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1. 发明申请

US20060093567A1 Method of inhibiting hair growth 审中-公开
标题翻译：抑制毛发生长的方法
公开(公告)号：US20060093567A1
公开(公告)日：2006-05-04
申请号：US11311170
申请日：2005-12-20
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号： A61K8/65
CPC分类号： A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要： Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and-use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译：本文公开了抑制毛发生长的方法，其包括施用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂，以及使用弹性蛋白酶样酶抑制剂或中性内肽酶抑制剂来制备毛发生长抑制剂。

2. 发明授权

US06436920B1 Wrinkling modifiers 有权
标题翻译：皱纹修饰
公开(公告)号：US06436920B1
公开(公告)日：2002-08-20
申请号：US09934837
申请日：2001-08-23
申请人： Tsutomu Fujimura , Noriko Ito , Minoru Nagai , Toshiya Ono , Akira Yamamuro , Yoshinori Takema
发明人： Tsutomu Fujimura , Noriko Ito , Minoru Nagai , Toshiya Ono , Akira Yamamuro , Yoshinori Takema
IPC分类号： A01N4300
CPC分类号： A61Q19/08 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494
摘要： The invention relates to wrinkling modifiers and anti-aging cosmetic compositions which each comprise a guanidine derivative represented by the following general formula (1): wherein is a heterocyclic group selected from azetidine, pyrrolidine, piperidine, piperazine or morpholine, and R1 and R2 are the same or different from each other and independently a hydrogen atom, or an alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino group, or a salt thereof. The cosmetic compositions are excellent in the effects of suppressing wrinkling and of removing wrinkles and give users a pleasant feeling upon use.
摘要翻译：本发明涉及起皱改性剂和抗衰老化妆品组合物，它们各自包含由以下通式（1）表示的胍衍生物：其中选自氮杂环丁烷，吡咯烷，哌啶，哌嗪或吗啉的杂环基，R1和R2为相同或不同，独立地为氢原子或烷基，羟基，羟基烷基，羧基，羧基烷基或脒基，或其盐。化妆品组合物在起皱和消除皱纹的效果方面具有优异的性能，并且在使用时给予使用者愉快的感觉。

3. 发明授权

US4923809A Polysaccharide and process for preparing the same 失效
标题翻译：多糖及其制备方法
公开(公告)号：US4923809A
公开(公告)日：1990-05-08
申请号：US165912
申请日：1988-03-09
申请人： Kazuya Otsuji , Yasuki Honda , Kikuhiko Okamoto , Hakaru Inaoka , Satoshi Takano , Yukio Sugimura , Noriko Okamura , Kazumi Saito , Yoshinori Takema , Toshiyuki Suzuki
发明人： Kazuya Otsuji , Yasuki Honda , Kikuhiko Okamoto , Hakaru Inaoka , Satoshi Takano , Yukio Sugimura , Noriko Okamura , Kazumi Saito , Yoshinori Takema , Toshiyuki Suzuki
IPC分类号： A61K8/73 , A61K31/715 , A61Q5/02 , A61Q19/00 , A61Q19/10 , B01F17/56 , C08B37/00 , C09J105/00 , C09K3/00 , C11D3/22 , C12N5/04 , C12P19/04 , C12R1/91
CPC分类号： C12P19/04 , A61K8/73 , A61Q19/00 , C08B37/0087 , C11D3/222 , A61Q19/10 , A61Q5/02
摘要： A novel acidic heteropolysaccharide which comprises as its structural units arabinose, mannose, galactose, glucuronic acid, and xylose, at a specific ratio. The polysaccharide can be prepared by culturing a callus induced from a plant belonging to the genus Polianthes L. in a culture medium containing plant hormones. The polysaccharide can be used as a component of agents for external application and detergents, and provides good moisturizing effects and a smooth, satisfying feeling upon use. When formulated in detergents, they produce remarkable improvement in a clean, rich feeling upon use.

4. 发明授权

US5709816A Singlet oxygen quenchers and external compositions containing the same 失效
标题翻译：单体氧猝灭剂和含有其的外用组合物
公开(公告)号：US5709816A
公开(公告)日：1998-01-20
申请号：US685926
申请日：1996-07-22
申请人： Masakazu Yamaguchi , Hiroyuki Ohsu , Eiichi Nishizawa , Mitsuru Sugiyama , Koichi Nakamura , Yoshinori Takema
发明人： Masakazu Yamaguchi , Hiroyuki Ohsu , Eiichi Nishizawa , Mitsuru Sugiyama , Koichi Nakamura , Yoshinori Takema
IPC分类号： A61K8/41 , A61K8/49 , A61K31/135 , A61K31/136 , A61K31/137 , A61K31/34 , A61K31/341 , A61Q17/00 , A61Q19/02 , A61Q19/08 , C07C217/28 , C07D307/52 , A61K7/50 , C07C211/00
CPC分类号： A61K8/4973 , A61K31/136 , A61K31/137 , A61K31/341 , A61K8/411 , A61Q17/00 , A61Q19/02 , A61Q19/08 , C07C217/28 , C07D307/52 , A61K2800/522 , A61Q17/04 , A61Q5/06 , A61Q5/12
摘要： Singlet oxygen quenchers containing as an active component a compound represented by the following formula or (2): ##STR1## wherein each of R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5, R.sup.10 and n are as described herein, and external compositions containing these compounds are provided for the prevention and treatment of various forms of damage to living bodies caused by singlet oxygen, and are thus quite useful as antiinflammation agents, anti-aging agents, agents preventing darkening of the skin, agents preventing protein denaturation, inhibitors against formation of sunburn cells, agents preventing lipid peroxidation, agents preventing DNA damage, and particularly in the fields of medicines and cosmetics as external compositions for the skin.
摘要翻译：含有作为活性成分的下述式（2）表示的化合物的单线态氧猝灭剂：其中R1，R2，R3，R4，R5，R10和n分别为提供含有这些化合物的外用组合物，用于预防和治疗由单线态氧引起的对活体的各种形式的损伤，因此作为抗炎剂，抗老化剂，防止皮肤变黑的药剂，防止蛋白质变性的药剂，防止晒伤细胞形成的抑制剂，防止脂质过氧化的药剂，防止DNA损伤的药剂，特别是作为皮肤外用组合物的药物和化妆品领域。

5. 发明授权

US06747017B2 Method of inhibiting hair growth 有权
标题翻译：抑制毛发生长的方法
公开(公告)号：US06747017B2
公开(公告)日：2004-06-08
申请号：US09220691
申请日：1998-12-28
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号： A01N5726
CPC分类号： A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要： Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译：本文公开了一种抑制毛发生长的方法，其包括施用弹性蛋白酶样酶或中性内肽酶抑制剂的抑制剂，以及使用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂来制备毛发生长抑制剂。

6. 发明授权

US4743441A Cosmetic composition 失效
标题翻译：化妆品组成
公开(公告)号：US4743441A
公开(公告)日：1988-05-10
申请号：US907160
申请日：1986-09-15
申请人： Yoshinori Takema , Rikio Tsushima , Yutaka Yasuda , Yoshinao Kono
发明人： Yoshinori Takema , Rikio Tsushima , Yutaka Yasuda , Yoshinao Kono
IPC分类号： C08F16/00 , A61K8/00 , A61K8/02 , A61K8/04 , A61K8/72 , A61K8/81 , A61Q3/02 , A61Q19/00 , C08F16/02 , C08F216/06 , A61K7/00 , A61K7/021 , A61K7/035 , A61K7/04 , A61K7/06 , A61K9/00 , C08F16/06
CPC分类号： A61K8/0212 , A61K8/046 , A61K8/8129 , A61Q3/02 , Y10S424/01 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/847
摘要： A film-forming cosmetic composition useful as a facial pack, nail enamel, eye liner etc., which comprises a copolymer of vinyl alcohol and alkyl vinyl ether, being referred to simply as PVA/AVE, consisting of 98 to 80 mole % of vinyl alcohol monomer units and 2 to 20 mole % of linear or branched alkyl vinyl monomer units having from 1 to 6 carbon atoms. The molar ratio of the vinyl alcohol monomer units to the alkyl vinyl ether monomer units is in the range of from 95/5 to 85/15. The PVA/AVE according to the invention has no acetic groups with ester bonds in a molecule. Instead, there are alkyl or alkenyl groups having ether bonds which serve for steric hindrance for preventing gelation of an aqueous solution of such copolymer. From this reason, the PVA/AVE does not undergo any hydrolysis as time passes and is thus excellent in storage stability.
摘要翻译：包含乙烯基醇和烷基乙烯基醚的共聚物的面包，指甲油，眼线浆等的成膜化妆品组合物简称为PVA / AVE，由98〜80摩尔％的乙烯基醇单体单元和2至20摩尔％的具有1至6个碳原子的直链或支链烷基乙烯基单体单元。乙烯醇单体单元与烷基乙烯基醚单体单元的摩尔比在95/5至85/15的范围内。根据本发明的PVA / AVE在分子中没有具有酯键的乙酸基团。相反，存在用于防止这种共聚物的水溶液凝胶化的空间位阻的具有醚键的烷基或烯基。由此，随着时间的流逝PVA / AVE不会发生水解，因此保存稳定性优异。

7. 发明授权

US6075052A Skin external preparation 有权
标题翻译：皮肤外用制剂
公开(公告)号：US6075052A
公开(公告)日：2000-06-13
申请号：US276504
申请日：1999-03-25
申请人： Yasuto Suzuki , Naoko Tsuji , Shigeru Moriwaki , Yoshinori Nishizawa , Yoshinori Takema , Satoshi Kanazawa , Genji Imokawa , Yukihiro Ohashi , Mikako Watanabe
发明人： Yasuto Suzuki , Naoko Tsuji , Shigeru Moriwaki , Yoshinori Nishizawa , Yoshinori Takema , Satoshi Kanazawa , Genji Imokawa , Yukihiro Ohashi , Mikako Watanabe
IPC分类号： C07D207/16 , A61K8/00 , A61K8/02 , A61K8/30 , A61K8/42 , A61K8/44 , A61K8/46 , A61K8/49 , A61K8/55 , A61K8/58 , A61K8/97 , A61K31/185 , A61K31/195 , A61K31/22 , A61K31/27 , A61K31/40 , A61K31/66 , A61P17/00 , A61Q5/00 , A61Q7/00 , A61Q9/04 , A61Q19/00 , A61Q19/08 , A01N37/12 , A01N37/02 , A01N37/10 , C07C51/16 , C07C229/00
CPC分类号： A61K8/97 , A61K8/44 , A61K8/442 , A61K8/55 , A61Q19/08 , A61Q7/00
摘要： The present invention provides a skin external preparation comprising a compound of the formula (1), (2), (3) or (4). ##STR1## wherein X represents COOH, etc., Z represents CONH.sub.2, etc. and R.sup.1 and R.sup.7 individually represent a hydrogen atom, etc.The above-described compound has excellent effects, for example, for preventing or alleviating skin aging or inhibiting hair growth.
摘要翻译：本发明提供包含式（1），（2），（3）或（4）的化合物的皮肤外用制剂。其中X表示COOH等，Z表示CONH 2等，R 1和R 7各自表示氢原子等。上述化合物具有优异的效果，例如用于预防或缓解皮肤老化或抑制毛发生长。

8. 发明授权

US5939078A Wrinkle-care product 失效
标题翻译：皱纹护理产品
公开(公告)号：US5939078A
公开(公告)日：1999-08-17
申请号：US746808
申请日：1996-11-18
申请人： Tsutomu Fujimura , Ayumi Ogawa , Kazue Tsukahara , Yoshinori Takema , Minoru Nagai , Toshiya Ono
发明人： Tsutomu Fujimura , Ayumi Ogawa , Kazue Tsukahara , Yoshinori Takema , Minoru Nagai , Toshiya Ono
IPC分类号： A61K8/43 , A61Q19/08 , A61K7/48
CPC分类号： A61Q19/08 , A61K8/43 , Y10S514/844 , Y10S514/845 , Y10S514/846 , Y10S514/944
摘要： A wrinkle-care product, an aging-preventive cosmetic and a skin cosmetic each comprising a guanidine derivative of formula (I) or an acid addition salt thereof: ##STR1## wherein R1 represents a hydrogen atom, a lower alkyl group or --(AO).sub.m --(BO).sub.n --D--E �wherein A and B may be the same or different and each represents an alkylene group having 2 to 8 carbon atoms; D represents a binding hand, --CO--, or an unsubstituted or substituted alkylene group having 1 to 6 carbon atoms; E represents a hydrogen atom, a lower alkyl group, an aralkyl group or an unsubstituted or substituted aryl group; m is a number of from 1 to 6; and n is a number of from 0 to 6!; k is a number of from 1 to 10; and G represents a hydrogen atom, a hydroxyl group, a carboxyl group, a sulfonate group or a phosphate group. These products are excellent in the effects of inhibiting wrinkling and smoothing wrinkles without damaging the physiological conditions of the skin.
摘要翻译：每个包含式（I）的胍衍生物或其酸加成盐的皱纹护理产品，防老化妆品和皮肤化妆品，其中R1表示氢原子，低级烷基或 - （AO）m- （BO）nDE [其中A和B可以相同或不同，并且各自表示具有2至8个碳原子的亚烷基; D表示结合手-CO-或未取代或取代的具有1至6个碳原子的亚烷基; E表示氢原子，低级烷基，芳烷基或未取代或取代的芳基; m是从1到6的数字; n为0〜6的数]。 k是从1到10的数字; G表示氢原子，羟基，羧基，磺酸酯基或磷酸酯基。这些产品在不损害皮肤生理条件的情况下，优异的抑制皱纹和皱纹的效果。

9. 发明授权

US07041658B2 Method of inhibiting hair growth 失效
标题翻译：抑制毛发生长的方法
公开(公告)号：US07041658B2
公开(公告)日：2006-05-09
申请号：US10800668
申请日：2004-03-16
申请人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
发明人： Naoko Tsuji , Shigeru Moriwaki , Atsushi Ohuchi , Yoshinori Takema , Yasuto Suzuki , Genji Imokawa
IPC分类号： A61K31/66
CPC分类号： A61K8/46 , A61K8/447 , A61K8/55 , A61K2800/782 , A61Q7/02
摘要： Disclosed herein are a method of inhibiting hair growth, which comprises administering an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor, and use of an inhibitor of elastase-like enzymes or a neutral endopeptidase inhibitor for the preparation of a hair-growth inhibitor.
摘要翻译：本文公开了一种抑制毛发生长的方法，其包括施用弹性蛋白酶样酶或中性内肽酶抑制剂的抑制剂，以及使用弹性蛋白酶样酶抑制剂或中性肽链内切酶抑制剂来制备毛发生长抑制剂。

10. 发明授权

US06306848B1 Method of modifying wrinkles using guanidine derivatives 有权
标题翻译：使用胍衍生物改善皱纹的方法
公开(公告)号：US06306848B1
公开(公告)日：2001-10-23
申请号：US09269744
申请日：1999-04-06
申请人： Tsutomu Fujimura , Noriko Ito , Minoru Nagai , Toshiya Ono , Akira Yamamuro , Yoshinori Takema
发明人： Tsutomu Fujimura , Noriko Ito , Minoru Nagai , Toshiya Ono , Akira Yamamuro , Yoshinori Takema
IPC分类号： A01N4300
CPC分类号： A61Q19/08 , A61K8/49 , A61K8/4913 , A61K8/4926 , A61K8/494
摘要： The invention relates to wrinkling modifiers and anti-aging cosmetic compositions which each comprise a guanidine derivative represented by the following general formula (1): wherein is a heterocyclic group selected from azetidine, pyrrolidine, piperidine, piperazine or morpholine, and R1 and R2 are the same or different from each other and independently a hydrogen atom, or an alkyl, hydroxyl, hydroxyalkyl, carboxyl, carboxyalkyl or amidino group, or a salt thereof. The cosmetic compositions are excellent in the effects of suppressing wrinkling and of removing wrinkles and give users a pleasant feeling upon use.
摘要翻译：本发明涉及起皱改性剂和抗衰老化妆品组合物，它们各自包含由以下通式（1）表示的胍衍生物：其中选自氮杂环丁烷，吡咯烷，哌啶，哌嗪或吗啉的杂环基，R1和R2为相同或不同，独立地为氢原子或烷基，羟基，羟基烷基，羧基，羧基烷基或脒基，或其盐。化妆品组合物在起皱和消除皱纹的效果方面具有优异的性能，并且在使用时给予使用者愉快的感觉。

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