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1. 发明授权

US06840956B1 Systems and methods for deploying a biosensor with a stent graft 失效
标题翻译：用支架移植物部署生物传感器的系统和方法
公开(公告)号：US06840956B1
公开(公告)日：2005-01-11
申请号：US09522724
申请日：2000-03-10
申请人： Lone Wolinsky , Avi Penner
发明人： Lone Wolinsky , Avi Penner
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/026 , A61B5/07 , A61B5/11 , A61B5/02
CPC分类号： A61B5/6876 , A61B5/01 , A61B5/02014 , A61B5/0215 , A61B5/026 , A61B5/076 , A61B5/11 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/6862 , A61B2560/0214
摘要： A stent graft includes a tubular prosthetic graft, a support structure expandable between contracted and enlarged conditions, and a biosensor attached thereto. The biosensor may be directly attached to an outer surface of the graft, to struts defining the support structure, or by one or more filaments configured to dispose the biosensor beyond an outer surface of the stent graft. When the biosensor is attached by one or more filaments, the stent graft is mounted in a contracted profile on a delivery apparatus with the biosensor disposed adjacent to the stent graft thereon. The stent graft is introduced into a blood vessel in the contracted profile, and advanced endolumenally until it is positioned across an aneurysm. The stent graft is expanded towards an enlarged profile such that ends of the stent graft engage healthy regions of the vessel adjacent to the aneurysm, thereby isolating the aneurysm from the rest of the vessel with the biosensor disposed within the aneurysmal sac, the biosensor allowing remote monitoring of pressure or other conditions to detect an endoleak or excessive pressure therein.
摘要翻译：支架移植物包括管状假体移植物，在收缩和扩大的病症之间可扩张的支撑结构和附接到其上的生物传感器。生物传感器可以直接附接到移植物的外表面，限定支撑结构的支柱，或由构造成将生物传感器配置成超过支架移植物外表面的一根或多根细丝。当生物传感器通过一根或多根细丝附着时，将支架移植物安装在输送装置上的收缩轮廓中，其中生物传感器邻近其上的支架移植物放置。将支架移植物引入到收缩型材中的血管中，并且先进的内窥镜直到其跨越动脉瘤定位。支架移植物朝向扩大的轮廓扩张，使得支架移植物的端部接合与动脉瘤邻近的血管的健康区域，从而将动脉瘤与容纳物的其余部分隔离，生物传感器设置在动脉瘤囊内，生物传感器允许远程监测压力或其他条件以检测其中的内泄或过压。

2. 再颁专利

USRE42378E1 Implantable pressure sensors and methods for making and using them 有权
标题翻译：可植入压力传感器及其制造和使用的方法
公开(公告)号：USRE42378E1
公开(公告)日：2011-05-17
申请号：US11491533
申请日：2006-07-20
申请人： Lone Wolinsky , Eyal Doron , Alon Ben-Yoseph , Avi Penner
发明人： Lone Wolinsky , Eyal Doron , Alon Ben-Yoseph , Avi Penner
IPC分类号： A61B5/04
CPC分类号： A61B5/0028 , A61B5/0031 , A61B5/01 , A61B5/0215 , A61B5/031 , A61B5/053 , A61B5/076 , A61B5/14539 , A61B2560/0219 , A61B2562/0247 , A61B2562/028 , A61N1/37217 , A61N1/3787 , A61N5/0601 , A61N5/062 , A61N2005/0651
摘要： An implant includes a pressure sensor, a controller for acquiring pressure data from the sensor, and an acoustic transducer for converting energy between electrical energy and acoustic energy. A capacitor is coupled to the acoustic transducer for storing electrical energy converted by the transducer and/or for providing electrical energy to operate the implant. The acoustic transducer may operate alternatively or simultaneously as an energy exchanger or an acoustic transmitter. During use, the implant is implanted within a patient's body, and an external transducer transmits a first acoustic signal into the patient's body, to energize the capacitor. The implant then obtains pressure data, and transmits a second acoustic signal to the external transducer, the second acoustic signal including the pressure data.
摘要翻译：植入物包括压力传感器，用于从传感器获取压力数据的控制器和用于在电能和声能之间转换能量的声换能器。电容器耦合到声换能器，用于存储由换能器转换的电能和/或用于提供电能以操作植入物。声换能器可以作为能量交换器或声发射器交替地或同时地操作。在使用期间，将植入物植入患者体内，并且外部换能器将第一声信号传送到患者体内，以激励电容器。然后，植入物获得压力数据，并将第二声学信号发送到外部换能器，第二声学信号包括压力数据。

3. 发明授权

US06699186B1 Methods and apparatus for deploying and implantable biosensor 有权
标题翻译：用于部署和植入生物传感器的方法和装置
公开(公告)号：US06699186B1
公开(公告)日：2004-03-02
申请号：US09523414
申请日：2000-03-10
申请人： Lone Wolinsky , Avi Penner
发明人： Lone Wolinsky , Avi Penner
IPC分类号： A61B500
CPC分类号： A61B5/6876 , A61B1/00147 , A61B5/02014 , A61B5/0215 , A61B5/026 , A61B5/076 , A61B5/11 , A61B5/14546 , A61B5/6862
摘要： An implantation device for delivering a biosensor to an implantation site in a patient's body comprises an elongate catheter equipped with a distally located cavity sized to house a biosensor. Once the distal end of the catheter is positioned adjacent the implantation site, the biosensor is released through an opening from the cavity into the site. A removable cover, such as a thin adhesive film, may be used to retain the biosensor in the cavity, while the catheter is guided through the body to the implantation site. The implantation device may include an actuator for displacing the biosensor from the cavity into the implantation site. By way of one example, the actuator may be a piston inserted through a lumen of the catheter.
摘要翻译：用于将生物传感器递送到患者体内的植入部位的植入装置包括：细长导管，其具有设置成容纳生物传感器的位于远侧的腔。一旦导管的远端位于植入位置附近，生物传感器通过从空腔的开口释放到现场。可以使用诸如薄的粘合剂膜的可移除的盖子将生物传感器保持在空腔中，同时导管被引导穿过身体到植入部位。植入装置可以包括用于将生物传感器从腔体移位到植入部位的致动器。作为一个示例，致动器可以是穿过导管的内腔插入的活塞。

4. 发明授权

US06743173B2 Systems and methods for deploying a biosensor in conjunction with a prosthesis 有权
标题翻译：与假体一起部署生物传感器的系统和方法
公开(公告)号：US06743173B2
公开(公告)日：2004-06-01
申请号：US10122015
申请日：2002-04-12
申请人： Avi Penner , Lone Wolinsky
发明人： Avi Penner , Lone Wolinsky
IPC分类号： A61B500
CPC分类号： A61B5/6876 , A61B5/0031 , A61B5/02007 , A61B5/02014 , A61B5/0215 , A61B5/036 , A61B5/6862 , A61F2/07 , A61F2/89 , A61F2002/075 , A61F2250/0002
摘要： A biosensor for monitoring pressure or other physical parameters at an aneurysm site is mountable to a tubular prosthesis that is expandable between contracted and enlarged conditions. A loop, having the biosensor attached thereto, is securable around the prosthesis. An apparatus is used to deliver the loop to an aneurysm site that includes a catheter having a connector on its distal end for detachably securing the loop thereto. The prosthesis is advanced in a contracted state to the aneurysm, and the apparatus, with the loop connected thereto, is advanced to the aneurysm site. The loop and the prosthesis are positioned coaxially with respect to one another, and the prosthesis is expanded towards its enlarged condition, thereby engaging the loop around the prosthesis and engaging the prosthesis with a wall of the blood vessel at the treatment site.
摘要翻译：用于监测动脉瘤部位的压力或其他物理参数的生物传感器可安装到管状假体，该假体在收缩和扩大的条件之间是可扩展的。具有连接到其上的生物传感器的环可绕假体保持。使用一种装置将循环递送到动脉瘤部位，该动脉瘤部位包括在其远端具有连接器的导管，用于将环可拆卸地固定到其上。假体在收缩状态下进入动脉瘤，并且将与其连接的环路的装置推进到动脉瘤部位。环和假体相对于彼此同轴地定位，并且假体向其扩大的状态扩张，从而使环绕假体接合并且将假体与治疗部位处的血管的壁接合。

5. 发明授权

US06764446B2 Implantable pressure sensors and methods for making and using them 有权
标题翻译：可植入压力传感器及其制造和使用的方法
公开(公告)号：US06764446B2
公开(公告)日：2004-07-20
申请号：US09888272
申请日：2001-06-21
申请人： Lone Wolinsky , Eyal Doron , Alon Ben-Yosefh , Avi Penner
发明人： Lone Wolinsky , Eyal Doron , Alon Ben-Yosefh , Avi Penner
IPC分类号： A61B504
CPC分类号： A61B5/0028 , A61B5/0031 , A61B5/01 , A61B5/0215 , A61B5/031 , A61B5/053 , A61B5/076 , A61B5/14539 , A61B2560/0219 , A61B2562/0247 , A61B2562/028 , A61N1/37217 , A61N1/3787 , A61N5/0601 , A61N5/062 , A61N2005/0651
摘要： An implant includes a pressure sensor, a controller for acquiring pressure data from the sensor, and an acoustic transducer for converting energy between electrical energy and acoustic energy. A capacitor is coupled to the acoustic transducer for storing electrical energy converted by the transducer and/or for providing electrical energy to operate the implant. The acoustic transducer may operate alternatively or simultaneously as an energy exchanger or an acoustic transmitter. During use, the implant is implanted within a patient's body, and an external transducer transmits a first acoustic signal into the patient's body, to energize the capacitor. The implant then obtains pressure data, and transmits a second acoustic signal to the external transducer, the second acoustic signal including the pressure data.
摘要翻译：植入物包括压力传感器，用于从传感器获取压力数据的控制器和用于在电能和声能之间转换能量的声换能器。电容器耦合到声换能器，用于存储由换能器转换的电能和/或用于提供电能以操作植入物。声换能器可以作为能量交换器或声发射器交替地或同时地操作。在使用期间，将植入物植入患者体内，并且外部换能器将第一声信号传送到患者体内，以激励电容器。然后，植入物获得压力数据，并将第二声学信号发送到外部换能器，第二声学信号包括压力数据。

6. 发明授权

US06416474B1 Systems and methods for deploying a biosensor in conjunction with a prosthesis 有权
标题翻译：与假体一起部署生物传感器的系统和方法
公开(公告)号：US06416474B1
公开(公告)日：2002-07-09
申请号：US09522370
申请日：2000-03-10
申请人： Avi Penner , Lone Wolinsky
发明人： Avi Penner , Lone Wolinsky
IPC分类号： A61B500
CPC分类号： A61B5/6876 , A61B5/0031 , A61B5/02007 , A61B5/02014 , A61B5/0215 , A61B5/036 , A61B5/6862 , A61F2/07 , A61F2/89 , A61F2002/075 , A61F2250/0002
摘要： A biosensor for monitoring pressure or other physical parameters at an aneurysm site is mountable to a tubular prosthesis that is expandable between contracted and enlarged conditions. A loop, having the biosensor attached thereto, is securable around the prosthesis. An apparatus is used to deliver the loop to an aneurysm site that includes a catheter having a connector on its distal end for detachably securing the loop thereto. The prosthesis is advanced in a contracted state to the aneurysm, and the apparatus, with the loop connected thereto, is advanced to the aneurysm site. The loop and the prosthesis are positioned coaxially with respect to one another, and the prosthesis is expanded towards its enlarged condition, thereby engaging the loop around the prosthesis and engaging the prosthesis with a wall of the blood vessel at the treatment site.
摘要翻译：用于监测动脉瘤部位的压力或其他物理参数的生物传感器可安装到管状假体，该假体在收缩和扩大的条件之间是可扩展的。具有连接到其上的生物传感器的环可绕假体保持。使用一种装置将循环递送到动脉瘤部位，该动脉瘤部位包括在其远端具有连接器的导管，用于将环可拆卸地固定到其上。假体在收缩状态下进入动脉瘤，并且将与其连接的环路的装置推进到动脉瘤部位。环和假体相对于彼此同轴地定位，并且假体向其扩大的状态扩张，从而使环绕假体接合并且将假体与治疗部位处的血管的壁接合。

7. 发明授权

US07283874B2 Acoustically powered implantable stimulating device 有权
标题翻译：声学动力植入式刺激装置
公开(公告)号：US07283874B2
公开(公告)日：2007-10-16
申请号：US10632265
申请日：2003-07-31
申请人： Avi Penner
发明人： Avi Penner
IPC分类号： A61N1/378
CPC分类号： A61N1/08 , A61B5/0031 , A61B2017/00026 , A61B2560/0219 , A61B2562/028 , A61N1/362 , A61N1/3718 , A61N1/37217 , A61N1/3787 , A61N7/00
摘要： An implantable stimulation system comprises an implantable stimulator and a control device. The control device is configured to transmit acoustic waves to the implantable stimulator, and the implantable stimulator is configured to transform the acoustic waves into electrical current, and generate stimulation energy based on the electrical current. For example, the electrical current can be transformed into electrical energy that can be used to generate the stimulation energy. Or the electrical current can contain signals used to directly or indirectly control the generation of the stimulation energy.
摘要翻译：可植入刺激系统包括可植入刺激器和控制装置。控制装置被配置为将声波传播到可植入刺激器，并且可植入刺激器被配置为将声波转换成电流，并且基于电流产生刺激能量。例如，电流可以转换成可用于产生刺激能量的电能。或者电流可以包含用于直接或间接地控制产生刺激能量的信号。

8. 发明授权

US06486588B2 Acoustic biosensor for monitoring physiological conditions in a body implantation site 有权
标题翻译：用于监测身体植入部位生理状况的声学生物传感器
公开(公告)号：US06486588B2
公开(公告)日：2002-11-26
申请号：US09872129
申请日：2001-06-01
申请人： Eyal Doron , Avi Penner
发明人： Eyal Doron , Avi Penner
IPC分类号： H01L4108
CPC分类号： A61B5/031 , A61B5/0031 , A61B5/02014 , A61B5/413 , A61B2562/028 , A61M2205/3523 , H01L41/1132 , H04R17/00
摘要： An acoustic biosensor is provided for deployment at an implantation site within a body, such as an abdominal aortic aneurysm. The biosensor includes a sensor element for measuring a physiological condition at the implantation site, and for generating an information signal representative of the physiological condition. The biosensor further includes a piezoelectric transducer element for converting an externally originated acoustic interrogation signal into energy for operating the sensor, and for modulating the interrogation signal, e.g., by employing a switching element to alternate the mechanical impedance of the transducer element, to transmit the information signal outside of the body.
摘要翻译：提供声学生物传感器用于在体内的植入部位，例如腹主动脉瘤。生物传感器包括用于测量植入部位的生理状况的传感器元件，并且用于生成表示生理状态的信息信号。生物传感器还包括用于将外部产生的声讯讯信号转换成用于操作传感器的能量的压电换能器元件，并且例如通过使用开关元件来交替换能器元件的机械阻抗来调制询问信号，身体外的信息信号。

9. 发明授权

US06475170B1 Acoustic biosensor for monitoring physiological conditions in a body implantation site 有权
公开(公告)号：US06475170B1
公开(公告)日：2002-11-05
申请号：US09523413
申请日：2000-03-10
申请人： Eyal Doron , Avi Penner
发明人： Eyal Doron , Avi Penner
IPC分类号： A61B5103
CPC分类号： A61B5/02014 , A61B5/0031 , A61B5/02158 , A61B5/026 , A61B5/031 , A61B5/413 , A61B2562/028 , A61M2205/3523 , G01F1/36 , G01F1/72 , H04R17/00
摘要： An acoustic biosensor is provided for deployment at an implantation site within a body, such as an abdominal aortic aneurysm. The biosensor includes a sensor element for measuring a physiological condition at the implantation site, and for generating an information signal representative of the physiological condition. The biosensor further includes a piezoelectric transducer element for converting an externally originated acoustic interrogation signal into energy for operating the sensor, and for modulating the interrogation signal, e.g., by employing a switching element to alternate the mechanical impedance of the transducer element, to transmit the information signal outside of the body.

10. 发明授权

US06198965B1 Acoustic telemetry system and method for monitoring a rejection reaction of a transplanted organ 失效
标题翻译：用于监测移植器官排斥反应的声学遥测系统和方法
公开(公告)号：US06198965B1
公开(公告)日：2001-03-06
申请号：US09312760
申请日：1999-05-17
申请人： Avi Penner , Eyal Doron , Yariv Porat
发明人： Avi Penner , Eyal Doron , Yariv Porat
IPC分类号： A61B500
CPC分类号： A61B5/0031 , A61B5/0535 , A61B5/413 , A61B2562/028 , A61N1/37252 , A61N1/37288 , H04R17/00
摘要： A telemetry system for monitoring a rejection reaction of a transplanted organ being transplanted within a patient's body is provided. The telemetry system includes (a) a telemetry control unit located outside the body of the patient; and (b) a telemetry monitoring unit implanted within the body of the patient, the telemetry monitoring unit including: (i) at least one acoustic transducer being for receiving an acoustic signal from the telemetry control unit and converting the acoustic signal into a first electrical signal, the at least one acoustic transducer further being for receiving a second electrical signal and converting the second electrical signal into a transmitted acoustic signal receivable by the telemetry monitoring unit; and (ii) a plurality of electrodes positionable in intimate contact with, or deep within, the transplanted organ and being in communication with the at least one acoustic transducer, the plurality of electrodes being for passing the first electrical signal through the transplanted organ for monitoring the electrical impedance thereof and further being for relaying the second electrical signal corresponding to the electrical impedance to the at least one acoustic transducer so as to enable the monitoring of the presence or absence of the rejection reaction.
摘要翻译：提供了一种用于监测被移植在患者体内的移植器官的排斥反应的遥测系统。遥测系统包括（a）位于患者体外的遥测控制单元; 遥测监测单元植入患者体内，遥测监测单元包括：（i）至少一个声换能器，用于接收来自遥测单元的声信号，并将声信号转换为第一电信号，所述至少一个声换能器还用于接收第二电信号并将所述第二电信号转换成可由所述遥测监测单元接收的传输声信号; 和（ii）多个电极，其定位成与移植的器官紧密接触或深入移动的器官并且与至少一个声换能器连通，所述多个电极用于使第一电信号通过移植器官用于监测其电阻抗并且还用于将对应于电阻抗的第二电信号中继到至少一个声换能器，以便能够监测是否存在排斥反应。

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