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1. 发明申请

US20080311276A1 Production of Glucosinolates from Agricultural By-Products & Waste 审中-公开
标题翻译：从农副产品和废物生产硫代葡萄糖苷
公开(公告)号：US20080311276A1
公开(公告)日：2008-12-18
申请号：US11761883
申请日：2007-06-12
申请人： Leslie George West , Theresa Pomerleau , Nathan V. Matusheski , Cathy Jean Ludwig , Jamie Hestekin , Colin Crowley , Nam-Cheol Kim
发明人： Leslie George West , Theresa Pomerleau , Nathan V. Matusheski , Cathy Jean Ludwig , Jamie Hestekin , Colin Crowley , Nam-Cheol Kim
IPC分类号： A23L1/28
CPC分类号： C07H15/14 , C07H1/08
摘要： The present invention relates to a process for producing glucosinolates, particularly glucoraphanin, from cruciferous plants. More particularly, a method is provided for producing glucosinolates from agricultural by-products and waste. The general method comprises providing a mixture of glucosinolate-containing plant material and liquid, heating the mixture to inactivate enzymes in the plant material, contacting the heat inactivated mixture with an anion exchange membrane whereby at least a portion of the glucosinolates are extracted from the liquid and absorbed onto the anion exchange membrane, and releasing the glucosinolates from the anion exchange membrane. Preferably, the extraction and release steps are repeated at least once. The glucosinolates produce by the method of the invention may be incorporated into a variety of food products, pharmaceuticals, and health supplements.
摘要翻译：本发明涉及一种从十字花科植物生产硫代葡萄糖苷，特别是葡糖多糖的方法。更具体地，提供了用于从农副产物和废物生产硫代葡萄糖苷的方法。通常的方法包括提供含有硫代葡萄糖苷的植物材料和液体的混合物，加热混合物以灭活植物材料中的酶，使热灭活的混合物与阴离子交换膜接触，由此至少一部分硫代葡萄糖苷从液体中提取并吸收到阴离子交换膜上，并从阴离子交换膜中释放硫代葡萄糖苷。优选地，提取和释放步骤重复至少一次。通过本发明的方法生产的硫代葡萄糖苷可以掺入各种食品，药物和保健品中。

2. 发明申请

US20080311192A1 Enteric-Coated Glucosinolates And Beta-Thioglucosidases 审中-公开
标题翻译：肠溶包被的硫代葡萄糖苷和β-硫葡糖苷酶
公开(公告)号：US20080311192A1
公开(公告)日：2008-12-18
申请号：US11761843
申请日：2007-06-12
申请人： Leslie George West , Nicole Lee Windsor , Anilkumar Ganapati Gaonkar , Nathan V. Matusheski , Nam-Cheol Kim , Cathy Jean Ludwig , Leslie Lewis Lawrence
发明人： Leslie George West , Nicole Lee Windsor , Anilkumar Ganapati Gaonkar , Nathan V. Matusheski , Nam-Cheol Kim , Cathy Jean Ludwig , Leslie Lewis Lawrence
IPC分类号： A61K9/14 , A61K38/47 , A61K9/48
CPC分类号： A61K9/1652 , A61K9/5063 , A61K31/375 , A61K31/7028 , A61K38/47 , A61K2300/00
摘要： The present invention relates to a particulate composition comprising enteric-coated glucosinolate and beta-thioglucosidase particles. The present invention further provides a method of converting glucosinolate to isothiocyanate in the small intestine comprising orally administering to a subject an enteric-coated chemoprotectant precursor composition comprising enteric-coated glucosinolate and beta-thioglucosinodase particles. In another aspect, uncoated glucosinolate and beta-thioglucosinodase particles may be provided in an enteric-coated capsule. Preferably, the glucosinolate is glucoraphanin and the beta-thioglucosidase is myrosinase. The enteric coating targets the compound for release in the small intestine where beta-thioglucosinodase enzyme converts glucosinolate to chemoprotectant isothiocyanate.
摘要翻译：本发明涉及包含肠溶包衣的硫代葡萄糖苷苷和β-硫代葡糖苷酶颗粒的颗粒组合物。本发明还提供了一种在小肠中将芥子油苷转化成异硫氰酸酯的方法，其包括向受试者口服施用包含肠溶包衣的硫代葡萄糖苷和β-硫代葡萄糖苷糖苷酶颗粒的肠溶衣化学保护剂前体组合物。在另一方面，可以在肠溶衣胶囊中提供未包衣的硫代葡萄糖苷和β-硫代葡糖苷调节酶颗粒。优选地，硫代葡萄糖苷是葡萄糖甙元，β-硫代葡萄糖苷酶是黑芥子酶。肠溶衣靶向化合物在小肠中释放，其中β-硫代葡糖苷异酶将芥子油苷转化成化学保护剂异硫氰酸酯。

3. 发明申请

US20080213441A1 Reduction of Astringency in Polyphenol Compositions 审中-公开
标题翻译：减少多酚组合物的收敛性
公开(公告)号：US20080213441A1
公开(公告)日：2008-09-04
申请号：US11958556
申请日：2007-12-18
申请人： Cathy Jean Ludwig , Nicole Lee Windsor , Anikumar Ganapati Gaonkar , Nam-Cheol Kim , Nathan V. Matusheski , Leslie George West , Maria Carolina de Almeida Fontes , Bary Lyn Zeller , Dominic J. Vellucci , Mark Kijowski , Gabriele Margarete Kopp
发明人： Cathy Jean Ludwig , Nicole Lee Windsor , Anikumar Ganapati Gaonkar , Nam-Cheol Kim , Nathan V. Matusheski , Leslie George West , Maria Carolina de Almeida Fontes , Bary Lyn Zeller , Dominic J. Vellucci , Mark Kijowski , Gabriele Margarete Kopp
IPC分类号： A23D7/005 , A23P1/04 , A23J1/20 , A23L1/0562
CPC分类号： A23D7/0053 , A23L29/284 , A23P10/30 , A23P10/35
摘要： Microencapsulated polyphenol compositions suitable for use in food and beverage products are provided. Microencapsulation significantly reduces the astringency and/or bitterness of the polyphenol compositions and protects the polyphenol compositions from oxidation, ingredient interactions, enzymatic degradation, and the like while maintaining gastrointestinal bioavailability within the digestive system.
摘要翻译：提供了适用于食品和饮料产品的微囊化多酚组合物。微囊化显着降低多酚组合物的涩味和/或苦味，并保护多酚组合物免于氧化，成分相互作用，酶降解等，同时保持消化系统内的胃肠生物利用度。

4. 发明授权

US07371419B1 Method of enriching glucoraphanin in radish seed preparations 失效
标题翻译：萝卜种子制剂中富含萝卜素的方法
公开(公告)号：US07371419B1
公开(公告)日：2008-05-13
申请号：US11617934
申请日：2006-12-29
申请人： Leslie G. West , Nam-Cheol Kim , George W. Haas , Nathan V. Matusheski
发明人： Leslie G. West , Nam-Cheol Kim , George W. Haas , Nathan V. Matusheski
IPC分类号： A61K36/00
CPC分类号： A61K36/31
摘要： The present invention relates to chemoprotective compounds and a method for producing chemoprotectant precursor-enriched extracts from crucifer seeds. More particularly, a method is provided for producing chemoprotectant precursor-enriched extracts from radish seeds with increased ratio of glucoraphanin to glucoraphenin. The general method comprises preparing an aqueous extract, contacting the aqueous extract with an adsorbent, removing the adsorbent to obtain a glucosinolate-containing extract, drying the glucosinolate-containing extract to obtain a dried glucosinolate-containing extract, mixing at least a portion of the dried glucosinolate-containing extract with a solvent to form a glucosinolate-containing suspension, clarifying the glucosinolate-containing suspension, contacting the glucosinolate-containing suspension with a catalyst, and introducing hydrogen for a time sufficient to obtain a chemoprotectant precursor-enriched extract. The chemoprotectant precursor-enriched extracts may be further processed to form a chemoprotectant precursor-enriched isolate or processed for use in various applications, including incorporation into a variety of food products and pharmaceuticals.
摘要翻译：本发明涉及化学保护性化合物和从十字花科植物种子生产富含化学保护素前体的提取物的方法。更具体地，提供了一种用于从萝卜种子生产富含富含化学保护素前体的提取物的方法，其中葡萄糖苷与葡糖蓝精蛋白的比例增加。一般方法包括制备水提取物，使含水提取物与吸附剂接触，除去吸附剂以获得含有硫代葡萄糖苷的提取物，干燥含有硫代葡萄糖苷的提取物以获得含有硫代葡萄糖苷的干燥提取物，将至少一部分干燥的含有硫代葡萄糖苷的提取物与溶剂形成含有硫代葡萄糖苷的悬浮液，澄清含有硫代葡萄糖苷的悬浮液，使含有硫代葡萄糖苷的悬浮液与催化剂接触，并引入氢气足以获得富含化学保护剂前体的提取物。可以进一步处理富含化学保护剂前体的提取物，以形成富含化学保护剂前体的分离物，或加工用于各种应用，包括掺入各种食品和药物中。

5. 发明申请

US20100056450A1 Method For Reducing Postprandial Blood Glucose Levels With A Whey Protein/Fiber Composition 审中-公开
标题翻译：降低餐后血糖水平与乳清蛋白/纤维组成的方法
公开(公告)号：US20100056450A1
公开(公告)日：2010-03-04
申请号：US12550107
申请日：2009-08-28
申请人： Peter Harris Brown , Nathan V. Matusheski , Raymond J. Laudano , Kyle Maxwell Kamp , Julia Leigh DesRochers , Andrew Edward McPherson
发明人： Peter Harris Brown , Nathan V. Matusheski , Raymond J. Laudano , Kyle Maxwell Kamp , Julia Leigh DesRochers , Andrew Edward McPherson
IPC分类号： A61K38/16 , A61P3/10
CPC分类号： A61K35/20 , A23L33/19 , A23V2002/00 , A61K38/018 , A23V2200/328 , A23V2250/54252
摘要： A method is provided that is effective for reducing postprandial blood glucose levels. The method includes administering a blend of native whey protein and viscosifying fiber to a subject in an amount and at a time prior to a meal or concurrent with a meal that is effective for reducing postprandial blood glucose levels and/or reducing food intake.
摘要翻译：提供一种有效减少餐后血糖水平的方法。该方法包括在膳食之前或之前的时间内向受试者施用天然乳清蛋白和增粘纤维的混合物，或同时进行有效减少餐后血糖水平和/或减少食物摄入的膳食。

6. 发明申请

US20100056449A1 Whey Protein Pre-Load 审中-公开
标题翻译：乳清蛋白预加载
公开(公告)号：US20100056449A1
公开(公告)日：2010-03-04
申请号：US12550091
申请日：2009-08-28
申请人： Peter Harris Brown , Nathan V. Matusheski , Martyn Rubin , Gerald Harvey Anderson , Tina Akhavan , Clara Euna Cho , Bohdan Lyubomyrovych Luhovyy
发明人： Peter Harris Brown , Nathan V. Matusheski , Martyn Rubin , Gerald Harvey Anderson , Tina Akhavan , Clara Euna Cho , Bohdan Lyubomyrovych Luhovyy
IPC分类号： A61K38/17 , A61P3/10
CPC分类号： A61K35/20 , A23L33/19 , A23V2002/00 , A61K38/018 , A23V2200/328 , A23V2250/54252
摘要： A method is provided that is effective for reducing postprandial blood glucose levels and/or food intake levels. The method includes administering native whey protein to a subject in an amount and at a time prior to a meal that is effective for reducing postprandial blood glucose levels and/or reducing food intake.
摘要翻译：提供了一种有效减少餐后血糖水平和/或食物摄取水平的方法。该方法包括以有效减少餐后血糖水平和/或减少食物摄取的有效量的餐前给予受试者的天然乳清蛋白。

7. 发明授权

US08920175B2 Method and apparatus for identifying dietary choices 有权
标题翻译：识别饮食选择的方法和装置
公开(公告)号：US08920175B2
公开(公告)日：2014-12-30
申请号：US12474155
申请日：2009-05-28
申请人： Richard Black , Todd Kevin Abraham , Keith Randall Eberhardt , Linda Lee Letcher , Nathan V. Matusheski , Sandra Jean Morreale , Kristin H. Rubin , Arlene Olea Sanoy , Barbara Ann Yehling
发明人： Richard Black , Todd Kevin Abraham , Keith Randall Eberhardt , Linda Lee Letcher , Nathan V. Matusheski , Sandra Jean Morreale , Kristin H. Rubin , Arlene Olea Sanoy , Barbara Ann Yehling
IPC分类号： G09B19/00
CPC分类号： G09B19/0092 , G06F19/3475
摘要： A method is provided for assigning a relative score number to foods. Assignment of a relative score number to foods allows consumers to select foods that will provide a desirable diet. Equations are provided which are effective to yield a predicted raw score based on measured characteristics. The predicted raw score statistically correlates to a raw score that would be determined by an actual panel. The predicted raw scores are further processed to provide a relative score number that can be easily tracked by a consumer.
摘要翻译：提供了一种为食物分配相对分数的方法。将食物相对分数分配给食物可以让消费者选择能提供理想饮食的食物。提供了基于测量特征产生预测原始分数的方程式。预测的原始分数与由实际面板确定的原始分数进行统计学相关。进一步处理预测的原始分数，以提供可以容易地由消费者跟踪的相对分数。

8. 发明申请

US20090298021A1 Method And Apparatus For Identifying Dietary Choices 有权
标题翻译：用于识别膳食选择的方法和装置
公开(公告)号：US20090298021A1
公开(公告)日：2009-12-03
申请号：US12474155
申请日：2009-05-28
申请人： Richard Black , Todd Kevin Abraham , Keith Randall Eberhardt , Linda Lee Letcher , Nathan V. Matusheski , Sandra Jean Morreale , Kristin H. Rubin , Arlene Olea Sanoy , Barbara Ann Yehling
发明人： Richard Black , Todd Kevin Abraham , Keith Randall Eberhardt , Linda Lee Letcher , Nathan V. Matusheski , Sandra Jean Morreale , Kristin H. Rubin , Arlene Olea Sanoy , Barbara Ann Yehling
IPC分类号： G09B19/00
CPC分类号： G09B19/0092 , G06F19/3475
摘要： A method is provided for assigning a relative score number to foods. Assignment of a relative score number to foods allows consumers to select foods that will provide a desirable diet. Equations are provided which are effective to yield a predicted raw score based on measured characteristics. The predicted raw score statistically correlates to a raw score that would be determined by an actual panel. The predicted raw scores are further processed to provide a relative score number that can be easily tracked by a consumer.
摘要翻译：提供了一种为食物分配相对分数的方法。将食物相对分数分配给食物可以让消费者选择能提供理想饮食的食物。提供了基于测量特征产生预测原始分数的方程式。预测的原始分数与由实际面板确定的原始分数进行统计学相关。进一步处理预测的原始分数，以提供可以容易地由消费者跟踪的相对分数。

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