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1. 发明申请

US20080279780A1 Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer 有权
标题翻译：荧光氯毒素结合物和癌症手术后可视化方法
公开(公告)号：US20080279780A1
公开(公告)日：2008-11-13
申请号：US11897721
申请日：2007-08-31
申请人： Miqin Zhang , Richard G. Ellenbogen , Raymond W. Sze , Omid Veiseh , James M. Olson , Mandana Veiseh , Patrick Gabikian , S-Bahram Bahrami
发明人： Miqin Zhang , Richard G. Ellenbogen , Raymond W. Sze , Omid Veiseh , James M. Olson , Mandana Veiseh , Patrick Gabikian , S-Bahram Bahrami
IPC分类号： A61K49/00
CPC分类号： A61B17/22 , A61K38/16 , A61K47/6415 , A61K49/0017 , A61K49/0032 , A61K49/0041 , A61K49/005 , A61K49/0056 , A61K51/08 , C07K14/43522 , G01N33/57492
摘要： A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
摘要翻译：通过荧光成像可检测的氯毒素缀合物，其允许癌组织的术中可视化，包括氯毒素缀合物的组合物，以及使用氯毒素缀合物的方法。

2. 发明授权

US08778310B2 Fluorescent chlorotoxin conjugate and method for intra-operative visualization of cancer 有权
标题翻译：荧光氯毒素缀合物和癌症手术中可视化的方法
公开(公告)号：US08778310B2
公开(公告)日：2014-07-15
申请号：US11897721
申请日：2007-08-31
申请人： Miqin Zhang , Richard G. Ellenbogen , Raymond W. Sze , Omid Veiseh , James M. Olson , Mandana Veiseh , Patrik Gabikian , S-Bahram Bahrami
发明人： Miqin Zhang , Richard G. Ellenbogen , Raymond W. Sze , Omid Veiseh , James M. Olson , Mandana Veiseh , Patrik Gabikian , S-Bahram Bahrami
IPC分类号： A61B5/00 , A61B8/00 , A61B10/00 , A61K49/00 , A61K38/16 , A61K51/08
CPC分类号： A61B17/22 , A61K38/16 , A61K47/6415 , A61K49/0017 , A61K49/0032 , A61K49/0041 , A61K49/005 , A61K49/0056 , A61K51/08 , C07K14/43522 , G01N33/57492
摘要： A chlorotoxin conjugate detectable by fluorescence imaging that allows for intra-operative visualization of cancerous tissues, compositions that include the chlorotoxin conjugate, and methods for using the chlorotoxin conjugate.
摘要翻译：通过荧光成像可检测的氯毒素缀合物，其允许癌组织的术中可视化，包括氯毒素缀合物的组合物，以及使用氯毒素缀合物的方法。

3. 发明授权

US5679159A Spinning substrate holder for cutting tool inserts for improved arc-jet diamond deposition 失效
标题翻译：用于切削工具刀片的旋转衬底支架，用于改进电弧喷射金刚石沉积
公开(公告)号：US5679159A
公开(公告)日：1997-10-21
申请号：US473198
申请日：1995-06-07
申请人： James M. Olson
发明人： James M. Olson
IPC分类号： B23B27/14 , B01J19/08 , B23P15/28 , C23C16/26 , C23C16/27 , C23C16/44 , C23C16/458 , C30B29/04 , C23C16/00
CPC分类号： C23C16/276 , C23C16/4584
摘要： A mandrel for use in an arc-jet spinning diamond deposition process for coating cutting tool inserts is disclosed. The mandrel has a plurality of cutouts or wells for receiving cutting tool inserts. The receiving wells are machined or otherwise provided to have the same contour as the cutting tool inserts that are placed in the wells. The receiving wells may all have an identical geometry, or different geometries. In one embodiment, the mandrel comprises a single element with the receiving wells machined into the upper surface of the mandrel. In another embodiment, the mandrel comprises a separate upper plate with the receiving wells cut through the plate to form a grid, and a lower base plate which is attached to the upper plate. An intermediate layer of a low melting metal foil may be placed between the grid and base plate to aid adhesion and to provide an interface of high thermal conductivity.
摘要翻译：公开了一种用于电弧喷射纺丝金刚石沉积工艺中用于涂覆刀具刀片的心轴。心轴具有用于接收切削刀具插入件的多个切口或孔。接收井被加工或以其他方式提供以具有与放置在井中的切削工具插入件相同的轮廓。接收井都可以具有相同的几何形状或不同的几何形状。在一个实施例中，心轴包括单个元件，其中接收孔被加工成心轴的上表面。在另一个实施例中，心轴包括单独的上板，其中接收井切穿板以形成格栅，以及附接到上板的下基板。低熔点金属箔的中间层可以放置在栅格和基板之间以辅助粘附并提供高导热性的界面。

4. 发明授权

US06267867B1 Composite article with adherent CVD diamond coating and method of making 失效
标题翻译：具有贴附CVD金刚石涂层的复合制品及其制造方法
公开(公告)号：US06267867B1
公开(公告)日：2001-07-31
申请号：US09300646
申请日：1999-04-27
申请人： James M. Olson
发明人： James M. Olson
IPC分类号： C25F300
CPC分类号： C23C16/276 , C23C16/02
摘要： A process for coating a tungsten carbide base material substrate with CVD diamond film includes carburization and gas-assisted vaporization of cobalt from the surface with simultaneous recrystallization of surface grains of tungsten carbide to change their stoichiometry for improved adherence. Also disclosed is a WC—Co cutting tool having a relatively fine WC grain size and being coated with adherent CVD diamond.
摘要翻译：用CVD金刚石膜涂覆碳化钨基材基板的方法包括从表面渗碳和气体辅助的钴蒸发，同时碳化钨表面晶粒再结晶以改变其化学计量以提高附着力。还公开了具有相对较细的WC晶粒尺寸并涂覆有粘附CVD金刚石的WC-Co切割工具。

5. 发明授权

US5795723A Expression of neurogenic bHLH genes in primitive neuroectodermal tumors 失效
标题翻译：神经源性bHLH基因在原始神经外胚层肿瘤中的表达
公开(公告)号：US5795723A
公开(公告)日：1998-08-18
申请号：US910973
申请日：1997-08-07
申请人： Stephen J. Tapscott , James M. Olson
发明人： Stephen J. Tapscott , James M. Olson
IPC分类号： A61K38/00 , C07K14/46 , C07K14/47 , C12Q1/68 , C07H21/04 , C12P21/02 , C12Q1/04
CPC分类号： C07K14/4702 , C07K14/463 , C07K14/4705 , C12Q1/6886 , A61K38/00 , C12Q2600/112
摘要： Provided are methods of classifying and prognosticating human neuroectodermal tumors by analyzing a sample of the tumor to determine whether various bHLH proteins are detectably expressed in the sample. In the methods disclosed herein, expression of the bHLH genes is assessed by measuring transcripts or proteins expressed from the genes.
摘要翻译：提供了通过分析肿瘤样品来分类和预测人类神经外胚层肿瘤的方法，以确定各种bHLH蛋白在样品中是否可检测地表达。在本文公开的方法中，通过测量从基因表达的转录物或蛋白质来评估bHLH基因的表达。

6. 发明授权

US08282620B2 Container for pump system 有权
标题翻译：泵系统容器
公开(公告)号：US08282620B2
公开(公告)日：2012-10-09
申请号：US12366165
申请日：2009-02-05
申请人： James M. Olson , Michael Hegland , Dale F. Seeley
发明人： James M. Olson , Michael Hegland , Dale F. Seeley
IPC分类号： A61B19/00 , B65B1/04 , B65B3/04
CPC分类号： A61M5/1486 , A61M5/1413 , A61M5/14248 , A61M5/152 , A61M2005/1587
摘要： A container for housing a fluid therapeutic composition includes a rigid housing, a collapsible bag and a seal. The housing has an opening and an interior surface. The interior surface forms a cavity having a volume. The bag is disposed in the housing and is expandable to contact the interior surface of the housing and occupy the entire volume of the cavity when filled with the fluid therapeutic composition. The bag has an opening that is fixed in proximity to the opening of the housing. The seal is configured to prevent air from entering the bag via the bag opening and to prevent air from entering the cavity of the housing via the housing opening.
摘要翻译：用于容纳流体治疗组合物的容器包括刚性壳体，可折叠袋和密封件。壳体具有开口和内表面。内表面形成具有体积的空腔。袋子设置在壳体中并且当被填充有流体治疗组合物时可扩张以接触壳体的内表面并占据空腔的整个体积。袋子具有固定在壳体开口附近的开口。密封件构造成防止空气经由袋开口进入袋中，并且防止空气经由壳体开口进入壳体的空腔。

7. 发明授权

US06447843B1 Synthetic diamond wear component and method 失效
标题翻译：合成金刚石磨损成分及方法
公开(公告)号：US06447843B1
公开(公告)日：2002-09-10
申请号：US08826209
申请日：1997-03-27
申请人： James M. Olson
发明人： James M. Olson
IPC分类号： C23C1626
CPC分类号： C23C16/274 , C23C16/01 , C23C16/276 , C23C16/279
摘要： A method is set forth for making a diamond film coated wear part, including the following steps: providing a part; depositing a first layer of polycrystalline diamond film on the part with non-{100} crystallographic faceting; and depositing on the first layer a second layer of polycrystalline diamond film having {100} crystallographic faceting, the second layer having a thickness sufficient to overgrow the roughness of said surface of said first layer with a continuous film.
摘要翻译：提出制造金刚石薄膜涂层磨损部件的方法，包括以下步骤：提供零件; 在非{100}晶面上在该部分上沉积第一层多晶金刚石膜; 以及在所述第一层上沉积具有{100}晶面的第二层多晶金刚石膜，所述第二层具有足以使连续膜过度生长所述第一层的所述表面的粗糙度的厚度。

8. 发明授权

US06278087B1 Ceramic igniters and methods for using and producing same 有权
标题翻译：陶瓷点火器及其使用和生产方法
公开(公告)号：US06278087B1
公开(公告)日：2001-08-21
申请号：US09491170
申请日：2000-01-25
申请人： Craig A. Willkens , James M. Olson , Scott M. Hamel
发明人： Craig A. Willkens , James M. Olson , Scott M. Hamel
IPC分类号： H05B300
CPC分类号： F23Q7/22
摘要： Ceramic igniters are provided that comprise two cold zones with an interposed hot zone, the hot zone having an electrical path length of from 0.51 cm to about 2 cm. Igniters of the invention can effectively diffuse power density throughout the igniter hot zone region, without producing isolated temperature gradients which can lead to premature igniter degradation and failure. The invention also provides new methods for forming ceramic igniters.
摘要翻译：提供陶瓷点火器，其包括具有插入的热区域的两个冷区域，热区域具有从0.51cm至约2cm的电路径长度。本发明的点火器可以有效地扩散整个点火器热区域的功率密度，而不会产生隔离的温度梯度，这可能导致过早的点火器退化和失效。本发明还提供了形成陶瓷点火器的新方法。

9. 发明授权

US5891522A Composite article with adherent CVD diamond coating and method of making 失效
标题翻译：具有贴附CVD金刚石涂层的复合制品及其制造方法
公开(公告)号：US5891522A
公开(公告)日：1999-04-06
申请号：US963095
申请日：1997-11-03
申请人： James M. Olson
发明人： James M. Olson
IPC分类号： C23C16/02 , H05H1/00
CPC分类号： C23C16/0236
摘要： A process for coating a tungsten carbide base material substrate with CVD diamond film includes carburization and gas-assisted vaporization of cobalt from the surface with simultaneous recrystallization of surface grains of tungsten carbide to change their stoichiometry for improved adherence.Also disclosed is a WC-Co cutting tool having a relatively fine WC grain size and coated with adherent CVD diamond.
摘要翻译：用CVD金刚石膜涂覆碳化钨基材基板的方法包括从表面渗碳和气体辅助的钴蒸发，同时碳化钨表面晶粒再结晶以改变其化学计量以提高附着力。还公开了具有相对较细的WC晶粒尺寸并涂覆有粘附CVD金刚石的WC-Co切割工具。

10. 发明授权

US5635256A Method of making a diamond-coated composite body 失效
标题翻译：制作金刚石复合体的方法
公开(公告)号：US5635256A
公开(公告)日：1997-06-03
申请号：US633344
申请日：1996-04-17
申请人： James M. Olson
发明人： James M. Olson
IPC分类号： B23B27/14 , B23P15/28 , C23C16/02 , C23C16/26 , C23C16/27 , C30B29/04 , B05D3/06
CPC分类号： C23C16/02 , C23C16/0209 , C23C16/0227 , C23C16/0245 , C23C16/0272 , C23C16/27 , C23C16/274
摘要： At least the surface region of a cutting tool substrate made of tungsten carbide in a cobalt matrix is carburized to chemically passivate the cobalt prior to deposition of diamond film on it. The passivation improves adhesion by preventing reaction of the cobalt with the diamond in the course of the deposition process. To further improve adhesion of the diamond, cobalt is removed from the exposed surfaces of the tungsten carbide grains by heat treatment in inert gas or by hydrogen plasma.
摘要翻译：在钴基体中由碳化钨制成的切削工具基板的至少表面区域被渗碳以在沉积金刚石膜之前化学钝化钴。该钝化通过在沉积过程中防止钴与金刚石反应来提高粘合性。为了进一步提高金刚石的附着力，通过在惰性气体中或通过氢等离子体进行热处理，从碳化钨晶粒的暴露表面除去钴。

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