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1. 发明申请

US20180275104A1 A Chromatography System and a Method Therefor 审中-公开
公开(公告)号：US20180275104A1
公开(公告)日：2018-09-27
申请号：US15763520
申请日：2016-09-29
申请人： GE HEALTHCARE BIO-SCIENCES AB
发明人： Helena Skoglar , Bjorn Olovsson
IPC分类号： G01N30/38 , G01N30/74 , G01N30/20 , G01N30/78 , B01D15/18
CPC分类号： G01N30/38 , B01D15/1807 , B01D15/1885 , G01N30/20 , G01N30/42 , G01N30/74 , G01N30/78 , G01N35/1097 , G01N2030/202 , G01N2030/385 , G01N2030/626
摘要： The present invention relates to a chromatography system and a method therefor. The chromatography system comprising an inlet port (102) for receiving a sample, an outlet port (106) for delivering the sample, a detector (201), a column (104), and a valve (202) in fluid communication with the inlet port, the outlet port, the detector, and the column. The valve (202) comprises a first position (304) wherein the inlet port is in fluid communication with the outlet port via a first fluid path comprising the detector and the column, wherein the detector is arranged upstream the column. The valve comprises a second position (404) wherein the inlet port is in fluid communication with the outlet port via a second fluid path comprising the detector and the column, wherein the detector is arranged downstream the column.

2. 发明授权

US09679757B2 Liquid chromatography systems and methods 有权
公开(公告)号：US09679757B2
公开(公告)日：2017-06-13
申请号：US14248662
申请日：2014-04-09
申请人： Waters Technologies Corporation
发明人： Jeremy D. Netto , Mark Ritchie
IPC分类号： G01N30/46 , G01N30/20 , G01N30/72 , G01N30/38 , G01N30/40 , B01D15/18 , B01D15/16 , B01D15/14 , B01D15/30 , B01D15/32 , H01J49/26 , G01N30/08 , G01N30/04 , G01N30/34
CPC分类号： H01J49/26 , B01D15/14 , B01D15/166 , B01D15/1864 , B01D15/1871 , B01D15/1878 , B01D15/305 , B01D15/325 , G01N30/08 , G01N30/461 , G01N30/462 , G01N30/463 , G01N30/468 , G01N30/72 , G01N30/7233 , G01N2030/085 , G01N2030/201 , G01N2030/202 , G01N2030/347 , G01N2030/382 , G01N2030/385 , G01N2030/388
摘要： One aspect of the invention provides a liquid chromatography system including: a first solvent manager configured to dispense various ratios of a first solvent and a second solvent; a first column in fluid communication with the first solvent manager; a mixer in fluid communication with the first column; a first valve in fluid communication with the mixer; a second column having a first end in fluid communication with a first port of the first valve and a second end in fluid communication with a second port of the first valve; a second solvent manager adapted and configured to dispense various ratios of a third solvent and a fourth solvent; and a second valve in fluid communication with the second solvent manager, the first valve, and the mixer. The first valve and the second valve are adapted and configured for actuation between and a second position. In the first position: solvent dispensed by the first solvent manager and an injected sample flow over the first column; eluent from the first column is mixed with solvent dispensed by the second solvent manager in the mixer to produce a combined mobile phase; and the combined mobile phase is passed through the first valve and over the second column in a first direction to trap analytes of interest on the first column. In the second position, solvent dispensed by the second solvent manager is passed over the second column in a second direction to release the analytes of interest from the second column.

3. 发明授权

US09651526B2 Liquid chromatograph 有权
公开(公告)号：US09651526B2
公开(公告)日：2017-05-16
申请号：US14668000
申请日：2015-03-25
申请人： SHIMADZU CORPORATION
发明人： Kengo Aoki , Keisuke Ogawa
IPC分类号： G01N30/34 , B01D15/16 , B01D15/18 , B01D15/08 , G01N30/20 , G01N30/38 , G01N30/86
CPC分类号： G01N30/34 , B01D15/08 , B01D15/16 , B01D15/166 , B01D15/18 , G01N30/20 , G01N30/8658 , G01N30/8665 , G01N30/8675 , G01N2030/347 , G01N2030/383 , G01N2030/385
摘要： A liquid chromatograph has a mobile phase delivery section including, between mobile phase channels connected respectively to a plurality of mobile phase containers and a delivery pump, channel switching valves for selecting one of the mobile phase channels. This liquid chromatograph whose channel switching valves have a hierarchical structure including at least two stages includes a valve connection state setting section that is configured to set the connection state between the channel switching valves and the connection state between the channel switching valves and the mobile phase channels, and further includes a per channel total delivery amount calculation section that is configured to calculate the total delivery amount of mobile phase per mobile phase channel based on a connection state according to the valve connection state setting section, the delivery amount per unit time by the delivery pump, and the operation time of the delivery pump.

4. 发明授权

US09389208B2 Hermetic manifold for analytical instruments 有权
标题翻译：用于分析仪器的密封歧管
公开(公告)号：US09389208B2
公开(公告)日：2016-07-12
申请号：US13826774
申请日：2013-03-14
申请人： Rosemount Analytical Inc.
发明人： Edward J. Bailey , Jason P. Pratt , Shane Hale , Gregory J. Golden
IPC分类号： G01N30/38 , G01N30/32 , G01N30/88 , G01N30/02 , B01D53/02
CPC分类号： G01N30/38 , B01D53/025 , G01N30/32 , G01N30/88 , G01N2030/025 , G01N2030/385 , G01N2030/8881 , Y10T137/85938
摘要： A planar manifold includes a first, generally planar, layer having a plurality of apertures therethrough. A second layer has a plurality of apertures therethrough. A channel layer defines a plurality of channels therein and is interposed between the first layer and the second layer. At least one channel extends in a direction parallel to a plane of the planar manifold and couples an aperture of the first layer to an aperture of the second layer.
摘要翻译：平面歧管包括具有穿过其中的多个孔的第一大致平面的层。第二层具有穿过其中的多个孔。通道层在其中限定多个通道，并且介于第一层和第二层之间。至少一个通道在平行于平面歧管的平面的方向上延伸，并将第一层的孔与第二层的孔耦合。

5. 发明申请

US20140352406A1 GAS CHROMATOGRAPH APPARATUS 有权
标题翻译：气体色谱仪
公开(公告)号：US20140352406A1
公开(公告)日：2014-12-04
申请号：US13905652
申请日：2013-05-30
申请人： SHIMADZU CORPORATION
发明人： Shuichi KAWANA
IPC分类号： G01N30/38
CPC分类号： G01N30/38 , G01N2030/324 , G01N2030/385
摘要： A gas chromatograph having a column which separates respective components contained in a gas sample introduced via a carrier gas over time, wherein an analysis mode and a standby mode can be switched and executed. The gas chromatograph apparatus comprises: a carrier gas flow path, a column protection gas flow path, a flow path switching part provided between the carrier gas flow path and the column protection gas flow path and a column so that only one of the carrier gas or a column protection gas is introduced into the column, and a flow path control part for controlling the flow switching part so as to introduce the carrier gas into the column at the time of the analysis mode and introduce the column protection gas into the column at the time of the standby mode.
摘要翻译：一种气相色谱仪，其具有分离随着时间经由载气引入的气体样品中所含的各成分的柱，其中可以切换并执行分析模式和待机模式。气相色谱装置包括：载气流路，柱保护气流路径，设置在载气流路和柱保护气流路之间的流路切换部，以及列，仅使一个载气或柱保护气体被引入塔中，流路控制部分用于控制流动切换部分，以便在分析模式时将载气引入塔中，并将塔保护气体引入塔中待机模式的时间。

6. 发明申请

US20070110628A1 Apparatus and method for dispensing fractions of an analyte solution 审中-公开
$Apparatus and method for dispensing fractions of an analyte solution$
标题翻译：用于分配分析物溶液的分数的装置和方法
公开(公告)号：US20070110628A1
公开(公告)日：2007-05-17
申请号：US10555784
申请日：2004-05-28
申请人： Alexandre Loboda
发明人： Alexandre Loboda
IPC分类号： B01L3/02
CPC分类号： B01L3/0265 , B01L3/0268 , B01L2300/0867 , B01L2400/0415 , B01L2400/0439 , B01L2400/0487 , B01L2400/0666 , G01N30/10 , G01N30/6095 , G01N30/7233 , G01N30/84 , G01N35/1016 , G01N2030/385 , G01N2030/8411 , G01N2030/8417 , G01N2030/8464 , G01N2030/847 , G01N2035/1034 , H01J49/00
摘要： An apparatus and method for dispensing low volumes of an analyte solution. The apparatus comprises: (a) a receiver defining an ejection cavity and an outlet downstream of and in fluid communication with the ejection cavity; (b) first and second fluid conduits coupled to the receiver and defining respective first and second fluid flow paths in fluid communication with the ejection cavity; (c) an analyte generating apparatus operatively coupled to the first fluid conduit and operable to deliver analyte solution along the first fluid flow path to the ejection cavity; and (d) a dispensing mechanism operatively coupled to the second fluid conduit and operable to deliver a fluid buffer along the second fluid flow path into the ejection cavity to displace analyte solution present therein through the outlet. The method involves filling the ejection cavity with an analyte solution at a selected rate and injecting a fluid buffer into the injection cavity to displace the analyte solution through the outlet.
摘要翻译：用于分配低体积分析物溶液的装置和方法。所述装置包括：（a）接收器，其限定出射腔和与所述喷射腔流体连通的下游出口; （b）第一和第二流体管道，其耦合到所述接收器并且限定与所述喷射腔流体连通的相应的第一和第二流体流动路径; （c）分析物产生装置，其可操作地耦合到所述第一流体导管并且可操作以将分析物溶液沿着所述第一流体流动路径输送到所述喷射腔; 和（d）分配机构，其可操作地耦合到所述第二流体导管并且可操作以沿着所述第二流体流动路径将流体缓冲器输送到所述喷射腔中，以通过所述出口移动其中存在的分析物溶液。该方法包括以选定的速率向分析物溶液填充喷射腔，并将流体缓冲液注射到注射腔中以通过出口移动分析物溶液。

7. 发明授权

US5205845A Mechanical gas chromatography injection valves and column multiplexing techniques 失效
标题翻译：机械气相色谱注入阀和色谱柱复用技术
公开(公告)号：US5205845A
公开(公告)日：1993-04-27
申请号：US817306
申请日：1992-01-06
申请人： Richard D. Sacks , Anita J. Peters
发明人： Richard D. Sacks , Anita J. Peters
IPC分类号： G01N1/00 , G01N1/22 , G01N1/26 , G01N1/28 , G01N1/40 , G01N30/12 , G01N30/20 , G01N30/24 , G01N30/30 , G01N30/38 , G01N30/40 , G01N30/46 , G01N30/62 , G01N30/86
CPC分类号： G01N30/20 , G01N1/26 , G01N30/12 , G01N30/40 , G01N1/2214 , G01N1/40 , G01N2030/121 , G01N2030/122 , G01N2030/201 , G01N2030/202 , G01N2030/204 , G01N2030/3046 , G01N2030/383 , G01N2030/385 , G01N2030/402 , G01N2030/405 , G01N2030/407 , G01N2030/623 , G01N2030/628 , G01N30/24 , G01N30/466 , G01N30/8651 , G01N35/1097
摘要： Several embodiments of gas chromatography systems are disclosed incorporating mechanical sample injection valves. The injection valves incorporate a delivery tube having an outlet which is swept past the inlet of a separation column to provide a short duration inlet plug into the separation column. Carrier gas and sample gas flow is managed through the valve to prevent inadvertent injection after an injection is desired and to assure that the sample is not contaminated by past sample flow. Embodiments of injections valve are described for providing inputs into several gas chromatography columns. In addition, a gas chromatography system is described in which multiple columns are used which are time multiplexed with a single detector to produce a complex combined chromatogram from the plural columns. By appropriate selection of column characteristics and injection sequence, the resulting chromatogram can provide an overlay of chromatograms which provide good resolution of all the constituents of the mixture of interest within a short analysis time.
摘要翻译：公开了气相色谱系统的几个实施例，其结合机械样品注射阀。注射阀包括具有出口的输送管，该出口被扫过经过分离塔的入口以向分离柱提供短持续时间的入口塞。载气和样品气体流量通过阀门进行管理，以防止在需要注射后意外注入，并确保样品不会被过去的样品流污染。描述了注射阀的实施例，用于向几个气相色谱柱提供输入。此外，描述了气相色谱系统，其中使用与单个检测器时间复用的多个色谱柱以从多个色谱柱产生复合组合色谱图。通过适当选择色谱柱特性和注射顺序，得到的色谱图可以提供色谱图的重叠，可以在短时间内提供所有感兴趣的混合物成分的良好分辨率。

8. 发明授权

US3220164A Recirculation chromatography 失效
标题翻译：再循环色谱
公开(公告)号：US3220164A
公开(公告)日：1965-11-30
申请号：US21064262
申请日：1962-07-18
申请人： PERKIN ELMER CORP
发明人： GOLAY MARCEL J E
IPC分类号： G01N30/20 , G01N30/38 , G01N30/40 , G01N30/44 , G01N30/46
CPC分类号： G01N30/468 , G01N30/40 , G01N30/44 , G01N2030/202 , G01N2030/385 , G01N2030/445 , G01N2030/402

9. 发明申请

US20180238841A1 PREPARATIVE SEPARATION AND PURIFICATION DEVICE AND PREPARATIVE SEPARATION AND PURIFICATION METHOD 审中-公开
公开(公告)号：US20180238841A1
公开(公告)日：2018-08-23
申请号：US15750856
申请日：2016-05-23
申请人： Shimadzu Corporation
发明人： Tomoyuki YAMAZAKI
IPC分类号： G01N30/38 , G01N30/80 , G01N30/32 , B01D15/24 , B01D15/14 , B01D15/16
CPC分类号： G01N30/38 , B01D15/14 , B01D15/161 , B01D15/163 , B01D15/247 , G01N30/32 , G01N30/80 , G01N30/84 , G01N2030/085 , G01N2030/328 , G01N2030/385
摘要： A target component is collected using a preparative separation and purification device having a holder for holding a trap column in which the target component has been captured, a liquid feeder for feeding a first solvent having compatibility with the water remaining in the trap column and a second solvent having low compatibility with water and high compatibility with the first solvent into the trap column, a flow-path switch for connecting the exit end of the trap column to a waste liquid flow path and a collection flow path, and a control unit for controlling the flow-path switch so that solution including water flows into the waste liquid flow path.

10. 发明申请

US20180128792A1 Method and device for sample loading 审中-公开
公开(公告)号：US20180128792A1
公开(公告)日：2018-05-10
申请号：US15809239
申请日：2017-11-10
申请人： DIONEX SOFTRON GMBH
发明人： Thomas WACHINGER , Christoph HOLLNAGEL
IPC分类号： G01N30/60 , G01N30/14
CPC分类号： G01N30/6034 , G01N30/14 , G01N30/20 , G01N30/24 , G01N2030/027 , G01N2030/201 , G01N2030/202 , G01N2030/385
摘要： A liquid chromatography system includes a separation column, a trap column, and a first switching valve. The first switching valve is adapted to assume a first switching position for bringing a sample into the trap column in a first flow direction. The switching valve is also adapted to assume a second switching position for fluidly connecting the trap column with the separation column and providing a flow from the trap column to the separation column in a second flow direction. The second flow direction is opposite to the first flow direction. The first switching valve is adapted to assume a third switching position for fluidly connecting the trap column, with the separation column and providing a flow from the trap column to the separation column in the first flow direction.

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