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1. 发明授权

US08850167B2 Loading/discarding acquired data for vector load instruction upon determination of prediction success of multiple preceding branch instructions 有权
标题翻译：在确定多个先前分支指令的预测成功之后，加载/丢弃用于向量加载指令的获取数据
公开(公告)号：US08850167B2
公开(公告)日：2014-09-30
申请号：US13240614
申请日：2011-09-22
申请人： Masao Fukagawa
发明人： Masao Fukagawa
IPC分类号： G06F9/38 , G06F17/16 , G06F9/30
CPC分类号： G06F9/38 , G06F9/30036 , G06F9/30043 , G06F9/3859 , G06F17/16
摘要： Provided is a processor including an instruction issue unit that issues a vector load instruction read from a main memory based on branch target prediction of a branch target in a branch instruction, a data acquisition unit that starts issue of a plurality of acquisition requests for acquiring a plurality of vector data based on the issued vector load instruction from the main memory, a determination unit that determines a success or a failure of the branch target prediction after the branch target is determined, and a vector load management unit that, when the branch target prediction is determined to be a success, acquires all vector data based on the plurality of acquisition requests and then transfers all the vector data to a vector register, and, when the branch target prediction is determined to be a failure, discards the vector data acquired by the issued acquisition requests.
摘要翻译：提供了一种处理器，包括：指令发布单元，其基于分支指令中的分支目标的分支目标预测发出从主存储器读取的向量加载指令;数据获取单元，其开始发出多个获取请求，基于来自主存储器的所发出的矢量加载指令的多个向量数据，确定分支目标确定之后的分支目标预测的成功或失败的确定单元;以及矢量负载管理单元，当分支目标确定预测成功，基于多个获取请求获取所有矢量数据，然后将所有矢量数据传送到向量寄存器，并且当分支目标预测被确定为故障时，丢弃所获取的矢量数据由发出的收购要求。

2. 发明申请

US20120089824A1 PROCESSOR AND VECTOR LOAD INSTRUCTION EXECUTION METHOD 有权
标题翻译：处理器和矢量负载指令执行方法
公开(公告)号：US20120089824A1
公开(公告)日：2012-04-12
申请号：US13240614
申请日：2011-09-22
申请人： MASAO FUKAGAWA
发明人： MASAO FUKAGAWA
IPC分类号： G06F9/38
CPC分类号： G06F9/38 , G06F9/30036 , G06F9/30043 , G06F9/3859 , G06F17/16
摘要： Provided is a processor including an instruction issue unit that issues a vector load instruction read from a main memory based on branch target prediction of a branch target in a branch instruction, a data acquisition unit that starts issue of a plurality of acquisition requests for acquiring a plurality of vector data based on the issued vector load instruction from the main memory, a determination unit that determines a success or a failure of the branch target prediction after the branch target is determined, and a vector load management unit that, when the branch target prediction is determined to be a success, acquires all vector data based on the plurality of acquisition requests and then transfers all the vector data to a vector register, and, when the branch target prediction is determined to be a failure, discards the vector data acquired by the issued acquisition requests.
摘要翻译：提供了一种处理器，包括：指令发布单元，其基于分支指令中的分支目标的分支目标预测发出从主存储器读取的向量加载指令;数据获取单元，其开始发出多个获取请求，基于来自主存储器的所发出的矢量加载指令的多个向量数据，确定分支目标确定之后的分支目标预测的成功或失败的确定单元;以及矢量负载管理单元，当分支目标确定预测成功，基于多个获取请求获取所有矢量数据，然后将所有矢量数据传送到向量寄存器，并且当分支目标预测被确定为故障时，丢弃所获取的矢量数据由发出的收购要求。

3. 发明申请

US20050203283A1 ISOFORMS OF NUCLEAR RECEPTOR RXR a 审中-公开
标题翻译：核受体RXR的ISOFORMS a
公开(公告)号：US20050203283A1
公开(公告)日：2005-09-15
申请号：US10507696
申请日：2003-03-25
申请人： Hitoshi Kojo , Kaoru Tajima , Masao Fukagawa , Shintaro Nishimura , Takao Isogai
发明人： Hitoshi Kojo , Kaoru Tajima , Masao Fukagawa , Shintaro Nishimura , Takao Isogai
IPC分类号： C07K14/705 , C12N1/19 , C12N1/21 , C12N15/12 , C12Q1/68 , A01K67/00 , C07H21/04 , C07K14/72 , C12N15/09
CPC分类号： C07K14/70567
摘要： The present invention relates to the novel isoforms, RXRα2 and RXRα3, of nuclear receptor RXRα. Unlike known isoform RXRα1, the transcriptional activation functions of RXRα2 and RXRα3 are augmented by SRC-1. The present invention provides methods for evaluating the function of regulating augmentation by co-activators of these RXRα isoforms, and screening methods based on these evaluation methods. By controlling the interaction between isoforms and co-activators, transcription-controlling activity can be regulated in an isoform-specific manner.
摘要翻译：本发明涉及核受体RXRα的新型异构体RXRalpha2和RXRalpha3。与已知同种型RXRalpha1不同，RXRalpha2和RXRalpha3的转录激活功能被SRC-1增强。本发明提供了通过这些RXRα同种型的共激活剂来评价调节功能的方法以及基于这些评价方法的筛选方法。通过控制异构体和共激活物之间的相互作用，转录调控活性可以以异构体特异性方式调节。

4. 发明授权

US5320948A Cephalosporin C acylase 失效
标题翻译：头孢菌素C酰基转移酶
公开(公告)号：US5320948A
公开(公告)日：1994-06-14
申请号：US935312
申请日：1992-08-26
申请人： Morita Iwami , Ichiro Aramori , Masao Fukagawa , Takao Isogai , Hitoshi Kojo
发明人： Morita Iwami , Ichiro Aramori , Masao Fukagawa , Takao Isogai , Hitoshi Kojo
IPC分类号： C12N1/21 , C12N9/80 , C12N15/09 , C12N15/56 , C12P35/04 , C12P35/06 , C12R1/19 , C12R1/38 , C12P35/00 , C12P21/02
CPC分类号： C12N9/80 , C12P35/04
摘要： A cephalosporin C acylase from Pseudomonas diminuta N-176 is characterized by its ability to catalyze the conversion of cephalosporin C, glutaryl 7-ACA, adipyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin, N-benzoylcephalosporin C and cephalothin into 7-aminocephalosporanic acid. The enzyme contains an .alpha.-subunit having a molecular weight of 26 kDA and a .beta.-subunit having a molecular weight of 58 kDa. A method for the recombinant production of the present cephalosporin C acylase in Escherichia coli is provided.
摘要翻译：来自假单胞菌N-176的头孢菌素C酰基转移酶的特征在于其能够催化头孢菌素C，戊二酰7-ACA，己二酰基7-ACA，琥珀酰基7-ACA，N-乙酰头孢菌素，N-苯甲酰头孢菌素C和头孢噻吩转化为7 - 氨基头孢烷酸。该酶含有分子量为26kDA的α亚基和分子量为58kDa的β亚基。提供了在大肠杆菌中重组生产本发明头孢菌素C酰基转移酶的方法。

5. 发明授权

US06938150B2 Processor for managing latest speculation states and efficiently reusing reorder buffer entries 有权
标题翻译：用于管理最新投机状态的处理器，并有效地重用重新排序缓冲区条目
公开(公告)号：US06938150B2
公开(公告)日：2005-08-30
申请号：US10040392
申请日：2002-01-09
申请人： Masao Fukagawa
发明人： Masao Fukagawa
IPC分类号： G06F9/38 , G06F9/00
CPC分类号： G06F9/3836 , G06F9/3838 , G06F9/384 , G06F9/3842 , G06F9/3855 , G06F9/3861
摘要： By using an entry number (WRB number) of a re-order buffer 6, each of function units such as an operation unit 3, a store unit 4, a load unit 5, etc. notifies to the re-order buffer 6 the processing end for a instruction stored in the entry concerned in the unit thereof. The load unit 5 manages the latest speculation state of a load instruction issued on the basis of a branch prediction success/failure signal output from the branch unit 2, and makes no notification to the re-order buffer 6 on the basis of WRB number for subsequent load instructions of a branch-prediction failed branch instruction even when the processing of the instruction is finished. Accordingly, the re-order buffer 6 can re-use entries in which the subsequent instructions of the branch prediction failed branch instruction are stored.
摘要翻译：通过使用重新排序缓冲器6的入口号（WRB号），诸如操作单元3，存储单元4，加载单元5等功能单元中的每个功能单元向重新排序缓冲器6通知处理结束存储在其单元中的相关条目中的指令。负载单元5管理基于从分支单元2输出的分支预测成功/失败信号而发出的加载指令的最新推测状态，并且根据WRB号不向重新排序缓冲器6发送通知即使当指令的处理结束时，分支预测失败分支指令的后续加载指令。因此，重新排序缓冲器6可以重新使用存储分支预测失败分支指令的后续指令的条目。

6. 发明授权

US5677141A Process for producing 7-aminocephem compound or salts thereof 失效
标题翻译： 7-氨基头孢烯化合物或其盐的制备方法
公开(公告)号：US5677141A
公开(公告)日：1997-10-14
申请号：US314309
申请日：1994-09-30
申请人： Takao Isogai , Masao Fukagawa , Morita Iwami , Ichiro Aramori , Hitoshi Kojo
发明人： Takao Isogai , Masao Fukagawa , Morita Iwami , Ichiro Aramori , Hitoshi Kojo
IPC分类号： C12N15/09 , C12N1/15 , C12N1/21 , C12N9/06 , C12N9/58 , C12N9/80 , C12N15/55 , C12N15/57 , C12N15/80 , C12P17/00 , C12P17/18 , C12P35/02 , C12R1/01 , C12R1/645 , C12P15/00
CPC分类号： C12N9/0024 , C12N15/80 , C12N9/58 , C12N9/80 , C12P35/02
摘要： The present invention provides a process for producing 7-aminocephem compounds or salts thereof. 7-Aminocephem compounds are produced via microorganisms transformed with a vector containing a gene capable of converting a cephalosporin compound of the formula (II): ##STR1## to a 7-aminocephem compound of the formula (I): ##STR2##
摘要翻译：本发明提供了一种生产7-氨基头孢烯化合物或其盐的方法。 7-氨基头孢烯化合物通过用含有能够将式（II）的头孢菌素化合物转化为（IMA）的基因的载体转化成通式（I）的7-氨基头孢烯化合物转化的微生物：

7. 发明授权

US5312750A GL-7ACA acylase 失效
标题翻译： GL-7ACA酰基转移酶
公开(公告)号：US5312750A
公开(公告)日：1994-05-17
申请号：US80240
申请日：1993-06-22
申请人： Ichiro Aramori , Masao Fukagawa , Hiroki Ono , Yosuke Ishitani , Mana Tsumura , Morita Iwami , Hitoshi Kojo
发明人： Ichiro Aramori , Masao Fukagawa , Hiroki Ono , Yosuke Ishitani , Mana Tsumura , Morita Iwami , Hitoshi Kojo
IPC分类号： C12N1/21 , C12N9/80 , C12N15/09 , C12N15/55 , C12P35/02 , C12R1/07 , C12R1/19 , C12D21/06 , C12N15/00
CPC分类号： C12N9/80 , C12P35/02
摘要： A GL-7ACA acylase having the following characteristics:(a) has ability to catalyze the enzymatic conversion of glutaryl 7-ACA, adipyl 7-ACA, and succinyl 7-ACA, into 7-aminocephalosporanic acid,(b) has a molecular weight of 70,000 dalton (SDS-PAGE) and(c) has N-terminal amino acid sequence (sea in No: 1) thereof: Gln-Ser-Glu-Gln-Glu-Lys-Ala-Glu-Glu-.A process for producing GL-7ACA acylase is also provided.
摘要翻译：具有以下特征的GL-7ACA酰基转移酶：（a）具有催化戊二酰7-ACA，己二酰基7-ACA和琥珀酰基7-ACA酶促转化成7-氨基头孢烷酸的能力，（b）具有分子量的70,000道尔顿（SDS-PAGE）和（c）具有N-末端氨基酸序列（海洋号：1）：Gln-Ser-Glu-Gln-Glu-Lys-Ala-Glu-Glu-。还提供了生产GL-7ACA酰基转移酶的方法。

8. 发明授权

US5192678A Cephalosporin C acylase 失效
标题翻译： CEPHALOSPORIN C ACYLASE
公开(公告)号：US5192678A
公开(公告)日：1993-03-09
申请号：US747901
申请日：1991-08-20
申请人： Morita Iwami , Ichiro Aramori , Masao Fukagawa , Takao Isogai , Hitoshi Kojo
发明人： Morita Iwami , Ichiro Aramori , Masao Fukagawa , Takao Isogai , Hitoshi Kojo
IPC分类号： C12N1/21 , C12N9/80 , C12N15/09 , C12N15/56 , C12P35/04 , C12P35/06 , C12R1/19 , C12R1/38
CPC分类号： C12N9/80 , C12P35/04
摘要： A cephalosporin C acylase from Pseudomonas diminuta N-176 is disclosed as well as the recombinant production of this enzyme in E. coli. The enzyme is characterized by the ability to catalyze the conversion of cephalosporin C, gultaryl 7-ACA, apidyl 7-ACA, succinyl 7-ACA, N-acetylcephalosporin C, N-benzoylcephalosporin C, and cephalothin into 7-aminocephalosporanic acid and is composed of an .alpha.-subunit with a molecular weight of 26,000 daltons and a .beta.-subunit with a molecular weight of 58,000 daltons.

9. 发明授权

US07402435B2 Method of transferring a selected molecule into a cell 有权
标题翻译：将选择的分子转移到细胞中的方法
公开(公告)号：US07402435B2
公开(公告)日：2008-07-22
申请号：US10470732
申请日：2002-02-08
申请人： Sousuke Miyoshi , Akiko Ohkubo , Noriyuki Morikawa , Yasuhiro Ogawa , Shintaro Nishimura , Masao Fukagawa , Hiroyuki Arakawa , Jyunko Zenkou , Susumu Sato
发明人： Sousuke Miyoshi , Akiko Ohkubo , Noriyuki Morikawa , Yasuhiro Ogawa , Shintaro Nishimura , Masao Fukagawa , Hiroyuki Arakawa , Jyunko Zenkou , Susumu Sato
IPC分类号： C12N15/00 , C12N15/02
CPC分类号： C12N15/87 , C12M35/02 , C12N15/02
摘要： A method of highly efficiently transferring various selected molecules into various cells and a method of fusing cells. Cells and/or selected molecules such as polynucleotide are treated with cold gas plasma to thereby transfer the selected molecules located around cells into the cells, or cells are fused by treating the cells with cold gas plasma. Moreover, an apparatus for transferring selected molecules or fusing cells having a cold gas plasma generation unit for transferring selected molecules into cells is provided.
摘要翻译：将各种选择的分子高效转移到各种细胞中的方法和融合细胞的方法。用冷气体等离子体处理细胞和/或选择的分子，例如多核苷酸，从而将位于细胞周围的选定分子转移到细胞中，或者通过用冷气体等离子体处理细胞来融合细胞。此外，提供了一种用于转移所选分子或具有用于将选定分子转移到细胞中的具有冷气体等离子体产生单元的融合电池的装置。

10. 发明申请

US20060148030A1 Nuclear receptor err y 3 审中-公开
标题翻译：核受体错误3
公开(公告)号：US20060148030A1
公开(公告)日：2006-07-06
申请号：US10507700
申请日：2003-03-25
申请人： Hitoshi Kojo , Kaoru Tajima , Masao Fukagawa , Shintaro Nishimura , Takao Isogai
发明人： Hitoshi Kojo , Kaoru Tajima , Masao Fukagawa , Shintaro Nishimura , Takao Isogai
IPC分类号： C12P21/06 , C07H21/04 , C07K14/72
CPC分类号： C07K14/70567 , A01K2217/05 , A61K38/00 , A61K48/00 , C12Q1/6897 , G01N33/6875 , G01N2333/70567 , G01N2333/723 , G01N2500/00
摘要： The present invention relates to novel nuclear receptor ERRγ3. Although ERRγ3 itself lacks a DNA binding domain, it comprises the function of enhancing the transcriptional activation function of arbitrary nuclear receptors, such as ERR, ER, or TR. Moreover, the present inventors found that, like ERRγ3, the known proteins ERRγ1 and ERRγ2 also comprise the function of enhancing the transcriptional activation function of other nuclear receptors. Thus, the present invention provides methods for evaluating the regulatory function of these ERRγ subtypes in enhancing the transcriptional activation function of other nuclear receptors, and screening methods based on these evaluation methods.
摘要翻译：本发明涉及新的核受体ERRγAM3。尽管ERRgamma3本身缺乏DNA结合结构域，但其包含增强任意核受体如ERR，ER或TR的转录激活功能的功能。此外，本发明人发现，与ERRγAM3一样，已知蛋白质ERRgamma1和ERRgamma2还包含增强其他核受体的转录激活功能的功能。因此，本发明提供了用于评估这些ERRγ亚型在增强其他核受体的转录激活功能中的调节功能的方法，以及基于这些评价方法的筛选方法。

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