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    • 2. 发明授权
    • Method for producing phenylacetamide compound
    • 苯乙酰胺化合物的制备方法
    • US08624062B2
    • 2014-01-07
    • US13147823
    • 2010-02-12
    • Hajime IshidaMasaji HirotaYoko MiyanagaYuya Mizushima
    • Hajime IshidaMasaji HirotaYoko MiyanagaYuya Mizushima
    • C07C233/05C07C231/06
    • C07C231/06C07C235/34
    • A method for producing a phenylacetamide compound represented by formula (1): wherein Q represents a hydrogen atom or a halogen atom, R2 represents a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, R4 represents an alkyl group having 1 to 4 carbon atoms, Ar represents an unsubstituted or substituted phenyl group, R5 represents R4 when R2 is a hydrogen atom, and R5 represents a hydrogen atom when R2 is an alkyl group having 1 to 4 carbon atoms; including reacting a phenylacetamide compound represented by formula (2): wherein Q, R2 and Ar have the same meanings as defined above; with a dialkyl sulfate represented by formula (3): wherein R4 has the same meaning as defined above; in the presence of a base.
    • 一种由式(1)表示的苯乙酰胺化合物的制备方法:其中Q表示氢原子或卤素原子,R2表示氢原子或碳原子数1〜4的烷基,R4表示1〜4的烷基 碳原子,Ar表示未取代或取代的苯基,当R2表示氢原子时,R5表示R4,R2表示碳原子数1〜4的烷基时,R5表示氢原子。 包括使由式(2)表示的苯乙酰胺化合物反应:其中Q,R 2和Ar具有与上述相同的含义; 与式(3)表示的二烷基硫酸盐:其中R4具有与上述相同的含义; 在一个基地的存在。