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1. 发明申请

US20110077284A1 DRY POWDER COMPOSITIONS FOR RNA INFLUENZA THERAPEUTICS 审中-公开
标题翻译：用于RNA流感病毒治疗的干粉组合物
公开(公告)号：US20110077284A1
公开(公告)日：2011-03-31
申请号：US12903814
申请日：2010-10-13
申请人： Luis Brito , Donghao Chen , Qing Ge , Douglas A. Treco
发明人： Luis Brito , Donghao Chen , Qing Ge , Douglas A. Treco
IPC分类号： A61K31/713 , A61P31/16
CPC分类号： A61K9/0075 , C12N15/111 , C12N15/1131 , C12N2310/14 , C12N2320/31 , C12N2320/32 , C12N2760/16111
摘要： A dry powder formulation for delivery to a mammal by inhalation, the formulation comprising particles comprising a lipid, a carrier, and one or more double-stranded siRNA molecules or dicer-active precursors targeted to influenza virus A method for treating or preventing influenza in a mammal comprising administering a therapeutically-effective amount of a dry powder formulation.
摘要翻译：一种用于通过吸入递送至哺乳动物的干粉制剂，该制剂包含包含脂质，载体和靶向流感病毒的一种或多种双链siRNA分子或切片剂活性前体的颗粒。用于治疗或预防流感病毒的方法哺乳动物包括施用治疗有效量的干粉制剂。

2. 发明申请

US20090042283A1 OPTIMIZED MESSENGER RNA 审中-公开
标题翻译：优化的信使RNA
公开(公告)号：US20090042283A1
公开(公告)日：2009-02-12
申请号：US11925167
申请日：2007-10-26
申请人： Richard F. Selden , Allan M. Miller , Douglas A. Treco
发明人： Richard F. Selden , Allan M. Miller , Douglas A. Treco
IPC分类号： C12N15/12 , C12N5/10 , C12N15/85
CPC分类号： C12N9/6437 , C07K14/755 , C07K2319/50 , C07K2319/61 , C12N9/2465 , C12N9/644 , C12N15/67 , C12Y304/21022
摘要： The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons.
摘要翻译：本发明涉及编码蛋白质的合成核酸序列，其中至少一个非共同密码子或更少共同密码子被共同密码子替代。合成核酸序列可以包括至少90个密码子的连续延伸，所有这些密码子都是常见的密码子。

3. 发明申请

US20120252117A1 OPTIMIZED MESSENGER RNA 审中-公开
标题翻译：优化的信使RNA
公开(公告)号：US20120252117A1
公开(公告)日：2012-10-04
申请号：US13085425
申请日：2011-04-12
申请人： Richard F Selden , Allan M. Miller , Douglas A. Treco
发明人： Richard F Selden , Allan M. Miller , Douglas A. Treco
IPC分类号： C12N15/12 , C12N5/10 , C12N5/28 , C12N15/56 , C12N15/13 , C12N15/24 , C12N15/17 , C12N15/54 , C12N15/85 , C12N15/58
CPC分类号： C12N9/6437 , C07K14/755 , C07K2319/50 , C07K2319/61 , C12N9/2465 , C12N9/644 , C12N15/67 , C12Y304/21022
摘要： The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons.
摘要翻译：本发明涉及编码蛋白质的合成核酸序列，其中至少一个非共同密码子或更少共同密码子被共同密码子替代。合成核酸序列可以包括至少90个密码子的连续延伸，所有这些密码子都是常见的密码子。

4. 发明申请

US20090017533A1 OPTIMIZED MESSENGER RNA 审中-公开
公开(公告)号：US20090017533A1
公开(公告)日：2009-01-15
申请号：US11925125
申请日：2007-10-26
申请人： Richard F. Selden , Allan M. Miller , Douglas A. Treco
发明人： Richard F. Selden , Allan M. Miller , Douglas A. Treco
IPC分类号： C12N15/12 , C12N15/85 , C12N5/10
CPC分类号： C12N9/6437 , C07K14/755 , C07K2319/50 , C07K2319/61 , C12N9/2465 , C12N9/644 , C12N15/67 , C12Y304/21022
摘要： The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons.

5. 发明授权

US06566099B1 Nucleic acid encoding a chimeric polypeptide 有权
标题翻译：编码嵌合多肽的核酸
公开(公告)号：US06566099B1
公开(公告)日：2003-05-20
申请号：US09491759
申请日：2000-01-27
申请人： Richard F. Selden , Marianne Borowski , Frances P. Gillispie , Carol M. Kinoshita , Douglas A. Treco , Melanie D. Williams
发明人： Richard F. Selden , Marianne Borowski , Frances P. Gillispie , Carol M. Kinoshita , Douglas A. Treco , Melanie D. Williams
IPC分类号： C12P2104
CPC分类号： C12N9/2465 , A61K38/00 , C07K14/61 , C07K2319/00 , C07K2319/02 , C12Y302/01022
摘要： A therapeutic method whereby an individual suspected of having an &agr;-galactosidase A deficiency, such as Fabry disease, is treated either with (1) human cells that have been genetically modified to overexpress and secrete human &agr;-gal A, or (2) purified human &agr;-gal A obtained from cultured, genetically modified human cells.
摘要翻译：一种治疗方法，其中怀疑患有α-半乳糖苷酶A缺乏症的个体，例如法布里病，用（1）已被遗传修饰以过表达和分泌人α-galA的人细胞或（2）纯化的人α-gal A从培养的，遗传修饰的人细胞获得。

6. 发明授权

US5783385A Method for homologous-recombination screening of recombinant-DNA clones in yeast host libraries 失效
标题翻译：酵母宿主文库中重组DNA克隆的同源重组筛选方法
公开(公告)号：US5783385A
公开(公告)日：1998-07-21
申请号：US300919
申请日：1994-09-06
申请人： Douglas A. Treco , Allan M. Miller
发明人： Douglas A. Treco , Allan M. Miller
IPC分类号： C12N15/09 , C12N15/10 , C12N15/81 , C12N15/90 , C12Q1/02 , C12Q1/68 , C12P19/34
CPC分类号： C12N15/1082 , C12N15/81 , C12N15/905 , C12Q1/02 , C12Q1/68
摘要： Materials and methods for homologous-recombination screening of r-DNA libraries constructed in a yeast host and methods for homologous-recombination chromosome walking for isolating overlapping DNA sequences for building an extended physical map of a chromosomal region.
摘要翻译：用于在酵母宿主中构建的r-DNA文库的同源重组筛选的材料和方法以及用于分离重叠DNA序列的同源重组染色体步行方法，用于构建染色体区域的扩展物理图谱。

7. 发明授权

US09267166B2 Treatment of α-galactosidase A deficiency 有权
公开(公告)号：US09267166B2
公开(公告)日：2016-02-23
申请号：US12761287
申请日：2010-04-15
申请人： Douglas A. Treco , Kenneth Loveday , Marianne Borowski
发明人： Douglas A. Treco , Kenneth Loveday , Marianne Borowski
IPC分类号： A61K8/73 , C12Q1/54 , A61K38/47 , A61K38/00
CPC分类号： A61K38/47 , A61K38/00 , C12Q1/54 , C12Y302/01022 , G01N2400/10
摘要： The invention provides methods of treating α-galactosidase A deficiency. Dosage forms, methods of administration, and methods of analyzing human α-galactosidase A are also included.

8. 发明授权

US06924365B1 Optimized messenger RNA 有权
标题翻译：优化信使RNA
公开(公告)号：US06924365B1
公开(公告)日：2005-08-02
申请号：US09407605
申请日：1999-09-28
申请人： Allan M. Miller , Douglas A. Treco , Richard F Selden
发明人： Allan M. Miller , Douglas A. Treco , Richard F Selden
IPC分类号： C07H21/04 , C07K14/755 , C12N9/64 , C12N15/00
CPC分类号： C12N9/644 , C07K14/755 , C12Y304/21022
摘要： The present invention is directed to a synthetic nucleic acid sequence which encodes a protein wherein at least one non-common codon or less-common codon is replaced by a common codon. The synthetic nucleic acid sequence can include a continuous stretch of at least 90 codons all of which are common codons.
摘要翻译：本发明涉及编码蛋白质的合成核酸序列，其中至少一个非共同密码子或更少共同密码子被共同密码子替代。合成核酸序列可以包括至少90个密码子的连续延伸，所有这些密码子都是常见的密码子。

9. 发明授权

US06458574B1 Treatment of a &agr;-galactosidase a deficiency 有权
标题翻译：治疗α-半乳糖苷酶缺乏症
公开(公告)号：US06458574B1
公开(公告)日：2002-10-01
申请号：US09266014
申请日：1999-03-11
申请人： Richard F Selden , Marianne Borowski , Carol M. Kinoshita , Douglas A. Treco , Melanie D. Williams , Thomas J. Schuetz , Peter F. Daniel
发明人： Richard F Selden , Marianne Borowski , Carol M. Kinoshita , Douglas A. Treco , Melanie D. Williams , Thomas J. Schuetz , Peter F. Daniel
IPC分类号： C12N940
CPC分类号： C07K14/61 , A61K38/00 , C07K2319/00 , C07K2319/02 , C12N9/2465 , C12Y302/01022
摘要： The invention provides highly purified &agr;-Gal A, and various methods for purifying it; &agr;-Gal A preparations with altered charge and methods for making those preparations; &agr;-Gal A preparations that have an extended circulating half-life in a mammalian host, and methods for making same; and methods and dosages for administering an &agr;-Gal A preparation to a subject.
摘要翻译：本发明提供了高度纯化的α-GalA和各种纯化方法; 具有改变电荷的α-GalA制剂和制备这些制剂的方法; α-Gal在哺乳动物宿主中具有延长的循环半衰期的制剂及其制备方法; 以及用于向受试者施用α-GalA制剂的方法和剂量。

10. 发明授权

US06270989B1 Protein production and delivery 失效
标题翻译：蛋白质生产和递送
公开(公告)号：US06270989B1
公开(公告)日：2001-08-07
申请号：US08406030
申请日：1995-03-17
申请人： Douglas A. Treco , Michael W. Heartlein , Brian M. Hauge , Richard F Selden
发明人： Douglas A. Treco , Michael W. Heartlein , Brian M. Hauge , Richard F Selden
IPC分类号： C12P2102
CPC分类号： A61K48/00 , A01K2217/05 , A61K38/00 , C07K14/505 , C07K14/524 , C07K14/565 , C07K14/605 , C07K14/61 , C07K2319/00 , C07K2319/02 , C12N9/16 , C12N15/67 , C12N15/85 , C12N15/907 , C12N2510/02 , C12N2840/44
摘要： The invention relates to novel human DNA sequences, targeting constructs, and methods for producing novel genes encoding thrombopoietin, DNase I, and &bgr;-interferon by homologous recombination. The targeting constructs comprise at least: a) a targeting sequence; b) a regulatory sequence; c) an exon; and d) a splice-donor site. The targeting constructs, which can undergo homologous recombination with endogenous cellular sequences to generate a novel gene, are introduced into cells to produce homologously recombinant cells. The homologously recombinant cells are then maintained under conditions which will permit transcription of the novel gene and translation of the mRNA produced, resulting in production of either thrombopoietin, DNase I, or &bgr;-interferon. The invention further relates to a methods of producing pharmaceutically useful preparations containing thrombopoietin, DNase I, or &bgr;-interferon from homologously recombinant cells and methods of gene therapy comprising administering homologously recombinant cells producing thrombopoietin, DNase I, or &bgr;-interferon to a patient for therapeutic purposes.
摘要翻译：本发明涉及新的人DNA序列，靶向构建体，以及通过同源重组产生编码血小板生成素，DNA酶I和β-干扰素的新基因的方法。靶向构建体至少包括：a）靶向序列; b）调节序列; c）外显子和d）剪接供体位点。将可与内源细胞序列进行同源重组以产生新基因的靶向构建体导入细胞以产生同源重组细胞。然后将同源重组细胞保持在允许新基因转录和产生的mRNA翻译的条件下，导致产生血小板生成素，DNA酶I或β-干扰素。本发明进一步涉及一种生产含有血浆生成素，DNA酶I或β-干扰素的同种重组细胞的药用制剂的方法和基因治疗方法，包括向患者施用产生血小板生成素，DNA酶I或β-干扰素的同源重组细胞，治疗目的。

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