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1. 发明授权

US08155750B2 System and method for avoiding, reversing, and managing neurological accommodation to electrical stimulation 有权
标题翻译：用于避免，逆转和管理神经系统适应电刺激的系统和方法
公开(公告)号：US08155750B2
公开(公告)日：2012-04-10
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/00
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

2. 发明申请

US20110160797A1 METHODS TO CONCURRENTLY STIMULATE DIFFERENT BRAIN TARGETS 审中-公开
标题翻译：同时刺激不同脑部目标的方法
公开(公告)号：US20110160797A1
公开(公告)日：2011-06-30
申请号：US12976764
申请日：2010-12-22
申请人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
发明人： James C. Makous , Courtney Lane , Kristen Jaax , Andrew DiGiore
IPC分类号： A61N1/36
CPC分类号： A61N1/36067 , A61N1/00 , A61N1/0534 , A61N1/36064 , A61N1/36171
摘要： A method for treating a patient having a dysfunction using a stimulation lead within the brain of a patient is provided. The stimulation lead carries a plurality of electrodes adjacent to a plurality of brain regions. Pulsed electrical waveforms having different sets of stimulation parameters are generated and then concurrently delivered to the plurality of electrodes, thereby concurrently stimulating the plurality of brain regions to treat the dysfunction.
摘要翻译：提供了一种使用患者脑内的刺激铅治疗具有功能障碍的患者的方法。刺激引线携带与多个脑区域相邻的多个电极。产生具有不同组刺激参数的脉冲电波形，然后同时传送到多个电极，从而同时刺激多个脑区域来治疗功能障碍。

3. 发明申请

US20110009919A1 METHOD TO ENHANCE AFFERENT AND EFFERENT TRANSMISSION USING NOISE RESONANCE 有权
标题翻译：使用噪声共振方法来提高实际和有效的传输
公开(公告)号：US20110009919A1
公开(公告)日：2011-01-13
申请号：US12501170
申请日：2009-07-10
申请人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
发明人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
IPC分类号： A61N1/36
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36128 , A61N1/36164
摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.
摘要翻译：提供了向患者提供治疗的方法。在一种方法中，患者具有应用亚阈值生物电刺激的神经元。该方法包括向神经元施加电噪声能量，其中产生生物电刺激和电噪声能量之间的共振，使得动作电位沿神经元的轴突传播。在另一种方法中，患者具有应用超临界生物电刺激的神经元。该方法包括将超阈值电噪声能量应用于神经元，从而防止动作电位沿神经元的轴突传播。另一种方法包括对神经元施加电刺激，以及向神经元施加超阈值电噪声能量，从而防止或反转可能响应于电刺激而发生的神经元的任何神经学适应。

4. 发明授权

US09737703B2 Method to enhance afferent and efferent transmission using noise resonance 有权
公开(公告)号：US09737703B2
公开(公告)日：2017-08-22
申请号：US12501170
申请日：2009-07-10
申请人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
发明人： Rafael Carbunaru , Michael Moffitt , Kristen Jaax , Andrew DiGiore , Courtney Lane
IPC分类号： A61N1/00 , A61N1/05 , A61N1/36
CPC分类号： A61N1/0551 , A61N1/0529 , A61N1/36057 , A61N1/36071 , A61N1/36114 , A61N1/36128 , A61N1/36164
摘要： Methods of providing therapy to a patient are provided. In one method, the patient has a neuron to which a sub-threshold biological electrical stimulus is applied. The method comprises applying electrical noise energy to the neuron, wherein resonance between the biological electrical stimulus and the electrical noise energy is created, such that an action potential is propagated along the axon of the neuron. In another method, the patient has a neuron to which a supra-threshold biological electrical stimulus is applied. This method comprises applying supra-threshold electrical noise energy to the neuron, thereby preventing an action potential from being propagated along the axon of the neuron. Still another method comprises applying an electrical stimulus to a neuron, and applying supra-threshold electrical noise energy to the neuron, thereby preventing or reversing any neurological accommodation of the neuron that may occur in response to the electrical stimulus.

5. 发明申请

US20100145357A1 BURR HOLE PLUG HAVING DUAL SLIDABLE CLAMPING MECHANISMS 有权
标题翻译：带双滑动夹紧机构的双孔插头
公开(公告)号：US20100145357A1
公开(公告)日：2010-06-10
申请号：US12630761
申请日：2009-12-03
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
IPC分类号： A61N1/05 , A61B17/00
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.
摘要翻译：毛刺孔塞包括构造成围绕钻孔安装的塞子基座。插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二夹紧机构将医疗装置固定在其间。

6. 发明申请

US20100023090A1 SYSTEM AND METHOD FOR AVOIDING, REVERSING, AND MANAGING NEUROLOGICAL ACCOMODATION TO ELETRICAL STIMULATION 有权
标题翻译：用于避免，反向和管理神经病学接受电子刺激的系统和方法
公开(公告)号：US20100023090A1
公开(公告)日：2010-01-28
申请号：US12509340
申请日：2009-07-24
申请人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
发明人： Kristen Jaax , Courtney Lane , Michael Moffitt , Andrew DiGiore , Mark Pierre , Kerry Bradley , Gregory Baldwin
IPC分类号： A61N1/08
CPC分类号： A61N1/37235 , A61N1/36132 , A61N1/36146 , A61N1/37264
摘要： A method and programmer for programming a neurostimulation device are provided. The method comprises varying a first stimulation parameter under user control, automatically varying a second stimulation parameter, generating a plurality of stimulation parameter sets from the varied first and second stimulation parameters, outputting a pulsed electrical waveform from the neurostimulation device between a plurality of electrodes in accordance with the stimulation parameter sets, such that neural tissue is stimulated without undergoing neurological accommodation that would otherwise occur if the second stimulation parameter were not varied, and programming the neurostimulation device with a new set of stimulation parameters based on a result of the neural tissue stimulation The programmer comprises a user interface capable of receiving an input from a user, a processor configured for performing the previous steps, and output circuitry configured for transmitting the stimulation parameter sets and the new stimulation parameter set to the neurostimulation device.
摘要翻译：提供了一种用于编程神经刺激装置的方法和编程器。该方法包括在用户控制下改变第一刺激参数，自动改变第二刺激参数，从变化的第一和第二刺激参数产生多个刺激参数集合，从神经刺激装置在多个电极之间输出脉冲电波形根据刺激参数集，使得神经组织被刺激而不经历如果第二刺激参数没有变化否则会发生神经学调节，并且基于神经组织的结果用新的一组刺激参数来编程神经刺激装置刺激编程器包括能够接收来自用户的输入，被配置为执行前述步骤的处理器的用户界面以及被配置为将刺激参数集和新刺激参数集发送到神经刺激装置的输出电路。

7. 发明申请

US20090112327A1 BURR HOLE PLUG DESIGNS 审中-公开
标题翻译： BURR HOLE插头设计
公开(公告)号：US20090112327A1
公开(公告)日：2009-04-30
申请号：US12258382
申请日：2008-10-24
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew Digiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
IPC分类号： A61F2/02 , A61F2/28
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base including a flange configured for being mounted around a burr hole, an aperture through which an elongated medical device may pass, and tabs configured for extending within the cranial burr hole to center the plug base relative to the cranial burr hole. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base to secure the medical device. A method may comprise locating the plug base within a burr hole, such that the tabs are disposed within the burr hole to center the plug base relative to the cranial burr hole, introducing the elongated medical device through the cranial burr hole and into the brain tissue of the patient, mounting the retainer within the aperture of the plug base, and actuating the retainer to secure the medical device.
摘要翻译：一个钻孔塞包括一个插头基座，它包括一个凸缘，该凸缘被配置成安装在一个钻孔周围，一个细长的医疗设备可以通过的孔，以及在头部钻孔内延伸的突出部分，以使插头基座相对于头部钻孔。毛刺孔塞还包括保持器，其构造成安装在插头基座的孔内以固定医疗装置。一种方法可以包括将插头基座定位在钻孔内，使得突出部设置在毛刺孔内，以使塞子基座相对于头颅毛孔中心，将细长的医疗装置通过头颅毛孔引入脑组织将保持器安装在插头基座的孔内，并致动保持器以固定医疗装置。

8. 发明授权

US09345878B2 System and method for compensating for shifting of neurostimulation leads in a patient 有权
标题翻译：用于补偿患者神经刺激导线移位的系统和方法
公开(公告)号：US09345878B2
公开(公告)日：2016-05-24
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译：提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化相对于刺激目标组织的距离测量的变化。该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。

9. 发明授权

US08731686B2 Burr hole plug having dual slidable clamping mechanisms 有权
标题翻译：钻孔塞具有双滑动夹紧机构
公开(公告)号：US08731686B2
公开(公告)日：2014-05-20
申请号：US12630761
申请日：2009-12-03
申请人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew DiGiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
发明人： Courtney Lane , Jesse Geroy , James C. Makous , Todd Whitehurst , Matthew Flowers , John Michael Barker , Terry Ferrell , John Swoyer , Brett Schleicher , Jeff Gagnon , Andrew DiGiore , Ellis Garai , Kristen Jaax , Rafael Carbunaru
IPC分类号： A61N1/00
CPC分类号： A61B17/0057 , A61B90/10 , A61B2090/103 , A61N1/0534 , A61N1/0539
摘要： A burr hole plug comprises a plug base configured for being mounted around a burr hole. The plug base includes an aperture through which an elongated medical device exiting the burr hole may pass. The burr hole plug further comprises a retainer configured for being mounted within the aperture of the plug base. The retainer further includes first and second slidable clamping mechanisms configured for securing the medical devices therebetween within the aperture of the plug base. A method comprises introducing the medical device through the burr hole, mounting a plug base around the burr hole, such that the medical device extends through the plug base aperture, mounting the retainer within the aperture of the plug base, and sliding the first and second clamping mechanisms secure the medical device therebetween.
摘要翻译：毛刺孔塞包括构造成围绕钻孔安装的塞子基座。插头基座包括一个孔，通过该孔可以使离开钻孔的细长医疗装置通过。毛刺孔塞还包括保持器，其构造成用于安装在插头基座的孔内。保持器还包括第一和第二可滑动夹紧机构，其被构造用于将医疗装置固定在插头基座的孔内。一种方法包括：通过毛刺孔引导医疗装置，将插头基座安装在毛刺孔周围，使得医疗装置延伸穿过插头基座孔口，将保持器安装在插头基座的孔内，并将第一和第二夹紧机构将医疗装置固定在其间。

10. 发明申请

US20100331922A1 SYSTEM AND METHOD FOR COMPENSATING FOR SHIFTING OF NEUROSTIMULATION LEADS IN A PATIENT 有权
标题翻译：用于补偿患者神经细胞发生突变的系统和方法
公开(公告)号：US20100331922A1
公开(公告)日：2010-12-30
申请号：US12495442
申请日：2009-06-30
申请人： Andrew DiGiore , Kristen Jaax , Courtney Lane
发明人： Andrew DiGiore , Kristen Jaax , Courtney Lane
IPC分类号： A61N1/08
CPC分类号： A61N1/08 , A61N2001/083
摘要： A method for determining a change in position of a neurostimulation lead relative to a stimulation target tissue of a patient is provided. The method comprises implanting a first proximity sensor on a surface of the patient, implanting a second proximity sensor on the surface of the patient, measuring a change in a distance between the first and second proximity sensors, and inferring the change in position of the lead relative to the stimulation target tissue from the measured change in distance. The method further comprises inferring an increase in a distance between the lead and the stimulation target tissue when the distance between the first and second proximity sensors increases. The method also comprises conveying electrical stimulation energy to therapeutically stimulate the stimulation target tissue, and modulating a stimulation parameter in response to the measured change in distance.
摘要翻译：提供了一种用于确定神经刺激引线相对于患者的刺激目标组织的位置变化的方法。该方法包括在患者的表面上植入第一接近传感器，在患者的表面上植入第二接近传感器，测量第一和第二接近传感器之间的距离的变化，并推断引线的位置变化相对于刺激目标组织的距离测量的变化。该方法还包括当第一和第二接近传感器之间的距离增加时，推断引线和刺激目标组织之间的距离的增加。该方法还包括传送电刺激能量以治疗刺激刺激目标组织，以及响应于所测量的距离变化来调制刺激参数。

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