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1. 发明申请

US20070092877A1 Bcrm-1 genes and uses thereof 审中-公开
标题翻译： Bcrm-1基因及其用途
公开(公告)号：US20070092877A1
公开(公告)日：2007-04-26
申请号：US10542558
申请日：2004-02-24
申请人： Lan Chen , Daniel Auclair , Yuhong Gong , Meiru Dai
发明人： Lan Chen , Daniel Auclair , Yuhong Gong , Meiru Dai
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/82
CPC分类号： C07K14/4748 , C07K14/705 , C12Q1/6883 , C12Q2600/158
摘要： A polypeptide capable of conferring multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, trasformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines are also within the scope of this invention.
摘要翻译：公开了能够赋予细胞多药耐药性的多肽。还公开了编码多肽，表达载体，表达多肽的trasformant宿主细胞系和与多肽结合的抗体的核酸。使用上述多肽，核酸，抗体和宿主细胞系的筛选，诊断和治疗方法也在本发明的范围内。

2. 发明申请

US20060228763A1 Periostin-based diagnostic assays 审中-公开
公开(公告)号：US20060228763A1
公开(公告)日：2006-10-12
申请号：US11454752
申请日：2006-06-16
申请人： Lan Chen , Meiru Dai , Hidefumi Sasaki , Daniel Auclair
发明人： Lan Chen , Meiru Dai , Hidefumi Sasaki , Daniel Auclair
IPC分类号： G01N33/53 , C07K16/28 , C12N5/06
CPC分类号： G01N33/689 , C07K14/475 , C07K16/22 , G01N33/57415 , G01N2800/368
摘要： The invention includes novel human periostin polypeptides and DNAs encoding them. Also embraced by the invention are human periostin specific antibodies, diagnostic assays for metastasis of breast cancer to bone, and preeclempsia.

3. 发明申请

US20080089950A1 Methods and compositions for modulating the immune system and uses thereof 审中-公开
标题翻译：用于调节免疫系统的方法和组合物及其用途
公开(公告)号：US20080089950A1
公开(公告)日：2008-04-17
申请号：US11800420
申请日：2007-05-04
申请人： Lan Chen , Stine-Kathrein Kraeft , Daniel Auclair
发明人： Lan Chen , Stine-Kathrein Kraeft , Daniel Auclair
IPC分类号： A61K33/36 , A61K31/122 , A61K31/235 , A61P35/00 , A61K31/27 , A61K31/337
CPC分类号： A61K45/06 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/557 , A61K31/7072 , A61K38/1709 , A61K2300/00
摘要： The present invention provides methods of preventing, treating or ameliorating one or more symptoms of disorders in which modulation of a subject's immune system is beneficial utilizing a lymphoid tissue inducing agent and an immunomodulatory agent. In particular, the present invention provides methods of preventing, treating or ameliorating a proliferative disorder, an infectious disease, a cardiovascular disease, an autoimmune disorder, or an inflammatory disorder or one or more symptoms thereof comprising administering to a subject in need thereof one or more lymphoid tissue inducing agents and one or immunomodulatory agents. The present invention also provides compositions and articles of manufacture for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to proliferative disorders, infectious diseases, cardiovascular diseases, autoimmune disorders and inflammatory disorders. The present invention further provides methods for screening and identifying lymphoid tissue inducing agents and/or immunomodulatory agents.
摘要翻译：本发明提供了使用淋巴组织诱导剂和免疫调节剂来预防，治疗或改善其中调节受试者免疫系统有益的一种或多种疾病症状的方法。特别地，本发明提供预防，治疗或改善增殖性疾病，感染性疾病，心血管疾病，自身免疫性疾病或炎症性疾病或其一种或多种症状的方法，其包括向有需要的受试者施用一种或多种更多的淋巴组织诱导剂和一种或免疫调节剂。本发明还提供用于预防，治疗或改善与调节受试者的免疫系统有益的疾病相关的一种或多种症状的组合物和制品，其包括但不限于增殖性疾病，感染性疾病，心血管疾病，自身免疫性疾病和炎症性疾病。本发明还提供筛选和鉴定淋巴组织诱导剂和/或免疫调节剂的方法。

4. 发明申请

US20070015913A1 Mrp3 genes and uses thereof 审中-公开
标题翻译： Mrp3基因及其用途
公开(公告)号：US20070015913A1
公开(公告)日：2007-01-18
申请号：US10542128
申请日：2004-02-24
申请人： Lan Chen , Daniel Auclair
发明人： Lan Chen , Daniel Auclair
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/82 , C07K16/46 , A61K48/00
CPC分类号： C07K14/705 , A61K38/00 , A61K2039/54 , C07K16/00 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N2800/44
摘要： A nucleic acid capable of driving the expression of a reporter gene in a cancer cell line is disclosed. A polypeptide able to confer multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, transformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines are also within the scope of this invention.
摘要翻译：公开了能够驱动癌细胞系中报道基因表达的核酸。公开了能够赋予细胞多药耐药性的多肽。还公开了编码多肽，表达载体，表达多肽的转化体宿主细胞系和与多肽结合的抗体的核酸。使用上述多肽，核酸，抗体和宿主细胞系的筛选，诊断和治疗方法也在本发明的范围内。

5. 发明授权

US09750901B2 Dry powder drug-dosing device 有权
公开(公告)号：US09750901B2
公开(公告)日：2017-09-05
申请号：US14125936
申请日：2012-06-08
申请人： Lan Chen , Dizheng Du , Lei Xu
发明人： Lan Chen , Dizheng Du , Lei Xu
IPC分类号： A61M15/00
CPC分类号： A61M15/0065 , A61M15/0006 , A61M15/005 , A61M2202/062 , A61M2202/064
摘要： A dry powder drug-dosing device comprises a flow passage member (10), a drug powder storage container (19), and a drug-dosing metering component. A drug powder storage container (19), an annular manual rotation portion (3) and a rotational slide passage (23) are disposed on the outer surface of the housing. A sliding block (26) is disposed at an inner side of the annular manual rotation portion (3) A stirring gear (28) disposed on a transmission sleeve (27) is fit with the raised vibration tooth (21), so as to form a vibration component for enabling an outlet of the inverted conical drug powder storage container (19) to generate vibration. The dry powder drug-dosing device is applicable to the inhalation administration of various medicines in the form of dry powder.

6. 发明授权

US09647806B2 Method for configuring coordinated multipoint transmission 有权
公开(公告)号：US09647806B2
公开(公告)日：2017-05-09
申请号：US14112270
申请日：2012-04-23
申请人： Satoshi Nagata , Jianchi Zhu , Mingju Li , Xiaoming She , Lan Chen
发明人： Satoshi Nagata , Jianchi Zhu , Mingju Li , Xiaoming She , Lan Chen
IPC分类号： H04W72/00 , H04L5/00 , H04W72/04 , H04B7/024 , H04L1/00 , H04L1/18 , H04B7/06
CPC分类号： H04L5/0035 , H04B7/024 , H04B7/0452 , H04B7/0617 , H04B7/0619 , H04B7/0626 , H04L1/0026 , H04L1/1887 , H04W72/04 , H04W72/1231
摘要： Provided is a method for configuring coordinated multipoint transmission (CoMP) of the present invention. The method includes: providing a transmission mode to support CoMP and, at a base station (eNB), configuring the transmission mode to support CoMP to a user terminal (UE) by radio resource control (RRC) signaling. According to the method of the present invention, it becomes possible to configure CoMP so that the LTE system can support the CoMP function.

7. 发明授权

US08971436B2 User equipment and channel state information feedback method 有权
标题翻译：用户设备和信道状态信息反馈方法
公开(公告)号：US08971436B2
公开(公告)日：2015-03-03
申请号：US13703913
申请日：2011-06-17
申请人： Satoshi Nagata , Yoshihisa Kishiyama , Xiang Yun , Jianchi Zhu , Xiaoming She , Lan Chen
发明人： Satoshi Nagata , Yoshihisa Kishiyama , Xiang Yun , Jianchi Zhu , Xiaoming She , Lan Chen
IPC分类号： H04B7/02 , H04B7/04 , H04B7/06 , H04L1/00 , H04L5/00
CPC分类号： H04B7/0478 , H04B7/024 , H04B7/0456 , H04B7/0482 , H04B7/0632 , H04L1/0015 , H04L1/0026 , H04L1/0031 , H04L5/0035
摘要： The present invention provides a user equipment and channel state information feedback method. The channel state information feedback method used in a coordinated multi-point system includes acquiring small-scale channel state information H′=[H′1, H′2, . . . , H′K] between a user equipment and all base stations joining coordination, acquiring large-scale channel state information li(i=1, . . . , K) between the user equipment and each of the base stations joining coordination, acquiring a CQI (CQIi=li▪|H′|, i=1, . . . , K) between the user equipment and each of the base stations joining coordination based on the small-scale channel state information and the large-scale channel state information, updating the source codebook C using the acquired CQI to acquire an updated codebook{tilde over (C)},performing quantization processing using the updated codebook to acquire CDI, and transmitting the CDI and the CQI associated with each of the base stations joining coordination to a base station as feedback to provide for channel reconstruction in the base station. According to the invention, the rate of utilization of feedback information is improved.
摘要翻译：本发明提供一种用户设备和信道状态信息反馈方法。在协调多点系统中使用的信道状态信息反馈方法包括获取小规模信道状态信息H'= [H'1，H'2，...] 。。，H'K]在用户设备和所有基站之间加入协调，获取用户设备和每个基站之间加入协调的大规模信道状态信息li（i = 1，...，K），获取基于小规模信道状态信息和大规模信道状态信息，用户设备与加入协调的每个基站之间的CQI（CQIi =li▪| H'|，i = 1，...，K）使用获取的CQI更新源码本C以获取更新的码本（（C）），使用更新的码本执行量化处理以获取CDI，以及发送与连接协调的每个基站相关联的CDI和CQI 作为反馈提供给基站中的信道重建的基站。根据本发明，提高了反馈信息的利用率。

8. 发明申请

US20140092697A1 READ TIMING GENERATION CIRCUIT 有权
标题翻译：阅读时序生成电路
公开(公告)号：US20140092697A1
公开(公告)日：2014-04-03
申请号：US14123104
申请日：2011-11-25
申请人： Weiwei Chen , Lan Chen , Shiyang Yang
发明人： Weiwei Chen , Lan Chen , Shiyang Yang
IPC分类号： G11C7/22 , G11C7/12
CPC分类号： G11C7/222 , G11C7/12 , G11C8/06 , G11C8/18
摘要： Disclosed is a read timing generation circuit, capable of reducing dynamic power consumption. After a multi-bit address Add1, Add2, . . . , and AddN passes through an address change monitoring unit (100), a response pulse signal corresponding the address is generated. After the response pulse signal passes through an address trigger determination unit (200), a single trigger determination signal ATDPRE is generated. The single trigger determination signal ATDPRE passes through an ATD timing generation unit (300) and a post-timing generation unit (1000), thereby forming a read timing generation circuit in a serial link and generating corresponding read timing. Compared with the conventional read timing generation circuit in which each bit of an address signal corresponds to a stage of structures to execute the trigger, ATD control timing output, and ATD determination process separately, the present invention greatly reduces the total dynamic power consumption of the circuit.
摘要翻译：公开了能够降低动态功耗的读定时生成电路。经过多位地址Add1，Add2，。。。，AddN通过地址变更监视部（100），生成与该地址对应的响应脉冲信号。在响应脉冲信号通过地址触发判定单元（200）之后，产生单个触发判定信号ATDPRE。单个触发判定信号ATDPRE通过ATD定时生成单元（300）和后定时生成单元（1000），从而在串行链路中形成读取定时生成电路并生成对应的读取定时。与常规读取定时生成电路相比，地址信号的每个位分别对应于执行触发，ATD控制定时输出和ATD确定处理的结构的一级，本发明大大降低了总体动态功耗电路。

9. 发明申请

US20140050111A1 RECEIVING APPARATUS, DATA RECEIVING METHOD, AND CHANNEL ESTIMATING APPARATUS AND METHOD THEREFOR 有权
标题翻译：接收装置，数据接收方法和信道估计装置及其方法
公开(公告)号：US20140050111A1
公开(公告)日：2014-02-20
申请号：US14112265
申请日：2012-04-20
申请人： Satoshi Nagata , Hidekazu Taoka , Jianchi Zhu , Xiaoming She , Lan Chen
发明人： Satoshi Nagata , Hidekazu Taoka , Jianchi Zhu , Xiaoming She , Lan Chen
IPC分类号： H04L25/02
CPC分类号： H04L25/0202 , H04J11/0036 , H04J11/005 , H04L25/0204 , H04L25/03891
摘要： Disclosed are a receiving apparatus, a data receiving method, a channel estimating apparatus and a channel estimating method for multi-user interference (MUI) signals according to the present invention. The channel estimating apparatus for MUI signals has: a user type determining section configured to determine whether a UE apparatus corresponding to an own station belongs to a first type user or a second type user and to determine demodulation information to use in channel estimation of MUI signals based on the type of the UE apparatus corresponding to the own station; and a second channel estimating section configured to perform channel estimation of a multi-user interference signal based on the determined demodulation information to use in channel estimation of MUI signals. In the present invention, the UE apparatus is classified by type and the demodulation information to use in channel estimation of MUI signals is determined based on the type of the UE apparatus. With this structure, it is possible to improve channel estimation accuracy and further to improve the performance of data reception and user and cell throughputs.
摘要翻译：公开了根据本发明的接收装置，数据接收方法，信道估计装置和用于多用户干扰（MUI）信号的信道估计方法。用于MUI信号的信道估计装置具有：用户类型确定部分，用于确定与本站对应的UE装置是属于第一类用户还是第二类用户，并确定在MUI信号的信道估计中使用的解调信息基于对应于本站的UE装置的类型; 以及第二信道估计部，被配置为基于所确定的解调信息来执行多用户干扰信号的信道估计，以在MUI信号的信道估计中使用。在本发明中，根据类型对UE装置进行分类，并根据UE装置的种类来确定在MUI信号的信道估计中使用的解调信息。利用这种结构，可以提高信道估计精度并进一步提高数据接收的性能和用户和小区吞吐量。

10. 发明授权

US08516429B2 Circuit optimization method and apparatus for analog circuit migration 有权
标题翻译：用于模拟电路迁移的电路优化方法和装置
公开(公告)号：US08516429B2
公开(公告)日：2013-08-20
申请号：US13640594
申请日：2011-11-15
申请人： Yuping Wu , Lan Chen
发明人： Yuping Wu , Lan Chen
IPC分类号： G06F17/50
CPC分类号： G06F17/5036
摘要： A circuit optimization apparatus and a circuit optimization method used in analog circuit migration which migrates a source circuit to a target circuit are disclosed. The circuit optimization method comprises: dividing the source circuit into at least one direct current path; determining an adaptation sequence of the at least one direct current path; and optimizing the at least one direct current path in the target circuit one by one in the adaptation sequence. The circuit optimization apparatus and the circuit optimization method improve an optimization efficiency of the analog circuit migration.
摘要翻译：公开了将源电路迁移到目标电路的模拟电路迁移中使用的电路优化装置和电路优化方法。电路优化方法包括：将源电路划分成至少一个直流路径; 确定所述至少一个直流路径的适配序列; 以及在所述适配序列中逐个优化所述目标电路中的至少一个直流路径。电路优化装置和电路优化方法提高了模拟电路迁移的优化效率。

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