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1. 发明授权

US09408969B2 Anesthetic solution-filled cartridge-type electric dental syringe 有权
标题翻译：麻醉溶液填充墨盒式电动牙科注射器
公开(公告)号：US09408969B2
公开(公告)日：2016-08-09
申请号：US13997864
申请日：2010-12-27
申请人： Fumio Tanaka , Mitsuhiro Haraguchi , Yoshihiko Kawasaki , Mutsumi Shibuya , Renji Hayashi , Yoshinori Kato , Akiko Kawasaki
发明人： Fumio Tanaka , Mitsuhiro Haraguchi , Yoshihiko Kawasaki , Mutsumi Shibuya , Renji Hayashi , Yoshinori Kato
IPC分类号： A61M5/20 , A61M5/24 , A61M5/315 , A61C19/08 , A61C5/06
CPC分类号： A61M5/20 , A61C5/62 , A61C19/08 , A61M5/24 , A61M5/31511 , A61M2005/31518
摘要： Provided is an anesthetic solution-filled cartridge-type electric dental syringe, wherein the plunger has been shortened but the plunger can nevertheless be extended to the distance necessary to evacuate the anesthetic solution from the cartridge. The syringe comprises: an extension tube into which a plunger is movably inserted, the extension tube being movably disposed in the through hole of a support block and having racks formed in the side surface thereof that are coordinated with the racks of the plunger; and a means for the plunger to draw the extension tube to engage the racks of the extension tube with a pinion when the plunger reaches the middle of the distance corresponding to the anesthetic solution accommodation length of the cartridge. By the engagement of the racks of the extension tube with the pinion, the plunger moves together with the extension tube for the remainder of the distance corresponding to the anesthetic solution accommodation length of the cartridge.
摘要翻译：提供了一种充满麻醉剂的药筒型电动牙科注射器，其中柱塞已经被缩短，但是柱塞可以延伸到从药筒排出麻醉溶液所需的距离。注射器包括：延伸管，柱塞可移动地插入该延伸管中，延伸管可移动地设置在支撑块的通孔中，并且具有形成在其侧表面中的与柱塞的齿条配合的齿条; 以及当柱塞达到对应于药筒的麻醉剂溶液容纳长度的距离的中间时，柱塞的一个装置用于拉伸延伸管以与小齿轮接合延伸管的齿条。通过延伸管的齿条与小齿轮的接合，柱塞与延伸管一起移动距离对应于药筒的麻醉剂溶液容纳长度的剩余距离。

2. 发明申请

US20140011158A1 ANESTHETIC SOLUTION-FILLED CARTRIDGE-TYPE ELECTRIC DENTAL SYRINGE 有权
公开(公告)号：US20140011158A1
公开(公告)日：2014-01-09
申请号：US13997864
申请日：2010-12-27
申请人： Akiko Kawasaki
发明人： Fumio Tanaka , Mitsuhiro Haraguchi , Yoshihiko Kawasaki , Mutsumi Shibuya , Renji Hayashi , Yoshinori Kato
IPC分类号： A61M5/20
CPC分类号： A61M5/20 , A61C5/62 , A61C19/08 , A61M5/24 , A61M5/31511 , A61M2005/31518
摘要： Provided is an anesthetic solution-filled cartridge-type electric dental syringe, wherein the plunger has been shortened but the plunger can nevertheless be extended to the distance necessary to evacuate the anesthetic solution from the cartridge. The syringe comprises: an extension tube (11) into which a plunger (5) is movably inserted, the extension tube being movably disposed in the through hole (14) of a support block (13) and having racks (15, 15) formed in the side surface thereof that are coordinated with the racks (9) of the plunger; and a means for the plunger to draw the extension tube to engage the racks (15, 15) of the extension tube with a pinion (21) when the plunger reaches the middle of the distance corresponding to the anesthetic solution accommodation length of the cartridge. By the engagement of the racks of the extension tube with the pinion, the plunger moves together with the extension tube for the remainder of the distance corresponding to the anesthetic solution accommodation length of the cartridge.
摘要翻译：提供了一种充满麻醉剂的药筒型电动牙科注射器，其中柱塞已经被缩短，但是柱塞可以延伸到从药筒排出麻醉溶液所需的距离。注射器包括：延伸管（11），柱塞（5）可移动地插入其中，延伸管可移动地设置在支撑块（13）的通孔（14）中，并且具有形成的齿条（15,15）在其侧表面上与柱塞的齿条（9）配合; 以及当所述柱塞达到对应于所述药筒的麻醉剂溶液容纳长度的距离的中间时，所述柱塞用于拉伸所述延伸管以使所述延伸管的齿条（15,15）与小齿轮（21）接合的装置。通过延伸管的齿条与小齿轮的接合，柱塞与延伸管一起移动距离对应于药筒的麻醉剂溶液容纳长度的剩余距离。

3. 发明授权

US08507690B2 Thiazole derivative and use thereof as VAP-1 inhibitor 有权
标题翻译：噻唑衍生物及其作为VAP-1抑制剂的用途
公开(公告)号：US08507690B2
公开(公告)日：2013-08-13
申请号：US12864773
申请日：2009-01-30
申请人： Tatsuya Matsukawa , Kazuhiro Masuzaki , Yosuke Kawai , Akiko Kawasaki , Akiko Akasaka , Makoto Takewaki
发明人： Tatsuya Matsukawa , Kazuhiro Masuzaki , Yosuke Kawai , Akiko Kawasaki , Akiko Akasaka , Makoto Takewaki
IPC分类号： C07D277/38 , A61K31/427 , A61K31/426
CPC分类号： C07D277/46 , C07D417/06
摘要： The invention provides a thiazole derivative useful as a VAP-1 inhibitor, as well as a pharmaceutical agent for the prophylaxis or treatment of VAP-1 associated diseases and the like, a method of inhibiting VAP-1 in a subject, and a method for the prophylaxis or treatment of VAP-1 associated disease in a subject. The thiazole derivative is a compound represented by the formula (I): R1—NH—X—Y—Z wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了可用作VAP-1抑制剂的噻唑衍生物，以及用于预防或治疗VAP-1相关疾病等的药剂，抑制受试者中VAP-1的方法，预防或治疗受试者中VAP-1相关疾病。噻唑衍生物是由式（I）表示的化合物：其中各符号如说明书中所定义，或其药学上可接受的盐，其中R1-NH-X-Y-Z。

4. 发明申请

US20110117038A1 Dopa Oxidase Inhibitor, Skin-Lightening Agent and External Preparation for Skin 审中-公开
标题翻译：多巴氧化酶抑制剂，皮肤增亮剂和皮肤外用剂
公开(公告)号：US20110117038A1
公开(公告)日：2011-05-19
申请号：US12939349
申请日：2010-11-04
申请人： Akiko KAWASAKI , Mitsuru Sugiyama , Yasuko Amano
发明人： Akiko KAWASAKI , Mitsuru Sugiyama , Yasuko Amano
IPC分类号： A61K8/97 , A61K8/49 , A61K36/9064 , A61K36/28 , A61K36/88 , A61K31/58 , C07J71/00 , A61Q19/02 , A61Q19/00 , A61P17/00
CPC分类号： C07J71/0021 , A61K8/63 , A61K8/97 , A61Q19/02 , A61Q19/10
摘要： A dopa oxidase inhibitor, a skin-lightening agent and an external preparation for skin; comprising an extract of at least one plant selected from the group consisting of Melia toosendan Sieb. et Zucc., Amomum tsao-ka Crevost et Lemaire. Senecio gracilis and Veratrum nigrum L., or a compound represented by the following Formula (1), as an active ingredient: wherein R represents an acyl group having 1 to 5 carbon atom(s).
摘要翻译：多巴氧化酶抑制剂，皮肤发光剂和皮肤外用剂; 包含至少一种选自Melia toosendan Sieb的植物的提取物。 et Zucc。，Amomum tsao-ka Crevost et Lemaire。（C），或者下述式（1）表示的化合物作为活性成分，式中，R表示碳原子数为1〜5的酰基。

5. 发明申请

US20110059957A1 BENZENE OR THIOPHENE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR 有权
标题翻译：苯并噻吩衍生物及其作为VAP-1抑制剂的用途
公开(公告)号：US20110059957A1
公开(公告)日：2011-03-10
申请号：US12991035
申请日：2009-05-29
申请人： Tatsuya Matsukawa , Kazuhiro Masuzaki , Akiko Kawasaki , Akiko Akasaka , Yosuke Kawai
发明人： Tatsuya Matsukawa , Kazuhiro Masuzaki , Akiko Kawasaki , Akiko Akasaka , Yosuke Kawai
IPC分类号： A61K31/167 , C07C243/18 , C07D213/74 , C07D233/64 , C07D413/04 , C07D241/20 , C07D241/24 , C07D265/36 , A61K31/44 , A61K31/4174 , A61K31/5377 , A61K31/4965 , A61K31/454 , A61K31/222 , A61K31/538 , A61P27/02 , A61P9/10 , A61P27/06 , A61P29/00 , A61P3/10 , A61P19/02 , A61P17/00 , A61P1/00 , A61P11/06 , A61P25/28
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/497 , A61K31/505 , A61K31/506 , C07C243/32 , C07C243/34 , C07C281/02 , C07C281/06 , C07D213/72 , C07D213/74 , C07D213/75 , C07D233/64 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/24 , C07D265/36 , C07D333/10 , C07D333/36 , C07D401/04 , C07D409/06 , C07D417/04 , C07D487/08
摘要： The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供可用作VAP-1抑制剂的新型苯衍生物或噻吩衍生物，或用于预防或治疗VAP-1相关疾病等的药物，即由式（I）表示的化合物：其中每个符号如本说明书中所定义，或其药学上可接受的盐。

6. 发明授权

US08999989B2 Benzene or thiophene derivative and use thereof as VAP-1 inhibitor 有权
标题翻译：苯或噻吩衍生物及其作为VAP-1抑制剂的用途
公开(公告)号：US08999989B2
公开(公告)日：2015-04-07
申请号：US12991035
申请日：2009-05-29
申请人： Tatsuya Matsukawa , Kazuhiro Masuzaki , Akiko Kawasaki , Akiko Akasaka , Yosuke Kawai
发明人： Tatsuya Matsukawa , Kazuhiro Masuzaki , Akiko Kawasaki , Akiko Akasaka , Yosuke Kawai
IPC分类号： A61K31/496 , C07D241/04 , C07D213/74 , C07C243/32 , C07C243/34 , C07C281/02 , C07C281/06 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/24 , C07D265/36 , C07D333/36 , C07D401/04 , C07D409/06 , C07D417/04 , C07D487/08
CPC分类号： A61K31/381 , A61K31/4025 , A61K31/422 , A61K31/425 , A61K31/427 , A61K31/44 , A61K31/4427 , A61K31/497 , A61K31/505 , A61K31/506 , C07C243/32 , C07C243/34 , C07C281/02 , C07C281/06 , C07D213/72 , C07D213/74 , C07D213/75 , C07D233/64 , C07D233/88 , C07D237/20 , C07D239/42 , C07D241/20 , C07D241/24 , C07D265/36 , C07D333/10 , C07D333/36 , C07D401/04 , C07D409/06 , C07D417/04 , C07D487/08
摘要： The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供可用作VAP-1抑制剂的新型苯衍生物或噻吩衍生物，或用于预防或治疗VAP-1相关疾病等的药物，即由式（I）表示的化合物：其中每个符号如本说明书中所定义，或其药学上可接受的盐。

7. 发明授权

US09486488B2 Skin-lightening agent 有权
标题翻译：护肤剂
公开(公告)号：US09486488B2
公开(公告)日：2016-11-08
申请号：US14241915
申请日：2012-07-18
申请人： Akiko Kawasaki , Mamiko Kikuchi
发明人： Akiko Kawasaki , Mamiko Kikuchi
IPC分类号： A61K36/19 , A61Q19/02 , A61K8/97
CPC分类号： A61K36/19 , A61K8/97 , A61K2800/782 , A61Q19/02
摘要： Provided are a very safe skin whitening agent, melanin production inhibitor, and dopa oxidase activity inhibitor. Use of kitsunenomago or an organic solvent extract thereof to inhibit the dopa oxidase activity.
摘要翻译：提供了非常安全的皮肤美白剂，黑色素生成抑制剂和多巴氧化酶活性抑制剂。使用kitunenomago或其有机溶剂提取物抑制多巴氧化酶活性。

8. 发明申请

US20130295207A1 Skin Whitening Agent 有权
标题翻译：皮肤美白剂
公开(公告)号：US20130295207A1
公开(公告)日：2013-11-07
申请号：US13979991
申请日：2012-01-20
申请人： Mamiko Kikuchi , Daiki Murase , Mitsuru Sugiyama , Akiko Kawasaki
发明人： Mamiko Kikuchi , Daiki Murase , Mitsuru Sugiyama , Akiko Kawasaki
IPC分类号： A61K8/97 , A61Q19/02 , A61K8/60 , A61K8/49
CPC分类号： A61K8/97 , A23L33/105 , A61K8/4973 , A61K8/602 , A61K31/365 , A61K31/7048 , A61K36/19 , A61K2800/782 , A61Q19/02
摘要： Use of haguro-so or an organic solvent extract thereof, or a compound represented by the following formula (I) or a salt thereof, for inhibiting a dopa oxidase activity, for inhibiting melanin production, or for whitening the skin; in the formula (I), R1 and R2, being the same or different, each represent a hydroxyl group, or a C1-4 linear or branched alkoxy group, or R1 and R2 together form a methylenedioxy group; R3 and R4, being the same or different, each represent a hydroxyl group, or a C1-4 linear or branched alkoxy group, or R3 and R4 together form a methylenedioxy group; R5 represents a hydrogen atom, a hydroxyl group, a C1-5 linear or branched alkoxy group, a C1-4 acyl group, or a sugar residue selected from the group consisting of (D-apio-β-D-furanosyl)oxy, (β-D-glucopyranosyl)oxy, (3-O,4-O-dimethyl-D-xylopyranosyl)oxy, (2-O,3-O,4-O-trimethyl-β-D-xylopyranosyl)oxy, and (3-O-methyl-β-D-glucopyranosyl)oxy; R6 and R7 are each a hydrogen atom and R8 and R9 together represent an oxygen atom, or R8 and R9 are each a hydrogen atom and R6 and R7 together represent an oxygen atom.
摘要翻译：或其有机溶剂提取物或由下式（I）表示的化合物或其盐用于抑制多巴氧化酶活性，抑制黑色素生成或使皮肤变白的用途; 在式（I）中，R 1和R 2相同或不同，各自表示羟基或C 1-4直链或支链烷氧基，或者R 1和R 2一起形成亚甲二氧基; R 3和R 4相同或不同，各自表示羟基或C 1-4直链或支链烷氧基，或者R 3和R 4一起形成亚甲二氧基; R5表示氢原子，羟基，C1-5直链或支链烷氧基，C1-4酰基或选自（D-api-β-D-呋喃糖基）氧基，（3-O，4-O-二甲基-D-木吡喃糖基）氧基（2-O，3-O，4-O-三甲基-β-D-吡喃木糖基）氧基和（3-O-甲基-β-D-吡喃葡萄糖基）氧基; R6和R7各自为氢原子，R8和R9一起表示氧原子，或R8和R9各自为氢原子，R6和R7一起表示氧原子。

9. 发明申请

US20110015240A1 THIAZOLE DERIVATIVE AND USE THEREOF AS VAP-1 INHIBITOR 有权
标题翻译：噻唑衍生物及其作为VAP-1抑制剂的用途
公开(公告)号：US20110015240A1
公开(公告)日：2011-01-20
申请号：US12864773
申请日：2009-01-30
申请人： Tatsuya Matsukawa , Kazuhiro Masuzaki , Yosuke Kawai , Akiko Kawasaki , Akiko Akasaka , Makoto Takewaki
发明人： Tatsuya Matsukawa , Kazuhiro Masuzaki , Yosuke Kawai , Akiko Kawasaki , Akiko Akasaka , Makoto Takewaki
IPC分类号： A61K31/426 , C07D277/46 , C07D417/06 , C07C217/54 , A61K31/135 , C07C211/03 , A61P3/10 , A61P9/00 , A61P17/00 , A61P19/00 , A61P25/00 , A61P27/02 , A61P35/00
CPC分类号： C07D277/46 , C07D417/06
摘要： The invention provides a thiazole derivative useful as a VAP-1 inhibitor, as well as a pharmaceutical agent for the prophylaxis or treatment of VAP-1 associated diseases and the like, a method of inhibiting VAP-1 in a subject, and a method for the prophylaxis or treatment of VAP-1 associated disease in a subject. The thiazole derivative is a compound represented by the formula (I): R1—NH—X—Y—Z wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了可用作VAP-1抑制剂的噻唑衍生物，以及用于预防或治疗VAP-1相关疾病等的药剂，抑制受试者中VAP-1的方法，预防或治疗受试者中VAP-1相关疾病。噻唑衍生物是由式（I）表示的化合物：其中各符号如说明书中所定义，或其药学上可接受的盐，其中R1-NH-X-Y-Z。

10. 发明授权

US09339454B2 Skin whitening agent 有权
标题翻译：皮肤美白剂
公开(公告)号：US09339454B2
公开(公告)日：2016-05-17
申请号：US13979991
申请日：2012-01-20
申请人： Mamiko Kikuchi , Daiki Murase , Mitsuru Sugiyama , Akiko Kawasaki
发明人： Mamiko Kikuchi , Daiki Murase , Mitsuru Sugiyama , Akiko Kawasaki
IPC分类号： A61K36/00 , A61K8/97 , A61K31/365 , A61K36/19 , A61K8/49 , A61Q19/02 , A61K8/60 , A61K31/7048 , A23L1/30
CPC分类号： A61K8/97 , A23L33/105 , A61K8/4973 , A61K8/602 , A61K31/365 , A61K31/7048 , A61K36/19 , A61K2800/782 , A61Q19/02
摘要： The invention provides a method for inhibiting dopa oxidase activity, for inhibiting melanin production, or for whitening skin using haguro-so or an organic solvent extract thereof, or a compound of formula (I):
摘要翻译：本发明提供一种抑制多巴氧化酶活性，抑制黑色素生成或使用其中有机溶剂提取物或式（I）的化合物使皮肤美白的方法：

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