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1. 发明授权

US07592139B2 High temperature flow-through device for rapid solubilization and analysis 失效
标题翻译：高温流通装置，用于快速溶解和分析
公开(公告)号：US07592139B2
公开(公告)日：2009-09-22
申请号：US11059079
申请日：2005-02-16
申请人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
发明人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
IPC分类号： C12Q1/68 , C12M1/34
CPC分类号： B01L3/5027 , B01L7/00 , B01L2300/0877 , B01L2300/0887 , B01L2300/1827 , C12M47/06 , C12M47/20 , C12N1/066
摘要： Devices and methods for thermally lysing of biological material, for example vegetative bacterial cells and bacterial spores, are provided. Hot solution methods for solubilizing bacterial spores are described. Systems for direct analysis are disclosed including thermal lysers coupled to sample preparation stations. Integrated systems capable of performing sample lysis, labeling and protein fingerprint analysis of biological material, for example, vegetative bacterial cells, bacterial spores and viruses are provided.
摘要翻译：提供了用于热裂解生物材料的装置和方法，例如营养细菌细菌和细菌孢子。描述了溶解细菌孢子的热溶解方法。公开了用于直接分析的系统，包括耦合到样品制备站的热裂解器。提供能够对生物材料进行样品裂解，标记和蛋白质指纹分析的集成系统，例如营养细菌细菌，细菌孢子和病毒。

2. 发明授权

US08450095B2 Systems and methods for effecting a physical change in a biological sample 有权
标题翻译：影响生物样品物理变化的系统和方法
公开(公告)号：US08450095B2
公开(公告)日：2013-05-28
申请号：US12835822
申请日：2010-07-14
申请人： Kyle W. Hukari , Jason A. A. West
发明人： Kyle W. Hukari , Jason A. A. West
IPC分类号： C12N13/00
CPC分类号： C12N13/00 , C12M47/06
摘要： The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present invention relates both to breaking apart biological species such as viruses and cells, as well as the formation of reactants from one or more reactive species. The sample has a volume in the range from about 1 microliter to 10 milliliters. The sample is processed by applying pressure, and either sonic energy or thermal energy to the sample, wherein the pressure achieved is usually at least 24 atmospheres, and the temperature of the sample is usually raised to at least 50° C.
摘要翻译：本发明一般涉及用于处理导致物理变化的生物样品的系统和方法，例如将两个分子一起反应以形成反应产物或用于裂解病毒或生物细胞用于使用生物测定系统进行分析。因此，本发明涉及分解生物物种如病毒和细胞，以及从一种或多种反应性物质形成反应物。样品的体积在约1微升至10毫升的范围内。通过对样品施加压力和声能或热能来处理样品，其中获得的压力通常为至少24个大气压，并且样品的温度通常升高至至少50℃。

3. 发明授权

US08426135B1 High temperature flow-through device for rapid solubilization and analysis 有权
公开(公告)号：US08426135B1
公开(公告)日：2013-04-23
申请号：US13308228
申请日：2011-11-30
申请人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
发明人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
IPC分类号： C12Q1/68 , C12M1/34 , C07H21/04
CPC分类号： B01L3/5027 , B01L7/00 , B01L2300/0877 , B01L2300/0887 , B01L2300/1827 , C12M47/06 , C12M47/20 , C12N1/066
摘要： Devices and methods for thermally lysing of biological material, for example vegetative bacterial cells and bacterial spores, are provided. Hot solution methods for solubilizing bacterial spores are described. Systems for direct analysis are disclosed including thermal lysers coupled to sample preparation stations. Integrated systems capable of performing sample lysis, labeling and protein fingerprint analysis of biological material, for example, vegetative bacterial cells, bacterial spores and viruses are provided.

4. 发明授权

US07781206B2 Systems and methods for effecting a physical change in a biological sample 有权
标题翻译：影响生物样品物理变化的系统和方法
公开(公告)号：US07781206B2
公开(公告)日：2010-08-24
申请号：US11402656
申请日：2006-04-11
申请人： Kyle W. Hukari , Jason A. A. West
发明人： Kyle W. Hukari , Jason A. A. West
IPC分类号： C12M1/00
CPC分类号： C12N13/00 , C12M47/06
摘要： The present invention relates generally to systems and methods for processing a biological sample that result in a physical change, such as reacting two molecules together to form a reaction product or for use in lysing viruses or biological cells for analysis using biological assay systems. As such, the present invention relates both to breaking apart biological species such as viruses and cells, as well as the formation of reactants from one or more reactive species. The sample has a volume in the range from about 1 microliter to 10 milliliters. The sample is processed by applying pressure, and either sonic energy or thermal energy to the sample, wherein the pressure achieved is usually at least 24 atmospheres, and the temperature of the sample is usually raised to at least 50° C.
摘要翻译：本发明一般涉及用于处理导致物理变化的生物样品的系统和方法，例如将两个分子一起反应以形成反应产物或用于裂解病毒或生物细胞用于使用生物测定系统进行分析。因此，本发明涉及分解生物物种如病毒和细胞，以及从一种或多种反应性物质形成反应物。样品的体积在约1微升至10毫升的范围内。通过对样品施加压力和声能或热能来处理样品，其中获得的压力通常为至少24个大气压，并且样品的温度通常升高至至少50℃。

5. 发明授权

US09028777B2 Automated cellular material preparation 有权
标题翻译：自动细胞材料制备
公开(公告)号：US09028777B2
公开(公告)日：2015-05-12
申请号：US13069820
申请日：2011-03-23
申请人： Kyle W. Hukari , Jason A. A. West , Michael A. Shultz , Richard Milson , Nikolas M. Isely , Michael C. DeRenzi
发明人： Kyle W. Hukari , Jason A. A. West , Michael A. Shultz , Richard Milson , Nikolas M. Isely , Michael C. DeRenzi
IPC分类号： B01D21/00 , G01N1/40 , C12N15/10 , C12Q1/68 , G01N35/10
CPC分类号： G01N1/405 , C12N15/1003 , C12Q1/6806 , G01N35/1095 , G01N2035/1053 , Y10T436/2575
摘要： Provided are cartridges and systems for effecting automated extraction, isolation, and purification of cellular components—such as nucleic acids—from a cellular sample in assay-ready form. Also provided are related methods of effecting such sample processing.
摘要翻译：提供了用于实现从测定准备形式的细胞样品中自动提取，分离和纯化细胞组分（例如核酸）的盒和系统。还提供了进行这种样品处理的相关方法。

6. 发明申请

US20090215023A1 HIGH TEMPERATURE FLOW-THROUGH DEVICE FOR RAPID SOLUBILIZATION AND ANALYSIS 失效
标题翻译：用于快速溶解和分析的高温流动装置
公开(公告)号：US20090215023A1
公开(公告)日：2009-08-27
申请号：US11059079
申请日：2005-02-16
申请人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
发明人： Jason A. A. West , Kyle W. Hukari , Kamlesh D. Patel , Kenneth A. Peterson , Ronald F. Renzi
IPC分类号： C12Q1/00 , C12M1/33
CPC分类号： B01L3/5027 , B01L7/00 , B01L2300/0877 , B01L2300/0887 , B01L2300/1827 , C12M47/06 , C12M47/20 , C12N1/066
摘要： Devices and methods for thermally lysing of biological material, for example vegetative bacterial cells and bacterial spores, are provided. Hot solution methods for solubilizing bacterial spores are described. Systems for direct analysis are disclosed including thermal lysers coupled to sample preparation stations. Integrated systems capable of performing sample lysis, labeling and protein fingerprint analysis of biological material, for example, vegetative bacterial cells, bacterial spores and viruses are provided.
摘要翻译：提供用于热裂解生物材料的装置和方法，例如营养细菌细菌和细菌孢子。描述了溶解细菌孢子的热溶解方法。公开了用于直接分析的系统，包括耦合到样品制备站的热裂解器。提供能够对生物材料进行样品裂解，标记和蛋白质指纹分析的集成系统，例如营养细菌细菌，细菌孢子和病毒。

7. 发明申请

US20120115143A1 Universal Probe Assay Methods 有权
标题翻译：通用探针测定方法
公开(公告)号：US20120115143A1
公开(公告)日：2012-05-10
申请号：US13280214
申请日：2011-10-24
申请人： Kenneth J. Livak , Jason A. A. West , Robert C. Jones
发明人： Kenneth J. Livak , Jason A. A. West , Robert C. Jones
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , C12Q1/6876 , C12Q2600/178 , C12Q2525/155 , C12Q2525/307 , C12Q2537/161
摘要： Reagents and methods are provided for detecting the presence of a target polynucleotide in a sample are disclosed. In one aspect, a method for producing a labeled amplification product by amplifying a target nucleic acid sequence to produce an amplification product comprising the target sequence, a first probe-binding sequence 5′ to the target sequence, and a second probe-binding sequence 3′ to the target sequence, thereby producing an amplification product; and hybridizing a first detection probe to the amplification product, said first detection probe comprising a first segment that hybridizes to the first probe-binding sequence and a second segment that hybridizes to the second probe-binding sequence, thereby producing a labeled amplification product is disclosed.
摘要翻译：提供了用于检测样品中靶多核苷酸的存在的试剂和方法。一方面，通过扩增靶核酸序列以产生包含靶序列的扩增产物，与靶序列的第一探针结合序列5'和第二探针结合序列3来产生标记的扩增产物的方法 '到靶序列，从而产生扩增产物; 并将第一检测探针与扩增产物杂交，所述第一检测探针包括与第一探针结合序列杂交的第一片段和与第二探针结合序列杂交的第二片段，从而产生标记的扩增产物。

8. 发明授权

US07452507B2 Portable apparatus for separating sample and detecting target analytes 有权
标题翻译：用于分离样品和检测目标分析物的便携式设备
公开(公告)号：US07452507B2
公开(公告)日：2008-11-18
申请号：US10633871
申请日：2003-08-04
申请人： Ronald F. Renzi , Karl Wally , Robert W. Crocker , James F. Stamps , Stewart K. Griffiths , Julia A. Fruetel , Brent A. Horn , Isaac R. Shokair , Daniel D. Yee , Victoria A. VanderNoot , Boyd J. Wiedenman , Jason A. A. West , Scott M. Ferko
发明人： Ronald F. Renzi , Karl Wally , Robert W. Crocker , James F. Stamps , Stewart K. Griffiths , Julia A. Fruetel , Brent A. Horn , Isaac R. Shokair , Daniel D. Yee , Victoria A. VanderNoot , Boyd J. Wiedenman , Jason A. A. West , Scott M. Ferko
IPC分类号： G01N21/64 , B01D59/42 , G01N21/76
CPC分类号： G01N21/645 , B01L3/5027 , B01L3/502715 , B01L9/527 , B01L2200/025 , B01L2200/027 , B01L2200/10 , B01L2300/0672 , B01L2300/0816 , G01N2021/6482
摘要： Portable devices and methods for determining the presence of a target analyte using a portable device are provided. The portable device is preferably hand-held. A sample is injected to the portable device. A microfluidic separation is performed within the portable device and at least one separated component detected by a detection module within the portable device, in embodiments of the invention. A target analyte is identified, based on the separated component, and the presence of the target analyte is indicated on an output interface of the portable device, in accordance with embodiments of the invention.
摘要翻译：提供了便携式设备和用于使用便携式设备确定目标分析物的存在的方法。便携式设备优选地是手持式的。将样品注入便携式设备。在本发明的实施例中，在便携式设备内执行微流体分离以及由便携式设备内的检测模块检测到的至少一个分离的部件。基于分离的组分鉴定目标分析物，并且根据本发明的实施方案，在便携式设备的输出界面上指示目标分析物的存在。

9. 发明授权

US09353406B2 Universal probe assay methods 有权
标题翻译：通用探针测定方法
公开(公告)号：US09353406B2
公开(公告)日：2016-05-31
申请号：US13280214
申请日：2011-10-24
申请人： Kenneth J. Livak , Jason A. A. West , Robert C. Jones
发明人： Kenneth J. Livak , Jason A. A. West , Robert C. Jones
IPC分类号： C12Q1/68
CPC分类号： C12Q1/682 , C12Q1/6876 , C12Q2600/178 , C12Q2525/155 , C12Q2525/307 , C12Q2537/161
摘要： Reagents and methods are provided for detecting the presence of a target polynucleotide in a sample are disclosed. In one aspect, a method for producing a labeled amplification product by amplifying a target nucleic acid sequence to produce an amplification product comprising the target sequence, a first probe-binding sequence 5′ to the target sequence, and a second probe-binding sequence 3′ to the target sequence, thereby producing an amplification product; and hybridizing a first detection probe to the amplification product, the first detection probe comprising a first segment that hybridizes to the first probe-binding sequence and a second segment that hybridizes to the second probe-binding sequence, thereby producing a labeled amplification product is disclosed.
摘要翻译：提供了用于检测样品中靶多核苷酸的存在的试剂和方法。一方面，通过扩增靶核酸序列以产生包含靶序列的扩增产物，与靶序列的第一探针结合序列5'和第二探针结合序列3来产生标记的扩增产物的方法 '到靶序列，从而产生扩增产物; 并且将第一检测探针与扩增产物杂交，所述第一检测探针包含与第一探针结合序列杂交的第一区段和与第二探针结合序列杂交的第二区段，从而产生标记的扩增产物。

10. 发明申请

US20080182759A1 SELECTION OF APTAMERS BASED ON GEOMETRY 有权
标题翻译：选择基于几何的APTAMERS
公开(公告)号：US20080182759A1
公开(公告)日：2008-07-31
申请号：US11959435
申请日：2007-12-18
申请人： Jason A. A. West , Brent Coleman Satterfield
发明人： Jason A. A. West , Brent Coleman Satterfield
IPC分类号： C40B30/04
CPC分类号： C40B20/08 , C07B2200/11 , C12N15/115 , C12N2310/16 , C12N2320/10 , C40B30/04 , C40B40/08
摘要： Disclosed are methods for performing aptamer preselection based on unique geometry and the content of stems or loops of the aptamer, which methods are capable of providing suitable binders and also permit selection of aptamers performed essentially entirely on a chip or other device. Also disclosed are kits for aptamer selection.
摘要翻译：公开了用于基于独特几何形状和适体的茎或环的含量进行适配体预选的方法，该方法能够提供合适的结合物，并且还允许选择基本上完全在芯片或其它装置上进行的适体。还公开了适配子选择的试剂盒。

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