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1. 发明申请

US20110003815A1 DIPHENYL SUBSTITUTED CYCLOALKANES 审中-公开
标题翻译：二苯基取代的环烷基
公开(公告)号：US20110003815A1
公开(公告)日：2011-01-06
申请号：US12682150
申请日：2008-10-06
申请人： Anthony Ogawa , Feroze Ujjainwalla , Bing Li , Lin Chu , Minal Patel , Helen M. Armstrong , Hyun O. Ok , Rosemary Sisco , Dwight MacDonald , John Hutchinson , Helene Perrier
发明人： Anthony Ogawa , Feroze Ujjainwalla , Bing Li , Lin Chu , Minal Patel , Helen M. Armstrong , Hyun O. Ok , Rosemary Sisco , Dwight MacDonald , John Hutchinson , Helene Perrier
IPC分类号： A61K31/5377 , C07D401/14 , C07D413/12 , C07D211/68 , C07D417/12 , C07D403/12 , A61K31/4439 , A61K31/444 , A61K31/501 , A61P9/10
CPC分类号： C07D401/12 , C07D213/30 , C07D213/55 , C07D213/56 , C07D237/20 , C07D239/26 , C07D277/24 , C07D401/14 , C07D403/04 , C07D403/12 , C07D403/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/10 , C07D417/12 , C07D417/14 , C07D453/02
摘要： The present invention provides compounds of Formula I which are FLAP inhibitors useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cytoprotective agents.
摘要翻译：本发明提供了可用作抗动脉粥样硬化，抗哮喘，抗过敏，抗炎和细胞保护作用的FLAP抑制剂的式I化合物。

2. 发明申请

US20060211677A1 Diphenyl substituted cycloalkanes, compositions containing such compounds and methods of use 失效
公开(公告)号：US20060211677A1
公开(公告)日：2006-09-21
申请号：US10565604
申请日：2004-07-20
申请人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
发明人： Lin Chu , Mark Goulet , Feroze Ujjainwalla , Linda Chang , Richard Frenette , Yves Girard , Michel Therien , Dwight Macdonald , John Hutchinson
IPC分类号： C07D471/02 , C07D215/12 , C07D237/28 , A61K31/50 , A61K31/4965 , A61K31/496 , A61K31/501 , A61K31/506 , A61K31/4164 , A61K31/4745 , A61K31/433 , A61K31/4245
CPC分类号： C07D215/14 , C07D215/12 , C07D237/28 , C07D277/64 , C07D401/12 , C07D413/12 , C07D417/12 , C07D471/02
摘要： The instant invention provides compounds of formula: (I) which are 5-lipoxygenase activating protein inhibitors: formula (I). Compounds of formula (I) are useful as anti-atherosclerotic, anti-asthmatic, anti-allergic, anti-inflammatory and cyto-protective agents.

3. 发明授权

US08556941B2 Methods for correction of spinal deformities 有权
标题翻译：矫正脊柱畸形的方法
公开(公告)号：US08556941B2
公开(公告)日：2013-10-15
申请号：US13205248
申请日：2011-08-08
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： A61B17/70
CPC分类号： A61B17/88 , A61B17/7002 , A61B17/7032 , A61B17/7038
摘要： A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.
摘要翻译：治疗脊柱形变形的方法包括将至少两个固定螺钉组件固定到相应的椎骨上，在每个固定螺钉组件上的臂延伸部之间滑动杆，相对于固定螺钉摆动螺钉组件的通道，使得通道变得不那么倾向于固定螺钉的轴线，并且使得杆大体位于脊柱的后方，锁定通道相对于螺钉摆动，相对于其中的至少一个将杆绕其轴线旋转通道，并且锁定杆相对于通道的运动。

4. 发明申请

US20110295321A1 Methods for Correction of Spinal Deformities 有权
标题翻译：矫正脊柱畸形的方法
公开(公告)号：US20110295321A1
公开(公告)日：2011-12-01
申请号：US13205248
申请日：2011-08-08
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： A61B17/88
CPC分类号： A61B17/88 , A61B17/7002 , A61B17/7032 , A61B17/7038
摘要： A method of treating a spinal column shape deformation includes fixing at least two fixation screw assemblies to respective vertebrae, sliding a rod between the arm extensions on each of the fixation screw assemblies, swinging the channels of the screw assemblies relative to the fixation screws so that the channels become less inclined to the axes of the fixation screws, and so that the rod is located generally posteriorly of the spinal column, locking the channel against swinging relative to the screw, rotating the rod about its axis relative to at least one of the channels, and locking the rod against movement relative to the channel.
摘要翻译：治疗脊柱形变形的方法包括将至少两个固定螺钉组件固定到相应的椎骨上，在每个固定螺钉组件上的臂延伸部之间滑动杆，相对于固定螺钉摆动螺钉组件的通道，使得通道变得不那么倾向于固定螺钉的轴线，并且使得杆大体位于脊柱的后方，锁定通道相对于螺钉摆动，相对于其中的至少一个将杆绕其轴线旋转通道，并且锁定杆相对于通道的运动。

5. 发明申请

US20070287716A1 Pyrimidine and Quinoline Potentiators of Metabotropic Glutamate Receptors 审中-公开
标题翻译：代谢型谷氨酸受体的嘧啶和喹啉电位
公开(公告)号：US20070287716A1
公开(公告)日：2007-12-13
申请号：US11665422
申请日：2005-10-24
申请人： Essa Hu , Jean-Michel Vernier , Peter Chua , John Hutchinson , Nicholas Cosford
发明人： Essa Hu , Jean-Michel Vernier , Peter Chua , John Hutchinson , Nicholas Cosford
IPC分类号： A61K31/47 , A61P25/00 , C07D215/12 , C07D239/28
CPC分类号： C07D239/26 , C07D215/06
摘要： The present invention is directed to compounds which are potentiators of metabotropic glutamate receptors, including the mGluR2 receptor, and which are useful in the treatment or prevention of neurological and psychiatric disorders associated with glutamate dysfunction and diseases in which metabotropic glutamate receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which metabotropic glutamate receptors are involved.
摘要翻译：本发明涉及作为代谢型谷氨酸受体的增强剂（包括mGluR2受体）的化合物，其可用于治疗或预防与谷氨酸能力障碍相关的神经和精神病学障碍以及其中涉及代谢型谷氨酸受体的疾病。本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及代谢型谷氨酸受体的疾病中的用途。

6. 发明申请

US20060142602A1 Method of making methyl ester surfactants 审中-公开
标题翻译：制备甲酯表面活性剂的方法
公开(公告)号：US20060142602A1
公开(公告)日：2006-06-29
申请号：US10534244
申请日：2003-11-21
申请人： John Hutchinson , Jungsik Lee , Timothy Eigley , Robert Krueger
发明人： John Hutchinson , Jungsik Lee , Timothy Eigley , Robert Krueger
IPC分类号： C07C67/02
CPC分类号： C08G65/332 , C07C67/03 , C11D1/74 , C07C69/24
摘要： A method of making a methyl ester based surfactants is provided. The method includes the transesterfication or esterification of a methyl ester feedstock and a poly(alkyl ether) feedstock.
摘要翻译：提供了制备甲酯基表面活性剂的方法。该方法包括甲酯原料和聚（烷基醚）原料的酯交换或酯化。

7. 发明申请

US20050097901A1 Apparatus and method for producing water from air 失效
标题翻译：用于从空气中生产水的设备和方法
公开(公告)号：US20050097901A1
公开(公告)日：2005-05-12
申请号：US10977143
申请日：2004-10-29
申请人： John Hutchinson
发明人： John Hutchinson
IPC分类号： B01D5/00 , E03B3/28 , F25D17/06 , F25D21/14
CPC分类号： B01D5/0081 , B01D5/0039 , B01D5/0051 , E03B3/28 , Y02A20/109
摘要： An apparatus and method are extracting water from the ambient air comprising drawing air through an particle ionizer grid, evaporator plates of a refrigerant system the system and recirculating the ionized air and mixing said ionized air with ambient air and recycling said mixed air through said ionizer and evaporator plates to extract moisture from the air. The system utilizes sensors to constantly sense and predictively respond to multiple parameters, monitored at multiple points in the system to predictively and efficiently adjust the system operation to continually maximize the extraction of water regardless of ambient temperature and humidity.
摘要翻译：一种装置和方法是从环境空气中提取水，包括抽吸空气通过颗粒离子发生器网格，制冷剂系统的蒸发器板系统并使离子化空气再循环并将所述离子化空气与环境空气混合，并将所述混合空气再循环通过所述离子发生器和蒸发器板从空气中提取水分。该系统利用传感器不断地感测和预测性地响应多个参数，在系统的多个点进行监测，以预测和有效地调整系统运行，以连续地最大限度地提取水，而不管环境温度和湿度如何。

8. 发明授权

US4231849A Process for the preparation of a perfluorinated cyclic ether 失效
标题翻译：制备全氟化环醚的方法
公开(公告)号：US4231849A
公开(公告)日：1980-11-04
申请号：US49787
申请日：1979-06-18
申请人： John Hutchinson , Graham Whittaker
发明人： John Hutchinson , Graham Whittaker
IPC分类号： C10M105/54 , B22C1/14 , C07D307/18 , C09K5/04 , C10N40/36 , H01B3/24 , H01G4/22 , C07D307/38
CPC分类号： C07D307/18
摘要： An inert fluid of high chemical stability which comprises a perfluorinated cyclic ether having the formula C.sub.10 F.sub.20 O, and its preparation by perfluorination of the corresponding ethylenically-unsaturated cyclic ether C.sub.10 F.sub.18 O with cobalt trifluoride, electrochemically or with fluorine gas.
摘要翻译：具有高化学稳定性的惰性流体，其包含具有式C10F20O的全氟化环醚，以及通过电化学或氟气将相应的烯属不饱和环醚C10F18O与三氟化钴全氟化制备。

9. 发明授权

US09692207B2 Tunable laser with integrated wavelength reference 有权
公开(公告)号：US09692207B2
公开(公告)日：2017-06-27
申请号：US13249753
申请日：2011-09-30
申请人： Alexander W. Fang , Gregory Alan Fish , John Hutchinson
发明人： Alexander W. Fang , Gregory Alan Fish , John Hutchinson
IPC分类号： H01S3/10 , H01S5/00 , H01S3/083 , H01S5/14 , H01S5/02 , H01S5/10 , H01S3/13 , H01S5/024 , H01S5/026
CPC分类号： H01S5/068 , H01S3/0014 , H01S3/0637 , H01S3/0675 , H01S3/10015 , H01S3/10023 , H01S3/1003 , H01S3/1055 , H01S3/1305 , H01S5/021 , H01S5/02453 , H01S5/026 , H01S5/0265 , H01S5/0612 , H01S5/1028 , H01S5/1209 , H01S5/142
摘要： In the prior art, tunable lasers utilizing silicon-based tunable ring filters and III-V semiconductor-based gain regions required the heterogeneous integration of independently formed silicon and III-V semiconductor based optical elements, resulting in large optical devices requiring a complex manufacturing process (e.g., airtight packaging to couple the devices formed on different substrates, precise alignment for the elements, etc.). Embodiments of the invention eliminate the need for bulk optical elements and hermetic packaging, via the use of hybridized III-V/silicon gain regions and silicon optical components, such as silicon wavelength filters and silicon wavelength references, thereby reducing the size and manufacturing complexity of tunable lasing devices. For example, embodiments of the invention may utilize hybridized III-V/silicon gain regions with ring filters on silicon form a tunable laser with efficient gain from the III-V region, while providing wide tunability, efficient tunability, and narrow linewidth due to the nature of the silicon rings.

10. 发明申请

US20130083815A1 TUNABLE LASER WITH INTEGRATED WAVELENGTH REFERENCE 有权
标题翻译：具有集成波长参考的可激光激光
公开(公告)号：US20130083815A1
公开(公告)日：2013-04-04
申请号：US13249753
申请日：2011-09-30
申请人： ALEXANDER W. FANG , Gregory Alan Fish , John Hutchinson
发明人： ALEXANDER W. FANG , Gregory Alan Fish , John Hutchinson
IPC分类号： H01S3/10
CPC分类号： H01S5/068 , H01S3/0014 , H01S3/0637 , H01S3/0675 , H01S3/10015 , H01S3/10023 , H01S3/1003 , H01S3/1055 , H01S3/1305 , H01S5/021 , H01S5/02453 , H01S5/026 , H01S5/0265 , H01S5/0612 , H01S5/1028 , H01S5/1209 , H01S5/142
摘要： In the prior art, tunable lasers utilizing silicon-based tunable ring filters and III-V semiconductor-based gain regions required the heterogeneous integration of independently formed silicon and III-V semiconductor based optical elements, resulting in large optical devices requiring a complex manufacturing process (e.g., airtight packaging to couple the devices formed on different substrates, precise alignment for the elements, etc.). Embodiments of the invention eliminate the need for bulk optical elements and hermetic packaging, via the use of hybridized III-V/silicon gain regions and silicon optical components, such as silicon wavelength filters and silicon wavelength references, thereby reducing the size and manufacturing complexity of tunable lasing devices. For example, embodiments of the invention may utilize hybridized III-V/silicon gain regions with ring filters on silicon form a tunable laser with efficient gain from the III-V region, while providing wide tunability, efficient tunability, and narrow linewidth due to the nature of the silicon rings.
摘要翻译：在现有技术中，使用基于硅的可调谐环形滤波器和基于III-V半导体的增益区域的可调谐激光器需要独立形成的基于硅和III-V半导体的光学元件的异质集成，导致需要复杂制造工艺的大型光学器件（例如，密封包装以联接形成在不同基底上的装置，元件的精确对准等）。本发明的实施例通过使用杂化的III-V /硅增益区域和诸如硅波长滤波器和硅波长参考的硅光学组件来消除对体光学元件和气密封装的需要，从而减小了尺寸和制造复杂度可调谐激光装置。例如，本发明的实施例可以利用具有硅上的环形滤波器的混合III-V /硅增益区域形成具有来自III-V区域的有效增益的可调谐激光器，同时提供宽的可调谐性，有效的可调谐性以及由于硅环的性质。

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