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1. 发明授权

US07386342B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
标题翻译：皮下心脏刺激装置提供抗心动过速起搏治疗和方法
公开(公告)号：US07386342B1
公开(公告)日：2008-06-10
申请号：US10937756
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/368
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

2. 发明授权

US07363081B1 System and method for providing preventive overdrive pacing and antitachycardia pacing using an implantable cardiac stimulation device 有权
标题翻译：使用可植入心脏刺激装置提供预防性超速起搏和抗心动过速起搏的系统和方法
公开(公告)号：US07363081B1
公开(公告)日：2008-04-22
申请号：US10657840
申请日：2003-09-08
申请人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
发明人： Mark W. Kroll , Eric Falkenberg , Paul A. Levine
IPC分类号： A61N1/362
CPC分类号： A61N1/3712 , A61N1/3624 , A61N1/3688 , A61N1/3714 , A61N1/395
摘要： Techniques for enabling both preventive overdrive pacing and antitachycardia pacing (ATP) within an implantable device are provided. The device gains the benefits of overdrive pacing for preventing the onset of a tachycardia and, if one nevertheless occurs, ATP is employed to terminate the tachycardia. In particular, a technique is provided for promptly detecting the onset of atrial tachycardia during preventive overdrive pacing based on loss of capture of atrial pacing pulses. A technique is also provided for using detection of loss of capture of atrial or ventricular pacing pulses to trigger automatic switching from overdrive pacing to ATP. A setup technique determines whether to enable the automatic switching from overdrive pacing to ATP within a particular patient. Also, techniques are provided for verifying loss of capture of atrial or ventricular backup pacing pulses and for detecting low amplitude ventricular fibrillation based on loss of capture of ventricular backup pacing pulses.
摘要翻译：提供了在植入式装置内实现预防性超速起搏和抗心动过速起搏（ATP）的技术。该装置获得超速起搏的好处，以防止心动过速的发作，并且如果仍然发生，则使用ATP来终止心动过速。特别地，提供了一种技术，用于基于心房起搏脉冲的捕获损失，在预防性超速起搏中及时检测心房心动过速的发生。还提供了一种技术，用于检测心房或心室起搏脉冲的捕获损失，以触发从过速起搏到ATP的自动切换。设置技术确定是否启用在特定患者内从过速起搏到ATP的自动切换。此外，提供了用于验证心房或心室起搏脉冲的捕获损失的技术，并且用于基于心室起搏脉冲的捕获损失来检测低振幅心室颤动。

3. 发明授权

US07340302B1 Treating sleep apnea in patients using phrenic nerve stimulation 有权
标题翻译：使用膈神经刺激治疗患者的睡眠呼吸暂停
公开(公告)号：US07340302B1
公开(公告)日：2008-03-04
申请号：US10951839
申请日：2004-09-27
申请人： Eric Falkenberg , Mark W. Kroll
发明人： Eric Falkenberg , Mark W. Kroll
IPC分类号： A61N1/00
CPC分类号： A61N1/3611 , A61N1/3601 , A61N1/3627
摘要： An exemplary implantable cardiac device is programmed to administer pacing therapy that treats both congestive heart failure (CHF) and sleep apnea. To treat CHF, the exemplary device delivers pacing pulses of a first voltage level via a lead in the left-sided veins of the heart. During periods of apnea, the device occasionally increases the pulse voltage and delivers one or more phrenic nerve stimulation pulses via the same lead to stimulate the phrenic nerve. This awakens the respiratory system to minimize or prevent episodes of sleep apnea. In an exemplary method, one or more phrenic nerve stimulation pulses are applied in synchronization with the pacing frequency so that the sleep apnea therapy does not disturb the normal cardiac rhythm. Other exemplary devices and methods are also disclosed.
摘要翻译：将示例性可植入心脏装置编程为施用治疗充血性心力衰竭（CHF）和睡眠呼吸暂停的起搏疗法。为了治疗CHF，示例性装置通过心脏的左侧静脉中的引线提供第一电压电平的起搏脉冲。在呼吸暂停期间，该装置偶尔会增加脉搏电压，并通过相同的导线传送一个或多个膈神经刺激脉冲，以刺激膈神经。这唤醒呼吸系统以最小化或预防睡眠呼吸暂停发作。在示例性方法中，与起搏频率同步地施加一个或多个膈神经刺激脉冲，使得睡眠呼吸暂停治疗不会干扰正常的心律。还公开了其它示例性的装置和方法。

4. 发明授权

US07043301B1 Implantable cardiac stimulation system providing high output far-field pacing and method 失效
标题翻译：植入式心脏刺激系统提供高输出远场起搏和方法
公开(公告)号：US07043301B1
公开(公告)日：2006-05-09
申请号：US10269397
申请日：2002-10-11
申请人： Mark W. Kroll , Eric Falkenberg
发明人： Mark W. Kroll , Eric Falkenberg
IPC分类号： A61N1/368 , A61N1/36
CPC分类号： A61N1/3627 , A61N1/365
摘要： An implantable cardiac stimulation device provides therapy for hearts having severe conduction abnormalities such as hearts suffering from congestive heart failure. The implantable cardiac stimulation device includes a pulse generator that provides pacing pulses having energies greater than about 0.1 millijoules and a lead system including a far-field electrode configuration that applies the pacing pulses to the heart. The lead system may further provide a near-field pacing electrode configuration and the device switches between the near-field pacing electrode configuration and the far-field pacing electrode configuration responsive to the measurement of a hemodynamic parameter such as QRS width.
摘要翻译：可植入心脏刺激装置为具有严重传导异常的心脏（例如患有充血性心力衰竭的心脏）提供治疗。可植入心脏刺激装置包括脉冲发生器，其提供具有大于约0.1毫焦耳的能量的起搏脉冲和包括将起搏脉冲施加到心脏的远场电极配置的引导系统。引导系统还可以提供近场起搏电极配置，并且该装置响应于诸如QRS宽度的血液动力学参数的测量而在近场起搏电极配置和远场起搏电极配置之间切换。

5. 发明授权

US08121680B2 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
标题翻译：皮下心脏刺激装置提供抗心动过速起搏治疗和方法
公开(公告)号：US08121680B2
公开(公告)日：2012-02-21
申请号：US12113895
申请日：2008-05-01
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/39
CPC分类号： A61N1/0504 , A61N1/3622 , A61N1/37252
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

6. 发明授权

US07565195B1 Failsafe satellite pacemaker system 有权
标题翻译：失速安全卫星起搏器系统
公开(公告)号：US07565195B1
公开(公告)日：2009-07-21
申请号：US11104383
申请日：2005-04-11
申请人： Mark W. Kroll , Eric S. Fain , Eric Falkenberg
发明人： Mark W. Kroll , Eric S. Fain , Eric Falkenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/3756
摘要： In one implementation, a failsafe method for implantable satellite pacemaker pacing is provided, which includes pacing with a satellite pacemaker and monitoring for a local pacing pulse with an other satellite pacemaker. This implementation further includes, pacing with a surrogate satellite pacemaker if the local pacing pulse is not detected by the other satellite pacemaker. Certain implementations may include transmitting a wireless signal from the other satellite pacemaker to a master pacemaker if the local pacing pulse is not detected by the other satellite pacemaker and using the master pacemaker to select the surrogate satellite pacemaker. Certain implementations may include monitoring for the local pacing pulse with a plurality of satellite and causing the plurality of satellite pacemakers to select the surrogate satellite pacemaker.
摘要翻译：在一个实施方案中，提供了一种用于植入式卫星起搏器起搏器的故障安全方法，其包括使用卫星起搏器起搏并且与另一个卫星起搏器监测局部起搏脉冲。该实施还包括如果另一个卫星起搏器没有检测到本地起搏脉冲，则可以用替代卫星起搏器进行起搏。如果局部起搏脉冲没有被另一个卫星起搏器检测到并且使用主起搏器来选择替代卫星起搏器，某些实现可以包括将无线信号从另一个卫星起搏器传输到主起搏器。某些实施方案可以包括用多个卫星监测局部起搏脉冲，并且使多个卫星起搏器选择替代卫星起搏器。

7. 发明授权

US07260433B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
公开(公告)号：US07260433B1
公开(公告)日：2007-08-21
申请号：US10937656
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/00 , A61B5/02 , A61B5/04
CPC分类号： A61N1/3627 , A61N1/0504 , A61N1/3702 , A61N1/37288 , A61N1/3756
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.

8. 发明授权

US07277755B1 Subcutaneous cardiac stimulation device providing anti-tachycardia pacing therapy and method 有权
标题翻译：皮下心脏刺激装置提供抗心动过速起搏治疗和方法
公开(公告)号：US07277755B1
公开(公告)日：2007-10-02
申请号：US10937623
申请日：2004-09-08
申请人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
发明人： Eric Falkenberg , Mark W. Kroll , Gene A. Bornzin
IPC分类号： A61N1/04 , A61N1/39 , A61N1/38
CPC分类号： A61N1/05 , A61N1/36071 , A61N1/36114 , A61N1/3622 , A61N1/3962
摘要： An implantable subcutaneous cardiac device includes at least two subcutaneous electrodes adapted for placement external to a heart beneath the skin of a patient. The device further includes an arrhythmia detector that detects a sustained tachyarrhythmia of the heart and a pulse generator that delivers anti-tachycardia pacing pulses to the subcutaneous electrodes in response to detection of a sustained tachyarrhythmia. The pacing pulses preferably have waveforms devoid of any exponential voltage decay and include rounded or substantially constant portions to minimize pain.
摘要翻译：植入式皮下心脏装置包括至少两个皮下电极，其适于放置在患者皮肤下方的心脏外部。该装置还包括检测心脏持续快速性心律失常的心律失常检测器和响应于持续快速性心律失常的检测而向皮下电极递送抗心动过速起搏脉冲的脉冲发生器。起搏脉冲优选具有没有任何指数电压衰减的波形，并且包括圆形或基本恒定的部分以最小化疼痛。

9. 发明授权

US07194304B1 Implantable cardiac defibrillation assembly including a self-evaluation system and method 失效
标题翻译：植入式心脏除颤组件包括自我评估系统和方法
公开(公告)号：US07194304B1
公开(公告)日：2007-03-20
申请号：US10702562
申请日：2003-11-05
申请人： Gene A. Bornzin , Eric Falkenberg , Mark W. Kroll , Gabriel A. Mouchawar
发明人： Gene A. Bornzin , Eric Falkenberg , Mark W. Kroll , Gabriel A. Mouchawar
IPC分类号： A61N1/365
CPC分类号： A61N1/3943
摘要： An implantable cardiac defibrillation assembly includes at least one implantable lead having a defibrillation electrode adapted for placement in a chamber of the heart. The lead includes a connector. The assembly further includes an implantable defibrillation device having a pulse generator that provides defibrillation pulses and that is configured to receive the connector to couple the defibrillation electrode to the pulse generator. The device further includes a system that evaluates and conditions the assembly to provide defibrillation therapy to the heart without requiring arrhythmia induction of the heart. The system may condition the device for defibrillation therapy by reforming the defibrillation output capacitor and evaluate defibrillation lead DC resistance, and R wave sensing and detection. In addition, the system may estimate defibrillation thresholds and electrical fields and condition the device by setting the device to provide an output voltage above the estimated threshold. All of the foregoing may be accomplished without inducing ventricular fibrillation.
摘要翻译：植入式心脏除颤组件包括至少一个可植入引线，其具有适于放置在心脏腔室中的除颤电极。引线包括一个连接器。组件还包括具有脉冲发生器的可植入除颤装置，该脉冲发生器提供除颤脉冲，并且被配置为接收连接器以将除颤电极耦合到脉冲发生器。该装置还包括一个系统，该系统评估和调节组件以向心脏提供除颤疗法，而不需要心律的心律失常诱导。该系统可以通过重整除颤输出电容器并评估去纤颤引导直流电阻和R波感测和检测来调节器件进行除颤治疗。此外，系统可以通过设置设备来提供高于估计阈值的输出电压来估计除颤阈值和电场并调节设备。所有上述可以在不引起心室颤动的情况下完成。

10. 发明授权

US07634313B1 Failsafe satellite pacemaker system 有权
公开(公告)号：US07634313B1
公开(公告)日：2009-12-15
申请号：US11104382
申请日：2005-04-11
申请人： Mark W. Kroll , Eric S. Fain , Eric Falkenberg
发明人： Mark W. Kroll , Eric S. Fain , Eric Falkenberg
IPC分类号： A61N1/00
CPC分类号： A61N1/37288 , A61N1/3756
摘要： In one implementation, a failsafe method for implantable satellite pacemaker pacing is provided, which includes pacing with a satellite pacemaker and monitoring for a local pacing pulse with an other satellite pacemaker. This implementation further includes, pacing with a surrogate satellite pacemaker if the local pacing pulse is not detected by the other satellite pacemaker. Certain implementations may include transmitting a wireless signal from the other satellite pacemaker to a master pacemaker if the local pacing pulse is not detected by the other satellite pacemaker and using the master pacemaker to select the surrogate satellite pacemaker. Certain implementations may include monitoring for the local pacing pulse with a plurality of satellite and causing the plurality of satellite pacemakers to select the surrogate satellite pacemaker.

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