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1. 发明授权

US06846313B1 One-piece biocompatible absorbable rivet and pin for use in surgical procedures 失效
标题翻译：一体式生物相容性可吸收铆钉和针脚用于外科手术
公开(公告)号：US06846313B1
公开(公告)日：2005-01-25
申请号：US09667729
申请日：2000-09-22
申请人： Laurel L. Rogers , Mariann Sayer , David W. Overaker , Shawn T. Huxel , Kevin Cooper , Dennis D. Jamiolkowski , Joseph R. Thomas
发明人： Laurel L. Rogers , Mariann Sayer , David W. Overaker , Shawn T. Huxel , Kevin Cooper , Dennis D. Jamiolkowski , Joseph R. Thomas
IPC分类号： A61B17/58 , A61B17/68 , A61B17/56
CPC分类号： A61B17/68
摘要： A bioabsorbable rivet and pin fastener is formed as an elongated unit that may be used for anchoring, or for attachment of a fixation plate. The rivet has a head mechanically connected to two or more legs that extend generally distally from the head and may flex outwardly from a central rivet axis. The pin is integral with the rivet and oriented along the central axis by a connection such as a web or a plurality of braces, forming an integral, aligned, one-piece assembly that may, for example, be molded as a single piece. The connection breaks under force as the pin is driven into the rivet, so that the pin contacts internal surfaces of the legs and pushes the legs outward into frictional engagement with the surrounding bone. The one-piece assembly may be formed in a gated mold having a central pin with a relief passage that defines the braces between upper and lower portions of the rivet. The braces so formed at the weld line readily part from the mold, and are easily sheared when the pin is advanced during installation of the rivet.
摘要翻译：生物可吸收的铆钉和销紧固件形成为可用于锚定或用于附接固定板的细长单元。铆钉具有机械连接到两个或更多个腿的头部，该两个或多个腿部从头部大致向远侧延伸并且可以从中心铆钉轴线向外弯曲。该销与铆钉成一体并且通过诸如幅材或多个支架的连接件沿着中心轴线定向，形成整体的，对齐的整体式组件，其可以例如被模制成单件。当销被驱动到铆钉中时，连接断裂，使得销接触腿的内表面并向外推动腿与周围的骨摩擦接合。一体式组件可以形成在具有中心销的门控模具中，该中心销具有在铆钉的上部和下部之间限定支架的释放通道。在焊接线处形成的支架容易地与模具成一部分，并且在铆钉安装期间当销前进时容易剪切。

2. 发明授权

US06241732B1 Biocompatible absorbable rivets and pins for use in surgical procedures 有权
标题翻译：生物相容的可吸收铆钉和针脚用于外科手术
公开(公告)号：US06241732B1
公开(公告)日：2001-06-05
申请号：US09185051
申请日：1998-11-03
申请人： David W. Overaker , Shawn T. Huxel , Kevin Cooper , Dennis D. Jamiolkowski
发明人： David W. Overaker , Shawn T. Huxel , Kevin Cooper , Dennis D. Jamiolkowski
IPC分类号： A61B1756
CPC分类号： A61B17/68
摘要： A bioabsorbable rivet and pin fastening device that may be used for attachment of a fixation plate to bone is described herein. The rivet having a head that is mechanically connected to two or more legs that extend generally distally from the head. The pin being radially compressible and less compliant than the legs of the rivet. The pin when inserted into the rivet will contact the internal surface of said legs to apply force on said legs in a direction perpendicular to the central axis to frictionally engage with the adjacent bone.
摘要翻译：本文描述了可用于将固定板附接到骨骼上的生物可吸收的铆钉和销固定装置。该铆钉具有机械连接到两个或更多个腿部的头部，该两个或多个腿部从头部大致向远侧延伸。该销可径向压缩，并且比铆钉的腿部柔顺。当插入铆钉中时，销将接触所述腿部的内表面，以在垂直于中心轴线的方向上对所述腿施加力以与邻近的骨摩擦接合。

3. 发明授权

US5550172A Utilization of biocompatible adhesive/sealant materials for securing surgical devices 失效
标题翻译：利用生物相容的粘合剂/密封剂材料来固定外科手术器械
公开(公告)号：US5550172A
公开(公告)日：1996-08-27
申请号：US385015
申请日：1995-02-07
申请人： Donald W. Regula , Kevin Cooper , Michael F. Bregen , Shawn T. Huxel , Daniel C. Rosenman
发明人： Donald W. Regula , Kevin Cooper , Michael F. Bregen , Shawn T. Huxel , Daniel C. Rosenman
IPC分类号： A61L24/00 , A61L24/02 , A61L24/04 , A61L24/06 , A61L27/00 , C08K5/10 , A61B17/56 , A61B17/58 , C01B15/16
CPC分类号： A61L24/046 , A61L24/02 , A61L24/06
摘要： A process for enhancing the security of implantable surgical devices secured to bone tissue comprising implanting in bone tissue a surgical device with a biocompatible adhesive and/or sealant selected from the group consisting of: p1 (a) a material made from monomers of the formula:CHR.sup.1 .dbd.CX.sup.1 Y.sup.1 wherein X.sup.1 and Y.sup.1 are each strong electron withdrawing groups, and R.sup.1 is hydrogen or, provided that X.sup.1 and Y.sup.1 are both cyano groups, a C.sub.1 -C.sub.4 alkyl group;(b) a semi-crystalline aliphatic poly(ester) of the formula:[--0--R.sup.11 --C(0)--].sub.y, wherein R.sup.11 is selected from the group consisting of --CR.sup.12 H--, --(CH.sub.2).sub.3 --0--, --CH.sub.2 --CH.sub.2 --O--CH.sub.2 --, CR.sub.12 H--CH.sub.2, --(CH.sub.2).sub.4 --, --(CH.sub.2).sub.z --O--C(O)-- and --(CH.sub.2).sub.z --C(O)--CH.sub.2 --; R.sup.12 is hydrogen or methyl; z is an integer in the range of from 1 to 7 and y is an integer in the range of from about 10 to about 20,000; and(c) a slurry of water and a calcium containing compounds with the general formula:M.sup.2+.sub.10-n N.sup.1+.sub.2n (WO.sub.4.sup.3-).sub.6 mU.sup.2- where n is an integer from 1 to 10, and m is 2 when x is 1, or m is 1 when x is 2, M and N are alkali or alkaline earth metals; WO.sub.4 is an acid radical and w is phosphorus, vanadium, sulfur, silicon, or is substituted in whole or part with carbonate (CO.sub.3.sup.2-); and U is a halide, hydroxide, or carbonate; provided in an amount effective to increase the amount of force necessary to remove the implanted surgical device. Additionally provided is a surgical device that is at least partially coated with at least one biocompatible adhesive and/or sealant.
摘要翻译：一种用于增强固定到骨组织的可植入手术装置的安全性的方法，包括在骨组织中植入具有选自以下的生物相容性粘合剂和/或密封剂的手术装置：p1（a）由下式的单体制成的材料： CHR1 = CX1Y1，其中X1和Y1各自是强吸电子基团，R1是氢，或者X1和Y1都是氰基，C1-C4烷基; （b）下式的半结晶脂族聚（酯）：[-0-R11-C（O） - ] y，其中R11选自-CR12H - ， - （CH2）3-0 - ， - CH 2 - （CH 2）4 - ， - （CH 2）z OC（O） - 和 - （CH 2）z C（O） R 12是氢或甲基; z是1至7的整数，y是约10至约20,000的整数; 和（c）水和含钙化合物的浆料，通式为：M2 + 10-nN1 + 2n（WO43-）6mU2-其中n为1至10的整数，当x为1时，m为2，或当x为2时m为1，M和N为碱金属或碱土金属; WO4是酸基，w是磷，钒，硫，硅，或全部或部分被碳酸酯（CO32-）取代; U是卤化物，氢氧化物或碳酸盐; 提供有效量以增加去除植入的手术装置所需的力的量。另外提供了至少部分地涂覆有至少一种生物相容性粘合剂和/或密封剂的手术装置。

4. 发明授权

US5633343A High strength, fast absorbing, melt processable, gycolide-rich, poly(glycolide-co-p-dioxanone) copolymers 失效
标题翻译：高强度，快速吸收，可熔融加工，富含甘油醚的聚（乙交酯 - 共对二恶烷酮）共聚物
公开(公告)号：US5633343A
公开(公告)日：1997-05-27
申请号：US497127
申请日：1995-06-30
申请人： Rao S. Bezwada , Kevin Cooper , Dennis D. Jamiolkowski , Hugh D. Newman, Jr.
发明人： Rao S. Bezwada , Kevin Cooper , Dennis D. Jamiolkowski , Hugh D. Newman, Jr.
IPC分类号： A61L17/00 , A61L15/26 , A61L17/12 , A61L27/00 , A61L31/06 , C08G63/06 , C08G63/08 , C08G63/66 , C08G63/664 , C08G63/78 , C08G63/82 , C08L101/16
CPC分类号： C08G63/823 , A61L15/26 , A61L17/12 , A61L31/06 , C08G63/664
摘要： Absorbable, segmented copolymers of aliphatic polyesters based on lactone monomers glycolide, and p-dioxanone are described. The segmented copolymers exhibit a broad range of properties, especially high strength and stiffness, and fast absorption rates and breaking strength retention (BSR) profiles, useful in a variety of medical devices. Most importantly, for suture applications where Vicryl.RTM.-like polyglcolide-polylactide sutures with excellent tensile properties, but shorter BSR profiles than Vicryl.RTM. are needed. The copolymers of the present invention have such properties, making them useful in plastic surgery where faster absorption times would lead to less tissue scarring.
摘要翻译：描述了基于内酯单体乙交酯和对二恶烷酮的脂族聚酯的可吸收，分段的共聚物。分段共聚物表现出广泛的性能，特别是高强度和刚度，以及快速吸收速率和断裂强度保持（BSR）轮廓，可用于各种医疗设备。最重要的是，对于具有优异拉伸性能的Vicryl TM样聚丙交酯 - 聚丙交酯缝线的缝合应用，需要比Vicryl TM更短的BSR曲线。本发明的共聚物具有这样的性质，使得它们可用于整形手术，其中更快的吸收时间将导致较少的组织瘢痕形成。

5. 发明授权

US5264540A Aromatic polyanhydrides 失效
标题翻译：芳香族聚酐
公开(公告)号：US5264540A
公开(公告)日：1993-11-23
申请号：US916919
申请日：1992-07-20
申请人： Kevin Cooper , David Wasserman , Angelo G. Scopelianos , Dennis D. Jamiolkowski
发明人： Kevin Cooper , David Wasserman , Angelo G. Scopelianos , Dennis D. Jamiolkowski
IPC分类号： A61L17/10 , A61L27/18 , A61L29/06 , A61L31/06 , C08G67/04 , C08G63/00 , C08G63/02 , C08G67/00 , C08G69/00
CPC分类号： C08G67/04 , A61L17/10 , A61L27/18 , A61L29/06 , A61L31/06
摘要： An improved process for preparing an aromatic polyanhydride is disclosed. The aromatic polyanhydride is prepared by reacting an aromatic dicarboxylic acid with an anhydride to form an anhydride prepolymer, isolating and purifying the prepolymer, and subjecting the prepolymer to melt polycondensation conditions. The improvement specifically relates to the purification of the acid so it is essentially free of impurities before it is reacted with the anhydride.The polymers prepared from the improved process have higher molecular weights than the molecular weights achieved from the prior art processes, and exhibit outstanding thermal stability and mechanical properties. This combination of properties allows the aromatic polyanhydrides to be melt processed to prepare numerous devices. In addition, these aromatic polyanhydrides are bioabsorbable, and this attribute in combination with its ability for melt processing makes the polyanhydrides particularly well-suited for the preparation of implantable surgical devices such as wound closure devices which are designed to absorb in the body when exposed to moist bodily tissue.

6. 发明授权

US09492952B2 Super-hydrophilic structures 有权
标题翻译：超亲水结构
公开(公告)号：US09492952B2
公开(公告)日：2016-11-15
申请号：US13435544
申请日：2012-03-30
申请人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Murty N. Vyakarnam , Chee Tiong Lim
发明人： Emma Kim Luong-Van , Isabel Rodriguez , Hong Yee Low , Noha Elmouelhi , Kevin Cooper , Sriram Natarajan , Murty N. Vyakarnam , Chee Tiong Lim
IPC分类号： C08G63/66 , A61K38/02 , A61K9/70 , B29C33/52 , A61L27/18 , A61L31/06 , A61B17/00
CPC分类号： B29C33/52 , A61B2017/00871 , A61B2017/00938 , A61B2017/00942 , A61B2017/00951 , A61L27/18 , A61L31/06 , Y10T428/24355 , C08L67/04
摘要： A polydioxanone film comprising substantially cylindrical polydioxanone pillars on at least one side thereof, said pillars having diameters from about 0.2 μm to about 3 μm, and heights from about 2 μm to about 20 μm from the surface of the film, a process for adsorbing proteins using the film and medical devices incorporating the film.
摘要翻译：一种聚二恶烷酮薄膜，其至少在其一面上包括基本上圆柱形的聚二恶烷酮柱，所述柱具有约0.2μm至约3μm的直径，以及距膜的约2μm至约20μm的高度，用于吸附蛋白质的方法使用包含该膜的胶片和医疗装置。

7. 发明授权

US09298019B2 Surface enhanced ophthalmic lens 有权
标题翻译：表面增强型眼科镜片
公开(公告)号：US09298019B2
公开(公告)日：2016-03-29
申请号：US13094870
申请日：2011-04-27
申请人： Randall B. Pugh , Zohra Fadli , Sriram Natarajan , Kevin Cooper , Murty N. Vyakarnam
发明人： Randall B. Pugh , Zohra Fadli , Sriram Natarajan , Kevin Cooper , Murty N. Vyakarnam
IPC分类号： G02C7/04
CPC分类号： G02C7/04
摘要： This invention discloses methods and apparatus for providing an ophthalmic lens with a textured pattern within an optic zone and an ophthalmic lens with a textured pattern within the optic zone.
摘要翻译：本发明公开了一种用于在光学区域内提供具有纹理图案的眼科镜片和在光学区域内具有纹理图案的眼科镜片的方法和装置。

8. 发明授权

US08097535B2 Fabrication of self-assembled nanowire-type interconnects on a semiconductor device 失效
标题翻译：在半导体器件上制造自组装纳米线型互连
公开(公告)号：US08097535B2
公开(公告)日：2012-01-17
申请号：US12439734
申请日：2007-08-31
申请人： Kevin Cooper , Srdjan Kordic
发明人： Kevin Cooper , Srdjan Kordic
IPC分类号： H01L21/00
CPC分类号： H01L21/76895 , H01L21/2885 , H01L2221/1094
摘要： The present invention relates to a semiconductor device with nanowire-type interconnect elements and a method for fabricating the same. The device comprises a metal structure with at least one self-assembled metal dendrite and forming an interconnect element (424) between a first and a second metal structure. The fabrication comprises providing an ambient environment adjacent to an interconnect surface region of a substrate that is suitable for allowing growth of at least one metal dendrite between the first and second metal structures, and initiating and sustaining self-assembly of a metal structure comprising at least one metal dendrite in the interconnect surface region between the first and second metal structures by irradiating the pn junction with photons of an energy suitable for creating free charge carriers in the first and second doped substrate regions and thus creating an electric potential difference between the first and second metal structures, which is suitable for electrolysis of metal from at least one of the first and second metal structures.
摘要翻译：本发明涉及具有纳米线型互连元件的半导体器件及其制造方法。该装置包括具有至少一个自组装金属枝晶的金属结构，并在第一和第二金属结构之间形成互连元件（424）。该制造包括提供邻近衬底的互连表面区域的周围环境，其适于允许在第一和第二金属结构之间生长至少一个金属枝晶，以及起始和维持金属结构的自组装，所述金属结构至少包括在第一和第二金属结构之间的互连表面区域中的一个金属枝晶通过用适于在第一和第二掺杂衬底区域中产生自由电荷载体的能量的光子照射pn结，从而在第一和第二掺杂衬底区域之间产生电位差，第二金属结构，其适于从第一和第二金属结构中的至少一个电解金属。

9. 发明授权

US07862585B2 Tissue repair device and fabrication thereof 有权
标题翻译：组织修复装置及其制造
公开(公告)号：US07862585B2
公开(公告)日：2011-01-04
申请号：US11159536
申请日：2005-06-23
申请人： Zhigang Li , Kevin Cooper , Raymond S. Shissias , Qiang Zhang
发明人： Zhigang Li , Kevin Cooper , Raymond S. Shissias , Qiang Zhang
IPC分类号： A61B17/04
CPC分类号： A61B17/0401 , A61B2017/00526 , A61B2017/0412 , A61B2017/0414 , A61B2017/0427 , A61B2017/044 , A61B2017/0458
摘要： A device for use in tissue repair, a method of using the device in a surgical procedure and a method of making the device. The device is an assembly of a cannulated anchor with a cord passed through it, and a stopper to prevent the cord from passing back through the anchor.
摘要翻译：用于组织修复的装置，在外科手术中使用该装置的方法以及制造该装置的方法。该装置是具有穿过其的绳索的插管锚的组件，以及用于防止绳索穿过锚固件的塞子。

10. 发明授权

US07837762B2 Method of distancing a bubble and bubble displacement apparatus 有权
标题翻译：隔离气泡和气泡位移装置的方法
公开(公告)号：US07837762B2
公开(公告)日：2010-11-23
申请号：US11914669
申请日：2005-05-17
申请人： Kevin Cooper , Scott Warrick
发明人： Kevin Cooper , Scott Warrick
IPC分类号： B01D19/00
CPC分类号： G03F7/70341 , G03F7/70858
摘要： In the field of immersion lithography, it is known to provide a liquid between an optical exposure system and a wafer carrying layers of photosensitive material to be irradiated with a pattern by the optical exposure system. However, bubbles are known to form or exist in the liquid, sometimes close to a surface of the wafer resulting in scattering of light emitted from the optical exposure system. The scattering causes the pattern recorded in the layers of photosensitive material to be corrupted, resulting in defective wafers. Therefore, the present invention provides a bubble displacement apparatus comprising a drive signal generator for driving a force generator arranged to generate a force in response to a drive signal generated by the drive signal generator. The force generated urges the bubble away from the surface.
摘要翻译：在浸没式光刻领域中，已知在光学曝光系统和承载光敏材料层的晶片之间提供液体，以通过光学曝光系统照射图案。然而，已知气泡在液体中形成或存在，有时靠近晶片的表面导致从光学曝光系统发射的光的散射。散射使得记录在感光材料层中的图案被破坏，导致缺陷晶片。因此，本发明提供一种气泡移动装置，其包括用于驱动力发生器的驱动信号发生器，其被布置成响应于由驱动信号发生器产生的驱动信号而产生力。产生的力促使气泡离开表面。

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