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1. 发明授权

US10563246B2 Microfluidic device for production and collection of droplets of a fluid 有权
公开(公告)号：US10563246B2
公开(公告)日：2020-02-18
申请号：US13876960
申请日：2011-10-03
申请人： Marie-Claude Potier , Patrick Tabeling , Luce Dauphinot , Nadege Bois , Fabrice Monti , Pascaline Mary
发明人： Marie-Claude Potier , Patrick Tabeling , Luce Dauphinot , Nadege Bois , Fabrice Monti , Pascaline Mary
IPC分类号： C12Q1/68 , C12Q1/6806 , C12Q1/6813 , C12Q1/6844
摘要： A microfluidic device and method for producing and collecting single droplets of a first fluid, the device including a microfluidic platform having at least a droplet microchannel wherein is produced a flow of single droplets of the first fluid dispersed in a second fluid immiscible with the first fluid, the droplet microchannel having at least one inlet extremity and at least one outlet extremity for distributing the flow of droplets, the device further including: a collection device including a plurality of receiving areas adapted to collect at least one of the droplets, elements for changing the relative position of the collection device and the outlet of the microfluidic platform, elements for controlling the flow of droplets, and elements for synchronizing the flow of droplets at the outlet of the droplet microchannel and the relative movement of the collection device with regards to the microfluidic platform.

2. 发明申请

US20130236901A1 MICROFLUIDIC DEVICE FOR PRODUCTION AND COLLECTION OF DROPLETS OF A FLUID 审中-公开
标题翻译：用于生产和收集流体液滴的微流体装置
公开(公告)号：US20130236901A1
公开(公告)日：2013-09-12
申请号：US13876960
申请日：2011-10-03
申请人： Marie-Claude Potier , Patrick Tabeling , Luce Dauphinot , Nadege Bois , Fabrice Monti , Pascaline Mary
发明人： Marie-Claude Potier , Patrick Tabeling , Luce Dauphinot , Nadege Bois , Fabrice Monti , Pascaline Mary
IPC分类号： C12Q1/68
摘要： A microfluidic device and method for producing and collecting single droplets of a first fluid, the device including a microfluidic platform having at least a droplet microchannel wherein is produced a flow of single droplets of the first fluid dispersed in a second fluid immiscible with the first fluid, the droplet microchannel having at least one inlet extremity and at least one outlet extremity for distributing the flow of droplets, the device further including: a collection device including a plurality of receiving areas adapted to collect at least one of the droplets, elements for changing the relative position of the collection device and the outlet of the microfluidic platform, elements for controlling the flow of droplets, and elements for synchronizing the flow of droplets at the outlet of the droplet microchannel and the relative movement of the collection device with regards to the microfluidic platform.
摘要翻译：一种用于产生和收集第一流体的单液滴的微流体装置和方法，该装置包括具有至少液滴微通道的微流体平台，其中产生分散在与第一流体不混溶的第二流体中的第一流体的单液滴流所述液滴微通道具有至少一个入口末端和用于分配液滴流的至少一个出口末端，所述装置还包括：收集装置，其包括适于收集液滴中的至少一个的多个接收区域，用于改变微流体平台的收集装置和出口的相对位置，用于控制液滴流动的元件和用于使液滴微通道出口处的液滴流动同步的元件以及收集装置相对于液滴微通道的相对运动微流体平台。

3. 发明申请

US20150094232A1 MANAGING VARIATION IN SPECTROSCOPIC INTENSITY MEASUREMENTS THROUGH THE USE OF A REFERENCE COMPONENT 有权
标题翻译：通过使用参考组件来管理光谱强度测量的变化
公开(公告)号：US20150094232A1
公开(公告)日：2015-04-02
申请号：US14008990
申请日：2012-03-28
申请人： Adam Abate , John Lawrence Emhoff , Tony Hung , Adnan Moez Esmail , Sepehr Kiani , Pascaline Mary
发明人： Adam Abate , John Lawrence Emhoff , Tony Hung , Adnan Moez Esmail , Sepehr Kiani , Pascaline Mary
IPC分类号： G01N21/64 , G01N21/76 , G01N21/25
CPC分类号： G01N21/6486 , C12Q1/6806 , G01N21/255 , G01N21/76 , G01N2201/06113 , G01N2201/062 , C12Q2545/101 , C12Q2563/107 , C12Q2563/159 , C12Q2563/161 , C12Q2565/629
摘要： The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, “barcoded” by combinations of different colors and concentrations of spectroscopic substances, contained therein.
摘要翻译：本发明通常涉及用于通过使用参考组件来管理光谱强度测量的变化的方法和试剂盒。参考组分可以包含参考光谱物质，并且可以与待测试样品中的感兴趣样品一起包含，其中感兴趣的样品可以包含样品光谱物质。待测试的每个样品可以被唯一地识别，并因此被包含在其中的不同颜色和分光光度物质的浓度的组合“条形码”。

4. 发明授权

US09861979B2 Injection of multiple volumes into or out of droplets 有权
公开(公告)号：US09861979B2
公开(公告)日：2018-01-09
申请号：US14008998
申请日：2012-03-28
申请人： Adam Abate , Sepehr Kiani , Tony Hung , Pascaline Mary , Adnan Moez Esmail
发明人： Adam Abate , Sepehr Kiani , Tony Hung , Pascaline Mary , Adnan Moez Esmail
IPC分类号： B01L3/00 , B01F13/00 , F04B19/00 , F16K99/00
CPC分类号： B01L3/5027 , B01F13/0071 , B01F13/0076 , B01L3/502784 , B01L2300/0816 , B01L2300/0867 , B01L2300/1861 , B01L2400/0424 , B01L2400/0436 , B01L2400/0442 , F04B19/006 , F16K99/0019
摘要： The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.

5. 发明申请

US20160045914A1 INJECTION OF MULTIPLE VOLUMES INTO OR OUT OF DROPLETS 有权
标题翻译：将多个体积注入或倒入滴管中
公开(公告)号：US20160045914A1
公开(公告)日：2016-02-18
申请号：US14008998
申请日：2012-03-28
申请人： Adam Abate , Sepehr Kiani , Tony Hung , Pascaline Mary , Adnan Moez Esmail
发明人： Adam Abate , Sepehr Kiani , Tony Hung , Pascaline Mary , Adnan Moez Esmail
IPC分类号： B01L3/00 , F16K99/00 , F04B19/00
CPC分类号： B01L3/5027 , B01F13/0071 , B01F13/0076 , B01L3/502784 , B01L2300/0816 , B01L2300/0867 , B01L2300/1861 , B01L2400/0424 , B01L2400/0436 , B01L2400/0442 , F04B19/006 , F16K99/0019
摘要： The present invention generally pertains to a system for performing injection of multiple substantially controlled volumes into or out of a droplet, and methods and kits comprising the same. The system of the present invention comprises at least one microfluidic channel, one or more injection channels, an injection inlet associated with each of the one or more injection channels, and a mechanism for disrupting an interface between a droplet and a fluid and/or emulsion, wherein the at least one microfluidic channel comprises one or more droplets are flowing therein, and wherein each of the one or more injection channels comprises at least one fluid and/or emulsion therein.
摘要翻译：本发明通常涉及用于将多个基本上受控制的体积注入或流出液滴的系统，以及包含该液滴的方法和试剂盒。本发明的系统包括至少一个微流体通道，一个或多个注射通道，与一个或多个注射通道中的每一个相关联的注射入口，以及用于破坏液滴和流体和/或乳液之间的界面的机构，其中所述至少一个微流体通道包括一个或多个液滴在其中流动，并且其中所述一个或多个注射通道中的每一个在其中包括至少一种流体和/或乳液。

6. 发明申请

US20120132288A1 FLUID INJECTION 有权
标题翻译：流体注射
公开(公告)号：US20120132288A1
公开(公告)日：2012-05-31
申请号：US13379782
申请日：2010-06-25
申请人： David A. Weitz , Adam R. Abate , Tony Hung , Pascaline Mary
发明人： David A. Weitz , Adam R. Abate , Tony Hung , Pascaline Mary
IPC分类号： F15C1/00
CPC分类号： B01F5/0471 , B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00837 , B01J2219/00853 , B01J2219/00862 , B01J2219/00889 , B01L3/50273 , B01L3/502784 , B01L2300/0867 , B01L2400/0415 , F16K99/0042 , F16K99/0051 , G01N27/44791 , G01N2035/1034 , Y10T137/0391 , Y10T137/206
摘要： The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.
摘要翻译：本发明一般涉及用于控制流体的系统和方法，并且在一些情况下涉及将流体流入和/或流出其它流体的系统和方法。作为示例，流体可以被注入到包含在流体通道内的液滴中，或者可以将流体注入到流体通道中以产生液滴。在一些实施例中，可以使用电极将电场施加到一个或多个流体通道，例如至少两个流体通道的相交处。例如，可以通过电场促进第一流体进入和/或流出第二流体。在一些情况下，电场可能破坏第一流体和至少一种其它流体之间的界面。可以通过控制流体和/或流体液滴的各种性质（例如流体液滴的曲率）来控制被推入和/或流出第二流体的第一流体的体积，流速等的性质，和/或控制所施加的电场。

7. 发明授权

US09816931B2 Managing variation in spectroscopic intensity measurements through the use of a reference component 有权
公开(公告)号：US09816931B2
公开(公告)日：2017-11-14
申请号：US14008990
申请日：2012-03-28
申请人： Adam Abate , John Lawrence Emhoff , Tony Hung , Adnan Moez Esmail , Sepehr Kiani , Pascaline Mary
发明人： Adam Abate , John Lawrence Emhoff , Tony Hung , Adnan Moez Esmail , Sepehr Kiani , Pascaline Mary
IPC分类号： G01J3/30 , G01N21/64 , C12Q1/68 , G01N21/25 , G01N21/76
CPC分类号： G01N21/6486 , C12Q1/6806 , G01N21/255 , G01N21/76 , G01N2201/06113 , G01N2201/062 , C12Q2545/101 , C12Q2563/107 , C12Q2563/159 , C12Q2563/161 , C12Q2565/629
摘要： The present invention generally pertains to methods and kits for managing the variation in spectroscopic intensity measurements through the use of a reference component. The reference component may comprise a reference spectroscopic substance and may be contained together with a sample of interest in a sample to be tested, wherein the sample of interest may comprise a sample spectroscopic substance. Each sample to be tested may be uniquely identified and, hence, “barcoded” by combinations of different colors and concentrations of spectroscopic substances, contained therein.

8. 发明授权

US09757698B2 Fluid injection 有权
公开(公告)号：US09757698B2
公开(公告)日：2017-09-12
申请号：US13379782
申请日：2010-06-25
申请人： David A. Weitz , Adam R. Abate , Tony Hung , Pascaline Mary
发明人： David A. Weitz , Adam R. Abate , Tony Hung , Pascaline Mary
IPC分类号： F16K99/00 , B01F5/04 , B01F13/00 , B01J19/00 , B01L3/00 , G01N27/447 , G01N35/10
CPC分类号： B01F5/0471 , B01F13/0071 , B01F13/0076 , B01J19/0093 , B01J2219/00837 , B01J2219/00853 , B01J2219/00862 , B01J2219/00889 , B01L3/50273 , B01L3/502784 , B01L2300/0867 , B01L2400/0415 , F16K99/0042 , F16K99/0051 , G01N27/44791 , G01N2035/1034 , Y10T137/0391 , Y10T137/206
摘要： The present invention generally relates to systems and methods for the control of fluids and, in some cases, to systems and methods for flowing a fluid into and/or out of other fluids. As examples, fluid may be injected into a droplet contained within a fluidic channel, or a fluid may be injected into a fluidic channel to create a droplet. In some embodiments, electrodes may be used to apply an electric field to one or more fluidic channels, e.g., proximate an intersection of at least two fluidic channels. For instance, a first fluid may be urged into and/or out of a second fluid, facilitated by the electric field. The electric field, in some cases, may disrupt an interface between a first fluid and at least one other fluid. Properties such as the volume, flow rate, etc. of a first fluid being urged into and/or out of a second fluid can be controlled by controlling various properties of the fluid and/or a fluidic droplet, for example curvature of the fluidic droplet, and/or controlling the applied electric field.

9. 发明授权

US09581549B2 Nucleic acid target detection using a detector, a probe and an inhibitor 有权
标题翻译：使用检测器，探针和抑制剂进行核酸靶检测
公开(公告)号：US09581549B2
公开(公告)日：2017-02-28
申请号：US13992187
申请日：2011-12-07
申请人： Tal Raz , Pascaline Mary
发明人： Tal Raz , Pascaline Mary
IPC分类号： C12Q1/68 , C12P19/34 , G01N21/64
CPC分类号： G01N21/6486 , C12Q1/6818 , C12Q1/6858 , C12Q2535/125 , C12Q2565/101 , C12Q2563/159 , C12Q2565/629
摘要： The present invention generally pertains to methods for detecting the presence or absence of a particular nucleic acid sequence. The present invention generally relates to incorporating a detector into a target nucleic acid, adding an oligonucleotide probe, polymerase enzyme and an inhibitor to the reaction, and detecting interference of the oligonucleotide probe with the inhibitor as an indication of the presence of a particular target nucleic acid sequence as well as kits encompassing the same.
摘要翻译：本发明一般涉及检测特定核酸序列的存在或不存在的方法。本发明一般涉及将检测器结合到靶核酸中，向反应中加入寡核苷酸探针，聚合酶和抑制剂，以及检测寡核苷酸探针与抑制剂的干扰作为特定靶核酸的存在的指示酸序列以及包含其的试剂盒。

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