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    • 1. 发明授权
    • Alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction
    • 用于控制基于微生物相互作用的方法的烷氧基内酯,烷氧基内酰胺和烷氧基硫醇内酰胺
    • US07825268B2
    • 2010-11-02
    • US11473795
    • 2006-06-22
    • Stefan StumpeRoland BrevesUrsula HuchelFrank JanssenAndré Hätzelt
    • Stefan StumpeRoland BrevesUrsula HuchelFrank JanssenAndré Hätzelt
    • A61K31/4015A61K31/341C07D207/26C07D307/33
    • C07D307/33A61L2/0082A61L2/16
    • Compounds of the Formula I, wherein A1 is O or NH; A2 is O or S; each of R1 and R2 is independently hydrogen, a methyl or C2-C8-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R3 is a C1-C18-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R1, R2 and R3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C1-C6-alkyl, trifluoromethyl, C1-C6-alkoxy, C6-C10-aryl, and C1-C6-alkyl-C6-C10-aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.
    • 式I的化合物,其中A1是O或NH; A2为O或S; R 1和R 2各自独立地为氢,甲基或C 2 -C 8饱和或单或双不饱和,支链或直链烃基; 并且R 3是C 1 -C 18饱和或单或双不饱和,支链或直链烃基,其中R 1,R 2和R 3各自包含选自链和O中的O和S的杂原子和/或是单 或被选自卤素,羟基,C 1 -C 6 - 烷基,三氟甲基,C 1 -C 6 - 烷氧基,C 6 -C 10 - 芳基和C 1 -C 6 - 烷基-C 6 -C 10 - 芳基的取代基取代或多取代 可用于控制微生物之间的相互作用过程,例如在生物膜的开发和/或成熟中; 多细胞群体行为; 抗生素抗药性的协调发展; 协同合成抗生素; 色素的协同合成; 协同生产细胞外酶; 或协同生产的毒力因素。
    • 2. 发明申请
    • Novel alkoxylactones, alkoxylactams and alkoxythiolactams for controlling processes based on microbial interaction
    • 用于控制基于微生物相互作用的方法的新型烷氧基内酯,烷氧基内酰胺和烷氧基硫醇内酰胺
    • US20080207734A1
    • 2008-08-28
    • US11473795
    • 2006-06-22
    • Stefan StumpeRoland BrevesUrsula HuchelFrank JanssenAndre Hatzelt
    • Stefan StumpeRoland BrevesUrsula HuchelFrank JanssenAndre Hatzelt
    • A61K31/4015C07D207/46A61K31/341C07D307/33
    • C07D307/33A61L2/0082A61L2/16
    • Compounds of the Formula I, wherein A1 is O or NH; A2 is O or S; each of R1 and R2 is independently hydrogen, a methyl or C2-C8-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group; and R3 is a C1-C18-saturated or mono- or doubly unsaturated, branched or linear hydrocarbon group wherein, each of R1, R2 and R3 comprises a heteroatom selected from the group consisting of O and S in the chain and/or is mono- or multiply-substituted by a substituent selected from the group consisting of halogen, hydroxy, C1-C6-alkyl, trifluoromethyl, C1-C6-alkoxy, C6-C10-aryl, and C1-C6-alkyl-C6-C10-aryl are useful for controlling the interaction process between microorganisms such as in the development and/or maturation of biofilms; multicellular swarm behavior; the concerted development of antibiotic resistances; the concerted synthesis of antibiotics; the concerted synthesis of pigments; the concerted production of extracellular enzymes; or the concerted production of virulence factors.
    • 式I的化合物,其中A 1是O或NH; A 2是O或S; R 1和R 2中的每一个独立地是氢,甲基或C 2 -C 8 - 饱和或 单或双不饱和,支链或直链烃基; 和R 3是C 1 -C 18 - 饱和或单或双不饱和,支链或直链烃基,其中R R 1,R 2和R 3都包含选自链和O中的O和S的杂原子和/或是单 - 或 被选自卤素,羟基,C 1 -C 6 - 烷基,三氟甲基,C 1 -C 6烷基的取代基多取代, C 6 - 烷氧基,C 6 -C 10 - 芳基和C 1 -C 6 C 1-6烷基-C 6 -C 10 - 芳基可用于控制微生物之间的相互作用过程,例如生物膜的显影和/或成熟; 多细胞群体行为 抗生素抗药性的协调发展; 协同合成抗生素; 色素的协同合成; 协同生产细胞外酶; 或协同生产的毒力因素。
    • 4. 发明申请
    • STOPPER FOR A CONTAINER
    • 停止为集装箱
    • US20120261377A1
    • 2012-10-18
    • US13487456
    • 2012-06-04
    • Roland KneerFrank Janssen
    • Roland KneerFrank Janssen
    • B65D50/06
    • B65D50/045B65D39/16B65D50/069
    • A stopper which engages a neck of a container. The stopper includes a circular bottom section and a head section which rises above the container and encompasses a slide. The rim of the head section has a maximum diameter that does not exceed the external diameter of the opening of the container. The slide can be pushed against the force of a spring device in one direction and, when released, returns to its retracted initial position as a result of the spring force. Opposing sides of the slide each end in circumferential sections. A first one of the circumferential sections forming an outer surface for receiving a first applied force for advancing the slide and causing the second one of the circumferential sections to protrude from the stopper. The second one of the circumferential sections receiving a second different applied force to remove the stopper from the container.
    • 与容器的颈部接合的塞子。 止动器包括圆形底部部分和在容器上方并且包围滑动件的头部部分。 头部的边缘具有不超过容器开口的外径的最大直径。 滑动件可以克服弹簧装置的力在一个方向上推动,并且当释放时由于弹簧力而返回到其缩回的初始位置。 滑动件的相对侧每个端部在圆周部分。 圆周部分中的第一个形成外表面,用于接收用于推进滑块的第一施加力,并使第二个圆周部分从塞子突出。 周向部分中的第二个接收第二不同的施加力以从容器移除塞子。
    • 9. 发明授权
    • One-way valve for delivering a free-flowing material
    • 用于输送自由流动材料的单向阀
    • US08322578B2
    • 2012-12-04
    • US10511928
    • 2003-04-04
    • Frank JanssenRoland Kneer
    • Frank JanssenRoland Kneer
    • B65D25/40B65D33/38B65D5/72
    • B65D47/2081B65D81/24
    • A one-way valve for the recontamination-protected repeated discharge of a flowable material from a container of a preferably reducible volume contains a valve seat which consists of a rigid plastic material and which is arranged in the container neck and comprises a base body which rests on the inner wall of the container neck and contains at least one through hole, and a projection which extends in axial direction of the container neck towards the exit opening. The valve seat has arranged thereabove an elastic seal which comprises an annular section covering the at least one through hole, and a sleeve-like section which surrounds the projection at a radial distance with the exception of its end section which in the closed state of the one-way valve rests in the exit opening on the end section of the projection. A sterilization element of silver or of another metal having an oligodynamic action may be arranged in the intermediate space between the projection of the valve seat and the elastic seal. The application of pressure to the contents of the container has the effect that the annular section of the seal releases the at least one through hole of the valve seat, the end section of the sleeve-like part of the seal exiting from the exit opening and releasing the same. The seal will then return into the initial state. The contents of the container is safely sealed against the ingress of contaminants.
    • 用于再污染保护的可重复排出的可从优选可还原体积的容器重新排放可流动材料的单向阀包含由刚性塑料材料组成的阀座,该阀座布置在容器颈部中并且包括底座 在容器颈部的内壁上并且包含至少一个通孔,以及沿容器颈部的轴向方向朝向出口开口延伸的突起。 阀座在其上方布置有弹性密封件,弹性密封件包括覆盖至少一个通孔的环形部分,以及围绕突出部分的径向距离的套筒状部分,除了其端部部分之外,其端部处于闭合状态 单向阀安置在突起端部的出口处。 可以在阀座的突起和弹性密封件之间的中间空间中布置银或具有低动力作用的另一种金属的灭菌元件。 向容器内容物施加压力的作用是密封件的环形部分释放阀座的至少一个通孔,密封件的套筒状部分的端部从出口开口排出, 释放相同 密封件然后将返回初始状态。 容器内容物安全地密封,防止污染物的进入。