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1. 发明授权

US12090043B2 Vision correction with laser refractive index changes 有权
$Vision correction with laser refractive index changes$
公开(公告)号：US12090043B2
公开(公告)日：2024-09-17
申请号：US18095748
申请日：2023-01-11
申请人： University of Rochester
发明人： Leonard Zheleznyak , Scott Catlin
IPC分类号： A61F2/16 , A61F2/14 , A61F9/008 , G02B1/04 , G02C7/04 , H01S3/22
CPC分类号： A61F2/1618 , A61F2/1451 , A61F2/1613 , A61F2/1651 , A61F2/1654 , A61F9/00806 , A61F9/00812 , A61F9/00825 , A61F9/00827 , A61F9/00829 , A61F9/00834 , A61F9/00838 , G02B1/043 , G02C7/041 , G02C7/049 , A61F2002/1696 , A61F2009/00842 , A61F2009/00848 , A61F2009/0087 , A61F2009/00872 , A61F2009/00895 , A61F2250/0053 , G02C7/048 , G02C2202/12 , G02C2202/22 , G02C2202/24 , H01S3/2222
摘要： Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or optical tissues is performed to address various types of vision correction.

2. 发明授权

US11911261B2 Vision correction with laser refractive index changes 有权
$Vision correction with laser refractive index changes$
公开(公告)号：US11911261B2
公开(公告)日：2024-02-27
申请号：US17188273
申请日：2021-03-01
申请人： University of Rochester
发明人： Leonard Zheleznyak , Scott Catlin
IPC分类号： A61F2/16 , A61F2/14 , G02C7/04 , G02B1/04 , A61F9/008 , H01S3/22
CPC分类号： A61F2/1618 , A61F2/1451 , A61F2/1613 , A61F2/1651 , A61F2/1654 , A61F9/00806 , A61F9/00812 , A61F9/00825 , A61F9/00827 , A61F9/00829 , A61F9/00834 , A61F9/00838 , G02B1/043 , G02C7/041 , G02C7/049 , A61F2002/1696 , A61F2009/0087 , A61F2009/00842 , A61F2009/00848 , A61F2009/00872 , A61F2009/00895 , A61F2250/0053 , G02C7/048 , G02C2202/12 , G02C2202/22 , G02C2202/24 , H01S3/2222
摘要： Methods and systems wherein laser induced refractive index changes by focused femtosecond laser pulses in optical polymeric materials or optical tissues is performed to address various types of vision correction.

3. 发明申请

US20190060122A1 SYSTEMS AND METHODS FOR LENTICULAR LASER INCISION 审中-公开
公开(公告)号：US20190060122A1
公开(公告)日：2019-02-28
申请号：US16109654
申请日：2018-08-22
申请人： AMO Development, LLC
发明人： Hong Fu , Alireza Malek Tabrizi
IPC分类号： A61F9/008 , A61B3/107 , A61B3/00
CPC分类号： A61F9/00827 , A61B3/0008 , A61B3/107 , A61F9/00834 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00887 , A61F2009/00897
摘要： Embodiments of this invention generally relate to ophthalmic laser procedures and, more particularly, to systems and methods for lenticular laser incision. In an embodiment, an ophthalmic surgical laser system comprises a laser delivery system for delivering a pulsed laser beam to a target in a subject's eye, an XY-scan device to deflect the pulsed laser beam, a Z-scan device to modify a depth of a focus of the pulsed laser beam, and a controller configured to form a top lenticular incision and a bottom lenticular incision of a lens in the subject's eye, where each of the top and bottom lenticular incision includes a center spherical portion and an edge transition portion that is not located on the same spherical surface as the spherical portion but has a steeper shape.

4. 发明申请

US20180008462A1 METHODS OF LASER MODIFICATION OF INTRAOCULAR LENS 审中-公开
公开(公告)号：US20180008462A1
公开(公告)日：2018-01-11
申请号：US15688533
申请日：2017-08-28
申请人： AMO Development, LLC
发明人： Leander Zickler , Jim Deacon
IPC分类号： A61F9/008 , A61F2/16 , A61F9/00
CPC分类号： A61F9/008 , A61F2/16 , A61F2/1624 , A61F2/1629 , A61F9/0017 , A61F9/007 , A61F9/00834 , A61F2002/1681 , A61F2002/1699 , A61F2009/00848 , A61F2009/0087 , A61F2009/0088 , A61F2250/0006 , A61F2250/0008 , G02C2202/14
摘要： A method of modifying a refractive profile of an eye having an intraocular device implanted therein, wherein the method includes determining a corrected refractive profile for the eye based on an initial refractive profile, identifying one or more locations within the intraocular device based on the corrected refractive profile, and directing a pulsed laser beam at the locations to produce the corrected refractive profile. A system of modifying an intraocular device located within an eye, wherein the system includes a laser assembly and a controller coupled thereto. The laser assembly outputs a pulsed laser beam having a pulse width between 300 picoseconds and 10 femtoseconds. The controller directs the laser assembly to output the pulsed laser beam into the intraocular device. One or more slip zones are formed within the intraocular device in response thereto, and the slip zones are configured to modify a refractive profile of the intraocular device.

5. 发明授权

US09814621B2 Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权
公开(公告)号：US09814621B2
公开(公告)日：2017-11-14
申请号：US15439593
申请日：2017-02-22
申请人： AMO Development, LLC
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
IPC分类号： A61F9/008
CPC分类号： A61F9/00814 , A61B2017/00057 , A61B2017/00154 , A61F9/008 , A61F9/00802 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00885 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.

6. 发明申请

US20160361198A1 TREATMENT APPARATUS FOR SURGICAL CORRECTION OF DEFECTIVE EYESIGHT, METHOD OF GENERATING CONTROL DATA THEREFORE, AND METHOD FOR SURGICAL CORRECTION OF DEFECTIVE EYESIGHT 审中-公开
标题翻译：用于矫正眼睛的外科矫正器的治疗装置，产生其控制数据的方法和用于矫正眼睛的外科手术的方法
公开(公告)号：US20160361198A1
公开(公告)日：2016-12-15
申请号：US15184363
申请日：2016-06-16
申请人： Carl Zeiss Meditec AG
发明人： Martin Wiechmann , Michael Bergt , Mark Bischoff , Markus Sticker , Gregor Stobrawa
IPC分类号： A61F9/008 , A61B34/10
CPC分类号： A61F9/008 , A61B34/10 , A61F9/00829 , A61F9/00838 , A61F2009/00848 , A61F2009/00851 , A61F2009/00872 , A61F2009/00878 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： A treatment method and apparatus for surgical correction of defective-eyesight in an eye of a patient, wherein a laser device is controlled by a control device, said laser device separating corneal tissue by irradiation of laser radiation to isolate a volume located within a cornea, wherein the control device controls the laser device to focus the laser radiation, by providing target points located within the cornea, into the cornea, wherein the control device, when providing the target points, allows for focus position errors which lead to a deviation between the predetermined position and the actual position of the target points when focusing the laser radiation, by pre-offsets depending on the positions of the respective target points to compensate for said focus position errors.
摘要翻译：一种用于在患者眼睛中进行眼睛缺损视力的外科矫正的治疗方法和装置，其中激光装置由控制装置控制，所述激光装置通过照射激光辐射来分离角膜组织以分离位于角膜内的体积，其中所述控制装置通过将位于所述角膜内的目标点提供给所述角膜来控制所述激光装置将所述激光辐射聚焦，其中所述控制装置在提供所述目标点时允许焦点位置误差，所述焦点位置误差导致所述角膜之间的偏差预定位置以及当聚焦激光辐射时目标点的实际位置，通过预偏移量，取决于各个目标点的位置以补偿所述焦点位置误差。

7. 发明申请

US20160317021A1 Induced High Order Aberrations Corresponding to Geometrical Transformations 审中-公开
标题翻译：对应于几何变换的诱导高阶像差
公开(公告)号：US20160317021A1
公开(公告)日：2016-11-03
申请号：US15154214
申请日：2016-05-13
申请人： AMO Development, LLC
发明人： Guang-ming Dai
IPC分类号： A61B3/00 , A61B3/11 , A61F9/008 , A61B3/10
CPC分类号： A61B3/1015 , A61B3/0025 , A61B3/112 , A61F9/00806 , A61F9/00808 , A61F9/00817 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , G02C7/024 , G02C7/028
摘要： Wavefront measurements of eyes are typically taken when the pupil is in a first configuration in an evaluation context. The results can be represented by a set of basis function coefficients. Prescriptive treatments are often applied in a treatment context, which is different from the evaluation context. Hence, the patient pupil can be in a different, second configuration, during treatment. Systems and methods are provided for determining a transformed set of basis function coefficients, based on a difference between the first and second configurations, which can be used to establish the vision treatment.
摘要翻译：通常在瞳孔处于评估上下文中的第一配置时进行眼睛的波前测量。结果可以由一组基函数系数表示。处方情况常常应用处方，这与评估背景不同。因此，在治疗期间，患者瞳孔可以处于不同的第二构造。提供了系统和方法，用于基于可用于建立视力治疗的第一和第二配置之间的差异来确定基函数系数的变换集合。

8. 发明授权

US09420949B2 Integrated surgical microscope and wavefront sensor 有权
公开(公告)号：US09420949B2
公开(公告)日：2016-08-23
申请号：US14799482
申请日：2015-07-14
申请人： WaveTec Vision Systems, Inc.
发明人： Anthony Y. Van Heugten , Daniel S. Durrie
IPC分类号： A61B18/18 , A61B3/103 , A61F9/007 , A61F9/008 , A61F9/013 , A61B3/10 , A61B3/13
CPC分类号： A61B3/103 , A61B3/1015 , A61B3/13 , A61B90/20 , A61B90/36 , A61F9/007 , A61F9/00736 , A61F9/008 , A61F9/0081 , A61F9/00827 , A61F9/00831 , A61F9/00834 , A61F9/013 , A61F2009/00842 , A61F2009/00848 , A61F2009/00853 , A61F2009/00868 , A61F2009/00872 , A61F2009/00887
摘要： A wavefront sensor is integrated with a surgical microscope for allowing a doctor to make repeated wavefront measurements of a patient's eye while the patient remains on an operating table in the surgical position. The device includes a wavefront sensor optically aligned with a surgical microscope such that their fields of view at least partially overlap. The inclusion of lightweight, compact diffractive optical components in the wavefront sensor allows the integrated device to be supported on a balancing mechanism above a patient's head during a surgical procedure. As a result, the need to reposition the device and/or the patient between measuring optical properties of the eye and performing surgical procedures on the eye is eliminated. Many surgical procedures may be improved or enhanced using the integrated device, including but not limited to cataract surgery, Conductive Keratoplasty, Lasik surgery, and corneal corrective surgery.

9. 发明授权

US09370445B2 Treatment apparatus for surgical correction of defective eyesight, method of generating control data therefore, and method for surgical correction of defective eyesight 有权
标题翻译：因此，视力缺损的手术矫正处理装置，因此生成控制数据的方法以及缺陷视力的外科矫正方法
公开(公告)号：US09370445B2
公开(公告)日：2016-06-21
申请号：US14182074
申请日：2014-02-17
申请人： Carl Zeiss Meditec AG
发明人： Martin Wiechmann , Michael Bergt , Mark Bischoff , Markus Sticker , Gregor Stobrawa
IPC分类号： A61B18/18 , A61F9/008 , A61B19/00
CPC分类号： A61F9/008 , A61B34/10 , A61F9/00829 , A61F9/00838 , A61F2009/00848 , A61F2009/00851 , A61F2009/00872 , A61F2009/00878 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： A treatment method and apparatus for surgical correction of defective-eyesight in an eye of a patient, wherein a laser device is controlled by a control device, said laser device separating corneal tissue by irradiation of laser radiation to isolate a volume located within a cornea, wherein the control device controls the laser device to focus the laser radiation, by providing target points located within the cornea, into the cornea, wherein the control device, when providing the target points, allows for focus position errors which lead to a deviation between the predetermined position and the actual position of the target points when focusing the laser radiation, by pre-offsets depending on the positions of the respective target points to compensate for said focus position errors.
摘要翻译：一种用于在患者眼睛中进行眼睛缺损视力的外科矫正的治疗方法和装置，其中激光装置由控制装置控制，所述激光装置通过照射激光辐射来分离角膜组织以分离位于角膜内的体积，其中所述控制装置通过将位于所述角膜内的目标点提供给所述角膜来控制所述激光装置将所述激光辐射聚焦，其中所述控制装置在提供所述目标点时允许焦点位置误差，所述焦点位置误差导致所述角膜之间的偏差预定位置以及当聚焦激光辐射时目标点的实际位置，通过预偏移量，取决于各个目标点的位置以补偿所述焦点位置误差。

10. 发明授权

US09345621B2 High-order optical correction during corneal laser surgery 有权
标题翻译：角膜激光手术中的高阶光学校正
公开(公告)号：US09345621B2
公开(公告)日：2016-05-24
申请号：US13915776
申请日：2013-06-12
申请人： AMO Development, LLC
发明人： Julian D. Stevens
IPC分类号： A61B17/22 , A61F9/008
CPC分类号： A61F9/00806 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088
摘要： Systems and methods related to corneal ablation for treatment of one or more high-order optical aberrations are provided. A method includes providing a defect-correcting prescription, determining an ablation profile to impose the prescription on the cornea, and determining a sequence of laser-energy ablations to impose the ablation profile on the cornea. The prescription provides a high-order optical correction. The ablation profile includes a first-segment profile and a second-segment profile. The second-segment profile corresponds to at least one high-order optical correction. The ablation sequence includes applying ablations corresponding to the first-segment profile prior to applying ablations corresponding to the second-segment profile.
摘要翻译：提供了与用于治疗一个或多个高阶光学像差的角膜消融有关的系统和方法。一种方法包括提供缺陷校正处方，确定消融轮廓以将处方施加在角膜上，以及确定激光能量消融的序列以将消融轮廓施加在角膜上。处方提供高阶光学校正。消融轮廓包括第一段轮廓和第二段轮廓。第二段轮廓对应于至少一个高阶光学校正。消融序列包括在应用对应于第二节段轮廓的消融之前应用对应于第一段轮廓的消融。

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