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1. 发明授权

US08616216B2 Patterned laser treatment 有权
标题翻译：图案激光治疗
公开(公告)号：US08616216B2
公开(公告)日：2013-12-31
申请号：US12814051
申请日：2010-06-11
申请人： Mark S. Blumenkranz , Daniel V. Palanker , Dimitri Yellachich
发明人： Mark S. Blumenkranz , Daniel V. Palanker , Dimitri Yellachich
IPC分类号： A61B19/00 , A61B18/20
CPC分类号： A61F9/00823 , A61B2018/2025 , A61F9/00727 , A61F9/008 , A61F9/00821 , A61F2009/00863 , A61F2009/00897
摘要： Patterned laser treatment of the retina is provided. A visible alignment pattern having at least two separated spots is projected onto the retina. By triggering a laser subsystem, doses of laser energy are automatically provided to at least two treatment locations coincident with the alignment spots. All of the doses of laser energy may be delivered in less than about 1 second, which is a typical eye fixation time. A scanner can be used to sequentially move an alignment beam from spot to spot on the retina and to move a treatment laser beam from location to location on the retina.
摘要翻译：提供了图案化的视网膜激光治疗。具有至少两个分开的斑点的可见对准图案投影到视网膜上。通过触发激光子系统，自动将剂量的激光能量提供给与对准点重合的至少两个处理位置。激光能量的所有剂量可以在少于约1秒内递送，这是典型的眼睛注视时间。可以使用扫描仪来顺序地将定位光束从点到点移动到视网膜上，并且将处理激光束从位置移动到视网膜上。

2. 发明授权

US08500724B2 Method and apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation 有权
公开(公告)号：US08500724B2
公开(公告)日：2013-08-06
申请号：US13072646
申请日：2011-03-25
申请人： Mark S. Blumenkranz , Daniel V. Palanker , David H. Mordaunt , Dan E. Andersen
发明人： Mark S. Blumenkranz , Daniel V. Palanker , David H. Mordaunt , Dan E. Andersen
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B18/20 , A61B90/361 , A61B2018/00577 , A61F2/1602 , A61F9/00736 , A61F9/00754 , A61F9/00812 , A61F9/00814 , A61F9/00825 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F9/00838 , A61F9/0084 , A61F9/009 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00878 , A61F2009/00882 , A61F2009/00887 , A61F2009/00889 , A61F2009/00895 , A61F2009/00897
摘要： System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.

3. 发明申请

US20110178511A1 METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION 有权
标题翻译：用于图案等离子体介质激光照射镜片胶囊和三维PHACO分段的方法和装置
公开(公告)号：US20110178511A1
公开(公告)日：2011-07-21
申请号：US13072652
申请日：2011-03-25
申请人： Mark S. Blumenkranz , Daniel V. Palanker , David H. Mordaunt , Dan E. Andersen
发明人： Mark S. Blumenkranz , Daniel V. Palanker , David H. Mordaunt , Dan E. Andersen
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B18/20 , A61B90/361 , A61B2018/00577 , A61F2/1602 , A61F9/00736 , A61F9/00754 , A61F9/00812 , A61F9/00814 , A61F9/00825 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F9/00838 , A61F9/0084 , A61F9/009 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00878 , A61F2009/00882 , A61F2009/00887 , A61F2009/00889 , A61F2009/00895 , A61F2009/00897
摘要： System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.
摘要翻译：用于在不同深度进行眼组织切口的系统和方法。该系统和方法聚焦在眼睛组织内各种深度的各种焦点上，可能是模式。分段镜头可用于同时创建多个焦点。可以通过顺序或同时聚焦不同深度的光来实现最佳切口，产生扩张的等离子体柱，并且产生具有细长腰部的光束。

4. 发明授权

US06270749B1 Use of Texaphyrin in ocular diagnosis and therapy 失效
标题翻译：使用Texaphyrin进行眼部诊断和治疗
公开(公告)号：US06270749B1
公开(公告)日：2001-08-07
申请号：US09329720
申请日：1999-06-10
申请人： Mark S. Blumenkranz , Kathryn W. Woodburn , Richard A. Miller , Stuart W. Young
发明人： Mark S. Blumenkranz , Kathryn W. Woodburn , Richard A. Miller , Stuart W. Young
IPC分类号： A61K4900
CPC分类号： A61K41/0076 , A61K49/0021 , Y10S514/912
摘要： The use of texaphyrins for ocular diagnosis and therapy is provided, especially use of photosensitive texaphyrins for photodynamic therapy of conditions of the eye characterized by abnormal vasculature, such as macular degeneration, or pterygium, for example. The photosensitive texaphyrin may be a free-base texaphyrin or may be metallated with a diamagnetic metal. Preferably, the photosensitive texaphyrin is metallated with lutetium. Due to the dual wavelength absorption of texaphyrins, i.e., at 400-500 nm and at 700-800 nm, especially about 732 nm, as compared to porphyrins, texaphyrins are more effective and versatile for use in humans as compared to porphyrins. Texaphyrins serve as effective contrast agents in ocular angiography.
摘要翻译：提供了泰克萨菲瑞用于眼部诊断和治疗的用途，特别是使用感光性泰克萨菲瑞用于光动力学治疗眼睛状况的特征是异常脉管系统，例如黄斑变性或翼状ium肉。感光性泰克萨菲瑞可以是游离碱泰克萨菲瑞，也可以用抗磁性金属进行金属化。优选地，感光性泰克萨菲瑞用镥金属化。由于与卟啉相比，泰克萨菲瑞的双波长吸收，即在400-500nm和700-800nm，特别是约732nm，与卟啉相比，泰克萨菲素在人类中更有效和通用。 Texaphyrins作为眼部血管造影术中的有效造影剂。

5. 发明授权

US08709001B2 Method and apparatus for patterned plasma-mediated laser trephination of the lens capsule and three dimensional phaco-segmentation 有权
标题翻译：用于图案化等离子体介导的晶状体囊的激光治疗的方法和装置以及三维超声波分割
公开(公告)号：US08709001B2
公开(公告)日：2014-04-29
申请号：US13588966
申请日：2012-08-17
申请人： Mark S. Blumenkranz , Daniel V. Palanker , David H. Mordaunt , Dan E. Andersen
发明人： Mark S. Blumenkranz , Daniel V. Palanker , David H. Mordaunt , Dan E. Andersen
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B18/20 , A61B90/361 , A61B2018/00577 , A61F2/1602 , A61F9/00736 , A61F9/00754 , A61F9/00812 , A61F9/00814 , A61F9/00825 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F9/00838 , A61F9/0084 , A61F9/009 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00878 , A61F2009/00882 , A61F2009/00887 , A61F2009/00889 , A61F2009/00895 , A61F2009/00897
摘要： System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.
摘要翻译：用于在不同深度进行眼组织切口的系统和方法。该系统和方法聚焦在眼睛组织内各种深度的各种焦点上，可能是模式。分段镜头可用于同时创建多个焦点。可以通过顺序或同时聚焦不同深度的光来实现最佳切口，产生扩张的等离子体柱，并且产生具有细长腰部的光束。

6. 发明申请

US20120316545A1 METHOD AND APPARATUS FOR PATTERNED PLASMA-MEDIATED LASER TREPHINATION OF THE LENS CAPSULE AND THREE DIMENSIONAL PHACO-SEGMENTATION 有权
标题翻译：用于图案等离子体介质激光照射镜片胶囊和三维PHACO分段的方法和装置
公开(公告)号：US20120316545A1
公开(公告)日：2012-12-13
申请号：US13587833
申请日：2012-08-16
申请人： Mark S. Blumenkranz , Daniel V. Palanker , David H. Mordaunt , Dan E. Andersen
发明人： Mark S. Blumenkranz , Daniel V. Palanker , David H. Mordaunt , Dan E. Andersen
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B18/20 , A61B90/361 , A61B2018/00577 , A61F2/1602 , A61F9/00736 , A61F9/00754 , A61F9/00812 , A61F9/00814 , A61F9/00825 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F9/00838 , A61F9/0084 , A61F9/009 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00878 , A61F2009/00882 , A61F2009/00887 , A61F2009/00889 , A61F2009/00895 , A61F2009/00897
摘要： System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.
摘要翻译：用于在不同深度进行眼组织切口的系统和方法。该系统和方法聚焦在眼睛组织内各种深度的各种焦点上，可能是模式。分段镜头可用于同时创建多个焦点。可以通过顺序或同时聚焦不同深度的光来实现最佳切口，产生扩张的等离子体柱，并且产生具有细长腰部的光束。

7. 发明申请

US20120209051A1 METHOD AND APPARATUS FOR THE DELIVERY OF PHOTOCHEMICAL (CROSS-LINKING) TREATMENT TO SCLERAL TISSUE 有权
标题翻译：用于将化学（交联）处理给药物组织的方法和装置
公开(公告)号：US20120209051A1
公开(公告)日：2012-08-16
申请号：US13396454
申请日：2012-02-14
申请人： Mark S. Blumenkranz , Edward E. Manche , Satish V. Herekar , Donald J. Eaton
发明人： Mark S. Blumenkranz , Edward E. Manche , Satish V. Herekar , Donald J. Eaton
IPC分类号： A61M37/00 , A61F9/00
CPC分类号： A61F9/0017 , A61F9/0079 , A61K9/0051 , A61K31/525 , A61K41/0038 , A61K41/0057 , A61N5/062
摘要： Delivery systems and methods for delivering riboflavin (R/F) and UVA irradiation to the sclera are disclosed. The R/F is delivered and then activated with UVA irradiation through the use of LEDs or optical fibers, thereby causing cross-linking of the collagen tissue. Delivery systems include implantable structures which provide surfaces that conform to the sclera. The delivery systems include various types of structures for delivery of R/F onto the sclera surface. Additionally, the delivery systems include UVA sources which provide irradiation of R/F in sclera collagen tissue.
摘要翻译：公开了将核黄素（R / F）和UVA照射用于巩膜的递送系统和方法。传送R / F，然后通过使用LED或光纤进行UVA照射激活，从而引起胶原组织的交联。输送系统包括提供符合巩膜的表面的可植入结构。递送系统包括用于将R / F递送到巩膜表面上的各种类型的结构。另外，递送系统包括在巩膜胶原组织中提供R / F照射的UVA源。

8. 发明授权

US07766903B2 Patterned laser treatment of the retina 有权
标题翻译：图案化的视网膜激光治疗
公开(公告)号：US07766903B2
公开(公告)日：2010-08-03
申请号：US10745954
申请日：2003-12-24
申请人： Mark S. Blumenkranz , Daniel V. Palanker , Dimitri Yellachich
发明人： Mark S. Blumenkranz , Daniel V. Palanker , Dimitri Yellachich
IPC分类号： A61B18/20
CPC分类号： A61F9/00823 , A61B2018/2025 , A61F9/00727 , A61F9/008 , A61F9/00821 , A61F2009/00863 , A61F2009/00897
摘要： Patterned laser treatment of the retina is provided. A visible alignment pattern having at least two separated spots is projected onto the retina. By triggering a laser subsystem, doses of laser energy are automatically provided to at least two treatment locations coincident with the alignment spots. All of the doses of laser energy may be delivered in less than about 1 second, which is a typical eye fixation time. A scanner can be used to sequentially move an alignment beam from spot to spot on the retina and to move a treatment laser beam from location to location on the retina.
摘要翻译：提供了图案化的视网膜激光治疗。具有至少两个分开的斑点的可见对准图案投影到视网膜上。通过触发激光子系统，自动将剂量的激光能量提供给与对准点重合的至少两个处理位置。激光能量的所有剂量可以在少于约1秒内递送，这是典型的眼睛注视时间。可以使用扫描仪来顺序地将定位光束从点到点移动到视网膜上，并且将处理激光束从位置移动到视网膜上。

9. 发明申请

US20100191226A1 Method Of Patterned Plasma-Mediated Laser Trephination Of The Lens Capsule And Three Dimensional Phaco-Segmentation 审中-公开
标题翻译：图像等离子体介导的镜片胶囊激光治疗方法和三维Phaco分割
公开(公告)号：US20100191226A1
公开(公告)日：2010-07-29
申请号：US12510148
申请日：2009-07-27
申请人： Mark S. Blumenkranz , Daniel V. Palanker , Dan E. Andersen
发明人： Mark S. Blumenkranz , Daniel V. Palanker , Dan E. Andersen
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B18/20 , A61B90/361 , A61B2018/00577 , A61F2/1602 , A61F9/00736 , A61F9/00754 , A61F9/00812 , A61F9/00814 , A61F9/00825 , A61F9/00831 , A61F9/00834 , A61F9/00836 , A61F9/00838 , A61F9/0084 , A61F9/009 , A61F2009/00844 , A61F2009/00851 , A61F2009/00865 , A61F2009/0087 , A61F2009/00878 , A61F2009/00882 , A61F2009/00887 , A61F2009/00889 , A61F2009/00895 , A61F2009/00897
摘要： System and method for making incisions in eye tissue at different depths. The system and method focuses light, possibly in a pattern, at various focal points which are at various depths within the eye tissue. A segmented lens can be used to create multiple focal points simultaneously. Optimal incisions can be achieved by sequentially or simultaneously focusing lights at different depths, creating an expanded column of plasma, and creating a beam with an elongated waist.
摘要翻译：用于在不同深度进行眼组织切口的系统和方法。该系统和方法聚焦在眼睛组织内各种深度的各种焦点上，可能是模式。分段镜头可用于同时创建多个焦点。可以通过顺序或同时聚焦不同深度的光来实现最佳切口，产生扩张的等离子体柱，并且产生具有细长腰部的光束。

10. 发明申请

US20100103103A1 Method And Device for Input Of Information Using Visible Touch Sensors 审中-公开
标题翻译：使用可视触摸传感器输入信息的方法和设备
公开(公告)号：US20100103103A1
公开(公告)日：2010-04-29
申请号：US12543368
申请日：2009-08-18
申请人： Daniel V. Palanker , Mark S. Blumenkranz
发明人： Daniel V. Palanker , Mark S. Blumenkranz
IPC分类号： G06F3/042 , G09G5/08
CPC分类号： G06F3/023 , G06F3/0425 , G06F3/0426
摘要： A device and method for manual input of information into computing device using a camera and visible touch sensors. An image of a virtual input device is displayed on a screen, and the positions of the visible touch sensors, recorded by the video camera, are overlaid on the image of the virtual input device, thus allowing the user to see the placement of the touch sensors relative to the keys or buttons on the virtual input device. The touch sensors change their appearance upon contact with a surface, and the camera records their position at the moment of change. This way information about the position of intended touch is recorded. Touch sensors can be binary (ON-OFF) or may have a graded response reflecting the extent of displacement or pressure of the touch sensor relative to the surface of contact.
摘要翻译：使用相机和可见的触摸传感器将信息手动输入到计算装置中的装置和方法。虚拟输入设备的图像被显示在屏幕上，并且由摄像机记录的可见触摸传感器的位置覆盖在虚拟输入设备的图像上，从而允许用户看到触摸的位置相对于虚拟输入设备上的键或按钮的传感器。触摸传感器在与表面接触时改变其外观，并且相机在变化的时刻记录其位置。这样可以记录有关预期触摸位置的信息。触摸传感器可以是二进制（ON-OFF）或者可以具有反映触摸传感器相对于接触表面的位移或压力的程度的渐变响应。

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