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1. 发明授权

US10390714B2 Devices for fixing a sensor in a lumen 有权
公开(公告)号：US10390714B2
公开(公告)日：2019-08-27
申请号：US11559868
申请日：2006-11-14
申请人： Lone Wolinsky , Alon Ben-Yoseph , Abraham Penner
发明人： Lone Wolinsky , Alon Ben-Yoseph , Abraham Penner
IPC分类号： A61B5/00 , A61F2/82 , A61B5/0215
摘要： Sensing devices and methods of implanting sensing devices within an anatomical vessel network of a patient are provided. In one method, a fixation element (e.g., a stent or coil) of the sensing device is expanded into firm contact with a wall of a main anatomical vessel (e.g., a right pulmonary artery), and a stabilization element of the sensing device is placed into contact with a wall of an anatomical vessel branch of the main anatomical vessel. In another method, a first fixation element of the sensing device is expanded into firm contact with the wall of the main anatomical vessel (e.g., a right pulmonary artery) at a longitudinal location proximal to the anatomical vessel branch, and a second fixation element of the sensing device is expanded into firm contact with the wall of the main anatomical vessel at a longitudinal location distal to the anatomical vessel branch.

2. 发明授权

US06840956B1 Systems and methods for deploying a biosensor with a stent graft 失效
标题翻译：用支架移植物部署生物传感器的系统和方法
公开(公告)号：US06840956B1
公开(公告)日：2005-01-11
申请号：US09522724
申请日：2000-03-10
申请人： Lone Wolinsky , Avi Penner
发明人： Lone Wolinsky , Avi Penner
IPC分类号： A61B5/00 , A61B5/0215 , A61B5/026 , A61B5/07 , A61B5/11 , A61B5/02
CPC分类号： A61B5/6876 , A61B5/01 , A61B5/02014 , A61B5/0215 , A61B5/026 , A61B5/076 , A61B5/11 , A61B5/14532 , A61B5/14546 , A61B5/1473 , A61B5/6862 , A61B2560/0214
摘要： A stent graft includes a tubular prosthetic graft, a support structure expandable between contracted and enlarged conditions, and a biosensor attached thereto. The biosensor may be directly attached to an outer surface of the graft, to struts defining the support structure, or by one or more filaments configured to dispose the biosensor beyond an outer surface of the stent graft. When the biosensor is attached by one or more filaments, the stent graft is mounted in a contracted profile on a delivery apparatus with the biosensor disposed adjacent to the stent graft thereon. The stent graft is introduced into a blood vessel in the contracted profile, and advanced endolumenally until it is positioned across an aneurysm. The stent graft is expanded towards an enlarged profile such that ends of the stent graft engage healthy regions of the vessel adjacent to the aneurysm, thereby isolating the aneurysm from the rest of the vessel with the biosensor disposed within the aneurysmal sac, the biosensor allowing remote monitoring of pressure or other conditions to detect an endoleak or excessive pressure therein.
摘要翻译：支架移植物包括管状假体移植物，在收缩和扩大的病症之间可扩张的支撑结构和附接到其上的生物传感器。生物传感器可以直接附接到移植物的外表面，限定支撑结构的支柱，或由构造成将生物传感器配置成超过支架移植物外表面的一根或多根细丝。当生物传感器通过一根或多根细丝附着时，将支架移植物安装在输送装置上的收缩轮廓中，其中生物传感器邻近其上的支架移植物放置。将支架移植物引入到收缩型材中的血管中，并且先进的内窥镜直到其跨越动脉瘤定位。支架移植物朝向扩大的轮廓扩张，使得支架移植物的端部接合与动脉瘤邻近的血管的健康区域，从而将动脉瘤与容纳物的其余部分隔离，生物传感器设置在动脉瘤囊内，生物传感器允许远程监测压力或其他条件以检测其中的内泄或过压。

3. 发明授权

US06331189B1 Flexible medical stent 有权
标题翻译：柔性医用支架
公开(公告)号：US06331189B1
公开(公告)日：2001-12-18
申请号：US09419980
申请日：1999-10-18
申请人： Lone Wolinsky , Arvi Penner
发明人： Lone Wolinsky , Arvi Penner
IPC分类号： A61F206
CPC分类号： A61F2/915 , A61F2/91 , A61F2002/91533 , A61F2002/91558 , A61F2002/91583
摘要： The present invention is directed to a radially expandable medical stent having a chevron or “maple leaf” design geometry characterized by improved scaffolding, hoop strength and longitudinal flexibility. Also described are methods of making and deploying the stents.
摘要翻译：本发明涉及一种具有人字纹或“枫叶”设计几何特征的径向可扩张的医用支架，其特征在于脚手架，环箍强度和纵向柔性。还描述了制作和展开支架的方法。

4. 发明授权

US07572228B2 Devices for fixing a sensor in a lumen 有权
标题翻译：用于将传感器固定在管腔中的装置
公开(公告)号：US07572228B2
公开(公告)日：2009-08-11
申请号：US11034502
申请日：2005-01-12
申请人： Lone Wolinsky , Alon Ben-Yoseph , Abraham Penner
发明人： Lone Wolinsky , Alon Ben-Yoseph , Abraham Penner
IPC分类号： A61B5/00
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/145 , A61B5/6882 , A61B5/6886 , A61F2/82 , A61F2/86 , A61F2230/0091 , A61F2250/0002
摘要： Apparatus for positioning at least one sensor in a body lumen, the apparatus including a fixation element, a sensor, and a connecting element that connects the sensor to the fixation element, the connecting element extending at least partially into the lumen so that the sensor is located radially inward from a wall of the lumen.
摘要翻译：用于将至少一个传感器定位在体腔中的装置，所述装置包括固定元件，传感器和将传感器连接到固定元件的连接元件，连接元件至少部分地延伸到内腔中，使得传感器从管腔的壁径向向内定位。

5. 发明授权

US06918928B2 Medical device for intraluminal endovascular stenting 有权
标题翻译：用于管腔内血管内支架术的医疗装置
公开(公告)号：US06918928B2
公开(公告)日：2005-07-19
申请号：US10377392
申请日：2003-02-28
申请人： Lone Wolinsky , Amir David Loshakove , Arvi Penner , Offer Nativ , Gil Naor , Niall Duffy
发明人： Lone Wolinsky , Amir David Loshakove , Arvi Penner , Offer Nativ , Gil Naor , Niall Duffy
IPC分类号： A61F2/84 , A61F2/00 , A61F2/06 , A61F2/90
CPC分类号： A61F2/91 , A61F2/915 , A61F2002/91525 , A61F2002/91533 , A61F2002/91583 , A61F2230/0054 , A61F2250/0098
摘要： A medical device includes a catheter and a stent mounted on the catheter, the stent having a hollow, cylindrical body made with a plurality of rings. The rings each extend circumferentially around the cylindrical body and include an undulating series of peaks and valleys. The rings are joined together by a series of links which are shaped and arranged to promote longitudinal flexibility as the stent is delivered on the catheter and effective scaffolding after deployment. In one aspect of the invention, the rings are provided with inflection points on some portions of the rings which extend in a generally circumferential direction for a short distance. A link is joined at one end at the inflection point on one ring and also joined at a second end at a second inflection point on an adjacent ring. This construction allows the crimped stent to flex longitudinally when it is subjected to bending forces such as those encountered during delivery of the stent and catheter through a tortuous coronary artery.
摘要翻译：医疗装置包括导管和安装在导管上的支架，支架具有由多个环制成的中空的圆筒体。这些环各自围绕圆柱体圆周延伸并且包括起伏的一系列峰和谷。这些环通过一系列连接件连接在一起，这些连接件成形和布置成当支架在导管上被输送并且在部署之后有效的脚手架时促进纵向柔性。在本发明的一个方面中，环在环的某些部分上设置有拐点，所述拐点在大致圆周方向上延伸短距离。连杆在一个环的拐点的一端连接，并且在相邻环上的第二拐点处的第二端处连接。这种结构允许卷曲的支架在受到弯曲力时纵向弯曲，例如在通过曲折冠状动脉输送支架和导管期间遇到的弯曲力。

6. 发明授权

US06613079B1 Radially-expandable stent with controllable force profile 有权
标题翻译：具有可控力分布的径向扩张支架
公开(公告)号：US06613079B1
公开(公告)日：2003-09-02
申请号：US09244968
申请日：1999-02-05
申请人： Lone Wolinsky , Amir Loshakove , Ofer Nativ
发明人： Lone Wolinsky , Amir Loshakove , Ofer Nativ
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2/95 , A61F2/966 , A61F2002/91533 , A61F2002/91583 , A61F2230/0054 , A61F2250/0037
摘要： The present invention provides radially-expandable stents that, in various embodiments, provide controllable expansive force profiles. The expansive force profiles can be controlled by varying the unrestrained expanded diameter of the stents, by varying the longitudinal length of the circumferential support sections in the stents, and/or by varying the circumferential width of the struts in the support sections. Also disclosed are methods of deploying the stents.
摘要翻译：本发明提供了径向可扩张的支架，其在各种实施例中提供可控的膨胀力分布。可以通过改变支架的无限制扩张直径，通过改变支架中的周向支撑部分的纵向长度和/或通过改变支撑部分中的支柱的周向宽度来控制膨胀力分布。还公开了展开支架的方法。

7. 发明授权

US06533807B2 Radially-expandable stent and delivery system 失效
标题翻译：径向扩张支架和输送系统
公开(公告)号：US06533807B2
公开(公告)日：2003-03-18
申请号：US09019210
申请日：1998-02-05
申请人： Lone Wolinsky , Ofer Nativ , Amir Loshakove
发明人： Lone Wolinsky , Ofer Nativ , Amir Loshakove
IPC分类号： A61F206
CPC分类号： A61F2/91 , A61F2/915 , A61F2/95 , A61F2/966 , A61F2002/91533 , A61F2002/91583 , A61F2230/0054 , A61F2250/0037
摘要： The present invention provides radially-expandable stents that, in various embodiments, may reduce the bending stresses/strains associated with the compressed state of self-expanding stents and/or may prevent longitudinal expansion/contraction of radially expandable stents between the compressed and expanded states. In addition, stents according to the present invention preferably exhibit increased longitudinal flexibility in both the compressed and expanded states. The present invention also includes delivery systems in which threading of the guidewire through the delivery system may be simplified. In addition, the delivery systems according to the present invention may also incorporate a balloon to assist in radially expanding the stent and/or seating of the stent in the lumen during deployment without removing the stent delivery catheter. Further, the delivery systems may also include a support tube at the proximal end to assist in fixing the position of the stent relative to a guide catheter during deployment of the stent.
摘要翻译：本发明提供径向可扩张的支架，其在各种实施例中可以减少与自膨胀支架的压缩状态相关联的弯曲应力/应变和/或可以防止在压缩和膨胀状态之间的径向可扩张支架的纵向膨胀/收缩。此外，根据本发明的支架优选在压缩和膨胀状态下显示出增加的纵向柔性。本发明还包括可以简化通过输送系统的导丝的穿线的输送系统。此外，根据本发明的输送系统还可以包括气囊，以在展开期间辅助径向膨胀支架和/或将支架置于内腔中，而不需要移除支架输送导管。此外，输送系统还可以包括在近端处的支撑管，以有助于在展开支架期间相对于导向导管固定支架的位置。

8. 发明授权

US09149193B2 Devices for fixing a sensor in a lumen 有权
公开(公告)号：US09149193B2
公开(公告)日：2015-10-06
申请号：US12496904
申请日：2009-07-02
申请人： Lone Wolinsky , Alon Ben-Yoseph , Abraham Penner
发明人： Lone Wolinsky , Alon Ben-Yoseph , Abraham Penner
IPC分类号： A61B5/02 , A61B5/0215 , A61B5/00 , A61F2/86 , A61B5/145 , A61F2/82
CPC分类号： A61B5/0215 , A61B5/0031 , A61B5/145 , A61B5/6882 , A61B5/6886 , A61F2/82 , A61F2/86 , A61F2230/0091 , A61F2250/0002
摘要： Apparatus for positioning at least one sensor in a body lumen, the apparatus including a fixation element, a sensor, and a connecting element that connects the sensor to the fixation element, the connecting element extending at least partially into the lumen so that the sensor is located radially inward from a wall of the lumen.

9. 再颁专利

USRE42378E1 Implantable pressure sensors and methods for making and using them 有权
标题翻译：可植入压力传感器及其制造和使用的方法
公开(公告)号：USRE42378E1
公开(公告)日：2011-05-17
申请号：US11491533
申请日：2006-07-20
申请人： Lone Wolinsky , Eyal Doron , Alon Ben-Yoseph , Avi Penner
发明人： Lone Wolinsky , Eyal Doron , Alon Ben-Yoseph , Avi Penner
IPC分类号： A61B5/04
CPC分类号： A61B5/0028 , A61B5/0031 , A61B5/01 , A61B5/0215 , A61B5/031 , A61B5/053 , A61B5/076 , A61B5/14539 , A61B2560/0219 , A61B2562/0247 , A61B2562/028 , A61N1/37217 , A61N1/3787 , A61N5/0601 , A61N5/062 , A61N2005/0651
摘要： An implant includes a pressure sensor, a controller for acquiring pressure data from the sensor, and an acoustic transducer for converting energy between electrical energy and acoustic energy. A capacitor is coupled to the acoustic transducer for storing electrical energy converted by the transducer and/or for providing electrical energy to operate the implant. The acoustic transducer may operate alternatively or simultaneously as an energy exchanger or an acoustic transmitter. During use, the implant is implanted within a patient's body, and an external transducer transmits a first acoustic signal into the patient's body, to energize the capacitor. The implant then obtains pressure data, and transmits a second acoustic signal to the external transducer, the second acoustic signal including the pressure data.
摘要翻译：植入物包括压力传感器，用于从传感器获取压力数据的控制器和用于在电能和声能之间转换能量的声换能器。电容器耦合到声换能器，用于存储由换能器转换的电能和/或用于提供电能以操作植入物。声换能器可以作为能量交换器或声发射器交替地或同时地操作。在使用期间，将植入物植入患者体内，并且外部换能器将第一声信号传送到患者体内，以激励电容器。然后，植入物获得压力数据，并将第二声学信号发送到外部换能器，第二声学信号包括压力数据。

10. 发明授权

US06699186B1 Methods and apparatus for deploying and implantable biosensor 有权
标题翻译：用于部署和植入生物传感器的方法和装置
公开(公告)号：US06699186B1
公开(公告)日：2004-03-02
申请号：US09523414
申请日：2000-03-10
申请人： Lone Wolinsky , Avi Penner
发明人： Lone Wolinsky , Avi Penner
IPC分类号： A61B500
CPC分类号： A61B5/6876 , A61B1/00147 , A61B5/02014 , A61B5/0215 , A61B5/026 , A61B5/076 , A61B5/11 , A61B5/14546 , A61B5/6862
摘要： An implantation device for delivering a biosensor to an implantation site in a patient's body comprises an elongate catheter equipped with a distally located cavity sized to house a biosensor. Once the distal end of the catheter is positioned adjacent the implantation site, the biosensor is released through an opening from the cavity into the site. A removable cover, such as a thin adhesive film, may be used to retain the biosensor in the cavity, while the catheter is guided through the body to the implantation site. The implantation device may include an actuator for displacing the biosensor from the cavity into the implantation site. By way of one example, the actuator may be a piston inserted through a lumen of the catheter.
摘要翻译：用于将生物传感器递送到患者体内的植入部位的植入装置包括：细长导管，其具有设置成容纳生物传感器的位于远侧的腔。一旦导管的远端位于植入位置附近，生物传感器通过从空腔的开口释放到现场。可以使用诸如薄的粘合剂膜的可移除的盖子将生物传感器保持在空腔中，同时导管被引导穿过身体到植入部位。植入装置可以包括用于将生物传感器从腔体移位到植入部位的致动器。作为一个示例，致动器可以是穿过导管的内腔插入的活塞。

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