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    • 4. 发明申请
    • EXTRACTS OF CURCUMA AMADA AND USES THEREOF
    • CURCUMA AMADA的提取及其用途
    • US20160220627A1
    • 2016-08-04
    • US15011628
    • 2016-01-31
    • DHARMA BIOMEDICAL, LLCFLAVEX NATUREXTRAKTE GMBH
    • STEVEN J. MELNICKKARL-WERNER QUIRINCHEPPAIL RAMACHANDRANMELVIN ROTHBERG
    • A61K36/9066A61K45/06A61K31/015A61K31/01A01N65/48A61K31/11
    • The invention concerns carbon dioxide extracts of Curcuma amada (mango ginger), including supercritical carbon dioxide extracts of C. amada; methods for their production; compositions comprising the extracts; methods for treating or delaying the onset of conditions such as cell proliferation disorder (e.g., cancer), inflammation, infection, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hyperglycemia, platelet hyper-aggregation, immune disorder such as autoimmune disorder, or neurodegenerative condition; and methods for inhibiting expression of Bcl-2, Bak, and p53 genes; inhibiting expression of the COX-2 and NF-kB genes, inhibiting production of phosphorylated target of rapamycin (TOR), modulating AMP-activated protein kinase (AMPK), inhibiting protein kinase B (AKT) signaling, modulating the Ras/Raf/MEK/ERK signaling pathway, and modulating the Ras/PI3K/PTEN/Akt/mTOR signaling pathway. Another aspect of the invention concerns a method for inhibiting contamination, comprising applying the extract or composition of the invention to a surface. Another aspect of the invention concerns a method for promoting longevity of a cell in vitro or in vivo, comprising contacting a target cell in vitro or in vivo with an effective amount of the extract or composition of the invention. Another aspect of the invention concerns a method for promoting longevity of a subject, comprising administering an effective amount of the extract or composition of the invention. Another aspect of the invention concerns a method for inhibiting the metabolism of a cancer cell, comprising contacting the target cancer cell in vitro or in vivo with an effective amount of the extract or composition of the invention. Another aspect of the invention concerns a kit including the extract or composition; a container containing the extract or composition; and packaging material.
    • 本发明涉及莪术(芒果姜)的二氧化碳提取物,包括C.amada的超临界二氧化碳提取物; 生产方法; 包含提取物的组合物; 用于治疗或延缓诸如细胞增殖紊乱(例如癌症),炎症,感染,高脂血症,高胆固醇血症,高甘油三酯血症,高血糖症,血小板高聚集,免疫疾病如自身免疫性疾病或神经变性疾病的病症发作的方法。 以及抑制Bcl-2,Bak和p53基因表达的方法。 抑制COX-2和NF-kB基因的表达,抑制雷帕霉素磷酸化靶标(TOR)的产生,调节AMP激活蛋白激酶(AMPK),抑制蛋白激酶B(AKT)信号传导,调节Ras / Raf / MEK / ERK信号通路,并调节Ras / PI3K / PTEN / Akt / mTOR信号通路。 本发明的另一方面涉及一种抑制污染的方法,包括将本发明的提取物或组合物施用于表面。 本发明的另一方面涉及用于促进体外或体内细胞寿命的方法,包括使体外或体内的靶细胞与有效量的本发明的提取物或组合物接触。 本发明的另一方面涉及一种促进受试者寿命的方法,包括施用有效量的本发明的提取物或组合物。 本发明的另一方面涉及抑制癌细胞代谢的方法,包括使靶癌细胞在体外或体内与有效量的本发明的提取物或组合物接触。 本发明的另一方面涉及包含提取物或组合物的试剂盒; 含有提取物或组合物的容器; 和包装材料。