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1. 发明授权

US5709816A Singlet oxygen quenchers and external compositions containing the same 失效
标题翻译：单体氧猝灭剂和含有其的外用组合物
公开(公告)号：US5709816A
公开(公告)日：1998-01-20
申请号：US685926
申请日：1996-07-22
申请人： Masakazu Yamaguchi , Hiroyuki Ohsu , Eiichi Nishizawa , Mitsuru Sugiyama , Koichi Nakamura , Yoshinori Takema
发明人： Masakazu Yamaguchi , Hiroyuki Ohsu , Eiichi Nishizawa , Mitsuru Sugiyama , Koichi Nakamura , Yoshinori Takema
IPC分类号： A61K8/41 , A61K8/49 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/34 , A61K31/341 , A61Q17/00 , A61Q19/02 , A61Q19/08 , C07C217/28 , C07D307/52 , A61K7/50 , C07C211/00
CPC分类号： A61K8/4973 , A61K31/136 , A61K31/137 , A61K31/341 , A61K8/411 , A61Q17/00 , A61Q19/02 , A61Q19/08 , C07C217/28 , C07D307/52 , A61K2800/522 , A61Q17/04 , A61Q5/06 , A61Q5/12
摘要： Singlet oxygen quenchers containing as an active component a compound represented by the following formula or (2): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.10 and n are as described herein, and external compositions containing these compounds are provided for the prevention and treatment of various forms of damage to living bodies caused by singlet oxygen, and are thus quite useful as antiinflammation agents, anti-aging agents, agents preventing darkening of the skin, agents preventing protein denaturation, inhibitors against formation of sunburn cells, agents preventing lipid peroxidation, agents preventing DNA damage, and particularly in the fields of medicines and cosmetics as external compositions for the skin.
摘要翻译：含有作为活性成分的下述式（2）表示的化合物的单线态氧猝灭剂：其中R1，R2，R3，R4，R5，R10和n分别为提供含有这些化合物的外用组合物，用于预防和治疗由单线态氧引起的对活体的各种形式的损伤，因此作为抗炎剂，抗老化剂，防止皮肤变黑的药剂，防止蛋白质变性的药剂，防止晒伤细胞形成的抑制剂，防止脂质过氧化的药剂，防止DNA损伤的药剂，特别是作为皮肤外用组合物的药物和化妆品领域。

2. 发明申请

US20130295207A1 Skin Whitening Agent 有权
标题翻译：皮肤美白剂
公开(公告)号：US20130295207A1
公开(公告)日：2013-11-07
申请号：US13979991
申请日：2012-01-20
申请人： Mamiko Kikuchi , Daiki Murase , Mitsuru Sugiyama , Akiko Kawasaki
发明人： Mamiko Kikuchi , Daiki Murase , Mitsuru Sugiyama , Akiko Kawasaki
IPC分类号： A61K8/97 , A61Q19/02 , A61K8/60 , A61K8/49
CPC分类号： A61K8/97 , A23L33/105 , A61K8/4973 , A61K8/602 , A61K31/365 , A61K31/7048 , A61K36/19 , A61K2800/782 , A61Q19/02
摘要： Use of haguro-so or an organic solvent extract thereof, or a compound represented by the following formula (I) or a salt thereof, for inhibiting a dopa oxidase activity, for inhibiting melanin production, or for whitening the skin; in the formula (I), R1 and R2, being the same or different, each represent a hydroxyl group, or a C1-4 linear or branched alkoxy group, or R1 and R2 together form a methylenedioxy group; R3 and R4, being the same or different, each represent a hydroxyl group, or a C1-4 linear or branched alkoxy group, or R3 and R4 together form a methylenedioxy group; R5 represents a hydrogen atom, a hydroxyl group, a C1-5 linear or branched alkoxy group, a C1-4 acyl group, or a sugar residue selected from the group consisting of (D-apio-β-D-furanosyl)oxy, (β-D-glucopyranosyl)oxy, (3-O,4-O-dimethyl-D-xylopyranosyl)oxy, (2-O,3-O,4-O-trimethyl-β-D-xylopyranosyl)oxy, and (3-O-methyl-β-D-glucopyranosyl)oxy; R6 and R7 are each a hydrogen atom and R8 and R9 together represent an oxygen atom, or R8 and R9 are each a hydrogen atom and R6 and R7 together represent an oxygen atom.
摘要翻译：或其有机溶剂提取物或由下式（I）表示的化合物或其盐用于抑制多巴氧化酶活性，抑制黑色素生成或使皮肤变白的用途; 在式（I）中，R 1和R 2相同或不同，各自表示羟基或C 1-4直链或支链烷氧基，或者R 1和R 2一起形成亚甲二氧基; R 3和R 4相同或不同，各自表示羟基或C 1-4直链或支链烷氧基，或者R 3和R 4一起形成亚甲二氧基; R5表示氢原子，羟基，C1-5直链或支链烷氧基，C1-4酰基或选自（D-api-β-D-呋喃糖基）氧基，（3-O，4-O-二甲基-D-木吡喃糖基）氧基（2-O，3-O，4-O-三甲基-β-D-吡喃木糖基）氧基和（3-O-甲基-β-D-吡喃葡萄糖基）氧基; R6和R7各自为氢原子，R8和R9一起表示氧原子，或R8和R9各自为氢原子，R6和R7一起表示氧原子。

3. 发明授权

US09592183B2 Inhibitor of endothelin action and skin-whitening agent 有权
标题翻译：内皮素作用抑制剂和皮肤美白剂
公开(公告)号：US09592183B2
公开(公告)日：2017-03-14
申请号：US13993454
申请日：2011-11-24
申请人： Tsuyoshi Ohba , Daiki Murase , Mitsuru Sugiyama
发明人： Tsuyoshi Ohba , Daiki Murase , Mitsuru Sugiyama
IPC分类号： A61K8/37 , A61Q19/02 , A61K31/235 , A61K8/99 , A61K36/09
CPC分类号： A61K8/37 , A61K8/375 , A61K8/99 , A61K31/235 , A61K36/09 , A61K2800/782 , A61Q19/02
摘要： An inhibitor of endothelin action or a skin-whitening agent, comprising a compound represented by Formula (1) or a salt thereof as an active ingredient: wherein in Formula (1), R1 represents a formyl group or an alkyl group having 1 to 4 carbon atom(s), and R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atom(s).
摘要翻译：包含由式（1）表示的化合物或其盐作为活性成分的内皮素作用抑制剂或皮肤增白剂。其中，在式（1）中，R 1表示甲酰基或碳原子数1〜4的烷基，R 2表示氢原子或碳原子数1〜4的烷基。

4. 发明申请

US20110117038A1 Dopa Oxidase Inhibitor, Skin-Lightening Agent and External Preparation for Skin 审中-公开
标题翻译：多巴氧化酶抑制剂，皮肤增亮剂和皮肤外用剂
公开(公告)号：US20110117038A1
公开(公告)日：2011-05-19
申请号：US12939349
申请日：2010-11-04
申请人： Akiko KAWASAKI , Mitsuru Sugiyama , Yasuko Amano
发明人： Akiko KAWASAKI , Mitsuru Sugiyama , Yasuko Amano
IPC分类号： A61K8/97 , A61K8/49 , A61K36/9064 , A61K36/28 , A61K36/88 , A61K31/58 , C07J71/00 , A61Q19/02 , A61Q19/00 , A61P17/00
CPC分类号： C07J71/0021 , A61K8/63 , A61K8/97 , A61Q19/02 , A61Q19/10
摘要： A dopa oxidase inhibitor, a skin-lightening agent and an external preparation for skin; comprising an extract of at least one plant selected from the group consisting of Melia toosendan Sieb. et Zucc., Amomum tsao-ka Crevost et Lemaire. Senecio gracilis and Veratrum nigrum L., or a compound represented by the following Formula (1), as an active ingredient: wherein R represents an acyl group having 1 to 5 carbon atom(s).
摘要翻译：多巴氧化酶抑制剂，皮肤发光剂和皮肤外用剂; 包含至少一种选自Melia toosendan Sieb的植物的提取物。 et Zucc。，Amomum tsao-ka Crevost et Lemaire。（C），或者下述式（1）表示的化合物作为活性成分，式中，R表示碳原子数为1〜5的酰基。

5. 发明授权

US09339454B2 Skin whitening agent 有权
标题翻译：皮肤美白剂
公开(公告)号：US09339454B2
公开(公告)日：2016-05-17
申请号：US13979991
申请日：2012-01-20
申请人： Mamiko Kikuchi , Daiki Murase , Mitsuru Sugiyama , Akiko Kawasaki
发明人： Mamiko Kikuchi , Daiki Murase , Mitsuru Sugiyama , Akiko Kawasaki
IPC分类号： A61K36/00 , A61K8/97 , A61K31/365 , A61K36/19 , A61K8/49 , A61Q19/02 , A61K8/60 , A61K31/7048 , A23L1/30
CPC分类号： A61K8/97 , A23L33/105 , A61K8/4973 , A61K8/602 , A61K31/365 , A61K31/7048 , A61K36/19 , A61K2800/782 , A61Q19/02
摘要： The invention provides a method for inhibiting dopa oxidase activity, for inhibiting melanin production, or for whitening skin using haguro-so or an organic solvent extract thereof, or a compound of formula (I):
摘要翻译：本发明提供一种抑制多巴氧化酶活性，抑制黑色素生成或使用其中有机溶剂提取物或式（I）的化合物使皮肤美白的方法：

6. 发明授权

US4673596A Process for producing decorative sheet 失效
标题翻译：生产装饰板的工艺
公开(公告)号：US4673596A
公开(公告)日：1987-06-16
申请号：US775953
申请日：1985-09-13
申请人： Toru Shoji , Mitsuru Sugiyama , Makoto Takezawa , Yuichi Akiba , Akira Kaneko , Mituo Sato
发明人： Toru Shoji , Mitsuru Sugiyama , Makoto Takezawa , Yuichi Akiba , Akira Kaneko , Mituo Sato
IPC分类号： B05D5/06 , B05D1/02 , D06N7/00 , B05D3/02
CPC分类号： D06N7/0031
摘要： In the production of a decorative sheet, a synthetic resin paste is first applied onto the upper surface of a substrate sheet to form an undercoat layer. Then, one or more pastes, each being of the same material and having approximately the same viscosity as the paste of the undercoat layer, are laterally sprayed so as to drop onto the undercoat layer. The result is a smoothing phenomenon, with the pattern layer cooperating with the undercoat layer to form a smooth patterned surface. Finally, the pattern layer is heated and jelled.
摘要翻译：在装饰片的制造中，首先将合成树脂浆料涂布在基材片的上表面上，形成底涂层。然后，横向喷涂一个或多个各自具有相同材料并且具有与底涂层的糊料具有大致相同粘度的糊料，以便下落到底涂层上。结果是平滑现象，图案层与底涂层配合以形成光滑的图案表面。最后，图案层被加热和断裂。

7. 发明授权

US09056209B2 Apigenin-containing composition 有权
标题翻译：含芹菜素的组合物
公开(公告)号：US09056209B2
公开(公告)日：2015-06-16
申请号：US13320470
申请日：2010-06-02
申请人： Mitsuru Sugiyama , Shinya Kasamatsu
发明人： Mitsuru Sugiyama , Shinya Kasamatsu
IPC分类号： A61K8/34 , A61K8/49 , A61K31/353 , A61Q19/02 , A61K9/00 , A61K47/10 , A61K9/08 , A61K31/055
CPC分类号： A61Q19/02 , A61K8/347 , A61K8/498 , A61K9/0014 , A61K9/08 , A61K31/055 , A61K31/353 , A61K47/10 , A61K2300/00
摘要： Provided is a composition which maintains apigenin stably. The present invention provides the composition containing apigenin at 3 ppm or more and dibutylhydroxytoluene, wherein the mass ratio of the content of apigenin relative to the content of dibutylhydroxytoluene is 1 or greater, or the pH value is less than 7. Also provided is a method for preparing an apigenin-containing composition, the method including combining 3 ppm or more of apigenin with dibutylhydroxytoluene so that the mass ratio of the content of apigenin relative to the content of dibutylhydroxytoleune is 1 or greater, or including adjusting the ph of the composition to a value less than 7.
摘要翻译：提供维持芹菜碱稳定的组合物。本发明提供含有3ppm以上的芹菜素和二丁基羟基甲苯的组合物，其中芹菜素的含量相对于二丁基羟基甲苯的含量的质量比为1以上，或pH值小于7.还提供了一种方法为了制备含芹菜素的组合物，该方法包括将3ppm以上的芹菜素与二丁基羟基甲苯组合，使得芹菜素的含量相对于二丁基羟基甜菜碱的含量的质量比为1以上，或者包括将组合物的ph值调整为值小于7。

8. 发明申请

US20120100088A1 APIGENIN-CONTAINING COMPOSITION 有权
标题翻译：含APIGININ的组合物
公开(公告)号：US20120100088A1
公开(公告)日：2012-04-26
申请号：US13320470
申请日：2010-06-02
申请人： Mitsuru Sugiyama , Shinya Kasamatsu
发明人： Mitsuru Sugiyama , Shinya Kasamatsu
IPC分类号： A61K8/49 , A61Q19/02 , A61K31/35
CPC分类号： A61Q19/02 , A61K8/347 , A61K8/498 , A61K9/0014 , A61K9/08 , A61K31/055 , A61K31/353 , A61K47/10 , A61K2300/00
摘要： Provided is a composition which maintains apigenin stably. The present invention provides the composition containing apigenin at 3 ppm or more and dibutylhydroxytoluene, wherein the mass ratio of the content of apigenin relative to the content of dibutylhydroxytoluene is 1 or greater, or the pH value is less than 7. Also provided is a method for preparing an apigenin-containing composition, the method including combining 3 ppm or more of apigenin with dibutylhydroxytoluene so that the mass ratio of the content of apigenin relative to the content of dibutylhydroxytoleune is 1 or greater, or including adjusting the ph of the composition to a value less than 7.
摘要翻译：提供维持芹菜碱稳定的组合物。本发明提供含有3ppm以上的芹菜素和二丁基羟基甲苯的组合物，其中芹菜素的含量相对于二丁基羟基甲苯的含量的质量比为1以上，或pH值小于7.还提供了一种方法为了制备含芹菜素的组合物，该方法包括将3ppm以上的芹菜素与二丁基羟基甲苯组合，使得芹菜素的含量相对于二丁基羟基甜菜碱的含量的质量比为1以上，或者包括将组合物的ph值调整为值小于7。

9. 发明申请

US20130330286A1 Inhibitor of Endothelin Action and Skin-Whitening Agent 有权
标题翻译：内皮素作用和皮肤美白剂抑制剂
公开(公告)号：US20130330286A1
公开(公告)日：2013-12-12
申请号：US13993454
申请日：2011-11-24
申请人： Tsuyoshi Ohba , Daiki Murase , Mitsuru Sugiyama
发明人： Tsuyoshi Ohba , Daiki Murase , Mitsuru Sugiyama
IPC分类号： A61K8/37 , A61Q19/02
CPC分类号： A61K8/37 , A61K8/375 , A61K8/99 , A61K31/235 , A61K36/09 , A61K2800/782 , A61Q19/02
摘要： An inhibitor of endothelin action or a skin-whitening agent, comprising a compound represented by Formula (1) or a salt thereof as an active ingredient. wherein in Formula (1), R1 represents a formyl group or an alkyl group having 1 to 4 carbon atom(s), and R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atom(s).
摘要翻译：包含由式（1）表示的化合物或其盐作为活性成分的内皮素作用抑制剂或皮肤增白剂。其中，在式（1）中，R 1表示甲酰基或碳原子数1〜4的烷基，R 2表示氢原子或碳原子数1〜4的烷基。

10. 发明授权

US5508025A Naphthalenemethylenemalonic diesters, and UV absorbers and cosmetic compositions containing the diesters 失效
标题翻译：亚甲基丙二酸二酯，和含有二酯的紫外线吸收剂和化妆品组合物
公开(公告)号：US5508025A
公开(公告)日：1996-04-16
申请号：US363247
申请日：1994-12-23
申请人： Masahide Hoshino , Mitsuru Sugiyama , Akira Kawamata , Hiroko Joukura , Genji Imokawa
发明人： Masahide Hoshino , Mitsuru Sugiyama , Akira Kawamata , Hiroko Joukura , Genji Imokawa
IPC分类号： A61K8/37 , A61Q17/04 , C07C69/618 , C07C69/734 , A61K7/42
CPC分类号： A61Q17/04 , A61K8/37 , C07C69/618 , C07C69/734
摘要： The invention relates to UV absorbers and cosmetic compositions containing a naphthalenemethylenemalonic diester represented by the following formula (1): ##STR1## wherein NAP represents a naphthalene group which may optionally have a substituent, and R.sup.1 and R.sup.2 each independently represent a hydrocarbon group, an alkoxyalkyl group, or an alkoxyalkylenoxyalkyl group. The UV absorbers and the cosmetic compositions of the invention exhibit excellent ultraviolet ray absorbing action, and are stable to light.
摘要翻译：本发明涉及含有下式（1）表示的萘甲基丙二酸二酯的UV吸收剂和化妆品组合物：其中NAP表示可以具有取代基的萘基，R 1和R 2各自独立地表示烃基团，烷氧基烷基或烷氧基烷氧基烷基。本发明的紫外线吸收剂和化妆品组合物表现出优异的紫外线吸收作用，对光稳定。

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