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1. 发明授权

US07402406B2 Methods of evaluating phosphatase inhibitors 失效
标题翻译：评估磷酸酶抑制剂的方法
公开(公告)号：US07402406B2
公开(公告)日：2008-07-22
申请号：US10493057
申请日：2002-10-31
申请人： Masahiko Morita , Hiroyuki Arakawa , Mayako Yamazaki , Susumu Satoh , Shintaro Nishimura , Yasuhiro Kita , Takao Yamazaki
发明人： Masahiko Morita , Hiroyuki Arakawa , Mayako Yamazaki , Susumu Satoh , Shintaro Nishimura , Yasuhiro Kita , Takao Yamazaki
IPC分类号： C12Q1/42 , C12N9/14 , C07H21/04
CPC分类号： C12Q1/42 , G01N2333/4703 , G01N2500/02
摘要： The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using these genes, and/or proteins encoded by these genes. Furthermore, these proteins were found to enhance cell damage. Compounds that can be screened based on the evaluation methods of this invention are useful as agents for inhibiting the CREB dephosphorylation reaction, agents for suppressing enhancement of cell damage, and preventive and therapeutic agents for memory disorders and/or neurodegenerative disorders.
摘要翻译：本发明将OVARC1000473（SEQ ID NO：1）和NT2RM1000377（SEQ ID NO：3）鉴定为表达抑制福斯福林的CREB活化的克隆，并提供使用这些基因的评价方法和/或由这些基因编码的蛋白质。此外，发现这些蛋白质增强细胞损伤。可以根据本发明的评估方法筛选的化合物可用作抑制CREB去磷酸化反应的药剂，用于抑制细胞损伤增强的药剂，以及用于记忆障碍和/或神经变性疾病的预防和治疗剂。

2. 发明申请

US20050214888A1 Methods of eavaluating phosphatase inhibitors 失效
标题翻译：淘汰磷酸酶抑制剂的方法
公开(公告)号：US20050214888A1
公开(公告)日：2005-09-29
申请号：US10493057
申请日：2002-10-31
申请人： Masahiko Morita , Hiroyuki Arakawa , Mayako Yamazaki , Susumu Satoh , Shintaro Nishimura , Yasuhiro Kita , Takao Yamazaki
发明人： Masahiko Morita , Hiroyuki Arakawa , Mayako Yamazaki , Susumu Satoh , Shintaro Nishimura , Yasuhiro Kita , Takao Yamazaki
IPC分类号： A61K31/713 , A61P25/00 , C07K14/47 , C12Q1/42
CPC分类号： C12Q1/42 , G01N2333/4703 , G01N2500/02
摘要： The present invention identified OVARC1000473 (SEQ ID NO: 1) and NT2RM1000377 (SEQ ID NO: 3) as clones showing suppression of CREB activation by forskolin, and provides evaluation methods using these genes, and/or proteins encoded by these genes. Furthermore, these proteins were found to enhance cell damage. Compounds that can be screened based on the evaluation methods of this invention are useful as agents for inhibiting the CREB dephosphorylation reaction, agents for suppressing enhancement of cell damage, and preventive and therapeutic agents for memory disorders and/or neurodegenerative disorders.
摘要翻译：本发明将OVARC1000473（SEQ ID NO：1）和NT2RM1000377（SEQ ID NO：3）鉴定为表达抑制福斯福林的CREB活化的克隆，并提供使用这些基因的评价方法和/或由这些基因编码的蛋白质。此外，发现这些蛋白质增强细胞损伤。可以根据本发明的评估方法筛选的化合物可用作抑制CREB去磷酸化反应的药剂，用于抑制细胞损伤增强的药剂，以及用于记忆障碍和/或神经变性疾病的预防和治疗剂。

3. 发明授权

US07029860B2 Amyloid-β protein aggregation-regulating factors 失效
标题翻译：淀粉样蛋白β蛋白聚集调节因子
公开(公告)号：US07029860B2
公开(公告)日：2006-04-18
申请号：US11013400
申请日：2004-12-17
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Hio , Mayako Yamazaki , Susumu Satoh , Hiroyuki Arakawa , Masahiko Morita
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Hio , Mayako Yamazaki , Susumu Satoh , Hiroyuki Arakawa , Masahiko Morita
IPC分类号： G01N33/50 , A61K38/17 , C07K14/435
CPC分类号： C07K14/4702 , A01K2217/05 , A61K38/00 , C07K14/4711 , C07K14/4747 , C07K14/505 , C07K14/524
摘要： The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-β protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-β protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-β protein.
摘要翻译：本发明提供：抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的蛋白质; 编码蛋白质的多核苷酸; 筛选抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的化合物的方法; 以及用于治疗或预防阿尔茨海默病的治疗剂，其包含调节蛋白质抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的活性的化合物。

4. 发明授权

US06960435B1 Amyloid β protein agglutination-controlling factor 失效
标题翻译：淀粉样β蛋白凝集控制因子
公开(公告)号：US06960435B1
公开(公告)日：2005-11-01
申请号：US10030269
申请日：2000-07-06
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Hio , Mayako Yamazaki , Susumu Satoh , Hiroyuki Arakawa , Masahiko Morita
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Hio , Mayako Yamazaki , Susumu Satoh , Hiroyuki Arakawa , Masahiko Morita
IPC分类号： C07K14/47 , C12N1/21 , C12N5/10 , C12N15/63 , C12P21/02 , C12Q1/68
CPC分类号： C07K14/4711
摘要： The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-β protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-β protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-β protein.
摘要翻译：本发明提供：抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的蛋白质; 编码蛋白质的多核苷酸; 筛选抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的化合物的方法; 以及用于治疗或预防阿尔茨海默病的治疗剂，其包含调节蛋白质抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的活性的化合物。

5. 发明申请

US20050214813A1 Amyloid-beta protein aggregation-regulating factors 失效
标题翻译：淀粉样蛋白β蛋白聚集调节因子
公开(公告)号：US20050214813A1
公开(公告)日：2005-09-29
申请号：US11013400
申请日：2004-12-17
申请人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Hio , Mayako Yamazaki , Susumu Satoh , Hiroyuki Arakawa , Masahiko Morita
发明人： Toshio Ota , Takao Isogai , Tetsuo Nishikawa , Yuri Hio , Mayako Yamazaki , Susumu Satoh , Hiroyuki Arakawa , Masahiko Morita
IPC分类号： A61K38/00 , A61P25/00 , A61P25/28 , C07K14/47 , C07K14/505 , C07K14/52 , C12N1/15 , C12N1/19 , C12N1/21 , C12N15/12 , C12N15/16 , C12P21/08 , C12Q1/68 , C07H21/04 , C12N9/64
CPC分类号： C07K14/4702 , A01K2217/05 , A61K38/00 , C07K14/4711 , C07K14/4747 , C07K14/505 , C07K14/524
摘要： The present invention provides: proteins suppressing or promoting the aggregation or deposition of amyloid-β protein; polynucleotides encoding the proteins; a method for screening a compound suppressing or promoting the aggregation or deposition of amyloid-β protein; and therapeutic agents for treating or preventing Alzheimer's diseases comprising a compound that regulates the activity of a protein suppressing or promoting the aggregation or deposition of amyloid-β protein.
摘要翻译：本发明提供：抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的蛋白质; 编码蛋白质的多核苷酸; 筛选抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的化合物的方法; 以及用于治疗或预防阿尔茨海默病的治疗剂，其包含调节蛋白质抑制或促进淀粉样蛋白-β蛋白的聚集或沉积的活性的化合物。

6. 发明授权

US07402435B2 Method of transferring a selected molecule into a cell 有权
标题翻译：将选择的分子转移到细胞中的方法
公开(公告)号：US07402435B2
公开(公告)日：2008-07-22
申请号：US10470732
申请日：2002-02-08
申请人： Sousuke Miyoshi , Akiko Ohkubo , Noriyuki Morikawa , Yasuhiro Ogawa , Shintaro Nishimura , Masao Fukagawa , Hiroyuki Arakawa , Jyunko Zenkou , Susumu Sato
发明人： Sousuke Miyoshi , Akiko Ohkubo , Noriyuki Morikawa , Yasuhiro Ogawa , Shintaro Nishimura , Masao Fukagawa , Hiroyuki Arakawa , Jyunko Zenkou , Susumu Sato
IPC分类号： C12N15/00 , C12N15/02
CPC分类号： C12N15/87 , C12M35/02 , C12N15/02
摘要： A method of highly efficiently transferring various selected molecules into various cells and a method of fusing cells. Cells and/or selected molecules such as polynucleotide are treated with cold gas plasma to thereby transfer the selected molecules located around cells into the cells, or cells are fused by treating the cells with cold gas plasma. Moreover, an apparatus for transferring selected molecules or fusing cells having a cold gas plasma generation unit for transferring selected molecules into cells is provided.
摘要翻译：将各种选择的分子高效转移到各种细胞中的方法和融合细胞的方法。用冷气体等离子体处理细胞和/或选择的分子，例如多核苷酸，从而将位于细胞周围的选定分子转移到细胞中，或者通过用冷气体等离子体处理细胞来融合细胞。此外，提供了一种用于转移所选分子或具有用于将选定分子转移到细胞中的具有冷气体等离子体产生单元的融合电池的装置。

7. 发明授权

US07341864B2 Molecule transferring device, auxiliary for molecule transferring device, and molecule transferring method 有权
标题翻译：分子转移装置，分子转移装置辅助剂和分子转移方法
公开(公告)号：US07341864B2
公开(公告)日：2008-03-11
申请号：US10182262
申请日：2001-01-29
申请人： Yoshitaka Sakamoto , Masafumi Koide , Juichiro Nakashima , Susumu Satoh , Sousuke Miyoshi , Akiko Suzuki , Hiroyuki Arakawa , Hiroshi Marusawa
发明人： Yoshitaka Sakamoto , Masafumi Koide , Juichiro Nakashima , Susumu Satoh , Sousuke Miyoshi , Akiko Suzuki , Hiroyuki Arakawa , Hiroshi Marusawa
IPC分类号： C12M1/42 , C12M3/00 , C12N13/00 , C12N15/87 , C12N15/82
CPC分类号： C12N15/87 , A61K48/00 , A61K48/0083 , C12M35/02
摘要： A molecule introducing apparatus is provided with a power supply circuit 20 for supplying power, a step-up transformer 30 which is supplied with power from the power supply circuit 20 and which outputs a high voltage, a switching transistor 22 that blocks off and allows the supply of power from the power supply circuit 20 to the step-up transformer 30 and which generates an instantaneous high voltage, and a pair of electrode probes 50 for applying the instantaneous high voltage generated at the step-up transformer 30 to a predetermined region in a body. The molecule introducing apparatus oscillates DNA arranged outside a cell by the instantaneous high voltage so as to introduce the DNA into the cell.
摘要翻译：分子引入装置设置有用于供电的电源电路20，从电源电路20提供电力并输出高电压的升压变压器30，截止的开关晶体管22，从电源电路20向升压变压器30供电并产生瞬时高电压;以及一对电极探针50，用于将升压变压器30产生的瞬时高压施加到预定区域身体。分子导入装置通过瞬时高电压振荡排列在细胞外的DNA，以将DNA引入细胞。

8. 发明授权

US5689172A Charging battery system for video camera 失效
标题翻译：为摄像机充电电池系统
公开(公告)号：US5689172A
公开(公告)日：1997-11-18
申请号：US709324
申请日：1996-09-04
申请人： Toshio Koyama , Hiroyuki Arakawa
发明人： Toshio Koyama , Hiroyuki Arakawa
IPC分类号： G11B31/00 , G11B33/00 , G11B33/06 , H02J7/00 , H02J7/02 , H04N5/225 , H02J7/04 , H02J10/44
CPC分类号： H02J7/0024 , H02J7/0011 , H02J7/0013 , H02J7/0068 , Y10T307/832
摘要： An electronic equipment having a rechargeable battery in combination with a power source adapter. A rechargeable battery is detachably mounted in the electronic equipment. The power source adapter is adapted for supplying power to the electronic equipment from outside, and includes a first battery loading unit for loading a rechargeable battery, a charging voltage generating unit for generating a charging voltage for charging both the loaded rechargeable battery and the rechargeable battery mounted in the electronic equipment, a switching unit for switching between supplying the charging voltage to the charging unit and supplying the charging voltage to the electronic equipment, a detection unit for detecting completion of charging of the rechargeable battery loaded on the power source adapter, and a switching control unit for controlling the switching of the switching unit responsive to the output of the detection unit.
摘要翻译：具有与电源适配器组合的可再充电电池的电子设备。可再充电电池可拆卸地安装在电子设备中。电源适配器适于从外部向电子设备供电，并且包括用于装载可再充电电池的第一电池装载单元，用于产生用于对装载的可再充电电池和可再充电电池充电的充电电压的充电电压产生单元安装在电子设备中的开关单元，用于在向充电单元提供充电电压并向电子设备提供充电电压之间切换的开关单元，用于检测装载在电源适配器上的可再充电电池的充电完成的检测单元，以及切换控制单元，用于响应于检测单元的输出来控制切换单元的切换。

9. 发明授权

US07802190B2 Application display apparatus and application display system 有权
标题翻译：应用显示设备和应用显示系统
公开(公告)号：US07802190B2
公开(公告)日：2010-09-21
申请号：US10990504
申请日：2004-11-18
申请人： Koichi Uchida , Hiroyuki Arakawa
发明人： Koichi Uchida , Hiroyuki Arakawa
IPC分类号： G06F15/177 , G06F3/00 , G06F3/048 , G06F15/16
CPC分类号： G06F3/0482 , G06F9/445 , G06F9/44542
摘要： Apparatus and method for displaying menu lists and activating applications in conjunction with electronic devices that respectively load contents and an information device that reproduces the contents stored in the electronic devices. Connection to the electronic devices is detected, and a menu list is generated. The menu list automatically updates to include additional applications corresponding to electronic devices when connections to the electronic devices are respectively detected. This provides an updated menu list from which selection is made to activate a predetermined application to perform an operation related to the relevant electronic device.
摘要翻译：与分别加载内容的电子设备和再现存储在电子设备中的内容的信息设备一起显示菜单列表和激活应用的设备和方法。检测到与电子设备的连接，并生成菜单列表。当分别检测到与电子设备的连接时，菜单列表自动更新以包括对应于电子设备的附加应用。这提供了更新的菜单列表，从中进行选择以激活预定应用以执行与相关电子设备相关的操作。

10. 发明授权

US06304835B1 Simulation system using model 有权
标题翻译：模拟系统使用模型
公开(公告)号：US06304835B1
公开(公告)日：2001-10-16
申请号：US09390654
申请日：1999-09-07
申请人： Shigeki Hiramatsu , Yasuhiro Harada , Hiroyuki Arakawa , Satoshi Komori , Shizuo Sumida
发明人： Shigeki Hiramatsu , Yasuhiro Harada , Hiroyuki Arakawa , Satoshi Komori , Shizuo Sumida
IPC分类号： G06G748
CPC分类号： G06G7/64 , B60W2050/0037 , B60W2050/0039 , B60W2050/0041 , Y02T10/82
摘要： This invention proposes a simulation apparatus which can simulate by easily coping with changes in component and model. A simulation apparatus simulates, using a system model, the dynamic performance of a target apparatus to be simulated, which includes a driving source and is constructed by a plurality of units for transmitting the driving force output from the driving source, and expresses the target apparatus by functional and data models. The functional model expresses each of units that construct the target apparatus by exchange of energy by the dynamic performance of that unit, and a parameter which determines that dynamic performance. The parameter for each unit is computed using static characteristic data read out from a memory, thus expressing each unit as a data model.
摘要翻译：本发明提出一种可以通过容易地应对组件和模型的变化来模拟的仿真装置。模拟装置使用系统模型来模拟要被模拟的目标装置的动态性能，其包括驱动源，并且由用于传输从驱动源输出的驱动力的多个单元构成，并且表示目标装置通过功能和数据模型。功能模型通过该单元的动态性能交换能量来表示构建目标设备的每个单元，以及确定动态性能的参数。使用从存储器读出的静态特征数据计算每个单元的参数，从而将每个单元表示为数据模型。

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