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    • 3. 发明授权
    • Photodynamic activity of sapphyrins
    • SAPPHYR光谱动力学
    • US5120411A
    • 1992-06-09
    • US454301
    • 1989-12-21
    • Jonathan L. SesslerAnthony HarrimanBhaskar G. Maiya
    • Jonathan L. SesslerAnthony HarrimanBhaskar G. Maiya
    • A61K41/00C01B13/02
    • A61K41/0076C01B13/02
    • The present invention includes a method to produce singlet oxygen from molecular oxygen generated by reaction with a sapphyrin compound excited at an absorbing wavelength to form a triplet species. Specifically, the sapphyrin compound is an alkylated sapphyrin, most preferably diprotonated 3,8,12,13,17,22-hexaethyl-2,7,18,23-tetramethylsapphyrin. Generation of the triplet species may be accomplished in an organic solvent, of which the most preferable solvents are chloroform, methanol or acetonitrile.Also encompassed within the present invention is a method to selectively produce singlet oxygen in an aqueous environment. A sapphyrin compound is incorporated within a membranous vesicle, the vesicle is illuminated with exciting light and the resultant excited triplet state sapphyrin compound reacts with molecular oxygen to produce singlet oxygen. Singlet oxygen was not generated external to the vesicle where the sapphyrin compound is present in an aqueous medium.
    • 本发明包括通过与以吸收波长激发的卟啉化合物反应产生的分子氧产生单线态以形成三线态的方法。 具体地说,札幌化合物是烷基化卟啉,最优选的是二质子化的3,8,12,13,17,22-六乙基-2,7,18,23-四甲基卟啉。 三重物质的生成可以在有机溶剂中完成,其中最优选的溶剂是氯仿,甲醇或乙腈。 在本发明中还包括在水性环境中选择性地产生单线态氧的方法。 将sap卟啉化合物掺入膜泡内,用激发光照射囊泡,得到的激发的三线态曙红化合物与分子氧反应产生单线态氧。 在水性介质中存在卟啉化合物的小泡外部不产生单线态氧。