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1. 发明申请

US20060147347A1 Method and apparatus for improved light collection 审中-公开
公开(公告)号：US20060147347A1
公开(公告)日：2006-07-06
申请号：US11370672
申请日：2006-03-07
申请人： Leslie Leonard , David King
发明人： Leslie Leonard , David King
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01N2021/6439 , G01N2021/6469 , G01N2021/6482
摘要： An apparatus for enhancing the collection of optical signals comprises a waveguide, which comprises a structure in a channel adapted for the flow of assay fluid. In one embodiment, fluorophore is coupled to a surface of the structure, where the fluorophore has a receptor for an analyte (ligand) in the assay fluid and the structure is adapted to transmit optical signals from the fluorophore to a detector that is adapted to detect optical signals from the fluorophore coupled to the waveguide.

2. 发明授权

US07029631B2 Apparatus for improved light collection 有权
标题翻译：用于改进光采集的装置
公开(公告)号：US07029631B2
公开(公告)日：2006-04-18
申请号：US10126153
申请日：2002-04-19
申请人： Leslie Leonard , David King
发明人： Leslie Leonard , David King
IPC分类号： G01N21/64
CPC分类号： G01N21/645 , G01N2021/6439 , G01N2021/6469 , G01N2021/6482
摘要： An apparatus for enhancing the collection of optical signals comprises a waveguide, which comprises a structure in a channel adapted for the flow of assay fluid. In one embodiment, fluorophore is coupled to a surface of the structure, where the fluorophore has a receptor for an analyte (ligand) in the assay fluid and the structure is adapted to transmit optical signals from the fluorophore to a detector that is adapted to detect optical signals from the fluorophore coupled to the waveguide.
摘要翻译：用于增强光学信号收集的装置包括波导，其包括适于测定流体流动的通道中的结构。在一个实施方案中，荧光团耦合到结构的表面，其中荧光团具有分析流体中分析物（配体）的受体，并且该结构适于将光信号从荧光团传输到适于检测的检测器来自耦合到波导的荧光团的光信号。

3. 发明申请

US20050147975A1 Methods and compositions for amplification of genomic DNA 审中-公开
标题翻译：用于扩增基因组DNA的方法和组合物
公开(公告)号：US20050147975A1
公开(公告)日：2005-07-07
申请号：US10746871
申请日：2003-12-24
申请人： Carol Schembri , Leslie Leonard
发明人： Carol Schembri , Leslie Leonard
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6865
摘要： Methods for amplifying RNA from genomic DNA are provided. In the subject methods, a promoter-primer having a primer domain linked to an RNA polymerase promoter domain is first annealed to genomic DNA. The primer domain of the resultant annealed promoter-primer/genomic DNA complex is then extended to produce a double-stranded DNA molecule that has an RNA polymerase promoter domain. The resultant double-stranded DNA molecule is then transcribed into RNA product, e.g., labeled RNA product, using an RNA polymerase that is able to transcribe through the gap between the 5′ terminus of the promoter domain and the 3′ side of the genomic template. The subject methods find use a variety of different applications in which the preparation of amplified amounts of RNA from a genomic template is desired, where the amplification may be linear or geometric and may amplify the entire genome or only a select portion thereof. Also provided are kits for practicing the subject methods.
摘要翻译：提供了从基因组DNA扩增RNA的方法。在本方法中，首先将与RNA聚合酶启动子结构域连接的引物结构域的启动子 - 引物退火至基因组DNA。然后将所得退火的启动子 - 引物/基因组DNA复合物的引物结构域延伸以产生具有RNA聚合酶启动子结构域的双链DNA分子。然后将得到的双链DNA分子转录成RNA产物，例如标记的RNA产物，使用能够通过启动子结构域的5'末端和基因组模板的3'侧之间的间隙转录的RNA聚合酶。本发明方法发现使用各种不同的应用，其中需要从基因组模板制备扩增量的RNA，其中扩增可以是线性的或几何的，并且可以扩增整个基因组或仅扩增其选择部分。还提供了用于实践主题方法的工具包。

4. 发明授权

US07524462B2 Capillary flow for a heterogenous assay in a micro-channel environment 失效
标题翻译：在微通道环境中用于异源测定的毛细血管流
公开(公告)号：US07524462B2
公开(公告)日：2009-04-28
申请号：US10113112
申请日：2002-03-29
申请人： Leslie Leonard , Klaus Stefan Drese , Dirk Boecker
发明人： Leslie Leonard , Klaus Stefan Drese , Dirk Boecker
IPC分类号： G01N30/00 , G01N30/28
CPC分类号： B01L3/5027 , B01L3/502746 , B01L2200/0621 , B01L2200/16 , B01L2300/0636 , B01L2300/0681 , B01L2300/0861 , B01L2400/0406 , B01L2400/0688 , B01L2400/0694 , B01L2400/084 , B01L2400/086 , B01L2400/088 , G01N2035/00257 , Y10T436/25375 , Y10T436/2575
摘要： Apparatus and methods consistent with certain principles related to the present invention include a first channel, where a fluid flows through the first channel, where the first channel comprises an upstream region, a tagging region downstream of the upstream region, where at least one analyte is tagged when the fluid flows through the tagging region, a capture region downstream of the tagging region, where at least one tagged analyte is captured when the fluid flows through the capture region. A second channel communicating the upstream region of the first channel with the first channel intermediate the tagging region and capture regions, where a portion of the fluid flows through the second channel and subsequently flows into the capture region of the first channel, and where the fluid flowing through the tagging region flows into the capture region before the portion of the fluid flowing through the second channel flows into the capture region of the first channel.
摘要翻译：与本发明相关的某些原理一致的设备和方法包括第一通道，其中流体流过第一通道，其中第一通道包括上游区域，上游区域下游的标记区域，其中至少一个分析物是当流体流过标记区域时，标记标签，标签区域下游的捕获区域，其中当流体流过捕获区域时捕获至少一个带标签的分析物。第二通道将第一通道的上游区域与标记区域和捕获区域之间的第一通道相通，其中一部分流体流过第二通道并随后流入第一通道的捕获区域，并且其中流体在通过第二通道流动的流体的部分流入第一通道的捕获区域之前流过标记区域流入捕获区域。

5. 发明申请

US20050095595A1 Methods and systems for improving of polymer analysis 审中-公开
标题翻译：改进聚合物分析的方法和系统
公开(公告)号：US20050095595A1
公开(公告)日：2005-05-05
申请号：US10696177
申请日：2003-10-29
申请人： Richard Pittaro , Douglas Amorese , Carol Schembri , Leslie Leonard , Nicholas Sampas , Michael Caren
发明人： Richard Pittaro , Douglas Amorese , Carol Schembri , Leslie Leonard , Nicholas Sampas , Michael Caren
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q2545/101
摘要： Systems and methods for optimizing polymer analysis are provided. One such system includes a polymer analysis system having a polymer control system. The polymer analysis system is operative to: apply a set of conditions to a sample being analyzed by the polymer array, the set of conditions correspond to at least one characteristic of the polymer array; analyze the at least one characteristic using the polymer control system; and generate polymer array data.
摘要翻译：提供了优化聚合物分析的系统和方法。一种这样的系统包括具有聚合物控制系统的聚合物分析系统。聚合物分析系统可操作以：将一组条件应用于由聚合物阵列分析的样品，该组条件对应于聚合物阵列的至少一个特性; 使用聚合物控制系统分析至少一个特征; 并生成聚合物阵列数据。

6. 发明申请

US20050026154A1 Masking chemical arrays 审中-公开
标题翻译：掩蔽化学阵列
公开(公告)号：US20050026154A1
公开(公告)日：2005-02-03
申请号：US10633609
申请日：2003-07-31
申请人： Laurakay Bruhn , Douglas Amorese , Michael Caren , Leslie Leonard , Richard Pittaro , Carol Schembri , Peter Webb , Paul Wolber
发明人： Laurakay Bruhn , Douglas Amorese , Michael Caren , Leslie Leonard , Richard Pittaro , Carol Schembri , Peter Webb , Paul Wolber
IPC分类号： B01J19/00 , B01L3/00 , C12Q1/68 , C40B40/06 , G01N21/25 , G01N33/48 , G01N33/483 , G01N33/50 , G01N33/53 , G01N33/58 , G06F19/00
CPC分类号： B01L3/545 , B01J2219/00662 , B01J2219/00693 , B01J2219/00722 , B01L3/5088 , B01L2200/025 , B01L2300/024 , B01L2300/0819 , C40B40/06 , G01N21/253
摘要： A method of using a chemical array unit having a chemical array with probes at multiple feature locations. A request for test may be read, which test uses a sub-array of the array. A pattern of the sub-array may be retrieved from a memory using the test request, which memory carries a pattern for the sub-array which is retrievable with the different test request. Also, a method of reading a chemical array unit which has been exposed to a sample, and feature locations of which have been rendered incapable of providing signal data representative of binding of a sample component. Further methods, apparatus, and computer program products are provided.
摘要翻译：一种在多个特征位置使用具有化学阵列的化学阵列单元和探针的方法。可以读取测试请求，哪个测试使用数组的子阵列。可以使用测试请求从存储器检索子阵列的模式，该存储器携带用于使用不同测试请求可检索的子阵列的模式。此外，读取已经暴露于样品的化学阵列单元的方法，其特征位置已经不能提供表示样品组分的结合的信号数据。提供其他方法，装置和计算机程序产品。

7. 发明申请

US20050136416A1 Patient specific array-based assays 审中-公开
标题翻译：患者特异性阵列测定
公开(公告)号：US20050136416A1
公开(公告)日：2005-06-23
申请号：US10747004
申请日：2003-12-23
申请人： LauraKay Bruhn , Michael Barrett , Paul Wolber , Leslie Leonard , Richard Pittaro
发明人： LauraKay Bruhn , Michael Barrett , Paul Wolber , Leslie Leonard , Richard Pittaro
IPC分类号： C12Q1/68 , G01N33/50 , G01N33/68 , G01N33/48 , G01N33/53 , G06F19/00
CPC分类号： G01N33/6893 , C12Q1/6837 , G01N33/5091 , C12Q2565/515
摘要： Patient specific array-based assays are provided. A feature of the subject patient specific array-based assays is that they include a step of interrogating a set of array features that have been previously identified by a general array-based assay to be relevant to a specific disease and condition of the subject being assayed. Also provided are methods of producing the subject patient specific array-based assays, as well as compositions and kits for use in practicing the subject assays.
摘要翻译：提供了基于特定阵列的测定法。基于患者特异性基于阵列的测定的特征在于它们包括询问一组阵列特征的步骤，其先前已经通过基于阵列的测定法被识别为与被测定的受试者的特定疾病和状况相关。还提供了产生基于患者特异性阵列的测定法的方法，以及用于实践受试者测定的组合物和试剂盒。

8. 发明申请

US20050026304A1 Microarray based affinity purification and analysis device coupled with secondary analysis technologies 审中-公开
标题翻译：基于微阵列的亲和纯化和分析装置加上二次分析技术
公开(公告)号：US20050026304A1
公开(公告)日：2005-02-03
申请号：US10631033
申请日：2003-07-30
申请人： Laurakay Bruhn , Leslie Leonard , Peter Webb , Paul Wolber , Douglas Amorese
发明人： Laurakay Bruhn , Leslie Leonard , Peter Webb , Paul Wolber , Douglas Amorese
IPC分类号： G01N33/543
CPC分类号： G01N33/54366 , G01N33/54373
摘要： An apparatus and method for separating and identifying chemical moieties. The apparatus employs a microarray device coupled to a nanopore system. The apparatus both separates and identifies target molecules without the requirement of extraneous tags or fluorescent markers. Methods for using the apparatus are also disclosed.
摘要翻译：用于分离和鉴定化学部分的装置和方法。该装置采用耦合到纳米孔系统的微阵列装置。该装置既分离和鉴定靶分子，又不需要外来标签或荧光标记物。还公开了使用该装置的方法。

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