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1. 发明申请

US20080089950A1 Methods and compositions for modulating the immune system and uses thereof 审中-公开
标题翻译：用于调节免疫系统的方法和组合物及其用途
公开(公告)号：US20080089950A1
公开(公告)日：2008-04-17
申请号：US11800420
申请日：2007-05-04
申请人： Lan Chen , Stine-Kathrein Kraeft , Daniel Auclair
发明人： Lan Chen , Stine-Kathrein Kraeft , Daniel Auclair
IPC分类号： A61K33/36 , A61K31/122 , A61K31/235 , A61P35/00 , A61K31/27 , A61K31/337
CPC分类号： A61K45/06 , A61K31/337 , A61K31/426 , A61K31/427 , A61K31/557 , A61K31/7072 , A61K38/1709 , A61K2300/00
摘要： The present invention provides methods of preventing, treating or ameliorating one or more symptoms of disorders in which modulation of a subject's immune system is beneficial utilizing a lymphoid tissue inducing agent and an immunomodulatory agent. In particular, the present invention provides methods of preventing, treating or ameliorating a proliferative disorder, an infectious disease, a cardiovascular disease, an autoimmune disorder, or an inflammatory disorder or one or more symptoms thereof comprising administering to a subject in need thereof one or more lymphoid tissue inducing agents and one or immunomodulatory agents. The present invention also provides compositions and articles of manufacture for use in preventing, treating or ameliorating one or more symptoms associated with disorders in which modulation of a subject's immune system is beneficial, including, but not limited to proliferative disorders, infectious diseases, cardiovascular diseases, autoimmune disorders and inflammatory disorders. The present invention further provides methods for screening and identifying lymphoid tissue inducing agents and/or immunomodulatory agents.
摘要翻译：本发明提供了使用淋巴组织诱导剂和免疫调节剂来预防，治疗或改善其中调节受试者免疫系统有益的一种或多种疾病症状的方法。特别地，本发明提供预防，治疗或改善增殖性疾病，感染性疾病，心血管疾病，自身免疫性疾病或炎症性疾病或其一种或多种症状的方法，其包括向有需要的受试者施用一种或多种更多的淋巴组织诱导剂和一种或免疫调节剂。本发明还提供用于预防，治疗或改善与调节受试者的免疫系统有益的疾病相关的一种或多种症状的组合物和制品，其包括但不限于增殖性疾病，感染性疾病，心血管疾病，自身免疫性疾病和炎症性疾病。本发明还提供筛选和鉴定淋巴组织诱导剂和/或免疫调节剂的方法。

2. 发明申请

US20110071125A1 SUBSTITUTED PHENYLAMINO-BENZENE DERIVATIVES USEFUL FOR TREATING HYPER-PROLIFERATIVE DISORDERS AND DISEASES ASSOCIATED WITH MITOGEN EXTRACELLULAR KINASE ACTIVITY 审中-公开
标题翻译：用于治疗与增殖细胞激酶活性相关的超增殖性疾病和疾病的替代苯甲酰苯胺衍生物
公开(公告)号：US20110071125A1
公开(公告)日：2011-03-24
申请号：US12599641
申请日：2008-05-09
申请人： Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
发明人： Joachim Rudolph , Jaques Dumas , Li Yingfu , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther , Benjamin Bader
IPC分类号： A61K31/4178 , C12N9/99 , A61K31/397 , A61K31/535 , A61K31/4965 , A61K31/445 , A61K31/425 , A61K31/385 , A61K31/17 , A61K31/165 , C07D295/12 , C07D241/04 , C07D211/30 , C07D277/04 , C07D403/12 , C07D327/04 , C07C273/00 , C07C233/00 , A61P35/00 , A61P27/12
CPC分类号： C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要： This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及新的取代的苯基氨基苯化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。

3. 发明申请

US20060228763A1 Periostin-based diagnostic assays 审中-公开
公开(公告)号：US20060228763A1
公开(公告)日：2006-10-12
申请号：US11454752
申请日：2006-06-16
申请人： Lan Chen , Meiru Dai , Hidefumi Sasaki , Daniel Auclair
发明人： Lan Chen , Meiru Dai , Hidefumi Sasaki , Daniel Auclair
IPC分类号： G01N33/53 , C07K16/28 , C12N5/06
CPC分类号： G01N33/689 , C07K14/475 , C07K16/22 , G01N33/57415 , G01N2800/368
摘要： The invention includes novel human periostin polypeptides and DNAs encoding them. Also embraced by the invention are human periostin specific antibodies, diagnostic assays for metastasis of breast cancer to bone, and preeclempsia.

4. 发明申请

US20050083726A1 Soft errors handling EEPROM devices 失效
标题翻译：处理EEPROM设备的软错误
公开(公告)号：US20050083726A1
公开(公告)日：2005-04-21
申请号：US10974366
申请日：2004-10-26
申请人： Daniel Auclair , Jeffrey Craig , John Mangan , Robert Norman , Daniel Guterman , Sanjay Mehrotra
发明人： Daniel Auclair , Jeffrey Craig , John Mangan , Robert Norman , Daniel Guterman , Sanjay Mehrotra
IPC分类号： G06F11/10 , G11C16/10 , G11C29/50 , G11C29/52 , G11C11/00
CPC分类号： G11C29/028 , G06F11/1068 , G06F11/1072 , G06F2201/81 , G11C16/04 , G11C16/10 , G11C16/3431 , G11C29/50 , G11C29/50004 , G11C29/52 , G11C2029/5004 , G11C2029/5006
摘要： Soft errors occur during normal use of a solid-state memory such as EEPROM or Flash EEPROM. A soft error results from the programmed threshold voltage of a memory cell being drifted from its originally intended level. The error is initially not readily detected during normal read until the cumulative drift becomes so severe that it develops into a hard error. Data could be lost if enough of these hard errors swamps available error correction codes in the memory. A memory device and techniques therefor are capable of detecting these drifts and substantially maintaining the threshold voltage of each memory cell to its intended level throughout the use of the memory device, thereby resisting the development of soft errors into hard errors.
摘要翻译：正常使用固态存储器（如EEPROM或闪存EEPROM）时会发生软错误。存储器单元的编程阈值电压从原来的预期电平漂移导致软错误。在正常读取期间，最初不容易检测到该误差，直到累积漂移变得如此严重以致其发展为硬错误。数据可能会丢失，如果这些硬错误足够的可以在存储器中发出可用的纠错码。一种存储器件及其技术能够在整个使用存储器件的过程中检测这些漂移并且将每个存储器单元的阈值电压基本上保持在其预期的水平，从而抵抗将软错误发展成硬错误。

5. 发明申请

US20090082328A1 Substituted phenylamino-benzene derivatives useful for treating hyper-proliferative disorders and diseases associated with mitogen extracellular kinase activity 审中-公开
标题翻译：用于治疗高增殖性疾病和与丝裂原细胞外激酶活性相关的疾病的取代的苯基氨基苯衍生物
公开(公告)号：US20090082328A1
公开(公告)日：2009-03-26
申请号：US12151855
申请日：2008-05-09
申请人： Yingfu Li , Joachim Rudolph , Jacques P. Dumas , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther
发明人： Yingfu Li , Joachim Rudolph , Jacques P. Dumas , Daniel Auclair , Mario Lobell , Marion Hitchcock , Ingo Hartung , Marcus Koppitz , Dominic Brittain , Florian Puehler , Kirstin Petersen , Judith Guenther
IPC分类号： A61K31/445 , C07C205/45 , C07D211/32 , C07C255/58 , C07D317/30 , C07C237/28 , A61K31/397 , A61K31/40 , A61K31/27 , A61P35/00 , A61K31/44 , A61K31/166 , C07D295/14 , C07D279/12 , C07D265/30 , A61K31/54 , A61K31/5375
CPC分类号： C07D233/60 , C07C217/92 , C07C237/30 , C07C237/44 , C07C243/38 , C07C255/58 , C07C255/59 , C07C271/16 , C07C271/28 , C07C271/44 , C07C275/28 , C07C275/36 , C07C307/02 , C07C307/10 , C07C309/66 , C07C311/08 , C07C311/09 , C07C311/17 , C07C311/48 , C07C2601/08 , C07C2601/10 , C07D205/04 , C07D207/08 , C07D207/27 , C07D207/48 , C07D209/08 , C07D211/22 , C07D211/46 , C07D211/96 , C07D213/30 , C07D213/34 , C07D213/68 , C07D231/18 , C07D233/84 , C07D265/30 , C07D277/22 , C07D295/088 , C07D295/185 , C07D295/26 , C07D317/22 , C07D317/64 , C07D327/04 , C07D403/12
摘要： This invention relates to novel substituted phenylamino-benzene compounds, pharmaceutical compositions containing such compounds and the use of those compounds or compositions for treating hyper-proliferative and/or angiogenesis disorders, as a sole agent or in combination with other active ingredients.
摘要翻译：本发明涉及新的取代的苯基氨基苯化合物，含有这些化合物的药物组合物，以及这些化合物或组合物用于治疗高增殖和/或血管生成障碍，作为唯一试剂或与其它活性成分组合的用途。

6. 发明申请

US20070092877A1 Bcrm-1 genes and uses thereof 审中-公开
标题翻译： Bcrm-1基因及其用途
公开(公告)号：US20070092877A1
公开(公告)日：2007-04-26
申请号：US10542558
申请日：2004-02-24
申请人： Lan Chen , Daniel Auclair , Yuhong Gong , Meiru Dai
发明人： Lan Chen , Daniel Auclair , Yuhong Gong , Meiru Dai
IPC分类号： C12Q1/68 , C07H21/04 , C12P21/06 , C07K14/82
CPC分类号： C07K14/4748 , C07K14/705 , C12Q1/6883 , C12Q2600/158
摘要： A polypeptide capable of conferring multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, trasformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines are also within the scope of this invention.
摘要翻译：公开了能够赋予细胞多药耐药性的多肽。还公开了编码多肽，表达载体，表达多肽的trasformant宿主细胞系和与多肽结合的抗体的核酸。使用上述多肽，核酸，抗体和宿主细胞系的筛选，诊断和治疗方法也在本发明的范围内。

7. 发明申请

US20070015913A1 Mrp3 genes and uses thereof 审中-公开
标题翻译： Mrp3基因及其用途
公开(公告)号：US20070015913A1
公开(公告)日：2007-01-18
申请号：US10542128
申请日：2004-02-24
申请人： Lan Chen , Daniel Auclair
发明人： Lan Chen , Daniel Auclair
IPC分类号： C12Q1/68 , C07H21/04 , C07K14/82 , C07K16/46 , A61K48/00
CPC分类号： C07K14/705 , A61K38/00 , A61K2039/54 , C07K16/00 , C07K16/30 , C12Q1/6886 , C12Q2600/106 , C12Q2600/136 , G01N33/57415 , G01N33/57419 , G01N2800/44
摘要： A nucleic acid capable of driving the expression of a reporter gene in a cancer cell line is disclosed. A polypeptide able to confer multidrug-resistance on a cell is disclosed. Also disclosed are nucleic acids encoding the polypeptide, expression vectors, transformant host cell lines expressing the polypeptide, and antibodies binding to the polypeptide. Screening, diagnostic and treatment methods using the above polypeptide, nucleic acids, antibodies and host cell lines are also within the scope of this invention.
摘要翻译：公开了能够驱动癌细胞系中报道基因表达的核酸。公开了能够赋予细胞多药耐药性的多肽。还公开了编码多肽，表达载体，表达多肽的转化体宿主细胞系和与多肽结合的抗体的核酸。使用上述多肽，核酸，抗体和宿主细胞系的筛选，诊断和治疗方法也在本发明的范围内。

8. 发明授权

US07087727B2 Periostin-based diagnostic assays 失效
公开(公告)号：US07087727B2
公开(公告)日：2006-08-08
申请号：US10217371
申请日：2002-08-13
申请人： Lan Bo Chen , Meiru Dai , Hidefumi Sasaki , Daniel Auclair
发明人： Lan Bo Chen , Meiru Dai , Hidefumi Sasaki , Daniel Auclair
IPC分类号： C07K16/18 , C07K16/30 , C12N5/20 , C12P21/08 , G01N33/574
CPC分类号： G01N33/689 , C07K14/475 , C07K16/22 , G01N33/57415 , G01N2800/368
摘要： The invention includes novel human periostin polypeptides and DNAs encoding them. Also embraced by the invention are human periostin specific antibodies, diagnostic assays for metastasis of breast cancer to bone, and preeclempsia.

9. 发明申请

US20050058008A1 Soft errors handling in eeprom devices 失效
标题翻译： eeprom设备中的软错误处理
公开(公告)号：US20050058008A1
公开(公告)日：2005-03-17
申请号：US10917870
申请日：2004-08-13
申请人： Daniel Auclair , Jeffrey Craig , John Mangan , Robert Norman , Daniel Guterman , Sanjay Mehrotra
发明人： Daniel Auclair , Jeffrey Craig , John Mangan , Robert Norman , Daniel Guterman , Sanjay Mehrotra
IPC分类号： G06F11/10 , G11C16/10 , G11C29/50 , G11C29/52 , G11C7/00
CPC分类号： G11C29/028 , G06F11/1068 , G06F11/1072 , G06F2201/81 , G11C16/04 , G11C16/10 , G11C16/3431 , G11C29/50 , G11C29/50004 , G11C29/52 , G11C2029/5004 , G11C2029/5006
摘要： Soft errors occur during normal use of a solid-state memory such as EEPROM or Flash EEPROM. A soft error results from the programmed threshold voltage of a memory cell being drifted from its originally intended level. The error is initially not readily detected during normal read until the cumulative drift becomes so severe that it develops into a hard error. Data could be lost if enough of these hard errors swamps available error correction codes in the memory. A memory device and techniques therefor are capable of detecting these drifts and substantially maintaining the threshold voltage of each memory cell to its intended level throughout the use of the memory device, thereby resisting the development of soft errors into hard errors.
摘要翻译：正常使用固态存储器（如EEPROM或闪存EEPROM）时会发生软错误。存储器单元的编程阈值电压从原来的预期电平漂移导致软错误。在正常读取期间，最初不容易检测到该误差，直到累积漂移变得如此严重以致其发展为硬错误。数据可能会丢失，如果这些硬错误足够的可以在存储器中发出可用的纠错码。一种存储器件及其技术能够在整个使用存储器件的过程中检测这些漂移并且将每个存储器单元的阈值电压基本上保持在其预期的水平，从而抵抗将软错误发展成硬错误。

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