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1. 发明授权

US6111115A Preparation of 2-(10,11-dihydro-10-oxodibenzo-[b,f]thiepin-2-yl) propionic acid 失效
标题翻译：制备2-（10,11-二氢-10-氧代二苯并[b，f]硫杂-2-基）丙酸
公开(公告)号：US6111115A
公开(公告)日：2000-08-29
申请号：US242483
申请日：1999-02-17
申请人： Masao Yamamoto , Kunio Kobayashi , Katsumasa Harada , Shigeyoshi Nishino , Hiroshi Sasaki
发明人： Masao Yamamoto , Kunio Kobayashi , Katsumasa Harada , Shigeyoshi Nishino , Hiroshi Sasaki
IPC分类号： C07D337/14 , C07C205/56 , C07C229/40 , C07C323/62 , C07C205/00 , C07C229/00
CPC分类号： C07D337/14
摘要： A process for preparation of 2-(10,11-dihydro-10-oxodibenzo[b,f]thiepin-2-yl)propionic acid (i.e., Zaltoprofen) is performed by subjecting 2-(4-amino-3-carboxy-methylphenyl)propionic acid or its salt to diazotization and subsequent reaction with thiophenol to produce 2-(3-carboxymethyl-4-phenylthiophenyl)propionic acid or its salt, and subjecting the product to cyclization reaction. Other related processes and related compounds are also disclosed.
摘要翻译： PCT No.PCT / JP97 / 02922 Sec。 371日期1999年2月17日 102（e）日期1999年2月17日PCT提交1997年8月22日PCT公布。第WO98 / 07717号公报日期：1998年2月26日制备2-（4-甲氧基二苯并[b，f]硫杂-2-基）丙酸（即扎洛芬）的方法， -3-羧基 - 甲基苯基）丙酸或其盐进行重氮化，随后与苯硫酚反应，生成2-（3-羧甲基-4-苯硫基苯基）丙酸或其盐，并使产物环化反应。还公开了其它相关方法和相关化合物。

2. 发明授权

US07598254B2 Substituted 1,3-thiazolo[5,4-d]pyrimidines as xanthine oxidase inhibitors 有权
标题翻译：取代的1,3-噻唑并[5,4-d]嘧啶黄嘌呤氧化酶抑制剂
公开(公告)号：US07598254B2
公开(公告)日：2009-10-06
申请号：US11629277
申请日：2005-06-13
申请人： Shinichi Yoshida , Kunio Kobayashi , Nobutaka Mochiduki , Tomio Yamakawa , Tadashi Kobayashi , Yoriko Shinohara
发明人： Shinichi Yoshida , Kunio Kobayashi , Nobutaka Mochiduki , Tomio Yamakawa , Tadashi Kobayashi , Yoriko Shinohara
IPC分类号： C07D513/04 , A61K31/519 , A61P19/06 , C07D515/04
CPC分类号： C07D513/04 , C07D498/04
摘要： The invention relates to compounds of the following formula (I) or their salts: in which R1 is a group of phenyl, naphthyl, pyridyl or the like which may have a substituent such as an alkyl group having 1-8 carbon atoms, an alkoxy group having 1-8 carbon atoms, an alkoxycarbonyl group having 2-8 carbon atoms, carboxyl, halogen, hydroxyl, nitro, or cyano; R2 is cyano, nitro, or the like; R3 is hydroxyl or the like; X is oxygen, sulfur, or the like; and Y is oxygen or sulfur, and a xanthine oxidase inhibitor containing the compound.
摘要翻译：本发明涉及下式（I）的化合物或其盐：其中R 1为可具有取代基的苯基，萘基，吡啶基等基团，例如具有1-8个碳原子的烷基，烷氧基具有1-8个碳原子的基团，具有2-8个碳原子的烷氧基羰基，羧基，卤素，羟基，硝基或氰基; R2是氰基，硝基等; R3是羟基等; X是氧，硫等; Y为氧或硫，含有该化合物的黄嘌呤氧化酶抑制剂。

3. 发明申请

US20090030041A1 N-substituted N-(4-piperidinyl) Amide Derivative 审中-公开
标题翻译： N-取代的N-（4-哌啶基）酰胺衍生物
公开(公告)号：US20090030041A1
公开(公告)日：2009-01-29
申请号：US11662633
申请日：2005-09-13
申请人： Toshihiro Takahashi , Tsuyoshi Endo , Masatoshi Ushioda , Kunio Kobayashi , Tomio Yamakawa , Kiichi Shika , Toru Kawasaki , Toshiyasu Imai , Kenji Hirate , Takako Hirate
发明人： Toshihiro Takahashi , Tsuyoshi Endo , Masatoshi Ushioda , Kunio Kobayashi , Tomio Yamakawa , Kiichi Shika , Toru Kawasaki , Toshiyasu Imai , Kenji Hirate , Takako Hirate
IPC分类号： A61K31/4525 , C07D405/02 , A61P25/04
CPC分类号： C07D211/58 , C07D405/12 , C07D409/12
摘要： An N-substituted N-(4-piperininyl)amide derivative represented by the following formula (I): (wherein R1 represents C1-6 alkyl, furyl, etc.; R2 represents amino, acetylamino, ureido, etc.; R3 represents hydrogen, C2-8 alkoxycarbonyl, etc.; R4 represents optionally substituted phenyl, etc.; R5 represents hydroxyl, benzyloxy, etc.; R6 represents hydrogen or methyl; and m is 1 or 2) or a salt of the derivative, and an analgesic containing the derivative or salt.
摘要翻译：由下式（I）表示的N-取代的N-（4-哌啶基）酰胺衍生物：其中R1表示C1-6烷基，呋喃基等; R2表示氨基，乙酰氨基，脲基等; R3表示氢，C 2-8烷氧基羰基等; R 4表示任选取代的苯基等; R 5表示羟基，苄氧基等; R 6表示氢或甲基; m表示1或2）或该衍生物的盐，以及镇痛剂含有衍生物或盐。

4. 发明授权

US6163145A Transporting apparatus for semiconductor device 失效
标题翻译：半导体器件输送装置
公开(公告)号：US6163145A
公开(公告)日：2000-12-19
申请号：US917922
申请日：1997-08-27
申请人： Hiromichi Yamada , Kunio Kobayashi , Sekio Ito , Eiri Yuhara , Shinji Semba , Jiro Takamura , Shinji Sogabe , Hiroyuki Shinmen , Mitsuru Yamazaki
发明人： Hiromichi Yamada , Kunio Kobayashi , Sekio Ito , Eiri Yuhara , Shinji Semba , Jiro Takamura , Shinji Sogabe , Hiroyuki Shinmen , Mitsuru Yamazaki
IPC分类号： G01R31/26 , G01R1/067 , G01R1/04 , B65G59/02 , G01R31/02
CPC分类号： G01R1/06705
摘要： A transporting apparatus used in testing a plurality of semiconductor devices includes a magazine in which a plurality of pallets are stacked in plural stages, each pallet with a plurality of semiconductor device placed thereon; a distributing stocker mechanism for placing the plurality of pallets in the magazine onto a carrier; a carrier transporting mechanism for transporting the carrier into a test station in a constant temperature room and transporting the carrier after to outside the constant temperature room; and a recovery stocker mechanism for recovering the plurality of pallets after test on the carrier into the magazine. Thus, the transporting apparatus with high installing area efficiency and high test efficiency can be fabricated at low production cost.
摘要翻译：用于测试多个半导体器件的传送装置包括多个托盘以多个层叠的盒子，每个托盘上放置有多个半导体器件; 用于将所述多个托盘放置在所述盒中的分配储存器机构到载体上; 载体输送机构，用于将载体输送到恒温室内的试验台，并将载体运送到恒温室外; 以及回收储存器机构，用于在载体上测试之后将多个托盘回收到料盒中。因此，可以以低生产成本制造具有高安装面积效率和高测试效率的输送装置。

5. 发明授权

US5936418A Semiconductor device socket 失效
标题翻译：半导体器件插座
公开(公告)号：US5936418A
公开(公告)日：1999-08-10
申请号：US845473
申请日：1997-04-25
申请人： Yasushi Ideta , Akihiro Washitani , Tsunenori Umetsu , Keiko Kaneko , Kunio Kobayashi
发明人： Yasushi Ideta , Akihiro Washitani , Tsunenori Umetsu , Keiko Kaneko , Kunio Kobayashi
IPC分类号： G01R31/26 , H01L23/32 , H01R33/76 , H01R33/965 , H05K7/10 , G01R31/02 , H01R11/22
CPC分类号： H05K7/1023
摘要： A semiconductor device socket prevents adhesion of foreign material to mounting surfaces of external leads of a semiconductor device. A positioning base of the socket supports external leads of the semiconductor device such that the lead ends of the leads do not contact a body of the socket. Movable contact terminals of the socket disposed opposite the external leads can move into and out of contact with the external leads.
摘要翻译：半导体器件插座防止异物粘附到半导体器件的外部引线的安装表面。插座的定位座支持半导体器件的外部引线，使得引线的引线端不接触插座的本体。与外部引线相对设置的插座的可移动接触端子可以移动进入外部引线和与外部引线接触。

6. 发明授权

US5565008A Process of raising a semiconductor device out of a pallet using a positioning rod 失效
标题翻译：使用定位杆将半导体器件从托盘上升出的过程
公开(公告)号：US5565008A
公开(公告)日：1996-10-15
申请号：US234595
申请日：1994-04-28
申请人： Kunihiro Shigetomo , Jiro Takamura , Kunio Kobayashi , Kiyoji Imanaka
发明人： Kunihiro Shigetomo , Jiro Takamura , Kunio Kobayashi , Kiyoji Imanaka
IPC分类号： B65D85/86 , B65D85/38 , B65G47/74 , H01L21/50 , H01L21/673 , H01L21/677 , H01L21/68 , H01L23/00 , H05K13/00 , H01L21/58
CPC分类号： H05K13/0084 , Y10T29/41
摘要： A method of manufacturing semiconductor devices includes accommodating the semiconductor devices in the form of semimanufactures in accomodating tools having uniform outer dimensions regardless of the type of the semiconductor devices; receiving the semiconductor devices in the form of semimanufactures in each of a plurality of processing devices while maintaining the semiconductor devices in the accomodating tools; and processing the semiconductor devices in the form of semimanufactures in each of a plurality of processing devices.
摘要翻译：一种制造半导体器件的方法包括以半制造的形式容纳具有均匀外形尺寸的工具的半导体器件，而与半导体器件的类型无关; 在将所述半导体器件保持在所述适应工具中的同时，在多个处理装置的每一个中接收半制造形式的半导体器件; 以及在多个处理装置中的每一个中以半制造形式处理半导体器件。

7. 发明授权

US08962613B2 P2X4 receptor antagonist 有权
标题翻译： P2X4受体拮抗剂
公开(公告)号：US08962613B2
公开(公告)日：2015-02-24
申请号：US13807387
申请日：2011-07-13
申请人： Shogo Sakuma , Masahiko Arai , Kunio Kobayashi , Yoshikazu Watanabe , Toshiyasu Imai , Kazuhide Inoue
发明人： Shogo Sakuma , Masahiko Arai , Kunio Kobayashi , Yoshikazu Watanabe , Toshiyasu Imai , Kazuhide Inoue
IPC分类号： C07D243/12 , C07D403/10 , A61K31/551 , A61P25/04 , C07D243/10 , C07D401/10 , C07D409/04 , C07D413/10 , C07D417/10 , C07D471/04 , C07D491/056 , C07D401/04 , C07D403/04 , C07D243/24 , C07D487/04
CPC分类号： C07D243/10 , C07D243/12 , C07D243/24 , C07D401/04 , C07D401/10 , C07D403/04 , C07D403/10 , C07D409/04 , C07D413/10 , C07D417/10 , C07D471/04 , C07D487/04 , C07D491/056
摘要： A diazepine derivative having the following formula (III) or a pharmacologically acceptable salt thereof is used as A P2X4 receptor antagonist: wherein each of R21 and R22 is hydrogen, a C1-8 alkyl group or the like; R23 is hydrogen, a C1-8 alkyl group or the like; each of R24 and R25 is hydrogen, a C1-8 alkyl group or the like; R26 is hydrogen, a C1-8 alkyl group, a halogen atom, hydroxyl, nitro, cyano, phenyl optionally having one or more substituents, or a heterocyclic group optionally having one or more substituents or the like; and p is 0 or 1.
摘要翻译：使用具有下式（III）的二氮杂衍生物或其药理学上可接受的盐作为P2X4受体拮抗剂：其中R21和R22各自为氢，C1-8烷基等; R 23为氢，C 1-8烷基等; R 24和R 25各自为氢，C 1-8烷基等; R 26是氢，C 1-8烷基，卤素原子，羟基，硝基，氰基，任选具有一个或多个取代基的苯基，或任选具有一个或多个取代基的杂环基等; p为0或1。

8. 发明申请

US20070265283A1 Xanthine Oxidase Inhibitor 审中-公开
标题翻译：黄嘌呤氧化酶抑制剂
公开(公告)号：US20070265283A1
公开(公告)日：2007-11-15
申请号：US11829286
申请日：2007-07-27
申请人： Shinichi Yoshida , Atsushi Tendo , Kunio Kobayashi , Nobutaka Mochiduki , Tomio Yamakawa , Yoriko Shinohara
发明人： Shinichi Yoshida , Atsushi Tendo , Kunio Kobayashi , Nobutaka Mochiduki , Tomio Yamakawa , Yoriko Shinohara
IPC分类号： A61K31/416 , A61K31/421 , A61K31/426 , A61K31/437 , A61K31/52 , A61P7/00 , C07D221/02 , C07D235/00 , C07D263/54 , C07D277/62 , C07D473/00
CPC分类号： C07D263/57 , C07D235/18 , C07D277/66 , C07D401/14 , C07D471/04 , C07D473/00 , C07D473/30 , C07D473/34 , C07D473/40 , C07D487/04 , C07D513/04
摘要： The invention relates to compounds of the following formula (I) or their salts: in which R1 represents OR4 or others, in which R4 is an alkyl group having 1-8 carbon atoms which may have a substituent or the like; R2 is halogen, nitro, cyano, carboxyl, or the like; R3 is hydrogen, halogen, hydroxyl, amino, carboxyl, or the like; X is NR11, oxygen, or sulfur, in which R11 is hydrogen, or an alkyl group having 1-8 carbon atom which may have a substituent; and each of Y and Z is CR12 or nitrogen, in which R12 has the same meaning as R3 above, and a xanthine oxidase inhibitor containing the compound as an active ingredient.
摘要翻译：本发明涉及下式（I）的化合物或其盐：其中R 1表示OR 4或其它，其中R 4 O / >是具有1-8个碳原子的可以具有取代基等的烷基; R 2是卤素，硝基，氰基，羧基等; R 3是氢，卤素，羟基，氨基，羧基等; X是NR 11，其中R 11是氢的氧或硫，或可以具有取代基的具有1-8个碳原子的烷基; Y和Z各自为CR 12或氮，其中R 12具有与上述R 3相同的含义，并且黄嘌呤氧化酶含有该化合物作为活性成分的抑制剂。

9. 发明申请

US20050182606A1 Method, apparatus and program for quantitative competition and recording medium having recorded thereon the program 失效
公开(公告)号：US20050182606A1
公开(公告)日：2005-08-18
申请号：US11094183
申请日：2005-03-31
申请人： Koji Chida , Kunio Kobayashi , Hikaru Morita
发明人： Koji Chida , Kunio Kobayashi , Hikaru Morita
IPC分类号： G06F17/10 , G06Q20/38 , G06Q30/08 , G06Q40/00 , G06Q50/18
CPC分类号： G06Q40/04 , G06Q20/382 , G06Q30/08 , G06Q50/188
摘要： Numbers 1, 2, . . . , M are assigned to bidding prices from the minimum to maximum values V1 to VN. For a bidding value Vvi each user 11-i generates two sequences of information si={si,1, si,2, . . . , si,M} and ti={ti,1, ti,2, . . . , ti,M} such that si,1=ti,1, . . . , si,vi−1=ti,vi−1, si,vi≠ti,vi, . . . , si,M≠ti,M, then secretly sends the two sequences of information si and ti to quantitative competition apparatuses 15A and 15B, respectively, and sends hash values H1i=h(si) and H2i=h(ti) of the two sequences of information si and ti and a hash value h(Vvi∥ri) containing an intended value Vvi to a bulletin board apparatus 21. The quantitative competition apparatuses 15A and 15B extract w-th elements si,w from respective sequences s1 to sN and w-th elements ti,w from respective sequences t1 to tN, then create a concatenation Seqs,w of N elements si,w and a concatenation Seqt,w of N elements ti,w, then compare them using a one-way function without revealing their values, and, if they differ, deciding that the intended value Vvi equal to or smaller than a value Vw is present, and determines the minimum value by changing w.

10. 发明授权

US5118626A Apparatus for controlling the fermentation of moromi mash 失效
标题翻译：用于控制MOROMI MASH发酵的装置
公开(公告)号：US5118626A
公开(公告)日：1992-06-02
申请号：US419671
申请日：1989-10-11
申请人： Hikotaka Hashimoto , Kunio Kobayashi
发明人： Hikotaka Hashimoto , Kunio Kobayashi
IPC分类号： A23L11/00 , A23L27/50 , C12M1/36
CPC分类号： C12M41/48 , A23L11/09 , A23L27/50 , C12M41/26 , C12M41/32
摘要： An apparatus for controlling the fermentation of moromi mash comprises a sampling mechanism for sampling a portion of the prescribed amount of moromi mash stored in at least one storage tank, and an automatic multiple analyzer for receiving the portion of the prescribed amount of moromi mash from the sampling mechanism and simultaneously analyzing the concentrations of at least two ingredients of the sampled portion of the moromi mash. The apparatus also includes at least one control tank operatively communicating with the storage tank for storing at least one controlling element and supplying the controlling element to the moromi mash in the storage tank, control valves operatively coupled between the control tank and the storage tank for controlling the amount of the controlling element to be supplied to the moromi mash in the storage tank, and a controller for operating the control valves according to analytic results from the automatic multiple analyzer thereby to add the controlling element to the moromi wash in the storage tank to adjust the concentrations of the at least two ingredients of the prescribed amount of moromi mash to target values. The controller periodically actuates the sampling mechanism and the automatic analyzer and adds the controlling element to the moromi mash during the fermentation period thereof.

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