专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5459049A Motilin-like polypeptide and use thereof 失效
标题翻译：胃动素样多肽及其用途
公开(公告)号：US5459049A
公开(公告)日：1995-10-17
申请号：US3688
申请日：1993-01-13
申请人： Masayasu Kurono , Takahiko Matani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Yuji Hayashi , Yohei Kobayashi , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Matani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Yuji Hayashi , Yohei Kobayashi , Kiichi Sawai
IPC分类号： A61K38/00 , C07K14/63 , C12N15/16 , C12N15/63 , C12N15/67
CPC分类号： C07K14/63 , A61K38/00 , C07K2319/02
摘要： A process for the preparation of a polypeptide of the formula ##STR1## wherein A' is Pro, Gly, Asp or Ser; B' is Gly, Asn or Ser; C is Gln, Glu or Asp; D is Asn, Glu or Asp; X' is a residue of amino acid other than Met; E is Gln, Lys or Arg, and Y' is a residue of homoserine or homoserine-lactone, as well as a recombinant DNA and expression plasmid for preparing the polypeptide.
摘要翻译：制备式Phe-Val-A'-Ile-Phe-Thr-Tyr-B'-Glu-Leu-C-TR-Arg-X'-Gln-Glu-Lys-Glu的多肽的方法 -Arg-D-Lys-Gly-EY'，其中A'为Pro，Gly，Asp或Ser; B'是Gly，Asn或Ser; C是Gln，Glu或Asp; D是Asn，Glu或Asp; X'是Met以外的氨基酸残基; E是Gln，Lys或Arg，Y'是高丝氨酸或高丝氨酸 - 内酯的残基，以及用于制备多肽的重组DNA和表达质粒。

2. 发明授权

US5432261A Motlin-like polypeptide and use thereof 失效
标题翻译： Motlin样多肽及其用途
公开(公告)号：US5432261A
公开(公告)日：1995-07-11
申请号：US943992
申请日：1992-09-11
申请人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Yuji Hayashi , Yohei Kobayashi , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Yuji Hayashi , Yohei Kobayashi , Kiichi Sawai
IPC分类号： A61K38/00 , C07K14/63 , C12N15/16 , C07K14/00
CPC分类号： C07K14/63 , A61K38/00 , C07K2319/02
摘要： A pharmaceutical composition for stimulating peristaltic contraction in the intestinal canal which contains a pharmaceutically acceptable carrier or excipient and an effective amount of a polypeptide, or a salt thereof, having a pharmacological activity similar to motilin. The polypeptide has the formula B.sub.1 -Z.sub.1 -A.sub.1 -Z.sub.2 -B.sub.2 -Thr-B.sub.3 -A.sub.2 -Glu-Z.sub.3 -C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-E-Y, with Z.sub.1,Z.sub.2 and Z.sub.3 each being an amino acid residue having a hydrophobic side-chain, A.sub.1 and A.sub.2 each being an amino acid residue such as Pro, Gly, Asn and Ser, B.sub.1, B.sub.2 and B.sub.3 are each an amino acid residue having a side-chain with an aromatic ring, C is Gln, Glu or Asp, D is Asn, Glu or Asp, X' is an amino acid residue other than Met, E is Gln, Lys or Arg, and Y is homoserine, homoserine-lactone or a peptide chain having amino acid residues not exceeding 10 and containing homoserine or homoserine-lactone at the C-terminal where the first amino acid of said peptide chain is other than Lys, Arg or Pro.
摘要翻译：一种用于刺激肠道蠕动收缩的药物组合物，其含有药学上可接受的载体或赋形剂和有效量的具有与胃动素相似的药理活性的多肽或其盐。该多肽具有式B1-Z1-A1-Z2-B2-Thr-B3-A2-Glu-Z3-C-Arg-X'-Gln-Glu-Lys-Glu-Arg-D-Lys-Gly-EY， Z 1，Z 2和Z 3各自为具有疏水侧链的氨基酸残基，A1和A2各自为氨基酸残基，例如Pro，Gly，Asn和Ser，B1，B2和B3各自为具有具有芳环的侧链，C是Gln，Glu或Asp，D是Asn，Glu或Asp，X'是Met以外的氨基酸残基，E是Gln，Lys或Arg，Y是高丝氨酸，高丝氨酸 β-内酯或氨基酸残基不超过10的肽链，并且在所述肽链的第一个氨基酸不是Lys，Arg或Pro的C末端含有高丝氨酸或高丝氨酸 - 内酯。

3. 发明授权

US5474913A Process for the preparation of motilin-like polypeptide and expression thereof 失效
标题翻译：制备胃动素样多肽及其表达的方法
公开(公告)号：US5474913A
公开(公告)日：1995-12-12
申请号：US9349
申请日：1993-01-26
申请人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Kiichi Sawai
IPC分类号： C12N15/09 , C07K14/63 , C12N15/16 , C12P21/02 , C12R1/19 , C07H21/04 , C12P15/00
CPC分类号： C07K14/63
摘要： Process for the preparation of motilin-like polypeptide, a recombinant DNA therefor, and a plasmid, in which the recombinant DNA is inserted.
摘要翻译：用于制备胃动素样多肽的方法，其重组DNA和插入重组DNA的质粒。

4. 发明授权

US5106735A Cloning of a DNA sequence encoding a Sarcophaga peregrina antibacterial polypeptide precursor 失效
标题翻译：克隆编码SARCOPHAGA PEREGRINA抗生素多肽前体的DNA序列
公开(公告)号：US5106735A
公开(公告)日：1992-04-21
申请号：US223304
申请日：1988-07-25
申请人： Shunji Natori , Haruo Takahashi , Kenichi Tanaka , Takahiko Mitani , Masayasu Kurono , Kiichi Sawai
发明人： Shunji Natori , Haruo Takahashi , Kenichi Tanaka , Takahiko Mitani , Masayasu Kurono , Kiichi Sawai
IPC分类号： C12N15/09 , A61K38/00 , C07K14/435 , C12N1/21 , C12N15/31 , C12P21/02
CPC分类号： C07K14/43577 , A61K38/00
摘要： A cloned single-strand DNA comprising nucleotide sequence which encodes an antibacterial polypeptide precursor, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a DNA fragment of the single- or double-strand DNA, a process for the preparation thereof, and a plasmid, in which the double-strand DNA or its fragment is inserted.

5. 发明授权

US5017486A Cloning of DNA encoding antibacterial polypeptide precursor 失效
标题翻译：克隆编码抗菌多肽前体的DNA
公开(公告)号：US5017486A
公开(公告)日：1991-05-21
申请号：US223305
申请日：1988-07-25
申请人： Kiichi Sawai , Shunji Natori , Haruo Takahashi , Kenichi Tanaka , Takahiko Mitani , Masayasu Kurono
发明人： Kiichi Sawai , Shunji Natori , Haruo Takahashi , Kenichi Tanaka , Takahiko Mitani , Masayasu Kurono
IPC分类号： C12N15/09 , A61K38/00 , C07K14/435
CPC分类号： C07K14/43577 , A61K38/00
摘要： A cloned single-strand DNA comprising nucleotide sequence which encodes an antibacterial polypeptide precursor, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a DNA fragment of the single- or double-strand DNA, a process for the preparation thereof, and a plasmid, in which the double-strand DNA or its fragment is inserted are disclosed.

6. 发明授权

US4985356A Cloning of DNA encoding human motilin precursor and expression of the precursor 失效
标题翻译：克隆编码人类胃动素前体的DNA和前体的表达
公开(公告)号：US4985356A
公开(公告)日：1991-01-15
申请号：US190849
申请日：1988-05-06
申请人： Kiichi Sawai , Jun Takeda , Yutaka Seino , Hiroo Imura , Kenichi Tanaka , Haruo Takahashi , Takahiko Mitani , Masayasu Kurono
发明人： Kiichi Sawai , Jun Takeda , Yutaka Seino , Hiroo Imura , Kenichi Tanaka , Haruo Takahashi , Takahiko Mitani , Masayasu Kurono
IPC分类号： C12N15/09 , C07H21/02 , C07H21/04 , C07K14/63 , C12N15/12 , C12P21/02
CPC分类号： C07K14/63
摘要： A cloned single-strand DNA comprising nucleotide sequence which encodes human motilin precursor, a cloned double-strand DNA consisting of the single-strand DNA and its complementary single-strand DNA, a fragment of the single- or double-strand DNA, a plasmid, in which the double-strand DNA or its fragment is integrated, as well as a process for the preparation of the single- or double-strand DNA.

7. 发明授权

US5428015A Vasoactive intestinal polypeptide analogues and use thereof 失效
标题翻译：血管活性肠多肽类似物及其用途
公开(公告)号：US5428015A
公开(公告)日：1995-06-27
申请号：US201092
申请日：1994-02-24
申请人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kiichi Sawai
IPC分类号： A61K38/00 , C07K14/575 , C07K7/08
CPC分类号： C07K14/57563 , A61K38/00
摘要： Vasoactive intestinal polypeptide (VIP) analogues and use thereof are disclosed. The VIP analogues are shown by the formula ofHis-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Ywherein X is a residue of amino acid other than methionine (Met); and Y is homoserine, homoserine-lactone, amidized homoserine, a residue reacted homoserine-lactone with a primary alkyl amine having carbon atoms not exceeding 20, or an optional polypeptide chain and containing an amidized homoserine at C-terminal.Each of the VIP analogues is employed as an effective ingredient for various medicines and a hair tonic, and more particularly curing an asthma and impotence.
摘要翻译：公开了血管活性肠肽（VIP）类似物及其用途。 VIP类似物以His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-X-Ala-Val-Lys-Lys -Tyr-Leu-Asn-Ser-Ile-Leu-Asn-Y其中X是甲硫氨酸以外的氨基酸残基（Met）; 并且Y是高丝氨酸，高丝氨酸 - 内酯，酰胺化高丝氨酸，残基与高丝氨酸 - 内酯与碳原子数不超过20的伯烷基胺反应，或任选的多肽链，并且在C-末端含有酰胺化的高丝氨酸。每种VIP类似物被用作各种药物和头发补品的有效成分，更特别地治疗哮喘和阳。。

8. 发明授权

US5468728A Use of orally absorbable motilin preparations to enhance motility of digestive tract 失效
标题翻译：使用口服可吸收的胃动素制剂以增强消化道的运动能力
公开(公告)号：US5468728A
公开(公告)日：1995-11-21
申请号：US117653
申请日：1993-09-08
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Makoto Sato , Hiroyuki Oowaki , Bunkichi Kato , Haruo Takahashi
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Makoto Sato , Hiroyuki Oowaki , Bunkichi Kato , Haruo Takahashi
IPC分类号： A61K9/00 , A61K38/22 , A61K47/20 , A61K47/26 , A61K38/00 , C07K5/00 , C07K7/00 , C07K17/00
CPC分类号： A61K47/26 , A61K38/2214 , A61K47/20 , A61K9/0043
摘要： A readily absorbable type of motilin preparation containing a motilin-like active substance and a surface active agent is provided, in which the motilin-like active substance is mainly L-leucine-13-motilin-homoserine, and the surface active agent is selected from the group consisting of a bile salt, saponin and a polyethylene glycol higher-alcohol ether for nasal administration purposes and is a peptide lytic enzyme inhibitor for oral administration purposes.
摘要翻译：提供了含有胃动素样活性物质和表面活性剂的易吸收型胃动素制剂，其中胃动素样活性物质主要是L-亮氨酸-13-促胃动素高丝氨酸，表面活性剂选自由胆汁盐，皂苷和聚乙二醇高级醇醚组成的组，用于鼻腔给药目的，并且是用于口服给药目的的肽溶解酶抑制剂。

9. 发明授权

US5376637A Pharmaceutical preparation containing vasoactive intestinal polypeptide or its analogue 失效
标题翻译：含有血管活性肠多肽或其类似物的药物制剂
公开(公告)号：US5376637A
公开(公告)日：1994-12-27
申请号：US868906
申请日：1992-04-16
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Makoto Sato , Haruo Takahashi , Hiroyuki Ohwaki
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Makoto Sato , Haruo Takahashi , Hiroyuki Ohwaki
IPC分类号： A61K38/22 , A61K38/55 , A61K47/42 , A61P1/00 , A61P1/04 , A61P5/00 , A61P9/08 , A61P9/12 , A61P11/08 , A61P13/02 , A61P15/00 , G11C13/04 , A61K37/00 , A61K37/02 , C07K5/00 , C07K7/00
CPC分类号： G11C13/04 , A61K31/24 , A61K38/2278
摘要： There is disclosed a pharmaceutical preparation which contains vasoactive intestinal polypeptide (VIP), its analogue or a salt thereof, and a surfactant. The preparation shall contains further a peptidase inhibitor. The composition is administrated to suppress allergies, reduce blood pressure, increase secretion of tear, cure asthma and impotence and others.
摘要翻译：公开了含有血管活性肠多肽（VIP），其类似物或其盐和表面活性剂的药物制剂。该制剂还含有肽酶抑制剂。施用组合物以抑制过敏，降低血压，增加泪液分泌，治愈哮喘和阳ence等。

10. 发明授权

US5260056A Composition for enhancing biosynthesis of interferon 失效
标题翻译：用于增强干扰素生物合成的组合物
公开(公告)号：US5260056A
公开(公告)日：1993-11-09
申请号：US640750
申请日：1991-01-14
申请人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
发明人： Kiichi Sawai , Masayasu Kurono , Takahiko Mitani , Naohisa Ninomiya , Yoshiro Ishiwata , Syoji Yokochi , Kyoichi Asano , Kaneo Yamada , Masashi Taki , Takashi Meguro , Mikio Minamitani , Takao Matumoto , Yuichi Shiokawa
IPC分类号： A61K31/28 , A61K31/70 , A61K37/66 , A61K31/79 , A61K59/16
CPC分类号： A61K31/28 , A61K31/70
摘要： An organic germanium compound to be effectively used for curing AIDS or making AIDS asymtomatic in various forms is expressed by the following rational formula: ##STR1## wherein n is an integer of 1 or 2 or more, is in the form of a white acicular or needle crystal, shows a solubility of 1.570/100 ml in water at 25.degree. C. and exhibits a melting (decomposition) point of 240.degree. C.
摘要翻译：有效地用于治疗AIDS或以各种形式产生AIDS的有机锗化合物由以下有理式表示：其中n为1或2或更大的整数，为白色针状或针状结晶，在25℃的水中的溶解度为1.570 / 100ml，熔点（分解）为240℃。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式