睡眠呼吸暂停治疗不会干扰正常的心律。还公开了其它示例性的装置和方法。

7. 发明授权

US07043301B1 Implantable cardiac stimulation system providing high output far-field pacing and method 失效
标题翻译：植入式心脏刺激系统提供高输出远场起搏和方法
公开(公告)号：US07043301B1
公开(公告)日：2006-05-09
申请号：US10269397
申请日：2002-10-11
申请人： Mark W. Kroll , Eric Falkenberg
发明人： Mark W. Kroll , Eric Falkenberg
IPC分类号： A61N1/368 , A61N1/36
CPC分类号： A61N1/3627 , A61N1/365
摘要： An implantable cardiac stimulation device provides therapy for hearts having severe conduction abnormalities such as hearts suffering from congestive heart failure. The implantable cardiac stimulation device includes a pulse generator that provides pacing pulses having energies greater than about 0.1 millijoules and a lead system including a far-field electrode configuration that applies the pacing pulses to the heart. The lead system may further provide a near-field pacing electrode configuration and the device switches between the near-field pacing electrode configuration and the far-field pacing electrode configuration responsive to the measurement of a hemodynamic parameter such as QRS width.
摘要翻译：可植入心脏刺激装置为具有严重传导异常的心脏（例如患有充血性心力衰竭的心脏）提供治疗。可植入心脏刺激装置包括脉冲发生器，其提供具有大于约0.1毫焦耳的能量的起搏脉冲和包括将起搏脉冲施加到心脏的远场电极配置的引导系统。引导系统还可以提供近场起搏电极配置，并且该装置响应于诸如QRS宽度的血液动力学参数的测量而在近场起搏电极配置和远场起搏电极配置之间切换。

8. 发明申请

US20050149138A1 System and method for determining optimal pacing sites based on myocardial activation times 审中-公开
标题翻译：基于心肌激活时间确定最佳起搏部位的系统和方法
公开(公告)号：US20050149138A1
公开(公告)日：2005-07-07
申请号：US10745841
申请日：2003-12-24
申请人： Xiaoyi Min , Michael Yang , Kevin Morgan , Eric Falkenberg
发明人： Xiaoyi Min , Michael Yang , Kevin Morgan , Eric Falkenberg
IPC分类号： A61B5/04 , A61N1/05 , A61N1/08 , A61N1/362 , A61N1/365 , A61N1/368 , A61N1/37
CPC分类号： A61N1/36514 , A61B5/04012 , A61N1/056 , A61N1/0587 , A61N1/08 , A61N1/3627
摘要： The optimal location for delivering pacing pulses to a given cardiac chamber (such as the left ventricle) is determined by identifying the last electrically or mechanically activated site within the chamber. For example, the last site within the left ventricular myocardium to depolarize during an intrinsic ventricular contraction triggered by an initial atrial depolarization is identified as being the optimal pacing location for the left ventricle. A pacing electrode is then implanted as close as possible to that location. The technique is particularly effective for use in identifying optimal epicardial pacing locations for mounting satellite pacing devices for use in delivering cardiac resynchronization therapy. However, the techniques may also be applied to identify locations for mounting endocardial electrodes as well. Capture thresholds may also be taken into account in determining the optimal location. Examples are described for both master/satellite pacing systems as well as biventricular single device systems.
摘要翻译：通过识别腔室内最后一个电或机械激活的位置来确定向给定心室（如左心室）输送起搏脉冲的最佳位置。例如，在由初始心房去极化触发的内在心室收缩期间左心室心肌内去极化的最后位置被确定为左心室的最佳起搏位置。然后将起搏电极植入尽可能靠近该位置。该技术特别有效地用于鉴定用于安装用于递送心脏再同步治疗的卫星起搏装置的最佳心外膜起搏位置。然而，这些技术也可以应用于识别用于安装心内膜电极的位置。在确定最佳位置时也可以考虑采集阈值。描述了主/卫星起搏系统以及双心室单一设备系统的示例。

9. 发明授权

US06904317B2 Method and apparatus for dynamically adjusting overdrive pacing parameters 失效
标题翻译：动态调整超速起搏参数的方法和装置
公开(公告)号：US06904317B2
公开(公告)日：2005-06-07
申请号：US10043472
申请日：2002-01-09
申请人： Joseph J. Florio , Gene A. Bornzin , Peter Boileau , Eric Falkenberg , Janice Barstad
发明人： Joseph J. Florio , Gene A. Bornzin , Peter Boileau , Eric Falkenberg , Janice Barstad
IPC分类号： A61N1/362 , A61N1/36
CPC分类号： A61N1/3621
摘要： Dynamic overdrive pacing adjustment techniques are described for use in implantable cardiac stimulation devices. In a first technique, an overdrive pacing unit of a microcontroller of the implantable device operates to optimize various control parameters that affect overdrive pacing so as to achieve a desired degree of overdrive pacing for the particular patient in which the stimulation device is implanted. Parameters to be optimized include the number of overdrive beats paced once overdrive pacing is trigged, the overdrive pacing response function, the recovery rate, and various base rates. The control parameters are adjusted in a hierarchical order of priority until the desired degree of overdrive pacing is achieved. Adjustment of the number of overdrive beats, the recovery rate, and various base rates is iteratively performed by using incremental numerical adjustments. Adjustment of the overdrive pacing response function may be performed by selecting among a set of fixed predetermined linear response functions. In a second technique, the overdrive pacing unit operates to optimize the shape of a single non-linear dynamic overdrive pacing response function so as to achieve the desired degree of overdrive pacing for the patient. The second technique may either be employed alone or in combination with the first, hierarchical optimization technique.
摘要翻译：动态超速起搏调节技术被描述用于可植入心脏刺激装置。在第一技术中，可植入装置的微控制器的过驱动起搏单元操作以优化影响过驱动起搏的各种控制参数，以便为其中植入刺激装置的特定患者达到期望程度的过速起搏。要优化的参数包括一旦超速起搏起搏起搏，超速起搏响应功能，恢复速率和各种基准速率起搏的过载跳动次数。控制参数以优先级的等级顺序进行调整，直到达到期望的过速起搏程度。通过使用增量数值调整迭代地执行过载跳动次数的调整，恢复率和各种基本速率。可以通过在一组固定的预定线性响应函数中进行选择来执行过速起搏响应功能的调整。在第二种技术中，超速起搏单元操作以优化单个非线性动态超速起搏响应功能的形状，以便达到病人期望程度的超速起搏起搏。第二种技术可以单独使用，也可以与第一层级优化技术结合使用。

10. 发明授权

US07925343B1 Subcutaneous implantable cardiac device system with low defibrillation thresholds and improved sensing 有权
标题翻译：具有低除颤阈值和改进感测的皮下植入式心脏装置系统
公开(公告)号：US07925343B1
公开(公告)日：2011-04-12
申请号：US11539576
申请日：2006-10-06
申请人： Xiaoyi Min , Scott Salys , Yougandh Chitre , Eric Falkenberg , Gene A. Bornzin
发明人： Xiaoyi Min , Scott Salys , Yougandh Chitre , Eric Falkenberg , Gene A. Bornzin
IPC分类号： A61N1/39
CPC分类号： A61N1/3956 , A61B5/04014 , A61B5/046 , A61B5/7203 , A61N1/0563 , A61N1/37288
摘要： A subcutaneous implantable cardiac device system applies defibrillation currents in pathways aligned with the heart's own electrical system to decrease defibrillation thresholds. In one implementation, one or more subcutaneous sensors detect ventricular fibrillation. Positioning of subcutaneous sensors and filtering result in improved sensing with reduced noise. A subcutaneous patch component of the system that is in communication with a subcutaneous pacemaker or cardioverter-defibrillator may perform the sensing and apply the defibrillation. The subcutaneous patch may include one or more electrodes that perform both sensing and defibrillation. Variations of the subcutaneous patch may include battery and capacitor for generating onboard defibrillation current and may also include a microprocessor for advanced programmable operation.
摘要翻译：皮下植入式心脏装置系统在与心脏自身的电气系统对准的途径中应用除颤电流以降低除颤阈值。在一个实施方案中，一个或多个皮下传感器检测心室颤动。皮下传感器的定位和过滤导致改进的感测，噪音降低。与皮下起搏器或心律转复除颤器连通的系统的皮下补片部件可以执行感测并施加除颤。皮下补片可以包括执行感测和除颤的一个或多个电极。皮下贴片的变化可以包括用于产生板上除颤电流的电池和电容器，并且还可以包括用于高级可编程操作的微处理器。

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