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1. 发明授权

US08625094B2 DNA sequencing system 有权
标题翻译： DNA测序系统
公开(公告)号：US08625094B2
公开(公告)日：2014-01-07
申请号：US13619298
申请日：2012-09-14
申请人： Mark Oldham , Eric Norman , Richard Reel , Janice Shigeura
发明人： Mark Oldham , Eric Norman , Richard Reel , John Shigeura
IPC分类号： G01N21/00 , G01N27/447
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

2. 发明授权

US08384898B2 DNA sequencing system 有权
标题翻译： DNA测序系统
公开(公告)号：US08384898B2
公开(公告)日：2013-02-26
申请号：US13442107
申请日：2012-04-09
申请人： Mark Oldham , Eric Nordman , Richard Reel , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

3. 发明申请

US20080094627A1 Time-delay integration in a flow cytometry system 有权
标题翻译：流式细胞术系统中的延时整合
公开(公告)号：US20080094627A1
公开(公告)日：2008-04-24
申请号：US11644412
申请日：2006-12-22
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from detectable analytes in the one or more detection zones, which have been excited by the radiation, wherein at least one detector includes an output; a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector; and a sorting mechanism, for example, to effect flow cytometry. Methods for detecting analytes in a sample are also provided.
摘要翻译：提供了一种用于检测样品中分析物的装置。该装置可以包括：流式细胞术系统，其包括一个或多个检测区域; 一个或多个辐射源被设置用于用辐射照射一个或多个检测区域; 至少一个检测器，其被设置用于收集对应于已被所述辐射激发的所述一个或多个检测区域中的可检测分析物发射的光信号的电荷，其中至少一个检测器包括输出; 耦合到所述至少一个检测器的系统，用于通过在读取所述至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分; 以及分选机制，例如进行流式细胞术。还提供了检测样品中分析物的方法。

4. 发明申请

US20080043235A1 Electrophoretic system with multi-notch filter and laser excitation source 有权
标题翻译：具有多陷波滤波器和激光源的电泳系统
公开(公告)号：US20080043235A1
公开(公告)日：2008-02-21
申请号：US11894829
申请日：2007-08-22
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N21/6456 , B82Y10/00 , B82Y20/00 , G01N27/44721 , G01N2021/6417 , G01N2021/6419 , G01N2021/6471 , G01N2201/0628
摘要： Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.
摘要翻译：提供了用于检测样品中分析物的装置和方法。该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。各种实施例提供具有多陷波滤波器的装置。各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

5. 发明授权

US08169610B2 DNA sequencing system 有权
标题翻译： DNA测序系统
公开(公告)号：US08169610B2
公开(公告)日：2012-05-01
申请号：US13153902
申请日：2011-06-06
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura, legal representative
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.
摘要翻译：提供了一种用于检测标记珠粒的装置。该装置可以包括：一个或多个辐射源，被设置用于用辐射照射一个或多个检测区域; 至少一个检测器被设置用于收集对应于已经被辐射激发的一个或多个检测区域中的标记珠子发射的光信号的电荷; 以及耦合到所述至少一个检测器的系统，用于通过在读取至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分。

6. 发明申请

US20050036142A1 Electrophoretic system with multi-notch filter and laser excitation source 有权
标题翻译：具有多陷波滤波器和激光源的电泳系统
公开(公告)号：US20050036142A1
公开(公告)日：2005-02-17
申请号：US10887528
申请日：2004-07-08
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
IPC分类号： G01N21/00 , G01N21/63 , G01N27/27
CPC分类号： G01N21/6456 , B82Y10/00 , B82Y20/00 , G01N27/44721 , G01N2021/6417 , G01N2021/6419 , G01N2021/6471 , G01N2201/0628
摘要： Apparatus and methods for detecting analytes in a sample are provided. The apparatus can include: one or more channels having a detection zone; one or more irradiation sources disposed for irradiating the detection zone with radiation; a detector capable of collecting at least one charge corresponding to an emission beam emitted from the detection zone, the detector having an output; and a time delay integration system coupled to the detector for effecting time delay integration of the at least one charge by accumulating the at least one charge before reading the at least one charge at the output of the detector. Various embodiments provide an apparatus with a multi-notch filter. Various embodiments provide a solid state laser, a micro-wire laser, or an organic light-emitting diode as a irradiation source.
摘要翻译：提供了用于检测样品中分析物的装置和方法。该装置可以包括：具有检测区域的一个或多个通道; 设置用于辐射照射检测区域的一个或多个照射源; 检测器，其能够收集对应于从所述检测区域发射的发射光束的至少一个电荷，所述检测器具有输出; 以及耦合到所述检测器的时间延迟积分系统，用于通过在所述检测器的输出读取所述至少一个电荷之前积累所述至少一个电荷来实现所述至少一个电荷的时间延迟积分。各种实施例提供具有多陷波滤波器的装置。各种实施例提供固态激光器，微线激光器或有机发光二极管作为照射源。

7. 发明申请

US20050030534A1 Time-delay integration in a flow cytometry system 有权
标题翻译：流式细胞术系统中的延时整合
公开(公告)号：US20050030534A1
公开(公告)日：2005-02-10
申请号：US10887486
申请日：2004-07-08
申请人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura , Janice Shigeura
IPC分类号： G01N21/00 , G01N21/63 , G01N27/27
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting analytes in a sample is provided. The apparatus can include: a flow cytometry system including one or more detection zones; one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from detectable analytes in the one or more detection zones, which have been excited by the radiation, wherein at least one detector includes an output; a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector; and a sorting mechanism, for example, to effect flow cytometry. Methods for detecting analytes in a sample are also provided.
摘要翻译：提供了一种用于检测样品中分析物的装置。该装置可以包括：流式细胞术系统，其包括一个或多个检测区域; 一个或多个辐射源被设置用于用辐射照射一个或多个检测区域; 至少一个检测器，其被设置用于收集对应于已被所述辐射激发的所述一个或多个检测区域中的可检测分析物发射的光信号的电荷，其中至少一个检测器包括输出; 耦合到所述至少一个检测器的系统，用于通过在读取所述至少一个检测器的输出端的电荷之前累积电荷来实现电荷的时间延迟积分; 以及分选机制，例如进行流式细胞术。还提供了检测样品中分析物的方法。

8. 发明授权

US08384899B2 DNA sequencing system 有权
公开(公告)号：US08384899B2
公开(公告)日：2013-02-26
申请号：US13442143
申请日：2012-04-09
申请人： Mark Oldham , Eric Nordman , Richard Reel , Janice Shigeura
发明人： Mark Oldham , Eric Nordman , Richard Reel , John Shigeura
IPC分类号： G01N21/00
CPC分类号： G01N27/44721 , B82Y10/00 , B82Y20/00 , G01N2015/149 , G01N2015/1497
摘要： An apparatus for detecting labeled beads is provided. The apparatus can include: one or more irradiation sources disposed for irradiating the one or more detection zones with radiation; at least one detector disposed for collecting charges corresponding to light signals emitted from labeled beads in the one or more detection zones, which have been excited by the radiation; and a system coupled to the at least one detector for effecting time delay integration of the charges by accumulating the charges before reading the charges at the output of the at least one detector.

9. 发明授权

US09194772B2 Apparatus, system, and method using immiscible-fluid-discrete-volumes 有权
标题翻译：使用不混溶流体离散体的装置，系统和方法
公开(公告)号：US09194772B2
公开(公告)日：2015-11-24
申请号：US12557488
申请日：2009-09-10
申请人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
发明人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
IPC分类号： C12Q1/68 , C12M1/34 , G01N1/14 , B01L3/00 , F15C5/00 , F16K99/00 , G01N35/08 , B01L3/02 , B01L7/00
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575 , C12Q2535/101
摘要： Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
摘要翻译：本发明的各种实施方案涉及生物化学或分子生物学程序中用于样品制备或分析的系统或方法。样品制备可以涉及在离散部分或段或块中的小体积处理，在本文中称为离散体积。分子生物学程序可以是核酸分析。核酸分析可以是一个综合的DNA扩增/ DNA测序程序。

10. 发明申请

US20070141593A1 Apparatus, system, and method using immiscible-fluid-discrete-volumes 审中-公开
标题翻译：使用不混溶流体离散体的装置，系统和方法
公开(公告)号：US20070141593A1
公开(公告)日：2007-06-21
申请号：US11507735
申请日：2006-08-22
申请人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
发明人： Linda Lee , Sam Woo , Congcong Ma , Richard Reel , Mark Oldham , David Cox , Benjamin Schroeder , Jon Sorenson , Willy Wiyatno
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6869 , B01J2219/00353 , B01J2219/0036 , B01J2219/00364 , B01J2219/00608 , B01J2219/0061 , B01J2219/00612 , B01J2219/00619 , B01J2219/00626 , B01J2219/00637 , B01J2219/00653 , B01J2219/00657 , B01J2219/00659 , B01L3/0293 , B01L3/502715 , B01L3/502784 , B01L7/52 , B01L2200/0673 , B01L2200/10 , B01L2300/0864 , B01L2300/0867 , B01L2400/0421 , B01L2400/0487 , C12Q1/6806 , C12Q1/6874 , C12Q2535/101 , F15C5/00 , F16K99/0001 , F16K99/0011 , F16K99/0013 , F16K2099/0084 , G01N1/14 , G01N27/44743 , G01N27/44769 , G01N35/08 , Y10T137/0318 , Y10T137/4259 , Y10T137/85978 , Y10T137/85986 , Y10T137/86863 , Y10T436/2575
摘要： Various embodiments of the teachings relate to a system or method for sample preparation or analysis in biochemical or molecular biology procedures. The sample preparation can involve small volume processed in discrete portions or segments or slugs, herein referred to as discrete volumes. A molecular biology procedure can be nucleic acid analysis. Nucleic acid analysis can be an integrated DNA amplification/DNA sequencing procedure.
摘要翻译：本发明的各种实施方案涉及生物化学或分子生物学程序中用于样品制备或分析的系统或方法。样品制备可以涉及在离散部分或段或块中的小体积处理，在本文中称为离散体积。分子生物学程序可以是核酸分析。核酸分析可以是一个综合的DNA扩增/ DNA测序程序。

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