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1. 发明授权

US5888997A Radiation sensitization using texaphyrins 失效
标题翻译：使用泰克萨菲的辐射敏化
公开(公告)号：US5888997A
公开(公告)日：1999-03-30
申请号：US795393
申请日：1997-02-04
申请人： Jonathan L. Sessler , Anthony Harriman , Richard A. Miller , Darren Magda , Tarak D. Mody , Gregory W. Hemmi
发明人： Jonathan L. Sessler , Anthony Harriman , Richard A. Miller , Darren Magda , Tarak D. Mody , Gregory W. Hemmi
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , A61K51/04 , A61L2/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , A61K31/555
CPC分类号： A61K41/0038 , A61K41/0057 , A61K41/0076 , A61K47/48023 , A61K47/48069 , A61K49/0021 , A61K49/0054 , A61K49/0058 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/126 , A61K51/0485 , A61L2/0011 , B01J31/1658 , B01J31/1805 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/36 , B01J2531/37 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： The invention relates to the field of radiation sensitizers and the use of texaphyrins for radiation sensitization and other conditions for which X-ray radiation has proven to be therapeutic.
摘要翻译：本发明涉及辐射敏化剂领域，以及使用泰克萨菲精对辐射敏化和X射线辐射已被证明是治疗性的其他条件。

2. 发明授权

US5583220A Pyrole nitrogen-substituted texaphyrins 失效
标题翻译：吡咯氮取代的泰克萨菲
公开(公告)号：US5583220A
公开(公告)日：1996-12-10
申请号：US449681
申请日：1995-05-24
申请人： Jonathan L. Sessler , Anthony M. Harriman , Richard A. Miller , Tarak D. Mody , Gregory W. Hemmi , Vladimir A. Kral , Darren Magda
发明人： Jonathan L. Sessler , Anthony M. Harriman , Richard A. Miller , Tarak D. Mody , Gregory W. Hemmi , Vladimir A. Kral , Darren Magda
IPC分类号： A61K31/40 , A61K31/407 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/00 , A61K51/04 , A61L2/00 , A61P35/02 , A61P43/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00
CPC分类号： A61K51/0485 , A61K41/0038 , A61K41/0057 , A61K41/0076 , A61K47/48069 , A61K49/0021 , A61K49/0054 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/126 , A61L2/0011 , B01J31/1658 , B01J31/1805 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/36 , B01J2531/37 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
摘要翻译：特拉法芬被提供用作辐射敏化剂。泰克萨菲瑞用作辐射敏化剂的有利特性包括：i）低的氧化还原电位，其允许辐射诱导的水合电子流向泰克萨菲瑞而不是中和羟基，允许羟基自由基引起细胞损伤，ii）相对稳定的泰克萨菲瑞基其易于共价修饰相邻的分子，导致进一步的细胞损伤，iii）内在的生物定位，以及iv）不存在或不存在O 2。这些性质使得泰克萨菲瑞对于治疗实体性赘生物的缺氧区域特别有效。具有肿瘤或动脉粥样硬化的个体的治疗方法包括使用泰克萨菲林作为辐射敏化剂和作为光动力学肿瘤治疗的药剂，或者使用泰克萨菲瑞用于内部和外部电离辐射。提供了新的泰克萨菲标本。

3. 发明授权

US5632970A Fluoresence detection using texaphyrins 失效
标题翻译：使用泰克萨菲瑞的荧光检测
公开(公告)号：US5632970A
公开(公告)日：1997-05-27
申请号：US486967
申请日：1995-06-07
申请人： Jonathan L. Sessler , Tarak D. Mody , Gregory W. Hemmi , Vladimir A. Kr al , Darren Magda
发明人： Jonathan L. Sessler , Tarak D. Mody , Gregory W. Hemmi , Vladimir A. Kr al , Darren Magda
IPC分类号： A61K31/40 , A61K31/407 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/00 , A61K51/04 , A61L2/00 , A61P35/02 , A61P43/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , A61K31/555
CPC分类号： A61K51/0485 , A61K41/0038 , A61K41/0057 , A61K41/0076 , A61K47/48069 , A61K49/0021 , A61K49/0054 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/126 , A61L2/0011 , B01J31/1658 , B01J31/1805 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/36 , B01J2531/37 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocatization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
摘要翻译：特拉法芬被提供用作辐射敏化剂。泰克萨菲瑞用作辐射敏化剂的有利特性包括：i）低的氧化还原电位，其允许辐射诱导的水合电子流向泰克萨菲瑞而不是中和羟基，允许羟基自由基引起细胞损伤，ii）相对稳定的泰克萨菲瑞基其易于共价修饰相邻的分子，导致进一步的细胞损伤，iii）内在的生物定位，以及iv）对O2的存在或不存在的冷漠。这些性质使得泰克萨菲瑞对于治疗实体性赘生物的缺氧区域特别有效。具有肿瘤或动脉粥样硬化的个体的治疗方法包括使用泰克萨菲林作为辐射敏化剂和作为光动力学肿瘤治疗的药剂，或者使用泰克萨菲瑞用于内部和外部电离辐射。提供了新的泰克萨菲标本。

4. 发明授权

US5580543A Method of magnetic resonance image enhancement 失效
标题翻译：磁共振图像增强方法
公开(公告)号：US5580543A
公开(公告)日：1996-12-03
申请号：US458267
申请日：1995-06-02
申请人： Jonathan L. Sessler , Tarak D. Mody , Gregory W. Hemmi , Vladimir A. Kr al , Darren Magda
发明人： Jonathan L. Sessler , Tarak D. Mody , Gregory W. Hemmi , Vladimir A. Kr al , Darren Magda
IPC分类号： A61K31/40 , A61K31/407 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/00 , A61K51/04 , A61L2/00 , A61P35/02 , A61P43/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , G01N24/08 , A61K31/555
CPC分类号： A61K51/0485 , A61K41/0038 , A61K41/0057 , A61K41/0076 , A61K47/48069 , A61K49/0021 , A61K49/0054 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/126 , A61L2/0011 , B01J31/1658 , B01J31/1805 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/36 , B01J2531/37 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
摘要翻译：特拉法芬被提供用作辐射敏化剂。泰克萨菲瑞用作辐射敏化剂的有利特性包括：i）低的氧化还原电位，其允许辐射诱导的水合电子流向泰克萨菲瑞而不是中和羟基，允许羟基自由基引起细胞损伤，ii）相对稳定的泰克萨菲瑞基其易于共价修饰相邻的分子，导致进一步的细胞损伤，iii）内在的生物定位，以及iv）不存在或不存在O 2。这些性质使得泰克萨菲瑞对于治疗实体性赘生物的缺氧区域特别有效。具有肿瘤或动脉粥样硬化的个体的治疗方法包括使用泰克萨菲林作为辐射敏化剂和作为光动力学肿瘤治疗的药剂，或者使用泰克萨菲瑞用于内部和外部电离辐射。提供了新的泰克萨菲标本。

5. 发明授权

US5587371A Texaphyrin-oligonucleotide conjugates 失效
标题翻译： Texaphyrin-寡核苷酸共轭物
公开(公告)号：US5587371A
公开(公告)日：1996-12-24
申请号：US458909
申请日：1995-06-02
申请人： Jonathan L. Sessler , Tarak D. Mody , Gregory W. Hemmi , Vladimir A. Kr al , Darren Magda
发明人： Jonathan L. Sessler , Tarak D. Mody , Gregory W. Hemmi , Vladimir A. Kr al , Darren Magda
IPC分类号： A61K31/40 , A61K31/407 , A61K41/00 , A61K47/48 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/00 , A61K51/04 , A61L2/00 , A61P35/02 , A61P43/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , A61K31/715
CPC分类号： A61K51/0485 , A61K41/0038 , A61K41/0057 , A61K41/0076 , A61K47/48069 , A61K49/0021 , A61K49/0054 , A61K49/085 , A61K49/10 , A61K49/106 , A61K49/126 , A61L2/0011 , B01J31/1658 , B01J31/1805 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/23 , B01J2531/26 , B01J2531/27 , B01J2531/28 , B01J2531/36 , B01J2531/37 , B01J2531/38 , B01J2531/72 , B01J2531/842 , B01J2531/845 , B01J2531/847 , B01J2531/96 , B01J31/061
摘要： Texaphyrins are provided for use as radiation sensitizers. Advantageous properties of texaphyrins for use as a radiation sensitizer include: i) a low redox potential which allows radiation-induced hydrated electrons to flow to texaphyrin rather than neutralizing hydroxyl radicals, allowing hydroxyl radicals to cause cellular damage, ii) a relatively stable texaphyrin radical that reacts readily to covalently modify neighboring molecules causing further cellular damage, iii) intrinsic biolocalization, and iv) indifference to the presence or absence of O.sub.2. These properties allow texaphyrins to be particularly effective for treating the hypoxic areas of solid neoplasms. Methods of treatment for an individual having a neoplasm or atheroma include the use of a texaphyrin as a radiation sensitizer and as an agent for photodynamic tumor therapy, or the use of a texaphyrin for internal and for external ionizing radiation. Novel texaphyrins are provided.
摘要翻译：特拉法芬被提供用作辐射敏化剂。泰克萨菲瑞用作辐射敏化剂的有利特性包括：i）低的氧化还原电位，其允许辐射诱导的水合电子流向泰克萨菲瑞而不是中和羟基，允许羟基自由基引起细胞损伤，ii）相对稳定的泰克萨菲瑞基其易于共价修饰相邻的分子，导致进一步的细胞损伤，iii）内在的生物定位，以及iv）不存在或不存在O 2。这些性质使得泰克萨菲瑞对于治疗实体性赘生物的缺氧区域特别有效。具有肿瘤或动脉粥样硬化的个体的治疗方法包括使用泰克萨菲林作为辐射敏化剂和作为光动力学肿瘤治疗的药剂，或者使用泰克萨菲瑞用于内部和外部电离辐射。提供了新的泰克萨菲标本。

6. 发明授权

US5567687A Texaphyrins and uses thereof 失效
标题翻译： Texaphyrins及其用途
公开(公告)号：US5567687A
公开(公告)日：1996-10-22
申请号：US310501
申请日：1994-09-21
申请人： Darren Magda , Jonathan L. Sessler , Brent Iverson , Petra L. Jansen , Meredith Wright , Tarak D. Mody , Gregory W. Hemmi
发明人： Darren Magda , Jonathan L. Sessler , Brent Iverson , Petra L. Jansen , Meredith Wright , Tarak D. Mody , Gregory W. Hemmi
IPC分类号： A61K41/00 , A61K49/00 , A61K49/06 , A61K49/08 , A61K51/04 , A61L2/00 , B01J31/02 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , C12N15/113
CPC分类号： C07D487/22 , A61K41/0042 , A61K41/0076 , A61K47/48069 , A61K49/0021 , A61K49/0054 , A61K49/085 , A61K49/106 , A61K49/126 , A61K51/0485 , A61L2/0011 , B01J31/1658 , B01J31/1815 , C07H21/00 , C12N15/113 , B01J2531/025 , B01J2531/26 , B01J2531/27 , B01J2531/33 , B01J2531/37 , B01J2531/38 , B01J31/0201 , C12N2310/15 , C12N2310/321 , C12N2310/3511
摘要： A texaphyrin having substituents containing ethoxy groups, methods for using texaphyrins in photodynamic therapy, and cleavage of a polymer of deoxyribonucleic acid are disclosed. The in vivo treatment of tumors and atheroma is demonstrated using Lu(III)texaphyrin complexes. A preferred method of use is the site-specific cleavage of a polymer of deoxyribonucleic acid and a preferred texaphyrin is a derivatized texaphyrin having binding specificity, in particular, a texaphyrin covalently coupled to a site-directing molecule, preferably an oligonucleotide.
摘要翻译：公开了具有含乙氧基的取代基的泰克萨菲瑞，光动力学治疗中使用泰克萨菲瑞的方法和脱氧核糖核酸的聚合物的切割。使用Lu（III）泰克萨菲瑞复合物证明体内治疗肿瘤和动脉粥样硬化。优选的使用方法是脱氧核糖核酸的聚合物的位点特异性切割，优选的泰克萨菲瑞是具有结合特异性的衍生的泰克萨菲林，特别是共价偶联到位点定向分子，优选寡核苷酸的泰克萨菲林。

7. 发明授权

US5969111A Texaphyrins substituted with imidazole are provided 失效
标题翻译：取代的泰克萨菲
公开(公告)号：US5969111A
公开(公告)日：1999-10-19
申请号：US775261
申请日：1997-02-04
申请人： Jonathan L. Sessler , Gregory W. Hemmi , Tarak D. Mody , Darren Magda , Vladimir A. Kral
发明人： Jonathan L. Sessler , Gregory W. Hemmi , Tarak D. Mody , Darren Magda , Vladimir A. Kral
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , A61K51/04 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , A61K31/40 , A61K31/555 , C07K2/00
CPC分类号： A61K47/48069 , A61K41/0038 , A61K41/0076 , A61K47/48023 , A61K49/0021 , A61K51/0485 , B01J31/1658 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/36 , B01J2531/38 , B01J31/061
摘要： Texaphyrins substituted with imidazda are provided.
摘要翻译：提供了用咪唑代替的Texaphyrins。

8. 发明授权

US07547689B2 Methods and compositions for treating atheroma, tumors and other neoplastic tissues 有权
标题翻译：治疗动脉粥样硬化，肿瘤和其他肿瘤组织的方法和组合物
公开(公告)号：US07547689B2
公开(公告)日：2009-06-16
申请号：US11388385
申请日：2006-03-24
申请人： Jonathan L. Sessler , Darren Magda , Norbert Purro , Tarak D. Mody , Greg Hemmi
发明人： Jonathan L. Sessler , Darren Magda , Norbert Purro , Tarak D. Mody , Greg Hemmi
IPC分类号： A61K31/40 , A61K31/409
CPC分类号： A61K9/0019 , A61K41/0038 , A61K49/0004 , G01N33/5008
摘要： Compositions comprising motexafin gadolinium, as well as methods for using these compositions in the treatment of brain metastases, are described herein.
摘要翻译：包含motexafin钆的组合物以及使用这些组合物治疗脑转移瘤的方法在本文中描述。

9. 发明授权

US06375930B2 Membrane incorporation of texaphyrins 失效
标题翻译：丝裂霉素的膜结合
公开(公告)号：US06375930B2
公开(公告)日：2002-04-23
申请号：US08975090
申请日：1997-11-20
申请人： Stuart W. Young , Meredith Wright , Jonathan L. Sessler , Tarak D. Mody , Darren Magda
发明人： Stuart W. Young , Meredith Wright , Jonathan L. Sessler , Tarak D. Mody , Darren Magda
IPC分类号： A61B55055
CPC分类号： B82Y5/00 , A61K41/0076 , A61K47/554 , A61K47/6901 , A61K47/6911 , A61K49/085 , A61K49/1896
摘要： Compositions having a texaphyrin-lipophilic molecule conjugate loaded into a biological vesicle and methods for imaging, diagnosis and treatment using the loaded vesicle are provided. For example, liposomes or red blood cells loaded with a paramagnetic texaphyrin-lipophilic molecule conjugate have utility as a blood pool contrast agent, facilitating the enhancement of normal tissues, magnetic resonance angiography, and marking areas of damaged endothelium by their egress through fenestrations or damaged portions of the blood vascular system. Liposomes or cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate can be photolysed, allowing for a photodynamic therapy effect at the site of lysis. Availability of red blood cells loaded with a photosensitive texaphyrin-lipophilic molecule conjugate provides a method for delivering a photodynamic therapeutic agent to a desired site with a high concentration of oxygen. By presenting the agent in this way, it is expected that a patient will experience less toxicity.
摘要翻译：提供了具有加载到生物囊泡中的泰克萨菲瑞 - 亲脂性分子缀合物的组合物以及使用加载的囊泡进行成像，诊断和治疗的方法。例如，装载有顺磁性泰克萨菲瑞 - 亲脂性分子缀合物的脂质体或红细胞具有作为血液池造影剂的效用，有利于正常组织的增强，磁共振血管造影术，以及通过开窗口或损伤引起的出血损伤的内皮标记区域部分血管系统。可以光密化具有感光性泰克萨菲瑞 - 亲脂性分子缀合物的脂质体或细胞，从而在裂解部位产生光动力学治疗效果。载有感光性泰克萨菲瑞 - 亲脂性分子缀合物的红细胞的可获得性提供了一种将光动力治疗剂递送至具有高浓度氧的所需部位的方法。通过以这种方式呈现代理，预期患者的毒性将较低。

10. 发明授权

US5763172A Method of phosphate ester hydrolysis 失效
标题翻译：磷酸酯水解方法
公开(公告)号：US5763172A
公开(公告)日：1998-06-09
申请号：US486962
申请日：1995-06-07
申请人： Darren Magda , Jonathan L. Sessler , Meredith Wright , Richard A. Miller , William C. Dow
发明人： Darren Magda , Jonathan L. Sessler , Meredith Wright , Richard A. Miller , William C. Dow
IPC分类号： A61K41/00 , A61K47/48 , A61K49/00 , B01J31/06 , B01J31/16 , B01J31/18 , C07D487/22 , C07H21/00 , C12Q1/68 , A01N61/00 , C07H19/00
CPC分类号： A61K47/48069 , A61K41/0038 , A61K49/0021 , A61K49/0054 , B01J31/1658 , B01J31/1815 , C07D487/22 , C07H21/00 , B01J2531/025 , B01J2531/38 , B01J31/061
摘要： A method of phosphate ester hydrolysis including incubating a solution of an aqueous phosphate ester with a metallotexaphyrin complex under conditions and for a time sufficient to hydrolyze the phosphate ester. The metal is a metal cation having catalytic activity for ester bond hydrolysis in aqueous solution. Phosphate ester substrates include nucleic acid such as RNA, phosphoric anhydrides, phospholipids, and alkyl phosphate esters.
摘要翻译：一种磷酸酯水解方法，包括在足以水解磷酸酯的条件和时间下孵育磷酸酯水溶液与金属脱甲苯吡啶络合物的溶液。金属是在水溶液中具有酯键水解的催化活性的金属阳离子。磷酸酯底物包括核酸如RNA，磷酸酐，磷脂和磷酸烷基酯。

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