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1. 发明授权

US06270749B1 Use of Texaphyrin in ocular diagnosis and therapy 失效
标题翻译：使用Texaphyrin进行眼部诊断和治疗
公开(公告)号：US06270749B1
公开(公告)日：2001-08-07
申请号：US09329720
申请日：1999-06-10
申请人： Mark S. Blumenkranz , Kathryn W. Woodburn , Richard A. Miller , Stuart W. Young
发明人： Mark S. Blumenkranz , Kathryn W. Woodburn , Richard A. Miller , Stuart W. Young
IPC分类号： A61K4900
CPC分类号： A61K41/0076 , A61K49/0021 , Y10S514/912
摘要： The use of texaphyrins for ocular diagnosis and therapy is provided, especially use of photosensitive texaphyrins for photodynamic therapy of conditions of the eye characterized by abnormal vasculature, such as macular degeneration, or pterygium, for example. The photosensitive texaphyrin may be a free-base texaphyrin or may be metallated with a diamagnetic metal. Preferably, the photosensitive texaphyrin is metallated with lutetium. Due to the dual wavelength absorption of texaphyrins, i.e., at 400-500 nm and at 700-800 nm, especially about 732 nm, as compared to porphyrins, texaphyrins are more effective and versatile for use in humans as compared to porphyrins. Texaphyrins serve as effective contrast agents in ocular angiography.
摘要翻译：提供了泰克萨菲瑞用于眼部诊断和治疗的用途，特别是使用感光性泰克萨菲瑞用于光动力学治疗眼睛状况的特征是异常脉管系统，例如黄斑变性或翼状ium肉。感光性泰克萨菲瑞可以是游离碱泰克萨菲瑞，也可以用抗磁性金属进行金属化。优选地，感光性泰克萨菲瑞用镥金属化。由于与卟啉相比，泰克萨菲瑞的双波长吸收，即在400-500nm和700-800nm，特别是约732nm，与卟啉相比，泰克萨菲素在人类中更有效和通用。 Texaphyrins作为眼部血管造影术中的有效造影剂。

2. 发明授权

US5817017A Medical devices and materials having enhanced magnetic images visibility 失效
标题翻译：具有增强的磁图像可视性的医疗设备和材料
公开(公告)号：US5817017A
公开(公告)日：1998-10-06
申请号：US446652
申请日：1995-05-24
申请人： Stuart W. Young , Richard A. Miller
发明人： Stuart W. Young , Richard A. Miller
IPC分类号： A61B5/055 , A61B19/00 , A61M25/01
CPC分类号： A61M25/0108 , A61M25/0127 , A61B2090/3954 , A61B5/055
摘要： Catheters and other medical devices include a non-metallic member having paramagnetic ionic particles fixedly incorporated therethrough in order to provide enhanced detectability when viewed by magnetic imaging regardless of the orientation of the non-metallic member in the magnetic field. Catheters are usually formed from polymeric tubing, and the paramagnetic ionic particles are usually formed from paramagnetic ions incorporated with water or other proton-donating fluid into carrier particles, such as zeolites, molecular sieves, clays, synthetic ion exchange resins, and microcapsules. Catheters and other medical devices include a non-metallic member having small iron and/or superparamagnetic particles fixedly incorporated therethrough or thereover in order to provide enhanced detectability when viewed by magnetic imaging. Catheters are usually formed from polymeric tubing, and the iron and/or superparamagnetic particles at or near the surface of the catheter interact with the water protons of the surrounding patient's body to provide image enhancement regardless of the orientation of the polymeric or other non-metallic material in the magnetic field.
摘要翻译： PCT No.PCT / US94 / 04011 Sec。 371日期：1995年5月24日 102（e）日期1995年5月24日PCT 1994年4月12日PCT PCT。出版物WO94 / 23782 日期1994年10月27日食管和其他医疗装置包括具有固定地并入其中的顺磁性离子颗粒的非金属构件，以便在通过磁性成像观察时提供增强的可检测性，而不管非金属构件在磁场中的取向如何。导管通常由聚合物管形成，并且顺磁性离子颗粒通常由与水或其它质子供体流体结合的顺磁性离子形成载体颗粒，如沸石，分子筛，粘土，合成离子交换树脂和微胶囊。导管器和其它医疗装置包括具有小的铁和/或超顺磁性颗粒的非金属构件，其固定地并入其中或其上，以便在通过磁性成像观察时提供增强的可检测性。导管通常由聚合物管形成，导管表面处或附近的铁和/或超顺磁性颗粒与周围患者身体的水质相互作用，以提供图像增强，而不管聚合物或其它非金属的取向如何材料在磁场中。

3. 发明授权

US5776925A Methods for cancer chemosensitization 失效
标题翻译：癌症化学敏化方法
公开(公告)号：US5776925A
公开(公告)日：1998-07-07
申请号：US591318
申请日：1996-01-25
申请人： Stuart W. Young , Richard A. Miller
发明人： Stuart W. Young , Richard A. Miller
IPC分类号： C07D487/22 , A61K31/00 , A61K31/40 , A61K31/555 , A61K31/675 , A61K33/24 , A61K38/14 , A61K41/00 , A61P35/00 , A61P35/02 , A61P43/00
CPC分类号： A61K31/555 , A61K31/675 , A61K31/70 , A61K33/24 , A61K38/14 , A61K41/0076
摘要： Methods for cancer chemosensitization are provided. Texaphyrins are new chemosensitizers for enhancing the cytotoxicity of chemotherapeutic agents. The enhancement appears to be P-glycoprotein-independent since texaphyrins are effective in both a P-glycoprotein-expressing and a P-glycoprotein -nonexpressing cell line. Methods are provided for the treatment of cancers such as leukemia, lymphoma, carcinoma, and sarcoma using a texaphyrin as a chemosensitizer.
摘要翻译：提供了癌症化学敏化方法。 Texaphyrins是增加化学治疗剂细胞毒性的新型化学增敏剂。增强似乎是P-糖蛋白不依赖性，因为泰克萨菲精对p-糖蛋白表达和P-糖蛋白不受影响的细胞系都是有效的。提供了使用泰克萨菲瑞作为化学敏化剂治疗癌症如白血病，淋巴瘤，癌和肉瘤的方法。

4. 发明授权

US06663262B2 Backlighting transmissive displays 有权
标题翻译：背光透射显示屏
公开(公告)号：US06663262B2
公开(公告)日：2003-12-16
申请号：US09949948
申请日：2001-09-10
申请人： Gary Timothy Boyd , Leland Ray Whitney , Richard A. Miller , Keith Michael Kotchick
发明人： Gary Timothy Boyd , Leland Ray Whitney , Richard A. Miller , Keith Michael Kotchick
IPC分类号： F21V700
CPC分类号： G02B6/0031 , G02F1/133615
摘要： A backlight assembly for use in a transmissive display system is described. The backlight assembly includes a light source that illuminates a light chamber. A transmissive display is positioned adjacent the light chamber so that light that exits the chamber illuminates the transmissive display. The backlight assembly may include one or more specular reflectors and one or more other optical elements to ensure that the light that exits the light chamber has the desired spatial uniformity, polarization, color, and/or angular distribution
摘要翻译：描述了用于透射显示系统的背光组件。背光组件包括照亮灯室的光源。透射显示器定位在光室附近，使得离开室的光照射透射显示器。背光组件可以包括一个或多个镜面反射器和一个或多个其它光学元件，以确保离开光室的光具有期望的空间均匀性，偏振，颜色和/或角度分布

5. 发明授权

US06568822B2 Linear illumination source 有权
公开(公告)号：US06568822B2
公开(公告)日：2003-05-27
申请号：US09844745
申请日：2001-04-06
申请人： Gary T. Boyd , Leland R. Whitney , Richard A. Miller
发明人： Gary T. Boyd , Leland R. Whitney , Richard A. Miller
IPC分类号： F21V704
CPC分类号： G02B6/0041 , G02B6/0021 , G02B6/0048 , G02B6/4298
摘要： Shaped refractive articles having compound curved surfaces enable a light source to provide substantially uniform illumination of a linear or planar target. The refractive articles can comprise an input edge or face and an output edge or face, the input edge or face having at least one shaped notch or cavity that can at least partially envelop a light source, wherein the notch or cavity has at least two oppositely signed curved portions shaped to provide substantially uniform illumination of a target by the source. The articles can also be optically coupled to and at least partially envelop a light source, and can have an output edge or surface having at least two oppositely signed curved portions shaped to provide substantially uniform illumination of a target region by the source. The shaped articles can be used in, for example, lighting devices, frontlights, backlights and electronic displays.

6. 发明授权

US06347874B1 Wedge light extractor with risers 失效
标题翻译：带提升管的楔形光提取器
公开(公告)号：US06347874B1
公开(公告)日：2002-02-19
申请号：US09505312
申请日：2000-02-16
申请人： Gary T. Boyd , Richard A. Miller , Leland R. Whitney
发明人： Gary T. Boyd , Richard A. Miller , Leland R. Whitney
IPC分类号： F21V704
CPC分类号： G02B6/0038 , G02B6/0046 , Y10S385/901
摘要： A wedge-shaped light extractor having a light-redirecting surface with a plurality of projections having a riser segment, a plateau segment, and a facet segment, with land segments flanking the projections. The projections improve extraction efficiency, thereby facilitating use of available light from a light source.
摘要翻译：具有光重定向表面的楔形光提取器具有多个突起，所述多个突起具有提升板段，平台段和小平面段，其中所述突起的侧面具有陆片段。这些投影提高了提取效率，从而便于使用来自光源的可用光。

7. 发明授权

US5888997A Radiation sensitization using texaphyrins 失效
标题翻译：使用泰克萨菲的辐射敏化
公开(公告)号：US5888997A
公开(公告)日：1999-03-30
申请号：US795393
申请日：1997-02-04
申请人： Jonathan L. Sessler , Anthony Harriman , Richard A. Miller , Darren Magda , Tarak D. Mody , Gregory W. Hemmi
发明人： Jonathan L. Sessler , Anthony Harriman , Richard A. Miller , Darren Magda , Tarak D. Mody , Gregory W. Hemmi
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , A61K51/04 , A61L2/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , A61K31/555
CPC分类号： A61K41/0038 , A61K41/0057 , A61K41/0076 , A61K47/48023 , A61K47/48069 , A61K49/0021 , A61K49/0054 , A61K49/0058 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/126 , A61K51/0485 , A61L2/0011 , B01J31/1658 , B01J31/1805 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/36 , B01J2531/37 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： The invention relates to the field of radiation sensitizers and the use of texaphyrins for radiation sensitization and other conditions for which X-ray radiation has proven to be therapeutic.
摘要翻译：本发明涉及辐射敏化剂领域，以及使用泰克萨菲精对辐射敏化和X射线辐射已被证明是治疗性的其他条件。

8. 发明授权

US5475198A Weld pool viewing system 失效
标题翻译：焊池查看系统
公开(公告)号：US5475198A
公开(公告)日：1995-12-12
申请号：US798520
申请日：1985-11-15
申请人： Michael A. Burke , Donald T. Hackworth , Richard A. Miller , William H. Kasner
发明人： Michael A. Burke , Donald T. Hackworth , Richard A. Miller , William H. Kasner
IPC分类号： B23K9/127 , B23K9/12
CPC分类号： B23K9/1274
摘要： A weld pool viewing system including optical elements for enhancing the weld pool image is positioned at an angle relative to the axis of a welding torch to extract image information pertaining to the interface of the weld pool with a workpiece to control the welding parameters.
摘要翻译：包括用于增强焊池图像的光学元件的熔池观察系统相对于焊炬的轴线成一角度定位，以提取与焊池的界面相关的图像信息，以控制焊接参数。

9. 发明授权

US5274037A Elastomeric composition containing elastomer and amorphous propylene/hexene copolymer 失效
标题翻译：含弹性体和无定形丙烯/己烯共聚物的弹性组合物
公开(公告)号：US5274037A
公开(公告)日：1993-12-28
申请号：US923414
申请日：1992-07-31
申请人： Richard A. Miller
发明人： Richard A. Miller
IPC分类号： A61F13/49 , A61F13/58 , C08L23/14 , C08L23/16 , C08L23/18 , C08L23/20 , C08L53/00 , C08L53/02 , C09J123/02 , C09J123/14 , C09J123/18 , C09J123/20 , C09J153/00 , C08F210/14 , C08F10/14 , C08L9/06
CPC分类号： C08L53/02 , C08L23/142 , Y10T428/31931 , Y10T442/674
摘要： An elastomeric composition is prepared containing an amorphous propylene/hexene copolymer and an elastomer selected from styrene butadiene styrene block copolymers.
摘要翻译：制备含有无定形丙烯/己烯共聚物和选自苯乙烯丁二烯苯乙烯嵌段共聚物的弹性体的弹性体组合物。

10. 发明授权

US5210136A Elastomeric composition 失效
标题翻译：弹性组合物
公开(公告)号：US5210136A
公开(公告)日：1993-05-11
申请号：US615734
申请日：1990-11-16
申请人： Richard A. Miller , Herbert T. Zollman
发明人： Richard A. Miller , Herbert T. Zollman
IPC分类号： C08L23/22 , C08L51/06 , C09J123/22 , C09J151/06
CPC分类号： C09J123/22 , C08L23/22 , C08L51/06 , C09J151/06
摘要： An elastomer composition is prepared containing a maleated amorphous polypropylene and an elastomer selected from butyl elastomers, crosslinked butyl elastomers, and styrene ethylene butydiene styrene block copolymers.
摘要翻译：制备含有马来化无定形聚丙烯和选自丁基弹性体，交联丁基弹性体和苯乙烯乙烯丁二烯苯乙烯嵌段共聚物的弹性体的弹性体组合物。

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