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1. 发明授权

US08969087B2 Method of pre-treatment and staining of a biological sample and device for support of a biological sample and methods of using such device 有权
标题翻译：用于支持生物样品的生物样品和装置的预处理和染色方法以及使用这种装置的方法
公开(公告)号：US08969087B2
公开(公告)日：2015-03-03
申请号：US13605228
申请日：2012-09-06
申请人： Loren L. Bland , Marc E. Key , Lars Winther , David A. Stanforth , Martin N. Lindberg
发明人： Loren L. Bland , Marc E. Key , Lars Winther , David A. Stanforth , Martin N. Lindberg
IPC分类号： G01N33/00 , G01N1/30 , B01L3/00 , G01N1/31 , G01N35/00
CPC分类号： G01N1/30 , B01L3/545 , B01L2300/023 , B01L2300/024 , B01L2300/0822 , G01N1/312 , G01N35/00732 , G01N2035/00782 , Y10T436/255
摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.
摘要翻译：公开了根据方案对设置在载体表面上的生物样品进行预处理和染色的方法，所述方法包括以下步骤：将与至少一个方案步骤相关的至少一个参数记录在非 - 位于载体上或载体内的易失性存储器或包含载体的装置。还公开了一种装置，包括：非易失性存储器; 该装置的表面适于携带生物样品; 以及电连接到存储器的通信装置，用于使能到外部设备的数据传输。还公开了一种控制设置在载体上的生物样品的处理的方法，包括：在载体或保持载体的装置的上方或内部提供具有与样品处理优先级或方案有关的信息的非易失性存储器; 阅读信息; 并基于该信息调度处理。

2. 发明授权

US08283176B2 Method of pre-treatment and staining of a biological sample and device for support of a biological sample and methods of using such device 有权
标题翻译：用于支持生物样品的生物样品和装置的预处理和染色方法以及使用这种装置的方法
公开(公告)号：US08283176B2
公开(公告)日：2012-10-09
申请号：US11168987
申请日：2005-06-28
申请人： Loren L. Bland , Marc E. Key , Lars Winther , David A. Stanforth , Martin N. Lindberg
发明人： Loren L. Bland , Marc E. Key , Lars Winther , David A. Stanforth , Martin N. Lindberg
IPC分类号： G01N33/00
CPC分类号： G01N1/30 , B01L3/545 , B01L2300/023 , B01L2300/024 , B01L2300/0822 , G01N1/312 , G01N35/00732 , G01N2035/00782 , Y10T436/255
摘要： There is disclosed a method of pre-treatment and staining, according to a protocol, of a biological sample disposed upon the surface of a carrier, the method comprising the step of recording at least one parameter relating to at least one protocol step in a non-volatile memory located either upon or within the carrier or a device incorporating the carrier. Also disclosed is a device comprising: a non-volatile memory; a surface of the device adapted to carry a biological sample; and communications means electrically coupled to the memory for enabling data transmission to or from an external apparatus. Also disclosed is a method of controlling processing of a biological sample disposed upon a carrier, comprising: providing, upon or within the carrier or an apparatus holding the carrier, a non-volatile memory having information relating to sample processing priority or protocol; reading the information; and scheduling the processing based upon the information.
摘要翻译：公开了根据方案对设置在载体表面上的生物样品进行预处理和染色的方法，所述方法包括以下步骤：将与至少一个方案步骤相关的至少一个参数记录在非 - 位于载体上或载体内的易失性存储器或包含载体的装置。还公开了一种装置，包括：非易失性存储器; 所述装置的表面适于携带生物样品; 以及电连接到存储器的通信装置，用于使能到外部设备的数据传输。还公开了一种控制设置在载体上的生物样品的处理的方法，包括：在载体或保持载体的装置的上方或内部提供具有与样品处理优先级或方案有关的信息的非易失性存储器; 阅读信息; 并基于该信息调度处理。

3. 发明授权

US07875245B2 Method and apparatus for automated pre-treatment and processing of biological samples 有权
标题翻译：用于生物样品自动预处理和处理的方法和装置
公开(公告)号：US07875245B2
公开(公告)日：2011-01-25
申请号：US11156760
申请日：2005-06-20
申请人： John A. Favuzzi , Kristopher S. Buchanan , Michael T. Barber , Loren L. Bland , Dawn M. Rohrbacker , Robert M. Clark , Gordon A. Feingold , Benno M. Guggenheimer , Marc E. Key , Merritt M. Martin, Jr. , Robert L. Lathrop , Jeffery L. Rau , Jonathan R. Sweda , Douglas F. Sweet , John E. Van Bosch , Lars Winther , Rosanne Welcher
发明人： John A. Favuzzi , Kristopher S. Buchanan , Michael T. Barber , Loren L. Bland , Dawn M. Rohrbacker , Robert M. Clark , Gordon A. Feingold , Benno M. Guggenheimer , Marc E. Key , Merritt M. Martin, Jr. , Robert L. Lathrop , Jeffery L. Rau , Jonathan R. Sweda , Douglas F. Sweet , John E. Van Bosch , Lars Winther , Rosanne Welcher
IPC分类号： B01L3/02
CPC分类号： G01N35/0092 , B01L3/508 , B01L7/00 , B01L9/06 , B01L2200/025 , B01L2200/16 , B01L2300/021 , B01L2300/0822 , B01L2300/1822 , G01N1/312 , G01N35/00029 , G01N35/00871 , G01N35/0095 , G01N35/0099 , G01N35/1002 , G01N35/1004 , G01N35/1011 , G01N2035/00356 , G01N2035/00366 , G01N2035/00445 , G01N2035/00455 , G01N2035/00534 , G01N2035/00633 , G01N2035/00673 , G01N2035/00752 , G01N2035/00861 , G01N2035/00881 , G01N2035/102 , G01N2035/1058 , Y02A90/26 , Y10T436/11 , Y10T436/112499 , Y10T436/12 , Y10T436/2575
摘要： The present invention concerns a method and apparatus for automatic processing a biological sample on a carrier, perhaps robotically, by applying predetermined amounts of reagents in a predetermined sequence according to a processing protocol, the processing including pre-treatment steps, under the control of an adaptive processing control system using a sample process parameter input that may be independent and an independent process parameter memory that does not interrupt process operation when being used, such that samples may be added or removed without interrupting the processing of other samples. Also included is an image capture function for sample and reagent identification and process monitoring, as well as temperature regulation and environmental control functions.
摘要翻译：本发明涉及一种用于通过根据处理方案以预定顺序施加预定量的试剂来自动地处理载体上的生物样品的方法和装置，所述方法和装置可以机器人地处理，所述处理包括预处理步骤，在自适应处理控制系统使用可以是独立的样本过程参数输入和在使用时不中断处理操作的独立过程参数存储器，使得可以添加或移除样本而不中断其他样本的处理。还包括用于样品和试剂识别和过程监测以及温度调节和环境控制功能的图像捕获功能。

4. 发明申请

US20080194508A1 Cell Counting 有权
标题翻译：细胞计数
公开(公告)号：US20080194508A1
公开(公告)日：2008-08-14
申请号：US11884247
申请日：2006-02-06
申请人： Nanna K. Christensen , Jesper Laursen , Lars Winther
发明人： Nanna K. Christensen , Jesper Laursen , Lars Winther
IPC分类号： A61K31/70 , C12Q1/06 , G01N33/569 , A61P43/00 , A61K31/59 , C12M1/00
CPC分类号： G01N15/1459 , G01N33/543 , G01N33/54366 , G01N33/54393 , G01N2015/1486 , Y10T436/101666
摘要： The inventions relates to compositions and method for determining the absolute counts of cells per unit volume of a sample. Such a method comprises: (a) providing a container containing: (i) a predetermined quantity of microparticles; and (ii) a cell-binding agent; in which the microparticles are disposed in or on a matrix which adheres to at least one wall of the container such that substantially all the microparticles are thereby attached to the container; (b) adding a known volume of sample to the container; (c) determining the ratio of microparticles to cells by counting microparticles and cells in a volume of the sample; and (d) determining the absolute count of cells by multiplying the number of cells per microparticle by the concentration of microparticles in the sample. Preferably, the matrix retains substantially all the microparticles in or on the container during routine handling, including inversion, of the container, in the absence of mechanical retaining means such as a retainer grid in the container.
摘要翻译：本发明涉及用于确定样品每单位体积的细胞的绝对计数的组合物和方法。这种方法包括：（a）提供容器，其包含：（i）预定量的微粒; 和（ii）细胞结合剂; 其中微粒设置在基质中或基体上，该基质附着在容器的至少一个壁上，使得基本上所有的微粒从而附着到容器上; （b）向容器中加入已知体积的样品; （c）通过计数样品体积中的微粒和细胞来确定微粒与细胞的比例; 和（d）通过将每个微粒的细胞数乘以样品中微粒的浓度来确定细胞的绝对计数。优选地，在没有诸如容器中的保持架网格的机械保持装置的情况下，基体在基本上将容器内的所有微粒保持在容器的常规处理（包括反转）中。

5. 发明申请

US20050208529A1 Methods and compositions for immuno-histochemical detection 有权
标题翻译：免疫组织化学检测的方法和组成
公开(公告)号：US20050208529A1
公开(公告)日：2005-09-22
申请号：US10999102
申请日：2004-11-30
申请人： Lars Winther , Anthony Knoll , Kellyann Weckworth , Uffe Lovborg
发明人： Lars Winther , Anthony Knoll , Kellyann Weckworth , Uffe Lovborg
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/537 , G01N33/543 , G01N33/58
CPC分类号： G01N33/54306 , G01N33/543 , G01N33/58
摘要： In certain embodiments the invention relates to methods and compositions for detecting a biological marker in a sample. In certain embodiments the biological markers are detected immunologically.
摘要翻译：在某些实施方案中，本发明涉及用于检测样品中生物标志物的方法和组合物。在某些实施方案中，免疫学检测生物学标记。

6. 发明授权

US08632739B2 Apparatus and methods for processing biological samples and a reservoir therefor 有权
标题翻译：用于处理生物样品的装置和方法及其储存器
公开(公告)号：US08632739B2
公开(公告)日：2014-01-21
申请号：US13472777
申请日：2012-05-16
申请人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
发明人： Gregory A. Testa , Tim Svenstrup Poulsen , Steen Hauge Matthiesen , Ole Feldballe Rasmussen , Lars Winther
IPC分类号： B01L3/00
CPC分类号： C12Q1/6841 , B01L3/508 , B01L7/52 , B01L2200/142 , B01L2300/043 , B01L2300/069 , B01L2300/0822 , B01L2300/10 , B01L2300/1822 , B01L2300/1844 , C12M41/14 , C12M41/36 , G01N1/312 , Y10T436/143333
摘要： An apparatus for processing at least one biological sample accommodated on at least one carrier member (15) in a chamber includes, at least one reservoir (18) able to accommodate a fluid on a surface inside the chamber adjacent to and/or facing a substantial part of the at least one biological sample. The apparatus may comprise a bottom member (12) arranged to support at least one carrier member (15) carrying at least one biological sample and a lid (14) including at least one fluid reservoir (18). The reservoir filled with water provides humidity to the chamber and impedes drying out of the sample.
摘要翻译：用于处理容纳在腔室中的至少一个载体构件（15）上的至少一个生物样品的装置包括：至少一个储存器（18），其能够容纳与所述腔室内的表面相邻和/或面对实质的流体至少一种生物样品的一部分。该装置可以包括底部构件（12），该底部构件（12）被布置成支撑承载至少一个生物样品的至少一个载体构件（15）和包括至少一个流体储存器（18）的盖子（14）。充满水的储存器为室提供湿气并阻止样品干燥。

7. 发明授权

US08541227B2 Cell counting 有权
标题翻译：细胞计数
公开(公告)号：US08541227B2
公开(公告)日：2013-09-24
申请号：US11884247
申请日：2006-02-06
申请人： Nanna K Christensen , Jesper Laursen , Lars Winther
发明人： Nanna K Christensen , Jesper Laursen , Lars Winther
IPC分类号： C12M1/34 , G01N33/543 , G01N31/22
CPC分类号： G01N15/1459 , G01N33/543 , G01N33/54366 , G01N33/54393 , G01N2015/1486 , Y10T436/101666
摘要： The inventions relates to compositions and method for determining the absolute counts of cells per unit volume of a sample. Such a method comprises: (a) providing a container containing (i) a predetermined quantity of microparticles; and (ii) a cell-binding agent; in which the microparticles are disposed in or on a matrix which adheres to at least one wall of the container such that substantially all the microparticles are thereby attached to the container; (b) adding a known volume of sample to the container; (c) determining the ratio of microparticles to cells by counting microparticles and cells in a volume of the sample; and (d) determining the absolute count of cells by multiplying the number of cells per microparticle by the concentration of microparticles in the sample. Preferably, the matrix retains substantially all the microparticles in or on the container during routine handling, including inversion, of the container, in the absence of mechanical retaining means such as a retainer grid in the container.
摘要翻译：本发明涉及用于确定样品每单位体积的细胞的绝对计数的组合物和方法。这种方法包括：（a）提供容器，其容纳（i）预定量的微粒; 和（ii）细胞结合剂; 其中微粒设置在基质中或基体上，该基质附着在容器的至少一个壁上，使得基本上所有的微粒从而附着到容器上; （b）向容器中加入已知体积的样品; （c）通过计数样品体积中的微粒和细胞来确定微粒与细胞的比例; 和（d）通过将每个微粒的细胞数乘以样品中微粒的浓度来确定细胞的绝对计数。优选地，在没有诸如容器中的保持架网格的机械保持装置的情况下，基体在基本上将容器内的所有微粒保持在容器的常规处理（包括反转）中。

8. 发明授权

US08216512B2 Apparatus for automated processing biological samples 有权
标题翻译：用于自动处理生物样品的装置
公开(公告)号：US08216512B2
公开(公告)日：2012-07-10
申请号：US10539308
申请日：2003-12-19
申请人： Lars Winther , Marc Key , Kristopher S. Buchanan , John Favuzzi , Benno Guggenheimer
发明人： Lars Winther , Marc Key , Kristopher S. Buchanan , John Favuzzi , Benno Guggenheimer
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.
摘要翻译：本发明涉及一种用于根据处理方案以预定顺序施加预定量的试剂来自动处理容纳在载体构件如载玻片上的至少一种生物样品的装置，所述装置包括：一个框架; 至少一个处理部分，用于容纳至少一个滑块，所述至少一个处理部分设置在所述壳体内; 保护所述壳体中的至少一个处理部分的罩盖; 其中所述罩盖完全包围限定内部空间的所述处理部分; 并且其中所述装置还包括设置用于控制所述内部空间内的环境的气候控制装置。

9. 发明申请

US20060154234A1 Standard 审中-公开
标题翻译：标准
公开(公告)号：US20060154234A1
公开(公告)日：2006-07-13
申请号：US10563820
申请日：2004-07-08
申请人： Lars Winther , Kunt Pll
发明人： Lars Winther , Kunt Pll
IPC分类号： C12Q1/00 , C12Q1/68 , G01N33/567
CPC分类号： G01N33/5005 , C12Q1/6841 , G01N1/36 , G01N33/54346 , G01N33/54353 , G01N33/54386 , G01N33/96 , G01N2001/2893 , G01N2496/00 , C12Q2545/113
摘要： Disclosed is a reference standard for a detectable entity, the reference standard comprising a support medium, such as an embedding medium, a compact particle having a compact shape with a quantity of detectable entity coupled thereto and supported by the medium, in which the compact particle is a biological, such as a cellular compact particle. We also disclose a reference standard for a detectable entity, the reference standard comprising a support medium, such as an embedding medium, a compact particle having a compact shape with a quantity of detectable entity coupled thereto and supported by the medium, in which the compact particle is a non-biological compact particle, such as a non-cellular compact particle having cell-like dimensions, preferably less than 1.5 mm.
摘要翻译：公开了可检测实体的参考标准，参考标准包括支持介质，例如嵌入介质，具有紧凑形状的致密颗粒，其具有与其连接并由介质支持的可检测实体的量，其中致密颗粒是生物的，例如细胞紧密颗粒。我们还公开了可检测实体的参考标准，参考标准包括支持介质，例如嵌入介质，具有紧凑形状的致密颗粒，其具有与其连接并由介质支持的可检测实体的量，其中紧凑型颗粒是非生物致密颗粒，例如具有细胞样尺寸，优选小于1.5mm的非细胞致密颗粒。

10. 发明申请

US20060045806A1 Apparatus for automated processing biological samples 有权
公开(公告)号：US20060045806A1
公开(公告)日：2006-03-02
申请号：US10539308
申请日：2003-12-19
申请人： Lars Winther , Marc Key , Kristopher Buchanan , John Favuzzi , Benno Guggenheimer
发明人： Lars Winther , Marc Key , Kristopher Buchanan , John Favuzzi , Benno Guggenheimer
IPC分类号： G01N35/00
CPC分类号： G01N35/00732 , G01N1/30 , G01N1/31 , G01N1/312 , G01N35/00712 , G01N35/00871 , G01N35/0092 , G01N35/0099 , G01N2035/00039 , G01N2035/00089 , G01N2035/00306 , G01N2035/00326 , G01N2035/00366 , G01N2035/00376 , G01N2035/00435 , G01N2035/00881 , G01N2035/00891 , G16H50/20 , Y02A90/22 , Y02A90/26 , Y10S901/02 , Y10S901/41 , Y10T436/11 , Y10T436/112499 , Y10T436/113332 , Y10T436/114165 , Y10T436/114998 , Y10T436/25 , Y10T436/2575
摘要： The present invention concerns an apparatus for automatic processing at least one biological sample accommodated on a carrier member, such as a slide by applying a predetermined amount of reagents in a predetermined sequence according to a processing protocol, said apparatus comprising; a housing frame; at least one processing section for accommodating at least one slide, the at least one processing section is provided within the housing; a hood cover protecting the at least one processing section in said housing; wherein the hood cover completely encloses the processing section defining an interior space; and wherein the apparatus further comprises climate control device provided to control the environment within the interior space.

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