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1. 发明申请

US20060211677A1 Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use 失效
公开(公告)号：US20060211677A1
公开(公告)日：2006-09-21
申请号：US10565604
申请日：2004-07-20
申请人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
发明人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
IPC分类号： C07D471/02 , C07D215/12 , C07D237/28 , A61K31/50 , A61K31/4965 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/4164 , A61K31/4745 , A61K31/433 , A61K31/4245
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.

2. 发明申请

US20110003815A1 DIPHENYL SUBSTITUTED CYCLOALKANES 审中-公开
标题翻译：二苯基取代的环烷基
公开(公告)号：US20110003815A1
公开(公告)日：2011-01-06
申请号：US12682150
申请日：2008-10-06
申请人： Anthony Ogawa , Feroze Ujjainwalla , Bing Li , Lin Chu , Minal Patel , Helen M. Armstrong , Hyun O. Ok , Rosemary Sisco , Dwight MacDonald , John Hutchinson , Helene Perrier
发明人： Anthony Ogawa , Feroze Ujjainwalla , Bing Li , Lin Chu , Minal Patel , Helen M. Armstrong , Hyun O. Ok , Rosemary Sisco , Dwight MacDonald , John Hutchinson , Helene Perrier
IPC分类号： A61K31/5377 , C07D401/14 , C07D413/12 , C07D211/68 , C07D417/12 , C07D403/12 , A61K31/4439 , A61K31/444 , A61K31/501 , A61P9/10
CPC分类号： C07D401/12 , C07D213/30 , C07D213/55 , C07D213/56 , C07D237/20 , C07D239/26 , C07D277/24 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02
摘要： The present invention provides compounds of Formula I which are FLAP inhibitors useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译：本发明提供了可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护作用的FLAP抑制剂的式I化合物。

3. 发明授权

US5360815A Heteroaryl cinnamic acids as inhibitors of leukotriene biosynthesis 失效
标题翻译：杂芳基肉桂酸作为白三烯生物合成的抑制剂
公开(公告)号：US5360815A
公开(公告)日：1994-11-01
申请号：US81506
申请日：1993-06-23
申请人： Rejean Fortin , Yves Girard , Erich Grimm , John Hutchinson , John Scheigetz
发明人： Rejean Fortin , Yves Girard , Erich Grimm , John Hutchinson , John Scheigetz
IPC分类号： C07D309/10 , C07D407/12 , C07D409/12 , C07D493/08 , A61K31/38 , A61K31/335 , A61K31/35 , A61K31/385
CPC分类号： C07D407/12 , C07D309/10 , C07D409/12 , C07D493/08
摘要： Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
摘要翻译：具有式I的化合物：I是抑制白三烯生物合成。这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。它们也可用于治疗心绞痛，脑痉挛，肾小球性肾炎，肝炎，内毒素血症，葡萄膜炎和同种异体移植物排斥和预防动脉粥样硬化斑块的形成。

4. 发明授权

US5424320A Heteroaryl coumarins as inhibitors of leukotriene biosynthesis 失效
标题翻译：作为白三烯生物合成抑制剂的杂芳香香豆素
公开(公告)号：US5424320A
公开(公告)日：1995-06-13
申请号：US81528
申请日：1993-06-23
申请人： Rejean Fortin , Yves Girard , Erich Grimm , John Hutchinson , John Scheigetz
发明人： Rejean Fortin , Yves Girard , Erich Grimm , John Hutchinson , John Scheigetz
IPC分类号： A61K45/06 , C07D407/12 , C07D407/14 , C07D409/14 , C07D493/08 , A61K31/44 , C07C311/02
CPC分类号： C07D407/12 , A61K45/06 , C07D407/14 , C07D409/14 , C07D493/08
摘要： Compounds having the formula I: ##STR1## are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection and in preventing the formation of atherosclerotic plaques.
摘要翻译：具有式I的化合物：I是抑制白三烯生物合成。这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。它们也可用于治疗心绞痛，脑痉挛，肾小球性肾炎，肝炎，内毒素血症，葡萄膜炎和同种异体移植物排斥和预防动脉粥样硬化斑块的形成。

5. 发明授权

US5252585A Fluorinated quinoline indoles as inhibitors of the biosynthesis of leukotrienes 失效
标题翻译：氟化喹啉吲哚作为白三烯生物合成的抑制剂
公开(公告)号：US5252585A
公开(公告)日：1993-10-12
申请号：US903051
申请日：1992-06-22
申请人： Richard Frenette , John Hutchinson
发明人： Richard Frenette , John Hutchinson
IPC分类号： C07D401/12 , A61K31/475
CPC分类号： C07D401/12
摘要： This invention relates to compounds having the formula I: ##STR1## wherein R.sup.1 is H, F or MeO, which are inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating diarrhea, hypertension, angina, platelet aggregation, cerebral spasm, premature labor, spontaneous abortion, dysmenorrhea, and migraine.
摘要翻译：本发明涉及具有式I的化合物：其中R 1是H，F或MeO，它们是白三烯生物合成的抑制剂。这些化合物可用作抗哮喘，抗过敏，抗炎和细胞保护剂。它们也可用于治疗腹泻，高血压，心绞痛，血小板聚集，脑痉挛，早产，自然流产，痛经和偏头痛。

6. 发明授权

US08556941B2 Methods for correction of spinal deformities 有权
标题翻译：矫正脊柱畸形的方法
公开(公告)号：US08556941B2
公开(公告)日：2013-10-15
申请号：US13205248
申请日：2011-08-08
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： A61B17/70
CPC分类号： A61B17/88 , A61B17/7002 , A61B17/7032 , A61B17/7038
摘要： A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.
摘要翻译：治疗脊柱形变形的方法包括将至少两个固定螺钉组件固定到相应的椎骨上，在每个固定螺钉组件上的臂延伸部之间滑动杆，相对于固定螺钉摆动螺钉组件的通道，使得通道变得不那么倾向于固定螺钉的轴线，并且使得杆大体位于脊柱的后方，锁定通道相对于螺钉摆动，相对于其中的至少一个将杆绕其轴线旋转通道，并且锁定杆相对于通道的运动。

7. 发明申请

US20110295321A1 Methods for Correction of Spinal Deformities 有权
标题翻译：矫正脊柱畸形的方法
公开(公告)号：US20110295321A1
公开(公告)日：2011-12-01
申请号：US13205248
申请日：2011-08-08
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： A61B17/88
CPC分类号： A61B17/88 , A61B17/7002 , A61B17/7032 , A61B17/7038
摘要： A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.
摘要翻译：治疗脊柱形变形的方法包括将至少两个固定螺钉组件固定到相应的椎骨上，在每个固定螺钉组件上的臂延伸部之间滑动杆，相对于固定螺钉摆动螺钉组件的通道，使得通道变得不那么倾向于固定螺钉的轴线，并且使得杆大体位于脊柱的后方，锁定通道相对于螺钉摆动，相对于其中的至少一个将杆绕其轴线旋转通道，并且锁定杆相对于通道的运动。

8. 发明申请

US20070287716A1 Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors 审中-公开
标题翻译：代谢型谷氨酸受体的嘧啶和喹啉电位
公开(公告)号：US20070287716A1
公开(公告)日：2007-12-13
申请号：US11665422
申请日：2005-10-24
申请人： Essa Hu , Jean-Michel Vernier , Peter Chua , John Hutchinson , Nicholas Cosford
发明人： Essa Hu , Jean-Michel Vernier , Peter Chua , John Hutchinson , Nicholas Cosford
IPC分类号： A61K31/47 , A61P25/00 , C07D215/12 , C07D239/28
CPC分类号： C07D239/26 , C07D215/06
摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译：本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

9. 发明申请

US20060142602A1 Method of making methyl ester surfactants 审中-公开
标题翻译：制备甲酯表面活性剂的方法
公开(公告)号：US20060142602A1
公开(公告)日：2006-06-29
申请号：US10534244
申请日：2003-11-21
申请人： John Hutchinson , Jungsik Lee , Timothy Eigley , Robert Krueger
发明人： John Hutchinson , Jungsik Lee , Timothy Eigley , Robert Krueger
IPC分类号： C07C67/02
CPC分类号： C08G65/332 , C07C67/03 , C11D1/74 , C07C69/24
摘要： A method of making a methyl ester based surfactants is provided. The method includes the transesterfication or esterification of a methyl ester feedstock and a poly(alkyl ether) feedstock.
摘要翻译：提供了制备甲酯基表面活性剂的方法。该方法包括甲酯原料和聚（烷基醚）原料的酯交换或酯化。

10. 发明申请

US20050097901A1 Apparatus and method for producing water from air 失效
标题翻译：用于从空气中生产水的设备和方法
公开(公告)号：US20050097901A1
公开(公告)日：2005-05-12
申请号：US10977143
申请日：2004-10-29
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： B01D5/00 , E03B3/28 , F25D17/06 , F25D21/14
CPC分类号： B01D5/0081 , B01D5/0039 , B01D5/0051 , E03B3/28 , Y02A20/109
摘要： An apparatus and method are extracting water from the ambient air comprising drawing air through an particle ionizer grid, evaporator plates of a refrigerant system the system and recirculating the ionized air and mixing said ionized air with ambient air and recycling said mixed air through said ionizer and evaporator plates to extract moisture from the air. The system utilizes sensors to constantly sense and predictively respond to multiple parameters, monitored at multiple points in the system to predictively and efficiently adjust the system operation to continually maximize the extraction of water regardless of ambient temperature and humidity.
摘要翻译：一种装置和方法是从环境空气中提取水，包括抽吸空气通过颗粒离子发生器网格，制冷剂系统的蒸发器板系统并使离子化空气再循环并将所述离子化空气与环境空气混合，并将所述混合空气再循环通过所述离子发生器和蒸发器板从空气中提取水分。该系统利用传感器不断地感测和预测性地响应多个参数，在系统的多个点进行监测，以预测和有效地调整系统运行，以连续地最大限度地提取水，而不管环境温度和湿度如何。

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