专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11338294B2 Orthogonal polybiosensing and imaging systems 有权
公开(公告)号：US11338294B2
公开(公告)日：2022-05-24
申请号：US16664537
申请日：2019-10-25
申请人： Mandana Veiseh , Pirooz Parvarandeh , S. Bahram Bahrami , Oliver Peter King-Smith , Todd S. Rutherford , Aaron Peter Schellenberg , Timothy Scott Edward Hiller
发明人： Mandana Veiseh , Pirooz Parvarandeh , S. Bahram Bahrami , Oliver Peter King-Smith , Todd S. Rutherford , Aaron Peter Schellenberg , Timothy Scott Edward Hiller
IPC分类号： B01L3/00
摘要： Toward forming a single hybrid biosensing-imaging system that can operate inside an incubator, structures and methods are directed to placing modular and removable biosensors and biocompatible interfaces in 3D transparent test wells that contain biological samples. The technology enables continuous monitoring of multiple simultaneous parameters and functions of a living cell or cell clusters such as alterations of cellular ligands, physicochemical biomarkers, phenotypes, and/or extracellular compositions upon interactions with analytes or during progressions. Methods of capturing and analyzing direct orthogonal information from biological samples in 2D and 3D, which are conducive to generating new insights are presented.

2. 发明授权

US08672887B2 Needle array assembly and method for delivering therapeutic agents 有权
公开(公告)号：US08672887B2
公开(公告)日：2014-03-18
申请号：US13330106
申请日：2011-12-19
申请人： S. Bahram Bahrami , Mandana Veiseh , James Olson
发明人： S. Bahram Bahrami , Mandana Veiseh , James Olson
IPC分类号： A61M37/00
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

3. 发明授权

US08349554B2 Needle array assembly and method for delivering therapeutic agents 有权
公开(公告)号：US08349554B2
公开(公告)日：2013-01-08
申请号：US12674146
申请日：2008-08-14
申请人： S. Bahram Bahrami , Mandana Veiseh , James Olson
发明人： S. Bahram Bahrami , Mandana Veiseh , James Olson
IPC分类号： C12Q1/00
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

4. 发明申请

US20120296206A1 NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS 审中-公开
标题翻译：针阵列组装和递送治疗剂的方法
公开(公告)号：US20120296206A1
公开(公告)日：2012-11-22
申请号：US13489324
申请日：2012-06-05
申请人： S. Bahram Bahrami , Mandana Veiseh , James Olson
发明人： S. Bahram Bahrami , Mandana Veiseh , James Olson
IPC分类号： A61B6/00 , A61B10/02 , A61M5/00
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of liquid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
摘要翻译：流体递送装置包括针阵列，每个针与相应的储存器流体连通。相应的致动器被联接以便可操作以通过针端口驱动来自储存器的流体。每个针可以具有多个端口，并且端口可以布置成沿着其长度在任何给定位置处输送基本上相等量的流体。驱动器联接到致动器以选择性地控制通过针的液体的流速，体积和方向。该装置可以同时在体内在固体组织中沿相应的轴递送多个流体试剂。如果之后切除，则可以将组织切片以评估每种药剂对组织的影响，并且基于评估，选择或取消选择用于临床试验或治疗的候选药剂，以及选择或取消选择用于临床试验或治疗性治疗的受试者。

5. 发明申请

US20120087866A1 NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS 有权
公开(公告)号：US20120087866A1
公开(公告)日：2012-04-12
申请号：US13330106
申请日：2011-12-19
申请人： S. Bahram BAHRAMI , Mandana Veiseh , James Olson
发明人： S. Bahram BAHRAMI , Mandana Veiseh , James Olson
IPC分类号： A61K49/00 , C12Q1/02 , C40B30/06
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

6. 发明申请

US20080279780A1 Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer 有权
标题翻译：荧光氯毒素结合物和癌症手术后可视化方法
公开(公告)号：US20080279780A1
公开(公告)日：2008-11-13
申请号：US11897721
申请日：2007-08-31
申请人： Miqin Zhang , Richard G. Ellenbogen , Raymond W. Sze , Omid Veiseh , James M. Olson , Mandana Veiseh , Patrick Gabikian , S-Bahram Bahrami
发明人： Miqin Zhang , Richard G. Ellenbogen , Raymond W. Sze , Omid Veiseh , James M. Olson , Mandana Veiseh , Patrick Gabikian , S-Bahram Bahrami
IPC分类号： A61K49/00
CPC分类号： A61B17/22 , A61K38/16 , A61K47/6415 , A61K49/0017 , A61K49/0032 , A61K49/0041 , A61K49/005 , A61K49/0056 , A61K51/08 , C07K14/43522 , G01N33/57492
摘要： A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
摘要翻译：通过荧光成像可检测的氯毒素缀合物，其允许癌组织的术中可视化，包括氯毒素缀合物的组合物，以及使用氯毒素缀合物的方法。

7. 发明授权

US08926567B2 Needle array assembly and method for delivering therapeutic agents 有权
公开(公告)号：US08926567B2
公开(公告)日：2015-01-06
申请号：US13330124
申请日：2011-12-19
申请人： S. Bahram Bahrami , Mandana Veiseh , James Olson
发明人： S. Bahram Bahrami , Mandana Veiseh , James Olson
IPC分类号： A61M5/00 , A61M5/32 , A61M5/145 , A61M5/168 , A61B6/00
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

8. 发明授权

US08834428B2 Needle array assembly and method for delivering therapeutic agents 有权
标题翻译：针阵组装和递送治疗剂的方法
公开(公告)号：US08834428B2
公开(公告)日：2014-09-16
申请号：US13330044
申请日：2011-12-19
申请人： S. Bahram Bahrami , Mandana Veiseh , James Olson
发明人： S. Bahram Bahrami , Mandana Veiseh , James Olson
IPC分类号： A61M5/00 , A61M5/32 , A61M5/168 , A61M5/145
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
摘要翻译：流体递送装置包括针阵列，每个针与相应的储存器流体连通。相应的致动器被联接以便可操作以通过针端口驱动来自储存器的流体。每个针可以具有多个端口，并且端口可以布置成沿着其长度在任何给定位置处输送基本上相等量的流体。驱动器联接到致动器以选择性地控制通过针的流体的流速，体积和方向。该装置可以同时在体内在固体组织中沿相应的轴递送多个流体试剂。如果之后切除，则可以将组织切片以评估每种药剂对组织的影响，并且基于评估，选择或取消选择用于临床试验或治疗的候选药剂，以及选择或取消选择用于临床试验或治疗性治疗的受试者。

9. 发明授权

US08657786B2 Needle array assembly and method for delivering therapeutic agents 有权
公开(公告)号：US08657786B2
公开(公告)日：2014-02-25
申请号：US13330022
申请日：2011-12-19
申请人： S. Bahram Bahrami , Mandana Veiseh , James Olson
发明人： S. Bahram Bahrami , Mandana Veiseh , James Olson
IPC分类号： A61M37/00
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.

10. 发明申请

US20120094866A1 NEEDLE ARRAY ASSEMBLY AND METHOD FOR DELIVERING THERAPEUTIC AGENTS 有权
标题翻译：针阵列组装和递送治疗剂的方法
公开(公告)号：US20120094866A1
公开(公告)日：2012-04-19
申请号：US13330044
申请日：2011-12-19
申请人： S. Bahram Bahrami , Mandana Veiseh , James Olson
发明人： S. Bahram Bahrami , Mandana Veiseh , James Olson
IPC分类号： C40B30/06
CPC分类号： A61M5/3298 , A61B6/508 , A61M5/1452 , A61M5/14526 , A61M5/16827 , A61M5/20 , A61M5/3287 , A61M5/3291 , A61M5/3294 , A61M2205/50 , A61M2205/52
摘要： A fluid delivery device includes an array of needles, each in fluid communication with a respective reservoir. Respective actuators are coupled so as to be operable to drive fluid from the reservoirs via needle ports. Each needle can have a plurality of ports, and the ports can be arranged to deliver a substantially equal amount of fluid at any given location along its length. A driver is coupled to the actuators to selectively control the rate, volume, and direction of flow of fluid through the needles. The device can simultaneously deliver a plurality of fluid agents along respective axes in solid tissue in vivo. If thereafter resected, the tissue can be sectioned for evaluation of an effect of each agent on the tissue, and based on the evaluation, candidate agents selected or deselected for clinical trials or therapy, and subjects selected or deselected for clinical trials or therapeutic treatment.
摘要翻译：流体递送装置包括针阵列，每个针与相应的储存器流体连通。相应的致动器被联接以便可操作以通过针端口驱动来自储存器的流体。每个针可以具有多个端口，并且端口可以布置成沿着其长度在任何给定位置处输送基本上相等量的流体。驱动器联接到致动器以选择性地控制通过针的流体的流速，体积和方向。该装置可以同时在体内在固体组织中沿相应的轴递送多个流体试剂。如果之后切除，则可以将组织切片以评估每种药剂对组织的影响，并且基于评估，选择或取消选择用于临床试验或治疗的候选药剂，以及选择或取消选择用于临床试验或治疗性治疗的受试者。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式