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1. 发明申请

US20110014673A1 Systems and Methods for Effecting a Physical Change in a Biological Sample 有权
标题翻译：影响生物样品物理变化的系统和方法
公开(公告)号：US20110014673A1
公开(公告)日：2011-01-20
申请号：US12835822
申请日：2010-07-14
申请人： Kyle W. Hukari , Jason A.A. West
发明人： Kyle W. Hukari , Jason A.A. West
IPC分类号： C12N13/00 , C12N5/00 , C12M1/02
CPC分类号： C12N13/00 , C12M47/06
摘要： The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present invention relates both to breaking apart biological species such as viruses and cells, as well as the formation of reactants from one or more reactive species. The sample has a volume in the range from about 1 microliter to 10 milliliters. The sample is processed by applying pressure, and either sonic energy or thermal energy to the sample, wherein the pressure achieved is usually at least 24 atmospheres, and the temperature of the sample is usually raised to at least 50° C.
摘要翻译：本发明一般涉及用于处理导致物理变化的生物样品的系统和方法，例如将两个分子一起反应以形成反应产物或用于裂解病毒或生物细胞用于使用生物测定系统进行分析。因此，本发明涉及分解生物物种如病毒和细胞，以及从一种或多种反应性物质形成反应物。样品的体积在约1微升至10毫升的范围内。通过对样品施加压力和声能或热能来处理样品，其中获得的压力通常为至少24个大气压，并且样品的温度通常升高至至少50℃。

2. 发明申请

US20110294205A1 AUTOMATED CELLULAR MATERIAL PREPARATION 有权
标题翻译：自动细胞材料制备
公开(公告)号：US20110294205A1
公开(公告)日：2011-12-01
申请号：US13069820
申请日：2011-03-23
申请人： Kyle W. Hukari , Jason A.A. West , Michael A. Shultz , Richard Milson , Nikolas M. Isely , Michael C. DeRenzi
发明人： Kyle W. Hukari , Jason A.A. West , Michael A. Shultz , Richard Milson , Nikolas M. Isely , Michael C. DeRenzi
IPC分类号： C12M1/12 , C12N5/071
CPC分类号： G01N1/405 , C12N15/1003 , C12Q1/6806 , G01N35/1095 , G01N2035/1053 , Y10T436/2575
摘要： Provided are cartridges and systems for effecting automated extraction, isolation, and purification of cellular components—such as nucleic acids—from a cellular sample in assay-ready form. Also provided are related methods of effecting such sample processing.
摘要翻译：提供了用于实现从测定准备形式的细胞样品中自动提取，分离和纯化细胞组分（例如核酸）的盒和系统。还提供了进行这种样品处理的相关方法。

3. 发明申请

US20070238090A1 Systems and methods for effecting a physical change in a biological sample 有权
标题翻译：影响生物样品物理变化的系统和方法
公开(公告)号：US20070238090A1
公开(公告)日：2007-10-11
申请号：US11402656
申请日：2006-04-11
申请人： Kyle W. Hukari , Jason A.A. West
发明人： Kyle W. Hukari , Jason A.A. West
IPC分类号： C12Q1/00 , C12M3/00
CPC分类号： C12N13/00 , C12M47/06
摘要： The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present invention relates both to breaking apart biological species such as viruses and cells, as well as the formation of reactants from one or more reactive species. The sample has a volume in the range from about 1 microliter to 10 milliliters. The sample is processed by applying pressure, and either sonic energy or thermal energy to the sample, wherein the pressure achieved is usually at least 24 atmospheres, and the temperature of the sample is usually raised to at least 50° C.
摘要翻译：本发明一般涉及用于处理导致物理变化的生物样品的系统和方法，例如将两个分子一起反应以形成反应产物或用于裂解病毒或生物细胞用于使用生物测定系统进行分析。因此，本发明涉及分解生物物种如病毒和细胞，以及从一种或多种反应性物质形成反应物。样品的体积在约1微升至10毫升的范围内。通过对样品施加压力和声能或热能来处理样品，其中获得的压力通常为至少24个大气压，并且样品的温度通常升高至至少50℃。

4. 发明授权

US07781206B2 Systems and methods for effecting a physical change in a biological sample 有权
标题翻译：影响生物样品物理变化的系统和方法
公开(公告)号：US07781206B2
公开(公告)日：2010-08-24
申请号：US11402656
申请日：2006-04-11
申请人： Kyle W. Hukari , Jason A. A. West
发明人： Kyle W. Hukari , Jason A. A. West
IPC分类号： C12M1/00
CPC分类号： C12N13/00 , C12M47/06
摘要： The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present invention relates both to breaking apart biological species such as viruses and cells, as well as the formation of reactants from one or more reactive species. The sample has a volume in the range from about 1 microliter to 10 milliliters. The sample is processed by applying pressure, and either sonic energy or thermal energy to the sample, wherein the pressure achieved is usually at least 24 atmospheres, and the temperature of the sample is usually raised to at least 50° C.
摘要翻译：本发明一般涉及用于处理导致物理变化的生物样品的系统和方法，例如将两个分子一起反应以形成反应产物或用于裂解病毒或生物细胞用于使用生物测定系统进行分析。因此，本发明涉及分解生物物种如病毒和细胞，以及从一种或多种反应性物质形成反应物。样品的体积在约1微升至10毫升的范围内。通过对样品施加压力和声能或热能来处理样品，其中获得的压力通常为至少24个大气压，并且样品的温度通常升高至至少50℃。

5. 发明授权

US08426135B1 High temperature flow-through device for rapid solubilization and analysis 有权
公开(公告)号：US08426135B1
公开(公告)日：2013-04-23
申请号：US13308228
申请日：2011-11-30
申请人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
发明人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
IPC分类号： C12Q1/68 , C12M1/34 , C07H21/04
CPC分类号： B01L3/5027 , B01L7/00 , B01L2300/0877 , B01L2300/0887 , B01L2300/1827 , C12M47/06 , C12M47/20 , C12N1/066
摘要： Devices and methods for thermally lysing of biological material, for example vegetative bacterial cells and bacterial spores, are provided. Hot solution methods for solubilizing bacterial spores are described. Systems for direct analysis are disclosed including thermal lysers coupled to sample preparation stations. Integrated systems capable of performing sample lysis, labeling and protein fingerprint analysis of biological material, for example, vegetative bacterial cells, bacterial spores and viruses are provided.

6. 发明授权

US07883776B2 Protective layers for optical coatings 有权
标题翻译：光学涂层保护层
公开(公告)号：US07883776B2
公开(公告)日：2011-02-08
申请号：US11754848
申请日：2007-05-29
申请人： Kyle W. Hukari , Peter A. Maschwitz , Rand D. Dannenberg
发明人： Kyle W. Hukari , Peter A. Maschwitz , Rand D. Dannenberg
IPC分类号： B32B9/00 , B32B15/00
CPC分类号： C03C17/3618 , C03C17/3435 , C03C17/3441 , C03C17/36 , C03C17/3626 , C03C17/3634 , C03C17/3644 , C03C17/366 , C03C2217/78 , C03C2218/355 , Y10T428/24942 , Y10T428/24975 , Y10T428/265 , Y10T428/30
摘要： An optical coating on a transparent substrate is provided with a temporary layer of carbon as protection during manufacturing against scratches and corrosive environments. When the optical coating and/or substrate are tempered in an atmosphere reactive to carbon, such as air, the layer of carbon is removed as a carbon-containing gas. For an optical coating with a brittle, glassy, outermost layer furthest from the substrate, additional protection is provided by a scratch propagation blocker layer between the outermost layer and the carbon protective layer.
摘要翻译：在制造过程中，透明基板上的光学涂层具有临时的碳层作为保护，防止刮伤和腐蚀环境。当光学涂层和/或基底在与碳（如空气）反应的气氛中回火时，作为含碳气体除去碳层。对于具有离衬底最远的脆性，玻璃状最外层的光学涂层，通过在最外层和碳保护层之间的划痕传播阻挡层提供额外的保护。

7. 发明授权

US07592139B2 High temperature flow-through device for rapid solubilization and analysis 失效
标题翻译：高温流通装置，用于快速溶解和分析
公开(公告)号：US07592139B2
公开(公告)日：2009-09-22
申请号：US11059079
申请日：2005-02-16
申请人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
发明人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/5027 , B01L7/00 , B01L2300/0877 , B01L2300/0887 , B01L2300/1827 , C12M47/06 , C12M47/20 , C12N1/066
摘要： Devices and methods for thermally lysing of biological material, for example vegetative bacterial cells and bacterial spores, are provided. Hot solution methods for solubilizing bacterial spores are described. Systems for direct analysis are disclosed including thermal lysers coupled to sample preparation stations. Integrated systems capable of performing sample lysis, labeling and protein fingerprint analysis of biological material, for example, vegetative bacterial cells, bacterial spores and viruses are provided.
摘要翻译：提供了用于热裂解生物材料的装置和方法，例如营养细菌细菌和细菌孢子。描述了溶解细菌孢子的热溶解方法。公开了用于直接分析的系统，包括耦合到样品制备站的热裂解器。提供能够对生物材料进行样品裂解，标记和蛋白质指纹分析的集成系统，例如营养细菌细菌，细菌孢子和病毒。

8. 发明授权

US07524672B2 Microfluidic microarray systems and methods thereof 有权
标题翻译：微流体微阵列系统及其方法
公开(公告)号：US07524672B2
公开(公告)日：2009-04-28
申请号：US10946920
申请日：2004-09-22
申请人： Jay A. A. West , Kyle W. Hukari , Gary A. Hux
发明人： Jay A. A. West , Kyle W. Hukari , Gary A. Hux
IPC分类号： C12M1/34 , C12M3/00
CPC分类号： B01L3/0293 , B01J2219/00387 , B01J2219/00527 , B01J2219/00576 , B01J2219/00659 , B01J2219/00722 , B01L3/502715 , B01L3/565 , B01L7/52 , B01L9/527 , B01L2200/027 , B01L2200/10 , B01L2300/0636 , B01L2300/0654 , B01L2300/0877 , B01L2300/18 , B01L2300/1894 , B01L2400/0487 , C12Q1/6837 , G01N21/0303 , C12Q2565/629
摘要： Disclosed are systems that include a manifold in fluid communication with a microfluidic chip having a microarray, an illuminator, and a detector in optical communication with the microarray. Methods for using these systems for biological detection are also disclosed.
摘要翻译：公开了包括与具有微阵列的微流体芯片流体连通的歧管的系统，照射器和与微阵列光学通信的检测器。还公开了将这些系统用于生物检测的方法。

9. 发明授权

US08450095B2 Systems and methods for effecting a physical change in a biological sample 有权
标题翻译：影响生物样品物理变化的系统和方法
公开(公告)号：US08450095B2
公开(公告)日：2013-05-28
申请号：US12835822
申请日：2010-07-14
申请人： Kyle W. Hukari , Jason A. A. West
发明人： Kyle W. Hukari , Jason A. A. West
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , C12M47/06
摘要： The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present invention relates both to breaking apart biological species such as viruses and cells, as well as the formation of reactants from one or more reactive species. The sample has a volume in the range from about 1 microliter to 10 milliliters. The sample is processed by applying pressure, and either sonic energy or thermal energy to the sample, wherein the pressure achieved is usually at least 24 atmospheres, and the temperature of the sample is usually raised to at least 50° C.
摘要翻译：本发明一般涉及用于处理导致物理变化的生物样品的系统和方法，例如将两个分子一起反应以形成反应产物或用于裂解病毒或生物细胞用于使用生物测定系统进行分析。因此，本发明涉及分解生物物种如病毒和细胞，以及从一种或多种反应性物质形成反应物。样品的体积在约1微升至10毫升的范围内。通过对样品施加压力和声能或热能来处理样品，其中获得的压力通常为至少24个大气压，并且样品的温度通常升高至至少50℃。

10. 发明授权

US06770321B2 Method of making transparent articles utilizing protective layers for optical coatings 有权
标题翻译：利用光学涂层保护层制造透明制品的方法
公开(公告)号：US06770321B2
公开(公告)日：2004-08-03
申请号：US10054973
申请日：2002-01-25
申请人： Kyle W. Hukari , Peter A. Maschwitz , Rand D. Dannenberg
发明人： Kyle W. Hukari , Peter A. Maschwitz , Rand D. Dannenberg
IPC分类号： B65B3300
CPC分类号： C03C17/3618 , C03C17/3435 , C03C17/3441 , C03C17/36 , C03C17/3626 , C03C17/3634 , C03C17/3644 , C03C17/366 , C03C2217/78 , C03C2218/355 , Y10T428/24942 , Y10T428/24975 , Y10T428/265 , Y10T428/30
摘要： A method is provided for making transparent articles utilizing protective layers for optical coatings. An optical coating on a transparent substrate is provided with a temporary layer of carbon as protection during manufacturing against scratches and corrosive environments. When the optical coating and/or substrate are tempered in an atmosphere reactive to carbon, such as air, the layer of carbon is removed as a carbon-containing gas. For an optical coating with a brittle, glassy, outermost layer furthest from the substrate, additional protection is provided by a scratch propagation blocker layer between the outermost layer and the carbon protective layer.
摘要翻译：提供了一种利用光学涂层保护层制造透明制品的方法。在制造过程中，透明基板上的光学涂层具有临时的碳层作为保护，防止刮伤和腐蚀环境。当光学涂层和/或基底在与碳（如空气）反应的气氛中回火时，作为含碳气体除去碳层。对于具有离衬底最远的脆性，玻璃状最外层的光学涂层，通过在最外层和碳保护层之间的划痕传播阻挡层提供额外的保护。

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