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1. 发明授权

US09322829B2 Stabilized bioactive peptides and methods of identification, synthesis, and use 有权
标题翻译：稳定的生物活性肽和鉴定，合成和使用的方法
公开(公告)号：US09322829B2
公开(公告)日：2016-04-26
申请号：US13861732
申请日：2013-04-12
申请人： Peptide BioSciences, Inc.
发明人： Elliot Altman
IPC分类号： C12N15/63 , A61K38/46 , G01N33/68 , C07K7/06 , C07K7/08 , C07K7/14 , C07K14/195 , C07K14/245 , C07K14/425 , C07K14/585 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/645 , C12N15/10 , C12N15/62 , C12N15/67 , C12N15/72 , C40B40/02 , G01N33/50 , A61K38/00
CPC分类号： G01N33/5008 , C07K7/06 , C07K7/08 , C07K7/14 , C07K14/195 , C07K14/245 , C07K14/425 , C07K14/435 , C07K14/43536 , C07K14/43568 , C07K14/43572 , C07K14/463 , C07K14/575 , C07K14/58 , C07K14/585 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/63 , C07K14/645 , C07K14/655 , C07K14/665 , C07K2319/00 , C12N15/1037 , C12N15/62 , C12N15/635 , C12N15/67 , C12N15/72 , C40B40/02 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/68 , G01N33/6845
摘要： An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues.
摘要翻译：细胞内选择系统允许筛选肽的生物活性和稳定性。在紧密调节的表达系统中筛选随机重组肽的生物活性，优选衍生自野生型lac操纵子。因此鉴定的生物活性肽本身就是蛋白酶和肽酶抗性。还提供了在N末端，C末端或两者均由稳定基团稳定的生物活性肽。稳定基团可以是小的稳定蛋白质，例如Rop蛋白质，谷胱甘肽磺基转移酶，硫氧还蛋白，麦芽糖结合蛋白或谷胱甘肽还原酶，α-螺旋部分或一个或多个脯氨酸残基。

2. 发明授权

US08440201B2 Stabilized bioactive peptides and methods of identification, synthesis, and use 有权
公开(公告)号：US08440201B2
公开(公告)日：2013-05-14
申请号：US13222721
申请日：2011-08-31
申请人： Elliot Altman
发明人： Elliot Altman
IPC分类号： C07K14/00 , A61K38/46 , A61K38/00
CPC分类号： G01N33/5008 , C07K7/06 , C07K7/08 , C07K7/14 , C07K14/195 , C07K14/245 , C07K14/425 , C07K14/435 , C07K14/43536 , C07K14/43568 , C07K14/43572 , C07K14/463 , C07K14/575 , C07K14/58 , C07K14/585 , C07K14/59 , C07K14/605 , C07K14/61 , C07K14/62 , C07K14/63 , C07K14/645 , C07K14/655 , C07K14/665 , C07K2319/00 , C12N15/1037 , C12N15/62 , C12N15/635 , C12N15/67 , C12N15/72 , C40B40/02 , G01N33/5011 , G01N33/5014 , G01N33/502 , G01N33/68 , G01N33/6845
摘要： An intracellular selection system allows screening for peptide bioactivity and stability. Randomized recombinant peptides are screened for bioactivity in a tightly regulated expression system, preferably derived from the wild-type lac operon. Bioactive peptides thus identified are inherently protease- and peptidase-resistant. Also provided are bioactive peptides stabilized by a stabilizing group at the N-terminus, the C-terminus, or both. The stabilizing group can be a small stable protein, such as the Rop protein, glutathione sulfotransferase, thioredoxin, maltose binding protein, or glutathione reductase, an α-helical moiety, or one or more proline residues.

3. 发明授权

US07445919B2 Zsig33-like peptides and polynucleotides 有权
标题翻译： Zsig33样肽和多核苷酸
公开(公告)号：US07445919B2
公开(公告)日：2008-11-04
申请号：US10921371
申请日：2004-08-19
申请人： Stephen R. Jaspers , Paul O. Sheppard
发明人： Stephen R. Jaspers , Paul O. Sheppard
IPC分类号： C12N9/00 , C12N15/00 , C07H21/04 , C12Q1/00 , C12P21/04
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to polynucleotide related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译：本发明涉及与zsig33肽相关的多核苷酸，包括激动剂，拮抗剂和抗体。还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。

4. 发明申请

US20050009205A1 Fluorescent ligands for GPCR arrays 审中-公开
标题翻译： GPCR阵列的荧光配体
公开(公告)号：US20050009205A1
公开(公告)日：2005-01-13
申请号：US10741213
申请日：2003-12-19
申请人： Ye Fang , Yulong Hong , Jinlin Peng
发明人： Ye Fang , Yulong Hong , Jinlin Peng
IPC分类号： C07K7/08 , C07K14/63 , G01N33/543
CPC分类号： G01N33/582 , C07K7/083 , C07K14/63 , G01N33/6845 , G01N33/74 , G01N2333/63 , G01N2333/726
摘要： A fluorescent ligand includes a material having a binding affinity in the range of about 0.01 to about 25 nM, or about 0.1 to about 10 nM; a specificity to its cognate receptor in the range of about 50 to about 99%, or about 65 to about 99%; a cross-activity to other receptors of 0 to about 20%, or 0 to about 10%; a net charge per ligand of about −3 to about +5, or more preferably, about −2 to about +2 or most preferably for small compound ligands about −1 to about +2. The ligand may also have a hydrophobicity in the range of about 3 to about 55 minutes eluting time (as measured under specified eluting conditions). In some embodiments, the ligand including fluorescently labeled motilin 1-16 labeled with Bodipy-TMR, rhodamine or Cy5-. Other embodiments include fluorescently labeled Cy5-naltrexone, Cy5-neurotensin 2-13, N-terminal labeled neurotensin 2-13 or lys-labeled labeled neurotensin 2-13.
摘要翻译：荧光配体包括具有约0.01至约25nM，或约0.1至约10nM范围内的结合亲和力的材料; 在约50至约99％，或约65至约99％的范围内对其同源受体的特异性; 与其他受体的交叉活性为0至约20％，或0至约10％; 每个配体的净电荷为约-3至约+5，或更优选约-2至约+2，或最优选约为-1至约+2的小化合物配体。配体还可以具有约3至约55分钟洗脱时间（在规定的洗脱条件下测量）的疏水性。在一些实施方案中，配体包括用Bodipy-TMR，罗丹明或Cy5-标记的荧光标记的胃动素1-16。其他实施方案包括荧光标记的Cy5-纳曲酮，Cy5-神经丝氨酸2-13，N-末端标记的神经丝氨酸蛋白酶2-13或lys-标记的标记的神经丝氨酸素2-13。

5. 发明授权

US5474913A Process for the preparation of motilin-like polypeptide and expression thereof 失效
标题翻译：制备胃动素样多肽及其表达的方法
公开(公告)号：US5474913A
公开(公告)日：1995-12-12
申请号：US9349
申请日：1993-01-26
申请人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Kiichi Sawai
发明人： Masayasu Kurono , Takahiko Mitani , Haruo Takahashi , Kenichi Tanaka , Katsuya Fujimura , Kiichi Sawai
IPC分类号： C12N15/09 , C07K14/63 , C12N15/16 , C12P21/02 , C12R1/19 , C07H21/04 , C12P15/00
CPC分类号： C07K14/63
摘要： Process for the preparation of motilin-like polypeptide, a recombinant DNA therefor, and a plasmid, in which the recombinant DNA is inserted.
摘要翻译：用于制备胃动素样多肽的方法，其重组DNA和插入重组DNA的质粒。

6. 发明授权

US09657323B2 Polypeptide cleavage method using OmpT protease variant 有权
公开(公告)号：US09657323B2
公开(公告)日：2017-05-23
申请号：US10573821
申请日：2004-09-29
申请人： Kazuaki Okuno , Masayuki Yabuta
发明人： Kazuaki Okuno , Masayuki Yabuta
IPC分类号： C12N9/52 , C12P21/06 , C07K14/585 , C07K14/63 , C07K14/695
CPC分类号： C12P21/06 , C07K14/585 , C07K14/63 , C07K14/695 , C12N9/52
摘要： A polypeptide cleavage method characterized in that arginine or lysine is at the P1 position of a desired cleavage site in a polypeptide, an amino acid other than aspartic acid, glutamic acid or proline is at the P1′ position, a single basic amino acid or two or three consecutive basic amino acids are situated at any site in the amino acid sequence from the P10 position to the P3 position or from the P3′ position to the P5′ position (with the proviso that a single basic amino acid is not situated at the P6 or P4 position), and OmpT protease or its variant enzyme having a substitution at the 97th amino acid from the N-terminus is used to cleave the desired cleavage site in the polypeptide.

7. 发明申请

US20130296240A1 PNEUMONIA BIOMARKERS 审中-公开
公开(公告)号：US20130296240A1
公开(公告)日：2013-11-07
申请号：US13844449
申请日：2013-03-15
申请人： Christopher Joseph PEMBERTON , Arthur Mark RICHARDS , Mathew Simon BYERS
发明人： Christopher Joseph PEMBERTON , Arthur Mark RICHARDS , Mathew Simon BYERS
IPC分类号： G01N33/74 , C07K16/26 , C07K14/575
CPC分类号： G01N33/74 , C07K14/575 , C07K14/63 , C07K16/26 , G01N33/6893 , G01N2800/12 , G01N2800/325
摘要： Ghrelin signal peptide fragment assays and kits useful in the diagnosis, prognosis, risk stratification, assessing, staging, monitoring, categorizing and determination of further diagnoses and treatment regimens in subjects with various disorders, diseases and conditions including, pneumonia, heart failure, or pneumonia and heart failure or suspected pneumonia, heart failure, or pneumonia and heart failure, and methods for monitoring treatment.
摘要翻译：生长激素释放肽信号肽片段测定和试剂盒可用于各种疾病，疾病和病症（包括肺炎，心力衰竭或肺炎）的受试者的诊断，预后，风险分层，评估，分期，监测，分类和确定其他诊断和治疗方案心力衰竭或疑似肺炎，心力衰竭，肺炎和心力衰竭以及监测治疗方法。

8. 发明申请

US20100305031A1 PEPTIDE HAVING AN EXTENDING ACTION FOR HALF-LIFE OF OBJECT PEPTIDE IN PLASMA 有权
标题翻译：具有等离子体对象肽半衰期的延伸作用的肽
公开(公告)号：US20100305031A1
公开(公告)日：2010-12-02
申请号：US12675961
申请日：2009-05-22
申请人： Naomi Wakabayashi , Sato Seiji
发明人： Naomi Wakabayashi , Sato Seiji
IPC分类号： A61K38/08 , C07K7/06 , C07K7/08 , C07K14/00 , C07K14/435 , A61K38/10 , A61K38/16 , A61P9/00 , A61P19/02 , A61P3/10
CPC分类号： C07K14/00 , A61K47/62 , C07K14/58 , C07K14/63 , C07K16/26 , C07K2319/31
摘要： A peptide of the following (I) or (II). (I) a peptide represented by the formula B, A-B, B-C or A-B-C in which A, B and C each is represented by the following (1), (2) and (3) and, when it is bonded to other object peptide, it is able to extent the half-life in plasma as compared with the object peptide where the physiological activity of the object peptide is still retained. (II) a peptide comprising a reversed sequence of the peptide of (I); a sequence which is represented by A-B in (I) and A or B is reversed; a sequence which is represented by B-C in (I) and B or C is reversed; or a sequence which is represented by A-B-C in (I) and A, B, C, A and B, B and C or A and C is reserved. (1) A is a peptide comprising 1 to 14 of any amino acid(s) (2) B is a peptide represented by the formula 1: (Wk-Xl-Y-Zm-Wn)-(Wo-Xp-Y-Zq-Wr)s (In the formula 1, W is a basic amino acid; X and Z are any amino acids; Y is an acidic amino acid; k is 1 or 2; l is an integer of 4≧l≧0; m is an integer of 2≧m≧0; 4≧l+m≧0; n is 1 or 2; o is 1 or 2; p is an integer of 4≧p≧0; q is an integer of 2≧q≧0; 4≧p+q≧0; r is 1 or 2; and s is 0 or 1.) (3) C is a peptide comprising 2 to 14 of any amino acids.
摘要翻译：下列（I）或（II）的肽。（I）由式B，AB，BC或ABC表示的肽，其中A，B和C各自由以下（1），（2）和（3）表示，并且当其结合到其它目标肽与目标肽的生理活性仍然保留的目标肽相比，能够调节血浆中的半衰期。（II）包含（I）的肽的逆序列的肽; （I）和A或B中的A-B表示的序列相反; 由（I）中的B-C和B或C表示的序列相反; 或由A，B，C，A和B，B和C或A和C中的A-B-C表示的序列被保留。（1）A是包含1至14个任意氨基酸的肽（2）B是由式1表示的肽：（Wk-X1-Y-Zm-Wn） - （Wo-Xp-Y- Zq-Wr）s（式1中，W为碱性氨基酸，X为Z为任意氨基酸，Y为酸性氨基酸，k为1或2，l为4≥1≥0的整数。 m是2≥m≥0的整数;4≥1+m≥0; n是1或2; o是1或2; p是4≥P≥0的整数; q是2≥q的整数 ≥0;4≥p+q≥0; r为1或2; s为0或1.）（3）C为任意氨基酸2〜14个的肽。

9. 发明申请

US20050208626A1 SGIP peptides 审中-公开
标题翻译： SGIP肽
公开(公告)号：US20050208626A1
公开(公告)日：2005-09-22
申请号：US11133912
申请日：2005-05-19
申请人： Paul Sheppard , Stephen Jaspers , Theresa Deisher , Paul Bishop
发明人： Paul Sheppard , Stephen Jaspers , Theresa Deisher , Paul Bishop
IPC分类号： A61K38/00 , C07H21/04 , C07K7/06 , C07K7/08 , C07K14/47 , C07K14/575 , C07K14/63
CPC分类号： C07K7/06 , A61K38/00 , C07K14/47 , C07K14/575 , C07K14/63
摘要： The present invention is directed to polynucleotides, polypeptides, peptides, variants and uses thereof for novel peptide fragments which have homology to motilin. Tissue distribution of the mRNA for the novel polypeptide fragment is specific to the stomach, small intestine and pancreas. Binding of the peptide fragment has been shown in kidney and small intestine. The present invention further includes agonists, antagonists, variants, antibodies and host cells expressing the cDNA encoding the novel SGIP peptide.
摘要翻译：本发明涉及与胃动素同源的新型肽片段的多核苷酸，多肽，肽，变体和用途。新型多肽片段的mRNA的组织分布特异于胃，小肠和胰腺。肽片段的结合已显示在肾脏和小肠中。本发明还包括表达编码新型SGIP肽的cDNA的激动剂，拮抗剂，变体，抗体和宿主细胞。

10. 发明申请

US20020055156A1 Zsig33-like peptides 有权
标题翻译： Zsig33样肽
公开(公告)号：US20020055156A1
公开(公告)日：2002-05-09
申请号：US09853253
申请日：2001-05-10
发明人： Stephen R. Jaspers , Paul O. Sheppard , Theresa A. Deisher , Paul D. Bishop
IPC分类号： C12N009/00 , C07H021/04 , C12P021/02 , C12N005/06
CPC分类号： C07K14/63 , A61K38/00 , C07K14/575
摘要： The present invention relates to peptides related to the zsig33 peptide, including agonists, antagonists, and antibodies. Methods of modulating gastric contractility, nutrient uptake, growth hormones, the secretion of digestive enzymes and hormones, and/or secretion of enzymes and/or hormones in the pancreas are also included.
摘要翻译：本发明涉及与zsig33肽相关的肽，包括激动剂，拮抗剂和抗体。还包括调节胃收缩力，营养摄取，生长激素，消化酶和激素分泌和/或胰腺中酶和/或激素分泌的方法。

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