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1. 发明申请

US20070128118A1 POLYGLUTAMATE-AMINO ACID CONJUGATES AND METHODS 审中-公开
标题翻译：聚氨基酸 - 氨基酸共聚物和方法
公开(公告)号：US20070128118A1
公开(公告)日：2007-06-07
申请号：US11566141
申请日：2006-12-01
申请人： Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
发明人： Lei Yu , Gang Zhao , Sang Van , Sanjib Das , Zhongling Feng , Xiaoli Fu , Xinghe Wang , Yi Jin , Fu Chen
IPC分类号： A61K49/10 , A61K49/00 , A61K31/785
CPC分类号： A61K47/42 , A61K31/337 , A61K31/4745 , A61K31/704 , A61K47/56 , A61K47/62 , A61K47/64 , A61K47/645 , A61K49/0041 , A61K49/0056 , A61K49/146 , C08G69/10 , C08G69/48
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, biomolecule and imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这些聚合物可用于各种药物，生物分子和成像剂递送应用。

2. 发明申请

US20120189554A1 MULTI-FUNCTIONAL DRUG CARRIERS 审中-公开
标题翻译：多功能药物载体
公开(公告)号：US20120189554A1
公开(公告)日：2012-07-26
申请号：US13437557
申请日：2012-04-02
申请人： Lei Yu , Gang Zhao , Sang Van , Sanjib Kumar Das , Fu Chen , Yi Jin , Xiaoli Fu
发明人： Lei Yu , Gang Zhao , Sang Van , Sanjib Kumar Das , Fu Chen , Yi Jin , Xiaoli Fu
IPC分类号： A61K47/48 , A61K49/12 , A61P35/00 , C08G69/48
CPC分类号： A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这样的聚合物可用于各种药物，靶向，稳定和/或成像剂递送应用。

3. 发明申请

US20080181852A1 Multi-functional Drug Carriers 审中-公开
标题翻译：多功能药物载体
公开(公告)号：US20080181852A1
公开(公告)日：2008-07-31
申请号：US12019612
申请日：2008-01-24
申请人： Lei Yu , Gang Zhao , Sang Van , Sanjib Kumar Das , Fu Chen , Yi Jin , Xiaoli Fu
发明人： Lei Yu , Gang Zhao , Sang Van , Sanjib Kumar Das , Fu Chen , Yi Jin , Xiaoli Fu
IPC分类号： A61K31/337 , A61K47/30 , A61K31/435 , A61K31/70 , A61K49/12 , A61P35/00
CPC分类号： A61K49/0056 , A61K47/60 , A61K47/645 , A61K49/085 , A61K49/146
摘要： Various biodegradable polyglutamate-amino acids comprising recurring units of the general formulae (I) and (II) are prepared. Such polymers are useful for variety of drug, targeting, stabilizing and/or imaging agent delivery applications.
摘要翻译：制备包含通式（I）和（II）的重复单元的各种可生物降解的聚谷氨酸 - 氨基酸。这样的聚合物可用于各种药物，靶向，稳定和/或成像剂递送应用。

4. 发明申请

US20100028416A1 DRUG CARRIERS 审中-公开
标题翻译：药物承运人
公开(公告)号：US20100028416A1
公开(公告)日：2010-02-04
申请号：US12210125
申请日：2008-09-12
申请人： Lei Yu , Gang Zhao , Sang Van , Fu Chen
发明人： Lei Yu , Gang Zhao , Sang Van , Fu Chen
IPC分类号： A61K9/127 , A61K31/7088
CPC分类号： A61K47/34 , A61K9/127 , A61K31/00 , A61K31/337 , A61K31/7088 , A61K47/10 , A61K47/12 , A61K47/14 , A61K47/36 , A61K47/64
摘要： Compositions that can include a carrier, targeting agent, and therapeutic agent are disclosed herein. The therapeutic agent may have a therapeutic activity such as inhibiting fibrosis within a target organ or tissue or inhibiting the growth of a cancer cell.
摘要翻译：可以包括载体，靶向剂和治疗剂的组合物在本文中公开。治疗剂可以具有治疗活性，例如抑制靶器官或组织内的纤维化或抑制癌细胞的生长。

5. 发明申请

US20120107264A1 NUCLEIC ACID DELIVERY COMPOUNDS 审中-公开
标题翻译：核酸递送化合物
公开(公告)号：US20120107264A1
公开(公告)日：2012-05-03
申请号：US13273106
申请日：2011-10-13
申请人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Julia Zhu , Nianchun Ma , Chen-Chang Lee , Fu Chen , Lei Yu
发明人： Padmanabh Chivukula , Jian Liu , Akinobu Soma , Keisaku Okada , Sang Van , Julia Zhu , Nianchun Ma , Chen-Chang Lee , Fu Chen , Lei Yu
IPC分类号： A61K47/48 , C08F220/60 , A61P35/00 , A61K47/32 , C12N5/071 , C08F120/60 , C08G65/333
CPC分类号： C12N15/87 , C08F293/005 , C12N15/111 , C12N2310/14 , C12N2320/32
摘要： Polymers including two or more different recurring units are disclosed herein. Also disclosed herein are methods of using such polymers to deliver nucleic acids to a cell.
摘要翻译：包括两种或更多种不同重复单元的聚合物在本文中公开。本文还公开了使用这种聚合物将核酸递送至细胞的方法。

6. 发明授权

US06641754B2 Method for controlling scale formation and deposition in aqueous systems 有权
标题翻译：用于控制水系统中水垢形成和沉积的方法
公开(公告)号：US06641754B2
公开(公告)日：2003-11-04
申请号：US09878646
申请日：2001-06-11
申请人： Kristin E. Buentello , Stephen M. Kessler , Roger C. May , Julie A. Kaechelin , Fu Chen , Natalie A. Kolson
发明人： Kristin E. Buentello , Stephen M. Kessler , Roger C. May , Julie A. Kaechelin , Fu Chen , Natalie A. Kolson
IPC分类号： C08F510
CPC分类号： C08F216/14 , C02F5/10 , C02F5/12 , C02F5/14 , C02F2103/16 , C02F2103/28 , C23F11/10 , C23F11/173 , C23F14/02
摘要： A method of inhibiting the formation and deposition of scale forming moieties in aqueous systems by adding water-soluble or water-dispersible polymers is disclosed. The method comprises adding to an aqueous system a polymer having repeat units characterized by the Formula I: Wherein E is the repeat unit remaining after polymerization of an ethylenically unsaturated compound; preferably, a carboxylic acid, sulfonic acid, phosphonic acid, or amide form thereof or mixtures thereof. R1 is H or lower (C1-C4)alkyl. G is —CH2— or —CHCH3—; R2 is &Parenopenst;CH2—CH2—O&Parenclosest;n or &Parenopenst;CH2—CHCH3—O&Parenclosest;n where n ranges from about 1 to 100, preferably about 1 to 20. X is an anionic radical selected from the group consisting of SO3, PO3, or COO; Z is H or hydrogens or any water soluble cationic moiety which counterbalances the valence of the anionic radical X, including but not limited to Na, K, Ca, or NH4. F, when present, is a repeat unit having the structure of Formula II: wherein X and Z are the same as in Formula I. R4 is H or lower (C1-C4)alkyl. R5 is hydroxy substituted alkyl or alkylene having from about 1 to 6 of carbon atoms.
摘要翻译：公开了通过添加水溶性或水分散性聚合物来抑制水性体系中水垢形成部分的形成和沉积的方法。该方法包括向水性体系中加入具有由式I表征的重复单元的聚合物：其中E是烯键式不饱和化合物聚合后剩余的重复单元; 优选羧酸，磺酸，膦酸或其酰胺形式或其混合物。 R1是H或低级（C1-C4）烷基。 G是-CH 2 - 或-CHCH 3 - ; R2是＆Parenopenst; CH2-CH2-O和Parenclosest; n或＆Parenopenst; CH2-CHCH3-O和Parenclosest; n，其中n为约1至100，优选约1至20.X为选自SO 3，PO 3 ，或COO; Z是H或氢或任何水溶性阳离子部分，其使阴离子基团X的价态平衡，包括但不限于Na，K，Ca或NH 4。当存在时，F为具有式II结构的重复单元：其中X和Z与式I中相同.R4为H或低级（C1-C4）烷基。 R5是具有约1-6个碳原子的羟基取代的烷基或亚烷基。

7. 发明授权

US6020422A Aqueous dispersion polymers 失效
标题翻译：水分散体聚合物
公开(公告)号：US6020422A
公开(公告)日：2000-02-01
申请号：US749875
申请日：1996-11-15
申请人： Edward J. Connors , Michelle L. Cotter , Fu Chen
发明人： Edward J. Connors , Michelle L. Cotter , Fu Chen
IPC分类号： C08L57/00 , B41M7/00 , C02F1/56 , C08F2/10 , C08F251/00 , C08L1/00 , C08L3/04 , C08L5/00 , C08L33/26 , D21H21/10
CPC分类号： C08F220/34 , B41M7/0009 , C02F1/56 , C08F2/10 , C08F220/56 , C08F251/00 , D21H21/10 , C08K5/151 , C08L5/00 , D21H17/24 , D21H17/37 , D21H17/375 , D21H17/66 , D21H17/67
摘要： Water soluable, aqueous salt solution dispersible polymers and aqueous salt solutions containing dispersed polymers are produced by polymerization of ethylenically unsaturated soluble monomers in an aqueous salt solution in the presence of at least one carbohydrate. The polymers and aqueous salt solutions containing the dispersed polymers are useful for paper making, water clarification and emulsion breaking.
摘要翻译：通过在至少一种碳水化合物的存在下，通过烯键式不饱和可溶性单体在盐水溶液中聚合来制备含水溶解的盐水溶液可分散聚合物和含有分散聚合物的盐水溶液。含有分散聚合物的聚合物和含水盐溶液可用于造纸，水净化和乳液破碎。

8. 发明授权

US5851433A Method of and composition for breaking oil and water emulsions in crude oil processing operations 失效
标题翻译：原油加工作业中油和水乳化液破坏的方法和组成
公开(公告)号：US5851433A
公开(公告)日：1998-12-22
申请号：US899526
申请日：1997-07-24
申请人： Paul R. Hart , Jen-Chi Chen , Fu Chen , Thai H. Duong
发明人： Paul R. Hart , Jen-Chi Chen , Fu Chen , Thai H. Duong
IPC分类号： B01D17/04 , B01D17/05 , C02F1/56 , C10G33/04
CPC分类号： C10G33/04 , B01D17/047 , C02F1/56
摘要： Methods and compositions for breaking oil and water emulsions are disclosed. Oil and water emulsions are broken by treating the emulsion with a copolymer of tannin and a cationic monomer. The preferred composition is an aqueous solution of a copolymer of tannin and a cationic monomer, a water soluble organic multivalent salt and a glycol. The preferred salt is aluminum chlorohydrate and the preferred glycol is hexylene glycol.
摘要翻译：公开了用于破坏油和水乳液的方法和组合物。通过用单宁和阳离子单体的共聚物处理乳液来破坏油和水乳液。优选的组合物是单宁和阳离子单体的共聚物的水溶液，水溶性有机多价盐和二醇。优选的盐是水合氯化铝，优选的二醇是己二醇。

9. 发明授权

US5643462A Composition and method for water clarification 失效
标题翻译：水澄清的组成和方法
公开(公告)号：US5643462A
公开(公告)日：1997-07-01
申请号：US246544
申请日：1994-05-20
申请人： Jen-Chi Chen , Fu Chen , Gerald C. Walterick, Jr. , Stephen R. Vasconcellos
发明人： Jen-Chi Chen , Fu Chen , Gerald C. Walterick, Jr. , Stephen R. Vasconcellos
IPC分类号： C02F1/54 , C02F1/56 , C08F8/00 , C08F289/00 , C09D7/00 , B01D21/01
CPC分类号： C02F1/54 , C02F1/56 , C08F289/00 , C08F8/00 , C09D7/008
摘要： Tannin containing polymers, their method of production and methods of using as water treatment agents are disclosed. The tannin containing polymers comprise copolymers of tannin and a cationic monomer. Another embodiment comprises tannin containing polymers of tannin, cationic monomer and at least one monomer selected from the group consisting of an anionic monomer and a nonionic monomer.
摘要翻译：公开了含有单宁的聚合物，其生产方法和用作水处理剂的方法。单宁含聚合物包含单宁和阳离子单体的共聚物。另一个实施方案包括单宁含有聚合物的单宁，阳离子单体和至少一种选自阴离子单体和非离子单体的单体。

10. 发明授权

US5374336A Water soluble graft copolymers and methods of use thereof 失效
标题翻译：水溶性接枝共聚物及其使用方法
公开(公告)号：US5374336A
公开(公告)日：1994-12-20
申请号：US101139
申请日：1993-08-03
申请人： John T. Lin , Wen P. Liao , Fu Chen
发明人： John T. Lin , Wen P. Liao , Fu Chen
IPC分类号： C08F290/04 , D21H21/10 , C02F1/56 , C08F265/10
CPC分类号： C08F290/046
摘要： A water soluble graft copolymer useful as retention and drainage aids in papermaking processes having the structure: ##STR1## wherein E is the repeat unit obtained after polymerization of an .alpha.,.beta. ethylenically unsaturated compound, the molar percentage of a:b is from about 95:5 to 5:95, with the proviso that the sum of a and b equals 100%; G comprises the structure: ##STR2## wherein d is a cationic monomer, R.sub.1, R.sub.2 and R.sub.3 are the same or different and are hydrogen or a lower alkyl group having C.sub.1 to C.sub.3, F is the salt of an ammonium cation and the molar percentage of c:d is from 95:5 to 5:95 with the proviso that the sum of c and d equals 100%.
摘要翻译：一种水溶性接枝共聚物，其用作造纸方法中的保留和引流助剂，其结构如下：其中E是在α，β烯键式不饱和化合物聚合之后获得的重复单元，a：b的摩尔百分比为约95 ：5至5:95，条件是a和b之和等于100％; G包括以下结构：其中d为阳离子单体，R1，R2和R3相同或不同，为氢或C1至C3的低级烷基，F为铵阳离子的盐，摩尔百分数的c：d为95:5至5:95，条件是c和d之和等于100％。

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