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1. 发明申请

US20080287928A1 OPERATOR-CONTROLLED SCANNING LASER PROCEDURE DESIGNED FOR LARGE-AREA EPITHELIUM REMOVAL 有权
标题翻译：操作者控制的扫描激光程序设计用于大面积上移
公开(公告)号：US20080287928A1
公开(公告)日：2008-11-20
申请号：US12121635
申请日：2008-05-15
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
IPC分类号： A61F9/008 , A61B18/20
CPC分类号： A61F9/00814 , A61B2017/00057 , A61B2017/00154 , A61F9/008 , A61F9/00802 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00885 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置为增强光学反馈的脉冲序列的扫描允许大面积的上皮被消融，可以检测到上皮层的穿透。

2. 发明授权

US08926600B2 Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权
标题翻译：操作员控制的扫描激光程序设计用于大面积去皮
公开(公告)号：US08926600B2
公开(公告)日：2015-01-06
申请号：US12121635
申请日：2008-05-15
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
IPC分类号： A61F9/008 , A61B18/20 , A61B17/00
CPC分类号： A61F9/00814 , A61B2017/00057 , A61B2017/00154 , A61F9/008 , A61F9/00802 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00885 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置为增强光学反馈的脉冲序列的扫描允许大面积的上皮被消融，可以检测到上皮层的穿透。

3. 发明授权

US08251509B2 Accommodation compensation systems and methods 有权
标题翻译：住房补偿制度和方法
公开(公告)号：US08251509B2
公开(公告)日：2012-08-28
申请号：US13276704
申请日：2011-10-19
申请人： Guang-Ming Dai , Leander Zickler
发明人： Guang-Ming Dai , Leander Zickler
IPC分类号： A61B3/10 , A61B3/00
CPC分类号： A61B3/0025 , A61B3/1015 , A61B3/107 , A61B3/112 , A61B3/14 , A61F9/008 , A61F9/00804 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088 , A61F2009/00895 , A61F2009/00897 , G02C7/041
摘要： Methods and systems for obtaining an ocular aberration measurement of an eye of a patient are provided. Exemplary techniques involve obtaining a first induced metric for the eye that corresponds to a first accommodation state of the eye, obtaining a second induced metric for the eye that corresponds to a second accommodation state of the eye, and determining a natural metric of the eye based on the first and second induced metrics. An induced metric may include a pupil size or a spherical aberration. Techniques can also include determining a target metric for the eye base on the natural metric, determining whether an actual metric of the eye meets the target metric, obtaining an ocular aberration measurement of the eye if the actual metric meets the target metric, and determining a treatment for the eye based on the ocular aberration measurement.
摘要翻译：提供了用于获得患者眼睛的眼睛像差测量的方法和系统。示例性技术包括获得与眼睛的第一容纳状态相对应的眼睛的第一诱导度量，获得与眼睛的第二适应状态对应的眼睛的第二诱导度量，以及确定眼睛的自然度量关于第一和第二诱导度量。诱导度量可以包括瞳孔尺寸或球面像差。技术还可以包括基于自然度量来确定眼睛的目标度量，确定眼睛的实际度量是否符合目标度量，如果实际度量符合目标度量，则获得眼睛的眼睛像差测量值，以及确定基于眼睛像差测量治疗眼睛。

4. 发明授权

US07980699B2 Method for registering multiple data sets 有权
标题翻译：多个数据集的注册方法
公开(公告)号：US07980699B2
公开(公告)日：2011-07-19
申请号：US12418841
申请日：2009-04-06
申请人： Daniel R. Neal , Leander Zickler
发明人： Daniel R. Neal , Leander Zickler
IPC分类号： A61B3/00 , A61B3/10
CPC分类号： G06T5/50 , A61F9/00804 , A61F9/00827 , A61F2009/00848 , A61F2009/00851 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , G06T7/33 , G06T2207/20221 , G06T2207/30041
摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. Embodiments of the invention may facilitate the use of multi-modal diagnostic instruments and instrument systems, making it easier to acquire and fuse data from different measurements of the eye. For example, wavefront aberrometry may be fused with corneal topography, optical coherence topography and wavefront, optical coherence topography and topography, pachymetry and wavefront, etc. While some of these different optical datasets may be obtained simultaneously, it is often difficult and/or disadvantageous to attempt to acquire the images or other data at exactly the same time. Advantageously, both patient movement between measurements (and/or during a measurement sequence) can be identified, as well as changes in the eye itself (including those induced by the measurement, such as changes in the size of the pupil, changes in pupil location, etc.).
摘要翻译：便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。本发明的实施例可以促进多模式诊断仪器和仪器系统的使用，从而更容易地从眼睛的不同测量获取和融合数据。例如，波前像差法可以与角膜地形学，光学相干形貌和波前融合，光学相干形貌和地形学，厚度测量和波前等。虽然这些不同的光学数据集中的一些可以同时获得，但是通常是困难和/或不利的尝试在完全相同的时间获取图像或其他数据。有利的是，可以确定测量之间（和/或在测量序列期间）患者之间的移动以及眼睛本身的变化（包括由测量引起的变化，例如瞳孔尺寸的变化，瞳孔位置的变化等）。

5. 发明申请

US20070173797A1 Laser energy calibration based on optical measurement 有权
标题翻译：基于光学测量的激光能量校准
公开(公告)号：US20070173797A1
公开(公告)日：2007-07-26
申请号：US11341917
申请日：2006-01-26
申请人： Leander Zickler
发明人： Leander Zickler
IPC分类号： A61B18/18
CPC分类号： A61B18/20 , A61B2017/00725 , A61F9/00804 , A61F9/00812 , A61F2009/00848 , A61F2009/00855 , A61F2009/00872
摘要： Systems and method for determining ablation beam characteristics are provided. Methods include ablating an article with the ablation beam to form a test location having an ablation depth, transmitting a first beam through the test location of the article, transmitting a second beam through a reference location, and determining an ablation beam characteristic based on a phase relationship of the first beam and the second beam downstream of the article. Systems include a light source assembly transmitting a first beam through an ablated test location of an article and a second beam through a reference location disposed outside of the test location, a sensor assembly detecting a first beam and second beam superimposition downstream of the article, and a phase relationship code module for determining a phase relationship between the first beam and the second beam, based on the first beam and second beam superimposition.
摘要翻译：提供了确定消融光束特性的系统和方法。方法包括用消融束消融物品以形成具有消融深度的测试位置，透射穿过物品的测试位置的第一光束，通过参考位置传输第二光束，以及基于相位确定消融光束特性第一光束和第二光束在物品下游的关系。系统包括光源组件，其将第一光束穿过物品的消融测试位置和通过设置在测试位置外部的参考位置的第二光束传输;检测第一光束和第二光束叠加在物品下游的传感器组件，以及相位关系码模块，用于基于第一光束和第二光束叠加来确定第一光束和第二光束之间的相位关系。

6. 发明申请

US20110149239A1 OPTICAL DIAGNOSIS USING MEASUREMENT SEQUENCE 有权
标题翻译：使用测量顺序的光学诊断
公开(公告)号：US20110149239A1
公开(公告)日：2011-06-23
申请号：US12909756
申请日：2010-10-21
申请人： Daniel R. Neal , Thomas D. Raymond , Leander Zickler
发明人： Daniel R. Neal , Thomas D. Raymond , Leander Zickler
IPC分类号： A61B3/103 , A61B3/10 , A61B3/11
CPC分类号： A61B3/0025 , A61B3/1015 , A61B3/103 , A61B3/112 , G02C7/027 , G02C7/04
摘要： Devices, systems, and methods that facilitate optical analysis, particularly for the diagnosis and treatment of refractive errors of the eye. An optical diagnostic method for an eye includes obtaining a sequence of aberration measurements of the eye, identifying an outlier aberration measurement of the sequence of aberration measurements, and excluding the outlier aberration measurement from the sequence of aberration measurements to produce a qualified sequence of aberration measurements. The sequence of aberrations measurements can be obtained by using a wavefront sensor. An optical correction for the eye can be formulated in response to the qualified sequence of aberration measurements.
摘要翻译：便于光学分析的设备，系统和方法，特别是诊断和治疗眼睛屈光不正的方法。用于眼睛的光学诊断方法包括获得眼睛的像差测量序列，识别像差测量序列的异常像差测量，并从像差测量序列排除异常值像差测量，以产生合格的像差测量序列。可以通过使用波前传感器来获得像差测量序列。可以根据合格的像差测量序列来制定眼睛的光学校正。

7. 发明申请

US20080077239A1 INTRAOCULAR LENSES FOR MANAGING GLARE, ADHESION, AND CELL MIGRATION 有权
公开(公告)号：US20080077239A1
公开(公告)日：2008-03-27
申请号：US11534200
申请日：2006-09-21
申请人： Leander Zickler , Rakhi Jain , Jim Deacon
发明人： Leander Zickler , Rakhi Jain , Jim Deacon
IPC分类号： A61F2/16
CPC分类号： A61F2/1613 , A61F2002/009 , A61F2002/1681 , A61F2002/1696 , A61F2220/0008 , A61F2220/0016 , A61F2250/0053 , A61F2250/0096 , A61F2250/0098 , H04W52/146 , H04W52/367
摘要： An intraocular lens for providing vision to a subject contains an optic, a support structure coupled to the optic. The intraocular lens also includes a textured surface and/or subsurface layer. The optic is disposed about an optical axis and comprises an anterior surface and an opposing posterior surface, the surfaces being configured to focus light when implanted within an eye having a capsular bag. The textured surface is disposed over a surface portion of the intraocular lens and includes a plurality of periodically-spaced protrusions, each protrusion having a smooth distal face and a sharp corner edge configured to engage a wall of the capsular bag and/or at least one cell disposed along the wall. The subsurface layer is configured to scatter an amount of light that is at least twice the amount of light scattered by portions of the material adjacent the subsurface layer or at least twice the amount of light scattered by another intraocular lens that does not have the subsurface layer, but which is otherwise substantially equivalent.

8. 发明授权

US08246609B2 Intracorneal inlay, system, and method 有权
标题翻译：内角嵌体，系统和方法
公开(公告)号：US08246609B2
公开(公告)日：2012-08-21
申请号：US12494092
申请日：2009-06-29
申请人： Leander Zickler , Scott J. Catlin , Andrew Y Pang
发明人： Leander Zickler , Scott J. Catlin , Andrew Y Pang
IPC分类号： A61B18/18
CPC分类号： A61F2/145 , A61F2/1451 , A61F9/00804 , A61F2009/0088 , A61F2009/00882
摘要： Method and system for modifying a refractive profile associated with an eye having a recipient cornea. The method includes obtaining a corneal tissue inlay from a donor cornea, forming a recipient bed in the recipient cornea, and positioning the corneal tissue inlay into the recipient bed to correct the refractive profile of the eye with the refractive profile of the corneal tissue. The system includes a laser assembly outputting a pulsed laser beam, and a controller coupled to the laser assembly. The controller directs the laser assembly to incise a corneal tissue inlay from a donor cornea, form a recipient bed in the recipient cornea having a contour matching the contour of the inlay, register the inlay with the recipient bed, determine a position of the inlay, and determine a position change for the inlay based on the position of the inlay to align the refractive profile of the inlay with the refractive profile of the eye.
摘要翻译：用于修改与具有受体角膜的眼睛相关联的折射轮廓的方法和系统。该方法包括从供体角膜获得角膜组织镶嵌物，在接受者角膜中形成受体床，以及将角膜组织镶嵌物定位在受体床中，以校正眼睛的屈光轮廓与角膜组织的折射轮廓。该系统包括输出脉冲激光束的激光组件和耦合到激光组件的控制器。控制器指示激光组件切割来自供体角膜的角膜组织镶嵌物，在受体角膜中形成具有与镶嵌轮廓相匹配的轮廓的受体床，将嵌体与受体床注册，确定嵌体的位置，并且基于嵌体的位置来确定嵌体的位置变化，以使嵌体的折射轮廓与眼睛的折射轮廓对准。

9. 发明申请

US20120033183A1 ACCOMMODATION COMPENSATION SYSTEMS AND METHODS 有权
标题翻译：住宿补偿制度和方法
公开(公告)号：US20120033183A1
公开(公告)日：2012-02-09
申请号：US13276704
申请日：2011-10-19
申请人： Guang-Ming Dai , Leander Zickler
发明人： Guang-Ming Dai , Leander Zickler
IPC分类号： A61B3/10 , A61B3/00
CPC分类号： A61B3/0025 , A61B3/1015 , A61B3/107 , A61B3/112 , A61B3/14 , A61F9/008 , A61F9/00804 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088 , A61F2009/00895 , A61F2009/00897 , G02C7/041
摘要： Methods and systems for obtaining an ocular aberration measurement of an eye of a patient are provided. Exemplary techniques involve obtaining a first induced metric for the eye that corresponds to a first accommodation state of the eye, obtaining a second induced metric for the eye that corresponds to a second accommodation state of the eye, and determining a natural metric of the eye based on the first and second induced metrics. An induced metric may include a pupil size or a spherical aberration. Techniques can also include determining a target metric for the eye base on the natural metric, determining whether an actual metric of the eye meets the target metric, obtaining an ocular aberration measurement of the eye if the actual metric meets the target metric, and determining a treatment for the eye based on the ocular aberration measurement.
摘要翻译：提供了用于获得患者眼睛的眼睛像差测量的方法和系统。示例性技术包括获得与眼睛的第一容纳状态相对应的眼睛的第一诱导度量，获得与眼睛的第二适应状态对应的眼睛的第二诱导度量，以及确定眼睛的自然度量关于第一和第二诱导度量。诱导度量可以包括瞳孔尺寸或球面像差。技术还可以包括基于自然度量确定眼睛的目标度量，确定眼睛的实际度量是否符合目标度量，如果实际度量符合目标度量，则获得眼睛的眼睛像差测量值，以及确定基于眼睛像差测量治疗眼睛。

10. 发明授权

US07922328B2 Accommodation compensation systems and methods 有权
公开(公告)号：US07922328B2
公开(公告)日：2011-04-12
申请号：US12273481
申请日：2008-11-18
申请人： Guang-Ming Dai , Leander Zickler
发明人： Guang-Ming Dai , Leander Zickler
IPC分类号： A61B3/10 , A61B3/00
CPC分类号： A61B3/0025 , A61B3/1015 , A61B3/107 , A61B3/112 , A61B3/14 , A61F9/008 , A61F9/00804 , A61F2009/0087 , A61F2009/00872 , A61F2009/0088 , A61F2009/00895 , A61F2009/00897 , G02C7/041
摘要： Methods and systems for obtaining an ocular aberration measurement of an eye of a patient are provided. Exemplary techniques involve obtaining a first induced metric for the eye that corresponds to a first accommodation state of the eye, obtaining a second induced metric for the eye that corresponds to a second accommodation state of the eye, and determining a natural metric of the eye based on the first and second induced metrics. An induced metric may include a pupil size or a spherical aberration. Techniques can also include determining a target metric for the eye base on the natural metric, determining whether an actual metric of the eye meets the target metric, obtaining an ocular aberration measurement of the eye if the actual metric meets the target metric, and determining a treatment for the eye based on the ocular aberration measurement.

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