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1. 发明授权

US11766399B2 Method and system for drug delivery 有权
公开(公告)号：US11766399B2
公开(公告)日：2023-09-26
申请号：US17238278
申请日：2021-04-23
申请人： Syqe Medical Ltd.
发明人： Perry Davidson , Aaron Schorr , Arie Holtz , Will Pong , Binyamin Schwartz
IPC分类号： A61K9/00 , A61K9/70 , A61M11/04 , A61M15/00 , A24F40/50 , A61M16/00 , G16H20/13 , A24F40/20 , A24F40/485 , A24F40/10
CPC分类号： A61K9/0004 , A24F40/50 , A61K9/007 , A61K9/7007 , A61M11/041 , A61M11/042 , A61M15/002 , A61M15/0003 , A61M15/008 , A61M15/0016 , A61M15/0045 , A61M15/0051 , A61M15/0055 , A61M15/0065 , A61M15/0066 , A61M15/0081 , A61M15/0083 , A24F40/10 , A24F40/20 , A24F40/485 , A61M11/048 , A61M2016/0021 , A61M2016/0039 , A61M2202/062 , A61M2205/12 , A61M2205/13 , A61M2205/17 , A61M2205/18 , A61M2205/276 , A61M2205/3306 , A61M2205/3331 , A61M2205/3365 , A61M2205/3368 , A61M2205/3553 , A61M2205/3584 , A61M2205/3592 , A61M2205/364 , A61M2205/3606 , A61M2205/368 , A61M2205/3653 , A61M2205/3673 , A61M2205/502 , A61M2205/52 , A61M2205/581 , A61M2205/583 , A61M2205/587 , A61M2205/60 , A61M2205/6009 , A61M2205/6018 , A61M2205/6054 , A61M2205/6063 , A61M2205/6072 , A61M2205/8206 , A61M2207/00 , A61M2209/06 , A61M2209/10 , G16H20/13
摘要： There is provided in accordance with an exemplary embodiment of the invention, a device and a method for controlled extraction of at least one active substance from at least one type of plant matter by application of heat, the device comprising: a heating element adapted to apply heat to an area of the plant matter to extract the substance; and a mechanism adapted for moving the plant matter relative to the heating element. Optionally, the active substance is a restricted substance. There is also provided in accordance with an exemplary embodiment of the invention, a method of monitoring and controlling inhalation of a restricted substance. There is provided in accordance with an exemplary embodiment of the invention, a method of manufacturing a tape of plant matter comprising an active substance.

2. 发明申请

US20170056610A1 APPARATUS, SYSTEMS AND METHOD FOR COLLECTING AND RECLAIMING ANAESTHETIC AGENTS AND FOR REMOVING NITROUS OXIDE FROM EXHAUST GASES 审中-公开
标题翻译：收集和回收麻醉剂并从排气中去除氧化亚氮的装置，系统和方法
公开(公告)号：US20170056610A1
公开(公告)日：2017-03-02
申请号：US15350576
申请日：2016-11-14
申请人： Class 1 Inc.
发明人： Barry W. Hunt , Todd Eric Jarrett , Damian Ross Thorne , Katrina Marie Ahchong , Dean Paul Carr , Cesar Laurentino Martinez Vasquez
IPC分类号： A61M16/00 , B01D53/56 , B01D53/26 , G05D7/06 , A61L9/20 , B01J20/02 , G06Q40/00 , B01J19/08 , B01D53/047 , B01D53/75
CPC分类号： A61M16/0093 , A61L9/20 , A61L2209/14 , A61M16/0051 , A61M16/0066 , A61M16/009 , A61M16/01 , A61M16/024 , A61M16/0808 , A61M16/101 , A61M2016/0042 , A61M2202/0208 , A61M2202/0241 , A61M2202/0275 , A61M2202/0283 , A61M2202/062 , A61M2205/3653 , A61M2230/437 , B01D53/02 , B01D53/047 , B01D53/22 , B01D53/261 , B01D53/266 , B01D53/268 , B01D53/56 , B01D53/565 , B01D53/75 , B01D2257/102 , B01D2257/104 , B01D2257/40 , B01D2257/504 , B01D2259/4508 , B01D2259/4533 , B01J19/088 , B01J20/02 , G05D7/0623 , G06Q40/123 , Y02C10/08 , Y02C20/10 , Y10T137/0324 , Y10T137/7722 , Y10T137/7736 , Y10T137/7761
摘要： A system for collecting an anaesthetic agent, having at least one anaesthetic gas scavenging system (AGSS) for receiving exhaust gas from a plurality of sources, the exhaust gas including the anaesthetic agent to be collected, each AGSS comprising at least one power source for providing suction of the exhaust gas from the plurality of sources under negative pressure, and a central collection system for receiving the exhaust gas, the central collection system comprising at least one collector for collecting the anaesthetic agent from the exhaust gas, wherein the at least one collector is configured to adsorb the anaesthetic agent from the exhaust gas. The central collection system may be configured to received the exhaust gases from the at least one AGSS, with the central collection system being located downstream of the at least one AGSS.
摘要翻译：一种用于收集麻醉剂的系统，具有至少一个用于从多个源接收废气的麻醉气体清除系统（AGSS），所述排气包括待收集的麻醉剂，每个AGSS包括至少一个用于提供在负压下从多个源抽吸废气，以及用于接收废气的中央收集系统，所述中央收集系统包括至少一个用于从废气中收集麻醉剂的收集器，其中所述至少一个收集器被构造成从排气中吸附麻醉剂。中央收集系统可以被配置为从至少一个AGSS接收排气，中央收集系统位于至少一个AGSS的下游。

3. 发明授权

US09259376B2 Process for dry powder formulations 有权
标题翻译：干粉配方工艺
公开(公告)号：US09259376B2
公开(公告)日：2016-02-16
申请号：US13701599
申请日：2011-06-02
申请人： Mahmut Bilgic
发明人： Mahmut Bilgic
IPC分类号： A61K9/28 , A61J3/00 , A61K9/48 , A61J3/07 , A61K9/00 , A61M15/00
CPC分类号： A61J3/005 , A61J3/07 , A61K9/0075 , A61K9/4816 , A61M15/0028 , A61M15/0035 , A61M15/0038 , A61M2202/062 , A61M2202/064
摘要： The present invention relates to a process developed for production of a dry powder medicament used in respiratory tract diseases such as asthma and COPD.
摘要翻译：本发明涉及用于生产用于呼吸道疾病如哮喘和COPD的干粉药物的方法。

4. 发明申请

US20140158126A1 DRUG DELIVERY DEVICE FOR THE TREATMENT OF PATIENTS WITH RESPIRATORY DISEASES 审中-公开
标题翻译：用于治疗患有呼吸道疾病的患者的药物递送装置
公开(公告)号：US20140158126A1
公开(公告)日：2014-06-12
申请号：US14069755
申请日：2013-11-01
申请人： CHIESI FARMACEUTICI S.p.A.
发明人： Mark PARRY-BILLINGS , Mario Scuri , Maria Chiara Taverna
IPC分类号： A61M15/00 , A61M16/00
CPC分类号： A61M15/0093 , A61M15/0008 , A61M15/0026 , A61M15/0065 , A61M15/0075 , A61M15/0091 , A61M2016/0033 , A61M2202/062 , A61M2202/064 , A61M2205/3375 , A61M2205/3553 , A61M2205/3584 , A61M2205/50 , A61M2205/52 , A61M2206/16 , G06F19/3481
摘要： Drug delivery devices that include a microphone and processing circuitry that can detect operating events, such as peak inspiratory flow (PIF) and Breath Actuated Mechanism (BAM) in dry powder inhalers can be used to improve clinical trials by providing information about the way in which the inhalers under test are being used.
摘要翻译：包括麦克风和处理电路的药物输送装置可以用于检测干粉吸入器中的运动事件，如峰值吸气流量（PIF）和呼吸促进机制（BAM），以改善临床试验，提供有关其中正在使用被测试的吸入器。

5. 发明申请

US20130220320A1 Inhaler Comprising A Base Having A Plurality of Medicament Containing Sealed Cavities 审中-公开
标题翻译：吸入器包含具有多个含有密封腔的药物的基底
公开(公告)号：US20130220320A1
公开(公告)日：2013-08-29
申请号：US13761782
申请日：2013-02-07
申请人： AstraZeneca AB
发明人： Orest Lastow
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0043 , A61M15/0048 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/062 , A61M2202/064
摘要： An inhaler which comprises a base having a plurality of consecutive sealed cavities containing medicament. Foil portions are on one side attached to the base for sealing the medicament within respective associated cavities. A plurality of separating elements are attached to the other side of the foil portions, each separating element being associated with a respective cavity for separating a foil portion from that cavity. Each separating element can be moved-away from its associated cavity so that the sealing foil portion is separated from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow, and then returned with the attached foil portion to cover its associated cavity. A method of operating an inhaler is also disclosed.
摘要翻译：一种吸入器，其包括具有包含药物的多个连续密封腔的底座。箔部分在一侧附接到基部，用于将药物密封在相应的相关空腔内。多个分离元件附接到箔片部分的另一侧，每个分离元件与相应的腔体相关联，用于将箔片部分与该腔体分离。每个分离元件可以从其相关联的空腔移开，使得密封箔片部分与空腔分离，由此未被覆盖，使得其中容纳的药物能够被夹带在流体流中，然后与附着的箔片部分一起返回覆盖其相关腔。还公开了一种操作吸入器的方法。

6. 发明授权

US08430099B2 Apparatus, systems and method for collecting and reclaiming anaesthetic agents and for removing nitrous oxide from exhaust gases 有权
标题翻译：用于收集和回收麻醉剂并从废气中除去一氧化二氮的装置，系统和方法
公开(公告)号：US08430099B2
公开(公告)日：2013-04-30
申请号：US13231718
申请日：2011-09-13
申请人： Barry W. Hunt , Todd Eric Jarrett , Damian Ross Thorne , Katrina Marie Ahchong , Dean Paul Carr , Cesar Laurentino Martinez Vazquez
发明人： Barry W. Hunt , Todd Eric Jarrett , Damian Ross Thorne , Katrina Marie Ahchong , Dean Paul Carr , Cesar Laurentino Martinez Vazquez
IPC分类号： A61M16/01
CPC分类号： A61M16/0093 , A61L9/20 , A61L2209/14 , A61M16/0051 , A61M16/0066 , A61M16/009 , A61M16/01 , A61M16/024 , A61M16/0808 , A61M16/101 , A61M16/105 , A61M16/20 , A61M2016/0042 , A61M2202/0208 , A61M2202/0241 , A61M2202/0275 , A61M2202/0283 , A61M2202/062 , A61M2205/3653 , A61M2230/437 , B01D53/02 , B01D53/047 , B01D53/22 , B01D53/261 , B01D53/266 , B01D53/268 , B01D53/56 , B01D53/565 , B01D53/75 , B01D2257/102 , B01D2257/104 , B01D2257/40 , B01D2257/504 , B01D2259/4508 , B01D2259/4533 , B01J19/088 , B01J20/02 , G05D7/0623 , G06Q40/123 , Y02C10/08 , Y02C20/10 , Y10T137/0324 , Y10T137/7722 , Y10T137/7736 , Y10T137/7761
摘要： A system for collecting an anaesthetic agent, having at least one anaesthetic gas scavenging system (AGSS) for receiving exhaust gas from a plurality of sources, the exhaust gas including the anaesthetic agent to be collected, each AGSS comprising at least one power source for providing suction of the exhaust gas from the plurality of sources under negative pressure, and a central collection system for receiving the exhaust gas, the central collection system comprising at least one collector for collecting the anaesthetic agent from the exhaust gas, wherein the at least one collector is configured to adsorb the anaesthetic agent from the exhaust gas. The central collection system may be configured to received the exhaust gases from the at least one AGSS, with the central collection system being located downstream of the at least one AGSS.
摘要翻译：一种用于收集麻醉剂的系统，具有至少一个用于从多个源接收废气的麻醉气体清除系统（AGSS），所述排气包括待收集的麻醉剂，每个AGSS包括至少一个用于提供在负压下从多个源抽吸废气，以及用于接收废气的中央收集系统，所述中央收集系统包括至少一个用于从废气中收集麻醉剂的收集器，其中所述至少一个收集器被构造成从排气中吸附麻醉剂。中央收集系统可以被配置为从至少一个AGSS接收排气，中央收集系统位于至少一个AGSS的下游。

7. 发明授权

US08397718B2 Inhaler comprising a base having at least one sealed cavity containing medicament 有权
标题翻译：吸入器包括具有至少一个包含药物的密封腔的底座
公开(公告)号：US08397718B2
公开(公告)日：2013-03-19
申请号：US12867466
申请日：2009-02-11
申请人： Orest Lastow
发明人： Orest Lastow
IPC分类号： A61M15/00 , A61M15/08 , A61M16/10
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0028 , A61M15/0043 , A61M15/0048 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/062 , A61M2202/064
摘要： An inhaler which comprises a base having at least one sealed cavity containing medicament and a foil portion comprising two sides, one side being attached to the base for sealing the medicament within the cavity. A separating element is attached to the other side of the foil portion for separating the foil portion from the cavity, the separating element having a first end and an opposite second end, wherein the separating element is movable to an intermediate tilted position in which said first end is moved-away from the cavity. The separating element is further movable from the intermediate tilted position to a removed position in which also said second end is moved-away from the cavity so that the foil portion is removed from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow.
摘要翻译：一种吸入器，其包括具有至少一个包含药物的密封空腔的基座和包括两侧的箔片部分，一侧连接到所述底座上以将所述药物密封在所述空腔内。分离元件附接到箔部分的另一侧，用于将箔片部分与空腔分离，分离元件具有第一端和相对的第二端，其中分离元件可移动到中间倾斜位置，其中所述第一端部从腔体移开。分离元件还可以从中间倾斜位置移动到去除位置，在该位置中，所述第二端也从空腔移开，使得箔部分从空腔移除，从而使其不被覆盖，使得其中包含的药物能够被变成夹带在流体流中。

8. 发明授权

US07935081B2 Drug delivery cassette and a medical effector system 有权
标题翻译：药物输送盒和医疗执行器系统
公开(公告)号：US07935081B2
公开(公告)日：2011-05-03
申请号：US11158262
申请日：2005-06-21
申请人： Richard W. Flaker , Mark A. Burdorff , Gregory D. Bishop , DeWayne A. Davis , William T. Donofrio , Curt R. Eyster , Hal H. Katz , David J. Keilholz , Ross Krogh , Michael J. Miller , Anil K. Nalagatla , Paul J. Niklewski , Jeffery J. Wuennemann , Jason P. Derouen
发明人： Richard W. Flaker , Mark A. Burdorff , Gregory D. Bishop , DeWayne A. Davis , William T. Donofrio , Curt R. Eyster , Hal H. Katz , David J. Keilholz , Ross Krogh , Michael J. Miller , Anil K. Nalagatla , Paul J. Niklewski , Jeffery J. Wuennemann , Jason P. Derouen
IPC分类号： A61M37/00 , A61M31/00
CPC分类号： A61M5/142 , A61B5/0836 , A61B5/411 , A61B5/6819 , A61B5/682 , A61B5/7495 , A61M5/14228 , A61M5/162 , A61M5/16831 , A61M5/172 , A61M16/0051 , A61M16/024 , A61M16/0493 , A61M16/0672 , A61M16/0677 , A61M16/0688 , A61M16/0808 , A61M16/085 , A61M16/0858 , A61M21/02 , A61M2016/0027 , A61M2016/1025 , A61M2021/0027 , A61M2202/0208 , A61M2202/048 , A61M2202/062 , A61M2205/05 , A61M2205/12 , A61M2205/123 , A61M2205/13 , A61M2205/14 , A61M2205/273 , A61M2205/3334 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/505 , A61M2205/6072 , A61M2205/7536 , A61M2209/084 , A61M2210/0618 , A61M2210/0625 , A61M2210/0662 , A61M2230/04 , A61M2230/06 , A61M2230/205 , A61M2230/30 , A61M2230/432 , A61M2230/63 , G06F19/00 , G06Q50/22 , G06Q50/24
摘要： Disclosed is an interface between a drug delivery cassette and a medical effector system. The cassette may be mounted to the medical effector system in such a way that a fluid tube located on the cassette is positioned adjacent to a pump located on the medical effector system. The medical effector system may purge the fluid line of air by activating the pump and forcing fluid through the fluid line until a sensor positioned to monitor the fluid line indicates that fluid and not air is present in the tube. To prevent air purging of the fluid tube when connected to the patient, the medical effector system prohibits air purging unless the drug delivery end portion of the fluid tube is in a designated storage site located on the cassette. This is accomplished with a position sensor at the storage site that monitors the position of the fluid tube.
摘要翻译：公开了药物递送盒和医疗执行器系统之间的界面。盒可以以使得位于盒上的流体管被定位成邻近位于医疗执行器系统上的泵的方式安装到医疗执行器系统。医疗执行器系统可以通过激活泵并迫使流体通过流体管线来清洁流体管线，直到定位成监测流体管线的传感器指示管中存在流体而不存在空气。为了防止在连接到患者时空气吹扫流体管，医疗执行器系统禁止空气清除，除非流体管的药物输送端部位于位于盒上的指定的存储位置。这是通过在存储位置处的位置传感器来实现的，该位置传感器监测流体管的位置。

9. 发明申请

US20100326440A1 Inhaler Comprising A Base Having A Plurality Of Medicament Containing Sealed Cavities 有权
标题翻译：吸入器包含含有密封腔的多种药物的基础
公开(公告)号：US20100326440A1
公开(公告)日：2010-12-30
申请号：US12867423
申请日：2009-02-11
申请人： Orest Lastow
发明人： Orest Lastow
IPC分类号： A61M15/00
CPC分类号： A61M15/0045 , A61M15/0003 , A61M15/0043 , A61M15/0048 , A61M15/0091 , A61M15/0093 , A61M15/0096 , A61M2202/062 , A61M2202/064
摘要： An inhaler which comprises a base having a plurality of consecutive sealed cavities containing medicament. Foil portions are on one side attached to the base for sealing the medicament within respective associated cavities. A plurality of separating elements are attached to the other side of the foil portions, each separating element being associated with a respective cavity for separating a foil portion from that cavity. Each separating element can be moved-away from its associated cavity so that the sealing foil portion is separated from the cavity which is thereby uncovered so that medicament contained therein is enabled to become entrained in a fluid flow, and then returned with the attached foil portion to cover its associated cavity. A method of operating an inhaler is also disclosed.
摘要翻译：一种吸入器，其包括具有包含药物的多个连续密封腔的底座。箔部分在一侧附接到基部，用于将药物密封在相应的相关空腔内。多个分离元件附接到箔片部分的另一侧，每个分离元件与相应的腔体相关联，用于将箔片部分与该腔体分离。每个分离元件可以从其相关联的空腔移开，使得密封箔片部分与空腔分离，由此未被覆盖，使得其中容纳的药物能够被夹带在流体流中，然后与附着的箔片部分一起返回覆盖其相关腔。还公开了一种操作吸入器的方法。

10. 发明申请

US20100309020A1 Metering Device for the Inhalation of a Pulverulent Substance 有权
标题翻译：用于吸入有毒物质的计量装置
公开(公告)号：US20100309020A1
公开(公告)日：2010-12-09
申请号：US12744415
申请日：2008-10-29
申请人： Alfred Von Schuckmann , Yorick Kamlag , Stefan Mayer , Dennis Sandell
发明人： Alfred Von Schuckmann , Yorick Kamlag , Stefan Mayer , Dennis Sandell
IPC分类号： G08C19/16
CPC分类号： A61M15/0065 , A61M15/0006 , A61M15/0025 , A61M15/0086 , A61M15/0091 , A61M2202/062 , A61M2202/064 , A61M2206/16
摘要： A metering device can be activated by a suction airflow of a user for inhaling a powdery substance, in particular of medicinal type, which is arranged in a supply chamber and can be brought out of there into an apparent discharge standby position by removing a mouthpiece sealing cap by a metering chamber of a metering rod. The metering device provides piston-extensible tabs for sealing off the metering chamber, particularly for the facilitated opening of the metering chamber.
摘要翻译：计量装置可以由用户的吸入气流激活，用于吸入布置在供应室中的药物类型的粉末状物质，并且可以通过除去接口密封件而从其中排出到表观放电待机位置由计量杆的计量室盖住。计量装置提供了用于密封计量室的活塞可伸长突片，特别是用于便于打开计量室。

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