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1. 发明授权

US5212097A Method for analysis of catecholamine 失效
标题翻译：化合物分析方法
公开(公告)号：US5212097A
公开(公告)日：1993-05-18
申请号：US616246
申请日：1990-11-20
申请人： Masao Kamahori , Mamoru Taki , Junkichi Miura , Taro Nogami , Yoshio Watanabe
发明人： Masao Kamahori , Mamoru Taki , Junkichi Miura , Taro Nogami , Yoshio Watanabe
IPC分类号： G01N30/06 , G01N30/24 , G01N30/54 , G01N30/74 , G01N30/88 , G01N33/58 , G01N33/94
CPC分类号： G01N33/58 , G01N33/9453 , G01N2030/8804 , G01N2030/8813 , G01N2030/8822 , G01N30/24 , G01N30/54 , G01N30/74 , Y10T436/173845 , Y10T436/203332
摘要： Catecholamines in a living body fluid are analyzed by a process which involves reacting a living body fluid sample with a boron compound of the formula: ##STR1## wherein R is hydroxyl, aryl or alkyl, to form a complex of the boron compound with a catecholamine; deproteinizing the reaction solution containing the complex; decomposing the complex to release the catecholamine; labeling the released catecholamine to form a labeled catecholamine; eluting the labeled catecholamine adsorbed on a separation column; and detecting the eluted, labeled catecholamine. Advantageously, this process enables catecholamines to be measured with a high recovery ratio and high accuracy by forming the catecholamines into a complex with a boron compound.

2. 发明授权

US4823168A Flow-through cell for a photometer formed using a pair of cell body members 失效
标题翻译：用于使用一对电池体构件形成的光度计的流通池
公开(公告)号：US4823168A
公开(公告)日：1989-04-18
申请号：US116543
申请日：1987-11-04
申请人： Masao Kamahori , Yoshio Watanabe , Junkichi Miura , Mamoru Taki , Hiroyuki Miyagi
发明人： Masao Kamahori , Yoshio Watanabe , Junkichi Miura , Mamoru Taki , Hiroyuki Miyagi
IPC分类号： G01N21/05 , G01N30/74
CPC分类号： G01N21/05 , G01N2021/0346 , G01N2021/054 , G01N2030/746 , G01N30/74
摘要： A flow cell for a photometer, which comprises a cell body integrated from a pair of cell body members by joining, at least one of which is provided with a linear groove on the joining surface of the cell body member from one end to another to the full length, as exposed to the joining surface, the groove playing both roles of a liquid sample passage and a detecting light path by the integration of the cell body members, and is further provided with a liquid sample inlet passage at a position near one end of the groove and a liquid sample outlet passage at a position near the other end of the groove, both passages being communicated with the grooves, the linear groove being provided with a light reflecting layer to the full length of the linear groove, and a pair of light transmission window members joined with the flow cell body at both ends on the groove-open sides thereof is provided, where polishing of the grooves is readily carried out and random reflection of light or absorption of light due to poor reflection is reduced, and the turbulent flow of a liquid sample and generation of noise are suppressed.
摘要翻译：一种用于光度计的流动池，其包括通过接合从一对电池主体部件集成的电池体，其中至少一个在电池体部件的接合表面上从一端到另一端设置有线性槽全长，暴露于接合表面，沟槽通过集成电池主体部件而兼容液体样品通道和检测光路两者，并且在靠近一端的位置处进一步设置有液体样品入口通道的槽和在槽的另一端附近的位置处的液体样品出口通道，两个通道与槽连通，所述直线槽在直线槽的整个长度上设置有光反射层，以及一对提供了在其开槽侧的两端与流通池本体连接的透光窗构件，其中容易进行槽的抛光和光或吸收的随机反射o 由于反射不良导致的光衰减，液体试样的紊流和噪声的产生被抑制。

3. 发明授权

US5093267A Method for biochemical assay and an analyzer for the method 失效
标题翻译：生物化学测定方法和方法分析仪
公开(公告)号：US5093267A
公开(公告)日：1992-03-03
申请号：US267293
申请日：1988-11-04
申请人： Junkichi Miura , Mamoru Taki , Yoshio Watanabe , Masao Kamahori , Hiroyuki Miyagi
发明人： Junkichi Miura , Mamoru Taki , Yoshio Watanabe , Masao Kamahori , Hiroyuki Miyagi
IPC分类号： G01N30/06 , G01N30/88 , G01N33/94
CPC分类号： G01N33/9406 , G01N30/88 , Y10T436/142222 , Y10T436/173845 , Y10T436/203332 , Y10T436/255
摘要： Catecholamines can be detected with high sensitivity in a shortened time period, by introducing a sample containing catecholamines into an adsorption column packed with an adsorbent to adsorb catecholamines to the column, then introducing a reagent for derivatization to effect pre-column labeling and then analyzing the pre-column labeled catecholamines by means of high performance liquid chromatography. Connection of the adsorption column and a separation column of high performance liquid chromatography via a fluid path changeover valve enables to automated analysis of catecholamines.
摘要翻译：可以在缩短的时间内以高灵敏度检测儿茶酚胺，通过将含有儿茶酚胺的样品引入填充有吸附剂的吸附塔中将儿茶酚胺吸附到塔中，然后引入用于衍生化的试剂进行预柱标记，然后分析通过高效液相色谱法预柱标记的儿茶酚胺。通过流体路径切换阀连接吸附塔和高效液相色谱分离柱，可以自动分析儿茶酚胺。

4. 发明授权

US5005434A Autosampler with a means for detecting air bubble in specimen 失效
标题翻译：自动进样器，用于检测样品中的气泡
公开(公告)号：US5005434A
公开(公告)日：1991-04-09
申请号：US390720
申请日：1989-08-08
申请人： Yoshio Watanabe , Mamoru Taki , Junkichi Miura , Masao Kamahori , Hiroyuki Miyagi , Yasuhide Matsumura , Masafumi Kanetomo
发明人： Yoshio Watanabe , Mamoru Taki , Junkichi Miura , Masao Kamahori , Hiroyuki Miyagi , Yasuhide Matsumura , Masafumi Kanetomo
IPC分类号： G01N35/10 , G01N1/00 , G01N1/14 , G01N15/00 , G01N30/16 , G01N30/24 , G01N30/34
CPC分类号： G01N35/1097 , G01N1/14 , G01N2015/0011 , G01N2021/4735 , G01N2201/08 , G01N30/34
摘要： An autosampler consists of a needle to draw specimen from a specimen container into a passage therein; a block having a passage that follows the passge in the needle; a suction mechanism for drawing in the specimen by suction through the passages in the needle and the block; a discharge mechanism for discarding the specimen drawn in by the suction mechanism; and a detecting device for detecting air bubble in the specimen, the detecting device being embedded in the block in such a manner as to face the passage in the block. The detecting device detects the air bubbles in the specimen according to changes in physical or chemical properties of the specimen passing through the passage in the block. The discharge mechanism is activated by the detecting device to discharge air-mixed specimen. When even a small amount of air is drawn into the passage from the specimen container, in which only a small amount of specimen is contained, the air specimen can reliably be distinguished from normal specimen by this autosampler. Therefore the reliability of the system using the autosampler can be significantly improved.
摘要翻译：自动进样器由将样本从样本容器拉入其中的通道的针头组成; 具有跟随针头中的传递的通道的块; 抽吸机构，用于通过抽吸通过针和块中的通道抽吸样品; 用于废弃由抽吸机构吸入的试样的排出机构; 以及用于检测样本中的气泡的检测装置，所述检测装置以面对块中的通道的方式嵌入块中。检测装置根据通过块体中的通道的试样的物理或化学特性的变化来检测样品中的气泡。排出机构由检测装置启动，以排出空气混合样品。即使少量的空气从容纳少量试样的试样容器的通道中吸入，也可以通过该自动进样器将空气样本与正常试样区分开。因此，可以显着提高使用自动进样器的系统的可靠性。

5. 发明授权

US5294336A Apparatus for liquid chromatography for separating AIC components from hemoglobin in blood 失效
标题翻译：用于液体色谱法分离血液中血红蛋白的AIC成分的装置
公开(公告)号：US5294336A
公开(公告)日：1994-03-15
申请号：US896784
申请日：1992-06-09
申请人： Masako Mizuno , Kenji Tochigi , Yutaka Misawa , Hiroyuki Miyagi , Yoshio Watanabe , Taro Nogami , Junkichi Miura , Yoshinori Takata
发明人： Masako Mizuno , Kenji Tochigi , Yutaka Misawa , Hiroyuki Miyagi , Yoshio Watanabe , Taro Nogami , Junkichi Miura , Yoshinori Takata
IPC分类号： G01N30/32 , B01D15/08 , B01J20/281 , G01N30/02 , G01N30/86 , G01N30/88 , G01N33/487 , G01N33/72
CPC分类号： G01N33/723 , B01D15/08 , G01N2030/027
摘要： Stable hemoglobin A.sub.lc (s-A.sub.lc) can be separated from other hemoglobin components and quantitated in a short time by means of a liquid-chromatographic apparatus comprising a separation column packed with a packing material consisting essentially of a porous substance having a carboxyalkyl group combined thereinto, as ion exchanger, a means for injecting a sample into the separation column, a means for passing one or more eluents through the separation column, and a means for detecting hemoglobin, hemoglobin derivatives or glycosylated hemoglobin, the average particle size of the packing material in dry state being 4 .mu.m or less.
摘要翻译：稳定的血红蛋白Alc（s-Alc）可以与其他血红蛋白成分分离，并通过液相色谱装置在短时间内定量，该液相色谱装置包括一个分离柱，该分离柱填充有基本上由其中组合有羧基烷基的多孔物质组成的包装材料作为离子交换剂，将样品注入分离塔的方法，使一个或多个洗脱液通过分离塔的装置和用于检测血红蛋白，血红蛋白衍生物或糖基化血红蛋白的装置，包装材料的平均粒径在干燥状态下为4（my）m或更小。

6. 发明授权

US5783450A Analytical method and instrument for analysis of liquid sample by liquid chromatography 失效
标题翻译：通过液相色谱分析液体样品的分析方法和仪器
公开(公告)号：US5783450A
公开(公告)日：1998-07-21
申请号：US440359
申请日：1995-05-12
申请人： Kasumi Yoshida , Junkichi Miura , Yoshio Fujii , Hiroshi Satake , Masahito Ito , Masao Kamahori
发明人： Kasumi Yoshida , Junkichi Miura , Yoshio Fujii , Hiroshi Satake , Masahito Ito , Masao Kamahori
IPC分类号： G01N30/06 , G01N21/64 , G01N30/08 , G01N30/74 , G01N30/88 , G01N33/88 , G01N35/00 , G01N35/04 , G01N35/10 , G01N30/02
CPC分类号： G01N35/0092 , G01N30/88 , G01N2030/067 , G01N2030/8804 , G01N2030/8813 , G01N2035/00356 , G01N2035/0093 , G01N2035/106 , G01N21/64 , G01N30/06 , G01N35/028 , G01N35/109 , Y10T436/142222 , Y10T436/173845 , Y10T436/25375
摘要： A method and an instrument for separating and analyzing a very small quantity of constituents to be inspected contained in an analyte such as a class of catecholamines by liquid chromatography after labeling. The entire processes of analytical operations include principally three processes, a preparing process, an impurity elimination process and a separation process. When one sample is perceived, the sample is processed in these three processes. In this case, while one sample is being processed in an impurity elimination process, a sample preceeding the one sample is processed in a separation process, and a succeeding sample is processed in a preparing process. In other words, these three processes are performed essentially in parallel. With this, it is possible to remarkably reduce analysis time as compared with individual single sample analysis.
摘要翻译：一种方法和仪器，用于通过液相色谱法在标记后通过液相色谱法分离和分析非常少量待检查的成分，包含在分析物如一类儿茶酚胺中。分析操作的整个过程主要包括三个过程，制备过程，杂质消除过程和分离过程。当一个样品被感知时，样品在这三个过程中被处理。在这种情况下，当在杂质消除过程中处理一个样品时，在分离过程中处理先于一个样品的样品，并在制备过程中处理后续样品。换句话说，这三个过程基本上是并行执行的。与单个样品分析相比，可以显着减少分析时间。

7. 发明授权

US4338811A Method and apparatus for diagnosis of disease 失效
标题翻译：疾病诊断方法和装置
公开(公告)号：US4338811A
公开(公告)日：1982-07-13
申请号：US201723
申请日：1980-10-29
申请人： Hiroyuki Miyagi , Yoshinori Takata , Junkichi Miura , Mamoru Taki
发明人： Hiroyuki Miyagi , Yoshinori Takata , Junkichi Miura , Mamoru Taki
IPC分类号： G01N30/86 , G01N33/50 , G06F17/00
CPC分类号： G01N33/50 , G01N30/8606 , G01N30/8675
摘要： A disease diagnostic method and apparatus in which a two-dimensional pattern diagram representing the relation between integrated values of peaks and the retention times in a chromatogram of substances in a body fluid of a subject is obtained to be geographically compared, for disease diagnostic purpose, with a two-dimensional pattern diagram representing the relation between integrated values of peaks and the retention times in a chromatogram obtained through separating and detecting substances in a body fluid of a normal person, and also with two-dimensional pattern diagrams representing the relation between integrated values of peaks and the retention times in chromatograms obtained through separating and detecting substances in a body fluid of abnormal patients classified by diseases.
摘要翻译：疾病诊断方法和装置，其中获得代表对象的体液中的物质的色谱图中的峰的积分值与保留时间之间的关系的二维图案图，以进行地理上的比较，用于疾病诊断目的，具有表示通过分离和检测正常人的体液中的物质而获得的色谱图中峰的积分值与保留时间之间的关系的二维图案图，以及表示正常人的体液中的物质的二维图案图通过分离和检测通过疾病分类的异常患者的体液中的物质获得的色谱图中的峰值和保留时间。

8. 发明授权

US5132012A Liquid chromatograph 失效
标题翻译：液相色谱仪
公开(公告)号：US5132012A
公开(公告)日：1992-07-21
申请号：US369853
申请日：1989-06-22
申请人： Junkichi Miura , Andreas Manz , Yoshio Watanabe , Yuji Miyahara , Hiroyuki Miyagi , Keiji Tsukada
发明人： Junkichi Miura , Andreas Manz , Yoshio Watanabe , Yuji Miyahara , Hiroyuki Miyagi , Keiji Tsukada
IPC分类号： G01N30/18 , G01N30/32 , G01N30/38 , G01N30/60 , G01N30/64 , G01N35/00
CPC分类号： G01N30/6095 , G01N2030/385 , G01N2035/00237 , G01N30/18 , G01N30/32 , G01N30/64
摘要： A liquid chromatograph comprises an analyzing chip in which a capillary is formed in a substrate and a detector section is disposed downstream of the capillary. The capillary is covered so that an inlet opening end and an outlet opening end of said capillary flow path is opened. A frame member has a sample introduction path, a carrier liquid introduction path and a liquid discharge path. The analyzing chip is movably disposed in the frame member so that the inlet opening end and the outlet opening end of the capillary are selectively in communication with and/or under interruption against said sample introduction path, the carrier liquid introduction path and the liquid discharge path. The liquid chromatograph is very small in size but is easy to handle. Incidentally, there is disclosed also a sample introduction apparatus and method for the chromatograph, and an FET type detector suitable for the chromatograph.
摘要翻译：液相色谱仪包括分析芯片，其中在基板中形成毛细管，并且检测器部分设置在毛细管的下游。毛细管被覆盖，使得所述毛细管流路的入口开口端和出口开口端被打开。框架构件具有样品引入路径，载液引入路径和液体排出路径。分析芯片可移动地设置在框架构件中，使得毛细管的入口开口端和出口开口端选择性地与所述样品引入路径，载液引入路径和液体排出路径。液相色谱仪尺寸非常小，易于处理。顺便提及，还公开了用于色谱仪的样品引入装置和方法，以及适用于色谱仪的FET型检测器。

9. 发明授权

US08562910B2 Method and apparatus for analysis of poly (biphenyl chloride) in electrical insulating oil 失效
标题翻译：电绝缘油中聚（联苯氯）的分析方法和装置
公开(公告)号：US08562910B2
公开(公告)日：2013-10-22
申请号：US12994300
申请日：2009-05-20
申请人： Masako Kawarai , Junkichi Miura , Tami Hiruta , Yoshinori Inoue
发明人： Masako Kawarai , Junkichi Miura , Tami Hiruta , Yoshinori Inoue
IPC分类号： G01N30/02
CPC分类号： G01N30/14 , G01N30/44 , G01N33/2835 , G01N2030/143 , G01N2030/8845 , G01N2030/8872
摘要： An object of the present invention is to provide a method and an apparatus by which PCBs in insulating oil can be analyzed with high accuracy in a convenient, inexpensive, and rapid manner. The method for analyzing polychlorobiphenyls by measuring the concentration of polychlorobiphenyls in insulating oil comprises a step of, as pretreatment, bringing particles of a copolymer that contains divinylbenzene and a methacrylate organic monomer as monomer components into contact with insulating oil containing polychlorobiphenyls, so as to separate polychlorobiphenyls in insulating oil from oil content that is an impurity. The methacrylate organic monomer preferably has a diol type hydroxyl group.
摘要翻译：本发明的目的是提供一种可以以便利，便宜和快速的方式以高精度分析绝缘油中的PCB的方法和装置。通过测定绝缘油中聚氯联苯的浓度来分析聚氯联苯的方法包括以下步骤：将包含二乙烯基苯和甲基丙烯酸酯有机单体的共聚物的颗粒作为预处理使含有聚氯代联苯的绝缘油接触，绝缘油中的聚氯联苯与杂质含油量。甲基丙烯酸酯有机单体优选具有二醇型羟基。

10. 发明申请

US20070199874A1 Three-dimensional liquid chromatography 审中-公开
标题翻译：三维液相色谱
公开(公告)号：US20070199874A1
公开(公告)日：2007-08-30
申请号：US11700844
申请日：2007-02-01
申请人： Masahito Ito , Junkichi Miura , Kisaburo Deguchi
发明人： Masahito Ito , Junkichi Miura , Kisaburo Deguchi
IPC分类号： B01D15/08
CPC分类号： G01N30/463 , G01N30/461 , G01N30/7233 , G01N30/96 , B01D15/322 , B01D15/362 , B01D15/325 , B01D15/363
摘要： In a liquid chromatography apparatus, a separation column of intermediate stage is additionally connected between a separation column of first stage and a separation column of second stage. Preferably, a switching unit and a liquid feed unit for mixing and feeding a plurality of solutions are added to improve a separation capability. A three-dimensional liquid chromatography apparatus capable of avoiding the “solution interference” can be realized. Even a complex sample containing a hydrophilic component and a hydrophobic component in a mixed state can be separated and analyzed satisfactorily on-line.
摘要翻译：在液相色谱装置中，中间级分离塔另外连接在第一级分离塔和第二级分离塔之间。优选地，添加用于混合和供给多个溶液的切换单元和液体进料单元以提高分离能力。可以实现能够避免“溶液干扰”的三维液相色谱仪。即使是含有亲水性成分和混合状态的疏水性成分的复合物，也可以在线进行分离和分析。

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