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1. 发明授权

US5109844A Retinal microstimulation 失效
标题翻译：视网膜微刺激
公开(公告)号：US5109844A
公开(公告)日：1992-05-05
申请号：US595442
申请日：1990-10-11
申请人： Eugene de Juan, Jr. , Mark S. Humayun , D. Howard Phillips
发明人： Eugene de Juan, Jr. , Mark S. Humayun , D. Howard Phillips
IPC分类号： A61N1/36 , A61N1/372
CPC分类号： A61N1/0543 , A61N1/36046 , A61N1/37205
摘要： A method for stimulating a retinal ganglion cell in a retina without penetrating the retinal basement membrane at the surface of the retina comprises: (a) positioning a ganglion cell stimulating electrode on or above the retinal basement membrane; (b) providing a ground electrode in operative association with the ganglion cell stimulating electrode, with the ground electrode positioned on or above the retinal basement membrane and positioned for capturing electric current produced by the stimulating electrode; and (c) applying a voltage to said stimulating electrode sufficient to produce an electric current which penetrates the retina and produces an action potential in a retinal ganglion cell. Apparatus for practicing the foregoing method is also disclosed.
摘要翻译：用于刺激视网膜中视网膜神经节细胞而不穿透视网膜表面的视网膜基底膜的方法包括：（a）将神经节细胞刺激电极定位在视网膜基底膜上或上方; （b）提供与神经节细胞刺激电极可操作关联的接地电极，其中接地电极位于视网膜基底膜上或上方，并定位成用于捕获由刺激电极产生的电流; 和（c）向所述刺激电极施加足以产生穿透视网膜并在视网膜神经节细胞中产生动作电位的电流的电压。还公开了用于实施上述方法的装置。

2. 发明申请

US20120076742A1 Topical drug delivery system with dual carriers 审中-公开
标题翻译：具有双载体的局部药物递送系统
公开(公告)号：US20120076742A1
公开(公告)日：2012-03-29
申请号：US13066711
申请日：2011-04-21
申请人： D. Howard Phillips , Steven Keough
发明人： D. Howard Phillips , Steven Keough
IPC分类号： A61K8/46 , A61K47/16 , A61K47/26 , A61K47/22 , A61K47/10 , A61K47/44 , A61K47/42 , A61K33/06 , A61K33/00 , A61K36/8962 , A61K36/889 , A61K36/53 , A61K36/71 , A61K33/38 , A61K31/56 , A61K36/00 , A61K38/02 , A61Q17/04 , A61Q19/02 , A61K31/59 , A61K33/18 , A61P31/00 , A61P31/10 , A61P31/12 , A61P23/00 , A61P29/00 , A61P17/10 , A61P33/14 , A61P37/08 , A61P17/02 , A61P35/00 , A61P25/24 , A61P17/00 , A61P17/06 , A61P17/04 , A61P17/08 , A61P9/00 , A61P37/06 , A61P37/00 , A61K47/20
CPC分类号： A61K31/65 , A61K9/0014 , A61K31/575 , A61K31/593 , A61K45/06 , A61K47/10 , A61K47/20 , Y02A50/473 , A61K2300/00
摘要： A topical drug delivery system for use as a self-medication delivery system, formed as a multi-functional hygroscopic solution comprising a non-hygroscopic first chemical penetration enhancer, a hygroscopic second chemical penetration enhancer and an anti-oxidizing dispersant mixable in solution with the first and second chemical penetration enhancers and an active pharmaceutical ingredient, said dispersant being in a weight percent of the solution of between 3% and 10% and being suitable for providing multiple secondary therapeutic effects by interaction with the active pharmaceutical ingredient to ensure substantial homogenous distribution of the selected active pharmaceutical ingredient in the solution during delivery of the solution to all areas of the mammalian tissue location and by further reducing the water activity level of the solution.
摘要翻译：用作自我药物递送系统的局部药物递送系统，其形成为多功能吸湿溶液，其包含非吸湿性第一化学渗透增强剂，吸湿第二化学渗透增强剂和可与溶液中混合的抗氧化分散剂第一和第二化学渗透增强剂和活性药物成分，所述分散剂的溶液的重量百分比在3％至10％之间，并且适于通过与活性药物成分的相互作用提供多种二级治疗效果，以确保基本均匀的分布在将溶液递送到哺乳动物组织位置的所有区域的同时，通过进一步降低溶液的水活度水平，在溶液中选择的活性药物成分。

3. 发明授权

US4170666A Method for reducing surface recombination velocities in III-V compound semiconductors 失效
标题翻译：降低III-V族化合物半导体表面复合速度的方法
公开(公告)号：US4170666A
公开(公告)日：1979-10-09
申请号：US796118
申请日：1977-05-11
申请人： Ranjeet K. Pancholy , Gordon J. Kuhlmann , D. Howard Phillips
发明人： Ranjeet K. Pancholy , Gordon J. Kuhlmann , D. Howard Phillips
IPC分类号： H01L21/314 , H01L21/265 , H01L21/316 , B05D5/12
CPC分类号： H01L21/02241 , H01L21/02255 , H01L21/2654 , H01L21/31666
摘要： III-V compound semiconductors having native dielectrics thereon which are thermally grown from special composition surface layers thereof are provided with reduced surface recombination velocities by proper selection of the surface layer's composition and extent of conversion to the dielectric.
摘要翻译：通过适当选择表面层的组成和向电介质的转化程度，在其上由其特殊组成表面层热生长的具有天然电介质的III-V族化合物半导体具有降低的表面复合速度。

4. 发明申请

US20120076766A1 Topical drug delivery system with dual carriers 审中-公开
标题翻译：具有双载体的局部药物递送系统
公开(公告)号：US20120076766A1
公开(公告)日：2012-03-29
申请号：US13066710
申请日：2011-04-21
申请人： D. Howard Phillips , Steven Keough
发明人： D. Howard Phillips , Steven Keough
IPC分类号： A61K31/65 , A61P17/02
CPC分类号： A61K31/65 , A61K9/0014 , A61K31/575 , A61K31/593 , A61K45/06 , A61K47/10 , A61K47/20 , Y02A50/473 , A61K2300/00
摘要： A method of selecting the constituent elements of a therapeutic composition for application to wounds having a pathogen load is disclosed. The method includes selecting a pharmaceutical active agent selected from a list of pharmaceutical active agents approved for over the counter non-prescription use, and said pharmaceutical active agent having suitable activity to kill the desired pathogens; identifying a tissue permeation enhancer from a list of generally recognized and safe tissue permeation enhancers that facilitates penetration of a composition using the selected tissue permeation enhancer through the stratum corneum of mammalian tissue; selecting a hygroscopic carrier agent suitable for mixing in solution with the tissue permeation enhancer and the pharmaceutical active agent; said hygroscopic carrier agent being selected from a list of generally recognized and safe hygroscopic carrier agents; and ensuring that the activity/water (AW) measurement of the composition is less than the AW measurement for a target pathogen in a tissue wound.
摘要翻译：公开了一种选择用于具有病原体负荷的伤口的治疗组合物的组成元素的方法。该方法包括选择药物活性剂，其选自批准用于非处方药物的药物活性剂的列表，所述药物活性剂具有杀死所需病原体的合适活性; 从通常认可和安全的组织渗透增强剂的清单中鉴定组织渗透增强剂，其有助于使用所选择的组织渗透增强剂穿过哺乳动物组织的角质层渗透组合物; 选择适合于溶液与组织渗透增强剂和药物活性剂混合的吸湿载体; 所述吸湿性载体剂选自通常认可和安全的吸湿性载体剂的列表; 并确保组合物的活性/水（AW）测量值小于组织伤口中目标病原体的AW测量值。

5. 发明申请

US20120070390A1 Topical drug delivery system with dual carriers 审中-公开
标题翻译：具有双载体的局部药物递送系统
公开(公告)号：US20120070390A1
公开(公告)日：2012-03-22
申请号：US13066705
申请日：2011-04-21
申请人： D. Howard Phillips , Steven Keough
发明人： D. Howard Phillips , Steven Keough
IPC分类号： A61K31/165 , A61P17/02 , A61P31/00 , A61P31/10 , A61P31/12 , A61P23/00 , A61P25/04 , A61P29/00 , A61P17/12 , A61P35/00 , A61P17/10 , A61Q19/08 , A61P17/18 , A61K8/97 , A01P7/02 , A61P37/08 , A61Q5/00 , A61P25/24 , A61P17/00 , A61P7/10 , A61P17/04 , A61P17/06 , A61P17/08 , A61P9/00 , A01P3/00 , A61Q7/00 , A61K38/22 , A61P37/06 , A61P37/02 , A01P7/04 , A01P17/00 , A61P33/14 , A61Q19/02 , A61Q19/04 , A61K31/59
CPC分类号： A61K31/65 , A61K9/0014 , A61K31/575 , A61K31/593 , A61K45/06 , A61K47/10 , A61K47/20 , Y02A50/473 , A61K2300/00
摘要： An over-the-counter (OTC) regulated therapeutic composition for self-medication use for application to wounds having a potential pathogen load, in which the composition comprises a tissue penetration enhancer comprising a Class I pharmaceutical incipient; a pharmaceutical antibiotic agent in a dosing suitable for use in an OTC listing; a hygroscopic carrier agent comprising a Class I pharmaceutical incipient suitable for mixing in solution with the tissue penetration enhancer and the antibiotic agent; and wherein the activity/water (Aw) measurement of the composition is less than the Aw measurement for a target pathogen in a tissue wound.
摘要翻译：用于自身用药的非处方（OTC）调节治疗组合物用于具有潜在病原体负荷的伤口，其中所述组合物包含包含I类药物初期的组织穿透增强剂; 适合用于OTC清单的剂量的药物抗生素; 包含适于在溶液中与组织渗透增强剂和抗生素剂混合的I类药物初剂的吸湿性载体剂; 并且其中所述组合物的活性/水（Aw）测量值小于组织伤口中目标病原体的Aw测量值。

6. 发明申请

US20120082632A1 Topical drug delivery system with dual carriers 审中-公开
标题翻译：具有双载体的局部药物递送系统
公开(公告)号：US20120082632A1
公开(公告)日：2012-04-05
申请号：US13066704
申请日：2011-04-21
申请人： D. Howard Phillips , Steven Keough
发明人： D. Howard Phillips , Steven Keough
IPC分类号： A61K8/49 , A61K31/65 , A61K31/593 , A61K8/46 , A61K47/42 , A61Q17/04 , A61K47/26 , A61P31/00 , A61P31/12 , A61P31/10 , A61P43/00 , A61K47/20 , A61K47/22
CPC分类号： A61K31/65 , A61K9/0014 , A61K31/575 , A61K31/593 , A61K45/06 , A61K47/10 , A61K47/20 , Y02A50/473 , A61K2300/00
摘要： A drug delivery system, formed as a tissue penetrating solution, comprising: a solvent suitable for solubilizing a non-liquid active ingredient into a solution; a diluent for diluting the solvent to optimize the solution for mammalian tissue compatibility; and a stabilizer for maintaining the solution chemically stable and substantially free from oxidation during storage for a pre-determined shelf life period.
摘要翻译：形成为组织穿透溶液的药物递送系统，包括：适于将非液体活性成分溶解于溶液中的溶剂; 用于稀释溶剂以优化用于哺乳动物组织相容性的溶液的稀释剂; 以及稳定剂，用于在储存期间保持溶液化学稳定并且基本上没有氧化，以达到预定的保质期。

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