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1. 发明申请

US20060057674A1 Translocating enzyme as a selection marker 审中-公开
标题翻译：转移酶作为选择标记
公开(公告)号：US20060057674A1
公开(公告)日：2006-03-16
申请号：US11216333
申请日：2005-08-31
申请人： Maren Hintz , Roland Freudl , Jorg Feesche , Roland Breves
发明人： Maren Hintz , Roland Freudl , Jorg Feesche , Roland Breves
IPC分类号： C12P21/06 , C07H21/04 , C12N9/00 , C12N15/74
CPC分类号： C12P21/02 , C12N9/14 , C12N15/74
摘要： The subject of the present invention is a selection system for microorganisms, which is based on the inactivation of an essential translocating enzyme and the curing of this inactivation by means of an indentically acting factor which is made available to the cells concerned by means of a vector. One important area of application for this system is includes processses for protein production by culturing cells of a microorganism strain that are characterized by this selection system, particularly such that the transgene of interest is located on the same vector performing the cure. Appropriate microorganisms, possible uses for genes of translocation enzymes and vectors are likewise presented, including in particular the use of the gene secA from gram-negative or gram-positive bacteria such as B. licheniformis.
摘要翻译：本发明的主题是微生物的选择系统，其基于对基本易位酶的失活和通过借助于载体可用于相关细胞的潜在作用因子来固化该失活。该系统的一个重要应用领域包括通过培养以该选择系统为特征的微生物菌株的细胞进行蛋白质生产的方法，特别是使感兴趣的转基因位于执行固化的相同载体上。同样提供适当的微生物，易位酶和载体基因的可能用途，特别包括来自革兰氏阴性或革兰氏阳性细菌如地衣芽孢杆菌的基因secA的使用。

2. 发明授权

US07910647B2 Adhesion inhibition of microorganisms by non-ionic surfactants 有权
标题翻译：非离子表面活性剂对微生物的粘附抑制作用
公开(公告)号：US07910647B2
公开(公告)日：2011-03-22
申请号：US11450859
申请日：2006-06-08
申请人： Mirko Weide , Stefan Frey , Juergen Stodt , Andreas Bolte , Roland Breves , Thomas Gerke
发明人： Mirko Weide , Stefan Frey , Juergen Stodt , Andreas Bolte , Roland Breves , Thomas Gerke
IPC分类号： B08B17/00
CPC分类号： C11D3/48 , A61K31/00 , A61L2/16 , C11D1/66 , C11D1/72
摘要： Non-ionic surfactants are used to reduce the adhesion of microorganisms to surfaces of materials by coating such surfaces with the surfactants or incorporating the surfactants into the materials.
摘要翻译：非离子表面活性剂用于通过用表面活性剂涂布这些表面或将表面活性剂掺入材料中来减少微生物对材料表面的粘附。

3. 发明授权

US07803604B2 Amylolytic enzyme extracted from Bacillus sp. A 7-7 (DSM 12368) and washing and cleaning agents containing this novel amylolytic enzyme 有权
标题翻译：从芽孢杆菌提取的淀粉分解酶 A 7-7（DSM 12368）和含有该新型淀粉分解酶的洗涤和清洁剂
公开(公告)号：US07803604B2
公开(公告)日：2010-09-28
申请号：US11975898
申请日：2007-10-22
申请人： Roland Breves , Karl-Heinz Maurer , Beatrix Kottwitz , Laura Polanyi-Bald , Angela Hellebrandt , Irmgard Schmidt , Regina Stehr , Angrit Weber
发明人： Roland Breves , Karl-Heinz Maurer , Beatrix Kottwitz , Laura Polanyi-Bald , Angela Hellebrandt , Irmgard Schmidt , Regina Stehr , Angrit Weber
IPC分类号： C12N1/20
CPC分类号： C12N9/2417 , C11D3/386 , Y02E50/17 , Y10T156/10 , Y10T156/1111
摘要： The invention relates to a novel amylolytic enzyme extracted from the microorganism Bacillus sp. A 7-7 (DSM 12368), to sufficiently similar proteins having an amylolytic function, to methods for the production thereof and to diverse fields of application for these proteins. In addition, the aforesaid can be further developed beyond the implemented fields of application for other technical purposes. The invention particularly relates to washing and cleaning agents containing amylolytic proteins of the aforementioned type, to methods for cleaning textiles or hard surfaces that involve the use of the amylolytic proteins or analogous agents, and to their use for cleaning textiles or hard surfaces.
摘要翻译：本发明涉及一种从微生物芽孢杆菌中提取的新型淀粉分解酶。 A7-7（DSM12368），具有具有淀粉分解功能的足够相似的蛋白质，其制备方法以及这些蛋白质的应用领域。此外，上述可以进一步开发超出其他技术目的的实施应用领域。本发明特别涉及含有上述类型的淀粉分解蛋白质的洗涤和清洁剂，涉及使用淀粉分解蛋白质或类似剂的纺织品或硬质表面的清洁方法及其用于清洁纺织品或硬质表面的用途。

4. 发明申请

US20060024710A1 Method and device for identifying germs 审中-公开
标题翻译：用于鉴定细菌的方法和装置
公开(公告)号：US20060024710A1
公开(公告)日：2006-02-02
申请号：US11155457
申请日：2005-06-16
申请人： Tilo Weiss , Stefan Stumpe , Friedhelm Siepmann , Andreas Thuenchen , Frank Wienhausen , Andreas Katerkamp , Michael Heinzel , Roland Breves , Mirko Weide
发明人： Tilo Weiss , Stefan Stumpe , Friedhelm Siepmann , Andreas Thuenchen , Frank Wienhausen , Andreas Katerkamp , Michael Heinzel , Roland Breves , Mirko Weide
IPC分类号： C12Q1/68 , G01N33/554 , G01N33/569 , C12Q1/04
CPC分类号： C12Q1/24
摘要： A method for quantitative and/or qualitative determination of germs in a liquid sample comprises the steps of: (1) passing the sample through a filter thereby depositing the germs on a major portion of the filter so that a minor portion of the filter is free of germ deposits; (2) applying a fluorescent label to at least a portion of the deposited germs; (3) determining the presence and/or the amount of labeled germs by fluorescent reflection photometry. The method according to the present invention is suitable, for example, for quantitative and/or qualitative determination of germs in foodstuffs, surfactant-containing products such as washing and cleaning agents, surface treatment agents, dispersion products, cosmetics, hygiene products and personal care products, pharmaceuticals, adhesives, coolant lubricants, coatings and coating coagulations, as well as raw materials and starting materials for the aforesaid products.
摘要翻译：用于定量和/或定性地测定液体样品中的细菌的方法包括以下步骤：（1）使样品通过过滤器，由此将细菌沉积在过滤器的主要部分上，使得过滤器的一小部分是游离的的细菌沉积; （2）向沉积的细菌的至少一部分施加荧光标记; （3）通过荧光反射测光法测定标记的细菌的存在和/或数量。根据本发明的方法适用于例如定量和/或定性测定食品中的细菌，含表面活性剂的产品如洗涤和清洁剂，表面处理剂，分散体产品，化妆品，卫生产品和个人护理产品，药品，粘合剂，冷却剂润滑剂，涂料和涂料凝结剂，以及上述产品的原料和原料。

5. 发明授权

US07825268B2 Alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction 有权
标题翻译：用于控制基于微生物相互作用的方法的烷氧基内酯，烷氧基内酰胺和烷氧基硫醇内酰胺
公开(公告)号：US07825268B2
公开(公告)日：2010-11-02
申请号：US11473795
申请日：2006-06-22
申请人： Stefan Stumpe , Roland Breves , Ursula Huchel , Frank Janssen , André Hätzelt
发明人： Stefan Stumpe , Roland Breves , Ursula Huchel , Frank Janssen , André Hätzelt
IPC分类号： A61K31/4015 , A61K31/341 , C07D207/26 , C07D307/33
CPC分类号： C07D307/33 , A61L2/0082 , A61L2/16
摘要： Compounds of the Formula I, wherein A1 is O or NH; A2 is O or S; each of R1 and R2 is independently hydrogen, a methyl or C2-C8-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R3 is a C1-C18-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R1, R2 and R3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C1-C6-alkyl, trifluoromethyl, C1-C6-alkoxy, C6-C10-aryl, and C1-C6-alkyl-C6-C10-aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.
摘要翻译：式I的化合物，其中A1是O或NH; A2为O或S; R 1和R 2各自独立地为氢，甲基或C 2 -C 8饱和或单或双不饱和，支链或直链烃基; 并且R 3是C 1 -C 18饱和或单或双不饱和，支链或直链烃基，其中R 1，R 2和R 3各自包含选自链和O中的O和S的杂原子和/或是单或被选自卤素，羟基，C 1 -C 6 - 烷基，三氟甲基，C 1 -C 6 - 烷氧基，C 6 -C 10 - 芳基和C 1 -C 6 - 烷基-C 6 -C 10 - 芳基的取代基取代或多取代可用于控制微生物之间的相互作用过程，例如在生物膜的开发和/或成熟中; 多细胞群体行为; 抗生素抗药性的协调发展; 协同合成抗生素; 色素的协同合成; 协同生产细胞外酶; 或协同生产的毒力因素。

6. 发明申请

US20060040279A1 DNA chips used for bioprocess control 审中-公开
标题翻译：用于生物过程控制的DNA芯片
公开(公告)号：US20060040279A1
公开(公告)日：2006-02-23
申请号：US11077619
申请日：2005-03-11
申请人： Joerg Feesche , Karl-Heinz Maurer , Roland Breves , Thomas Schweder , Michael Hecker , Britta Juergen , Birgit Voigt
发明人： Joerg Feesche , Karl-Heinz Maurer , Roland Breves , Thomas Schweder , Michael Hecker , Britta Juergen , Birgit Voigt
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C12N9/88 , C12N15/74
CPC分类号： C07K14/32 , C12N15/52 , C12Q1/6837 , C12Q1/689 , C12Q2600/158
摘要： The present invention provides methods for determining the physiological state of cells isolated from an organism of interest utilizing chips to which nucleic acid probes are attached. In preferred embodiments of the invention, the cells undergo a biological process and the physiological state of the cells is determined at various points in time throughout the biological process.
摘要翻译：本发明提供了使用与核酸探针连接的芯片来确定从感兴趣生物分离的细胞的生理状态的方法。在本发明的优选实施方案中，细胞经历生物过程，并且在整个生物过程中在不同的时间点确定细胞的生理状态。

7. 发明申请

US20050002964A1 Adhesion inhibition of fungi 审中-公开
标题翻译：真菌的粘附抑制作用
公开(公告)号：US20050002964A1
公开(公告)日：2005-01-06
申请号：US10871124
申请日：2004-06-18
申请人： Dirk Bockmuhl , Roland Breves , Mirko Weide , Stefan Stumpe , Michael Heinzel
发明人： Dirk Bockmuhl , Roland Breves , Mirko Weide , Stefan Stumpe , Michael Heinzel
IPC分类号： A61P31/10 , A01N27/00 , A01N31/02 , A01N31/08 , A01N35/06 , A01N37/06 , A01N37/10 , A01N49/00 , A01N61/00 , A01N63/00 , A01N65/06 , A01N65/10 , A01N65/22 , A01N65/28 , A01N65/44 , A01N65/48 , A01P3/00 , A61K31/045 , C09J11/06 , C09J201/00 , C09K3/10 , C11B9/00 , C11D3/18 , C11D3/20 , C11D3/50 , C12N1/14 , C12R1/645 , D06M13/144 , A61K35/80 , A61K31/015
CPC分类号： A01N61/00 , A01N27/00 , A01N31/08 , A01N35/06 , A01N37/10 , A01N49/00 , A01N65/00
摘要： The invention relates to the use of substances that influence fungal dimorphism for reducing the adhesion of fungi to surfaces. The invention also relates to washing and/or cleaning agents, textile treating agents and cleaning agents for mouth, teeth or dentures and to the use of said substances in said agents. The inventive substances are selected from propolis extracts, plant extracts, cinnamic acid and the derivatives thereof, monoterpenes, sesquiterpenes and diterpenes and the derivatives thereof, especially fucoidine, anethol, geraniol, farnesol or farnesol acid.
摘要翻译：本发明涉及影响真菌二态性以减少真菌对表面粘附的物质的用途。本发明还涉及洗涤和/或清洁剂，纺织品处理剂和用于口，牙齿或义齿的清洁剂以及所述物质中所述物质的使用。本发明的物质选自蜂胶提取物，植物提取物，肉桂酸及其衍生物，单萜，倍半萜和二萜及其衍生物，特别是岩藻多糖，茴香醚，香叶醇，法呢醇或法呢醇酸。

8. 发明申请

US20090238889A1 Hyper-Branched Polymers for the Provision of Hygienic Characteristics 审中-公开
标题翻译：超支化聚合物用于提供卫生特性
公开(公告)号：US20090238889A1
公开(公告)日：2009-09-24
申请号：US12406243
申请日：2009-03-18
申请人： Mirko Weide , Steve Doering , Roland Breves , Anja Schloesser , Joerg Tiller , Andreas Fuchs
发明人： Mirko Weide , Steve Doering , Roland Breves , Anja Schloesser , Joerg Tiller , Andreas Fuchs
IPC分类号： A01N25/26 , A01P1/00
CPC分类号： A01N43/40 , A01N25/10 , C08G83/005
摘要： The invention relates to hyper-branched polymers having a hydrophobic core and an antimicrobial and/or anti-adhesive active shell for providing surfaces with semi-permanent hygienic characteristics.
摘要翻译：本发明涉及具有疏水性核心和用于提供具有半永久性卫生特性的表面的抗微生物和/或抗粘性活性壳的超支化聚合物。

9. 发明申请

US20080220034A1 Antiadhesive Polymers for Prevention of Adhesion of Microorganisms to Textiles and for Prevention of Laundry Odor 审中-公开
标题翻译：用于防止微生物粘附到纺织品和防止洗涤气味的防粘聚合物
公开(公告)号：US20080220034A1
公开(公告)日：2008-09-11
申请号：US11813430
申请日：2006-01-13
申请人： Dirk Bockmuhl , Heide-Marie Hohne , Noelle Wrubbel , Dorothee Heidemeter , Doris Dahlmann , Thomas Plantenberg , Hermann Jonke , Rolf Bayersdorfer , Andre Schafer , Roland Breves
发明人： Dirk Bockmuhl , Heide-Marie Hohne , Noelle Wrubbel , Dorothee Heidemeter , Doris Dahlmann , Thomas Plantenberg , Hermann Jonke , Rolf Bayersdorfer , Andre Schafer , Roland Breves
IPC分类号： A01N25/00 , A01N33/00 , A01N31/00
CPC分类号： D06M16/00 , C08G18/0823 , C08G18/10 , C08G18/6692 , C08L51/08 , C11D3/222 , C11D3/3707 , C11D3/3715 , C11D3/3719 , C11D3/3726 , C11D3/3788 , C11D3/48 , D06M15/53 , D06M15/564 , D06M23/12 , C08G18/2825 , C08G18/765 , C08L2666/02
摘要： Textile treatment agents and/or capsules comprising a polymer having antiadhesive action against microorganisms which adhere to a textile substrate, methods of treating textile substrates therewith and the textile so treated, wherein the polymer comprises a polymeric structural element selected from the group consisting of polyesters, polysaccharides, polyethers, polyurethanes, polyureas, polyamides, and heteropolymers thereof.
摘要翻译：纺织品处理剂和/或胶囊，其包含对粘附到织物基材上的微生物具有抗粘附作用的聚合物，以及如此处理的纺织品基材的处理方法，其中所述聚合物包含选自聚酯，多糖，聚醚，聚氨酯，聚脲，聚酰胺及其杂聚物。

10. 发明申请

US20080207734A1 Novel alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction 有权
标题翻译：用于控制基于微生物相互作用的方法的新型烷氧基内酯，烷氧基内酰胺和烷氧基硫醇内酰胺
公开(公告)号：US20080207734A1
公开(公告)日：2008-08-28
申请号：US11473795
申请日：2006-06-22
申请人： Stefan Stumpe , Roland Breves , Ursula Huchel , Frank Janssen , Andre Hatzelt
发明人： Stefan Stumpe , Roland Breves , Ursula Huchel , Frank Janssen , Andre Hatzelt
IPC分类号： A61K31/4015 , C07D207/46 , A61K31/341 , C07D307/33
CPC分类号： C07D307/33 , A61L2/0082 , A61L2/16
摘要： Compounds of the Formula I, wherein A1 is O or NH; A2 is O or S; each of R1 and R2 is independently hydrogen, a methyl or C2-C8-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R3 is a C1-C18-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R1, R2 and R3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C1-C6-alkyl, trifluoromethyl, C1-C6-alkoxy, C6-C10-aryl, and C1-C6-alkyl-C6-C10-aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.
摘要翻译：式I的化合物，其中A 1是O或NH; A 2是O或S; R 1和R 2中的每一个独立地是氢，甲基或C 2 -C 8 - 饱和或单或双不饱和，支链或直链烃基; 和R 3是C 1 -C 18 - 饱和或单或双不饱和，支链或直链烃基，其中R R 1，R 2和R 3都包含选自链和O中的O和S的杂原子和/或是单 - 或被选自卤素，羟基，C 1 -C 6 - 烷基，三氟甲基，C 1 -C 6烷基的取代基多取代， C 6 - 烷氧基，C 6 -C 10 - 芳基和C 1 -C 6 C 1-6烷基-C 6 -C 10 - 芳基可用于控制微生物之间的相互作用过程，例如生物膜的显影和/或成熟; 多细胞群体行为抗生素抗药性的协调发展; 协同合成抗生素; 色素的协同合成; 协同生产细胞外酶; 或协同生产的毒力因素。

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