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1. 发明授权

US08292878B2 Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权
标题翻译：操作员控制的扫描激光程序设计用于大面积去皮
公开(公告)号：US08292878B2
公开(公告)日：2012-10-23
申请号：US13073747
申请日：2011-03-28
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
IPC分类号： A61B18/18
CPC分类号： A61F9/008 , A61B2017/00057 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such that an operator can detect penetration of the epithelial layer.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置成增强光学反馈的脉冲序列的扫描允许上皮的大面积被消融，使得操作者可以检测上皮层的穿透。

2. 发明授权

US07931644B2 Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权
标题翻译：操作员控制的扫描激光程序设计用于大面积去皮
公开(公告)号：US07931644B2
公开(公告)日：2011-04-26
申请号：US11937760
申请日：2007-11-09
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
IPC分类号： A61B18/20
CPC分类号： A61F9/008 , A61B2017/00057 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such that an operator can detect penetration of the epithelial layer.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置成增强光学反馈的脉冲序列的扫描允许上皮的大面积被消融，使得操作者可以检测上皮层的穿透。

3. 发明授权

US07394595B2 Lenslet array for beam homogenization 有权
公开(公告)号：US07394595B2
公开(公告)日：2008-07-01
申请号：US11683963
申请日：2007-03-08
申请人： Seema Somani , Charles Munnerlyn , Mark E. Arnoldussen , John Osborn
发明人： Seema Somani , Charles Munnerlyn , Mark E. Arnoldussen , John Osborn
IPC分类号： G02B27/10
CPC分类号： G02B27/0927 , A61F9/00814 , G02B3/005 , G02B3/0068 , G02B27/0905 , G02B27/0961
摘要： Apparatus for homogenizing a laser beam includes a lenslet array. In some embodiments, the lenslets have a negative power. The lenslet array may include from 16 to 36 effective lenslets in some embodiments, or any other suitable number in alternative embodiments. Some embodiments additionally include a re-focusing lens for directing the beamlets onto a target so that the beamlets overlap and the energy distribution is homogenized. In an alternative embodiment, the lenslet array and re-focusing lens are combined in one optic.

4. 发明授权

US07355794B2 Lenslet array for beam homogenization 有权
标题翻译：用于光束均匀化的Lenslet阵列
公开(公告)号：US07355794B2
公开(公告)日：2008-04-08
申请号：US11683968
申请日：2007-03-08
申请人： Seema Somani , Charles Munnerlyn , Mark E. Arnoldussen , John Osborn
发明人： Seema Somani , Charles Munnerlyn , Mark E. Arnoldussen , John Osborn
IPC分类号： G02B27/10
CPC分类号： G02B27/0927 , A61F9/00814 , G02B3/005 , G02B3/0068 , G02B27/0905 , G02B27/0961
摘要： Apparatus for homogenizing a laser beam includes a lenslet array. In some embodiments, the lenslets have a negative power. The lenslet array may include from 16 to 36 effective lenslets in some embodiments, or any other suitable number in alternative embodiments. Some embodiments additionally include a re-focusing lens for directing the beamlets onto a target so that the beamlets overlap and the energy distribution is homogenized. In an alternative embodiment, the lenslet array and re-focusing lens are combined in one optic.
摘要翻译：用于使激光束均匀化的装置包括小透镜阵列。在一些实施例中，小透镜具有负功率。在一些实施例中，小透镜阵列可以包括16至36个有效小透镜，或者在替代实施例中可以包括任何其它合适的数目。一些实施例还包括用于将子束引导到靶上的再聚焦透镜，使得子束重叠并且能量分布均匀化。在替代实施例中，小透镜阵列和再聚焦透镜组合在一个光学元件中。

5. 发明授权

US08968279B2 Systems and methods for qualifying and calibrating a beam delivery system 有权
标题翻译：用于排放和校准射束输送系统的系统和方法
公开(公告)号：US08968279B2
公开(公告)日：2015-03-03
申请号：US11339984
申请日：2006-01-25
申请人： Mark E. Arnoldussen
发明人： Mark E. Arnoldussen
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61F9/00804 , A61F9/00817 , A61F2009/00855 , A61F2009/00872 , A61F2009/00897
摘要： Systems and methods for testing a laser eye surgery system are provided. Methods include establishing an image scale based on a calibration pattern, imageably altering a series of regions of a test surface with the laser system, laterally redirecting a laser beam to form a test pattern, imaging the test pattern, determining a lateral redirecting characteristic of the beam delivery system, and qualifying or calibrating the beam delivery system. Systems can include an input module that accepts an input member such as a calibration pattern parameter, a calibration pattern image, an intended pattern parameter, a test pattern image, an imaging device position, a calibration pattern position, a test pattern position, and a beam delivery system position, a characterization module that determines a beam delivery system characteristic, and an output module that generates a calibration for the beam delivery system of the laser eye surgery system.
摘要翻译：提供了一种用于测试激光眼睛手术系统的系统和方法。方法包括基于校准图案建立图像尺度，用激光系统成像地改变测试表面的一系列区域，横向地重定向激光束以形成测试图案，成像测试图案，确定测试图案的横向重定向特性射束输送系统，以及排放或校准射束输送系统。系统可以包括接收诸如校准图案参数，校准图案图像，预期图案参数，测试图案图像，成像设备位置，校准图案位置，测试图案位置和输入元件的输入模块的输入模块射束输送系统位置，确定射束输送系统特征的表征模块以及产生激光眼外科手术系统的束传递系统的校准的输出模块。

6. 发明授权

US08926600B2 Operator-controlled scanning laser procedure designed for large-area epithelium removal 有权
标题翻译：操作员控制的扫描激光程序设计用于大面积去皮
公开(公告)号：US08926600B2
公开(公告)日：2015-01-06
申请号：US12121635
申请日：2008-05-15
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
IPC分类号： A61F9/008 , A61B18/20 , A61B17/00
CPC分类号： A61F9/00814 , A61B2017/00057 , A61B2017/00154 , A61F9/008 , A61F9/00802 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00885 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置为增强光学反馈的脉冲序列的扫描允许大面积的上皮被消融，可以检测到上皮层的穿透。

7. 发明申请

US20110190744A1 Operator-Controlled Scanning Laser Procedure Designed for Large-Area Epithelium Removal 有权
标题翻译：操作员控制扫描激光程序设计用于大面积上皮去除
公开(公告)号：US20110190744A1
公开(公告)日：2011-08-04
申请号：US13073747
申请日：2011-03-28
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan
IPC分类号： A61F9/008
CPC分类号： A61F9/008 , A61B2017/00057 , A61F9/00806 , A61F9/00817 , A61F2009/00844 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such that an operator can detect penetration of the epithelial layer.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置成增强光学反馈的脉冲序列的扫描允许上皮的大面积被消融，使得操作者可以检测上皮层的穿透。

8. 发明申请

US20080287929A1 CUSTOMIZED LASER EPITHELIAL ABLATION SYSTEMS AND METHODS 有权
标题翻译：自定义激光上行系统和方法
公开(公告)号：US20080287929A1
公开(公告)日：2008-11-20
申请号：US12122319
申请日：2008-05-16
申请人： Keith Holliday , Mark E. Arnoldussen
发明人： Keith Holliday , Mark E. Arnoldussen
IPC分类号： A61B18/20
CPC分类号： A61F9/00806 , A61F9/00817 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , G01N1/10 , G01N33/04
摘要： Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.
摘要翻译：用于治疗具有设置在基质层上的上皮层的眼睛角膜区域的系统和方法。该系统包括用于映射角膜区域上的上皮层的厚度以在该区域上产生上皮厚度的图的装置，以及用于产生消融辐射的激光束的激光器。可移动扫描部件耦合到激光器以扫描该区域上的激光束。处理器系统耦合到激光器和可移动扫描部件，并且处理器系统被配置为响应于上皮厚度图布置激光束的脉冲以消融该区域的上皮层。

9. 发明授权

US09295584B2 Customized laser epithelial ablation systems and methods 有权
公开(公告)号：US09295584B2
公开(公告)日：2016-03-29
申请号：US12122319
申请日：2008-05-16
申请人： Keith Holliday , Mark E. Arnoldussen
发明人： Keith Holliday , Mark E. Arnoldussen
IPC分类号： A61B18/20 , A61F9/008
CPC分类号： A61F9/00806 , A61F9/00817 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , G01N1/10 , G01N33/04
摘要： Systems and methods to treat a region of a cornea of an eye having an epithelial layer disposed over a stromal layer. The system comprises a device to map a thickness of the epithelial layer over the region of the cornea to generate a map of epithelial thickness over the region, and a laser to generate a laser beam of an ablative radiation. A movable scan component is coupled to the laser to scan the laser beam over the region. A processor system is coupled to the laser and the movable scan component, and the processor system is configured to arrange pulses of laser beam to ablate the epithelial layer of the region in response to the map of epithelial thickness.

10. 发明申请

US20080287928A1 OPERATOR-CONTROLLED SCANNING LASER PROCEDURE DESIGNED FOR LARGE-AREA EPITHELIUM REMOVAL 有权
标题翻译：操作者控制的扫描激光程序设计用于大面积上移
公开(公告)号：US20080287928A1
公开(公告)日：2008-11-20
申请号：US12121635
申请日：2008-05-15
申请人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
发明人： Mark E. Arnoldussen , Jonathan Wong , Benjamin A. Logan , Leander Zickler
IPC分类号： A61F9/008 , A61B18/20
CPC分类号： A61F9/00814 , A61B2017/00057 , A61B2017/00154 , A61F9/008 , A61F9/00802 , A61F9/00817 , A61F2009/00844 , A61F2009/00846 , A61F2009/00848 , A61F2009/00872 , A61F2009/0088 , A61F2009/00882 , A61F2009/00885 , A61F2009/00897
摘要： Systems and methods for removing an epithelial layer disposed over a stromal layer in a cornea irradiate a region of the epithelial layer with a pulsed beam of ablative radiation. The ablative radiation is scanned to vary the location of the beam within the region in accordance with a pulse sequence. The pulse sequence is arranged to enhance optical feedback based on a tissue fluorescence of the epithelial layer. The penetration of the epithelial layer is detected in response to the optical feedback. The use of scanning with the pulse sequence arranged to enhance optical feedback allows large areas of the epithelium to be ablated such penetration of the epithelial layer can be detected.
摘要翻译：用于去除设置在角膜上的基质层上的上皮层的系统和方法用消融辐射的脉冲束照射上皮层的区域。根据脉冲序列扫描烧蚀辐射以改变该区域内的光束的位置。布置脉冲序列以增强基于上皮层的组织荧光的光学反馈。响应于光学反馈检测上皮层的穿透。使用布置为增强光学反馈的脉冲序列的扫描允许大面积的上皮被消融，可以检测到上皮层的穿透。

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