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1. 发明授权

US4539403A Process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine 失效
标题翻译：制备2-烷基-4-氨基-5-氨基甲基嘧啶的方法
公开(公告)号：US4539403A
公开(公告)日：1985-09-03
申请号：US461163
申请日：1983-01-26
申请人： Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Teruhiko Inoue , Kiyosi Oomori
发明人： Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Teruhiko Inoue , Kiyosi Oomori
IPC分类号： C07D239/42 , C07D239/02
CPC分类号： C07D239/42
摘要： There is disclosed a process for the preparation of a 2-alkyl-4-amino-5-aminomethylpyrimidine, which comprises subjecting a 2-alkyl-4-amino-5-formylpyrimidine to catalytic reaction with hydrogen and ammonia in the presence of a reduction catalyst.According to the process of this invention, the desired product can be obtained in much higher yield as compared with the processes known to the art.
摘要翻译：公开了2-烷基-4-氨基-5-氨基甲基嘧啶的制备方法，该方法包括使2-烷基-4-氨基-5-甲酰基嘧啶在还原反应的存在下与氢和氨进行催化反应催化剂。根据本发明的方法，与本领域已知的方法相比，可以以更高的收率获得所需产物。

2. 发明授权

US4492792A Process for preparing 4-amino-5-dialkoxy-methylpyrimidine derivatives 失效
标题翻译： 4-氨基-5-二烷氧基 - 甲基嘧啶衍生物的制备方法
公开(公告)号：US4492792A
公开(公告)日：1985-01-08
申请号：US461191
申请日：1983-01-26
申请人： Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Teruhiko Inoue
发明人： Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Teruhiko Inoue
IPC分类号： C07D239/42 , C07D317/32 , C07D239/02
CPC分类号： C07D239/42 , C07C255/00
摘要： A process for preparing a 4-amino-5-dialkoxymethylpyrimidine derivative of the formula: ##STR1## which comprises reacting a propanenitrile derivative represented by the formula (I) or the novel compound represented by formula (II): ##STR2## with an amidine of the formula: ##STR3## wherein R.sup.1 to R.sup.6 are as defined in the specification. Also disclosed is a process for making the novel compounds of formula (II).
摘要翻译：制备下式的4-氨基-5-二烷氧基甲基嘧啶衍生物的方法：包括使由式（I）表示的丙腈衍生物或由式（II）表示的新化合物：（I）（II），其具有下式的脒：其中R 1至R 6如说明书中所定义。还公开了制备式（II）的新型化合物的方法。

3. 发明授权

US4421925A 4-Alkoxy-1,3-dioxane-5-carbonitriles and process for preparing the same 失效
标题翻译： 4-烷氧基-1,3-二恶烷-5-腈和其制备方法
公开(公告)号：US4421925A
公开(公告)日：1983-12-20
申请号：US375203
申请日：1982-05-05
申请人： Sumio Umemura , Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Yoshiaki Kuroki
发明人： Sumio Umemura , Kozo Fujii , Keigo Nishihira , Hiroyuki Sawada , Shuji Tanaka , Mamoru Nakai , Hiroshi Yoshida , Yoshiaki Kuroki
IPC分类号： C07D319/06
CPC分类号： C07D319/06
摘要： There are disclosed a 4-alkoxy-1,3-dioxane-5-carbonitrile which is a novel compound represented by the formula ##STR1## wherein R represents a lower-alkyl group, and which is useful as an intermediate for the synthesis of Vitamin B.sub.1, and a process for preparing the novel compound by subjecting a 3-alkoxy-2-propenenitrile to reaction with a formaldehyde in the presence of an acid catalyst.
摘要翻译：公开了4-烷氧基-1,3-二恶烷-5-腈，它是由下式表示的新化合物：其中R代表低级烷基，可用作合成维生素的中间体 B1和通过在酸催化剂存在下使3-烷氧基-2-丙烯腈与甲醛反应来制备新化合物的方法。

4. 发明授权

US4514571A Process for the preparation of urea derivatives 失效
标题翻译：尿素衍生物的制备方法
公开(公告)号：US4514571A
公开(公告)日：1985-04-30
申请号：US496179
申请日：1983-05-19
申请人： Mamoru Nakai , Fumio Iwata , Teruhiko Inoue
发明人： Mamoru Nakai , Fumio Iwata , Teruhiko Inoue
IPC分类号： C07C67/00 , C07C239/00 , C07C273/02 , C07C275/06 , C07C275/26 , C07C275/28 , C07D213/75 , C07D261/14 , C07B29/00 , C07C126/00 , C07D213/89 , C07D263/48
CPC分类号： C07D213/75 , C07C275/06 , C07C275/28 , C07D261/14
摘要： A process for the preparation of a urea derivative having the formula: ##STR1## in which A represents a straight- or branched-chain alkyl group having 1-20 carbon atoms, an aryl group, or a heterocyclic group, and each of R.sup.1 and R.sup.2 represents hydrogen, a straight- or branched-chain alkyl group having 1-20 carbon atoms, an alicyclic group, or an aryl groups, which comprises:reacting sodium salt of an N-halogenamide with a quaternary ammonium salt to obtain its addition salt and then,reacting said addition salt with an amine derivative in the absence or presence of an organic solvent.
摘要翻译：一种制备具有下式的脲衍生物的方法：其中A表示具有1-20个碳原子的直链或支链烷基，芳基或杂环基，R1和 R2表示氢，具有1-20个碳原子的直链或支链烷基，脂环基或芳基，其包括：使N-卤代酰胺的钠盐与季铵盐反应以获得其加成盐然后在不存在或存在有机溶剂的情况下使所述加成盐与胺衍生物反应。

5. 发明授权

US4481362A Process for preparing optically active tryptophanes 失效
标题翻译：光学活性色氨酸的制备方法
公开(公告)号：US4481362A
公开(公告)日：1984-11-06
申请号：US494692
申请日：1983-05-17
申请人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
发明人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
IPC分类号： C12N9/80 , C12P13/04 , C12P13/22 , C12P41/00 , C12R1/025 , C12R1/05 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/145 , C12R1/20 , C12R1/225 , C12R1/265 , C12R1/32 , C12R1/365 , C12R1/38 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/65 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/78 , C12R1/80 , C12R1/84 , C12R1/845 , C12R1/85 , C12R1/88 , C12R1/885 , C07D209/20
CPC分类号： C12N9/80 , C12P13/04 , C12P13/227
摘要： Biochemical optical resolution of DL-tryptophanes in which DL-tryptophane amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-tryptophane amides in racemic DL-tryptophane amides are asymmetrically hydrolyzed to form optically active L-tryptophanes at a high yield and almost all D-tryptophane amides remain without being subjected to hydrolysis. The resultant D-tryptophane amides are readily hydrolyzed, after separating L-tryptophanes, to form optically active D-tryptophanes at a high yield.
摘要翻译：描述DL-色氨酰胺与能够产生酰胺酶的微生物或其处理产物相互作用的DL-色氨酸的生物化学光学拆分。外消旋的DL-色氨酰胺中的L-色氨酰胺不对称地水解，以高产率形成光学活性的L-色氨酸，并且几乎所有的D-色氨酸酰胺保持不被水解。得到的D-色氨酰胺在分离L-色氨酸后容易水解，以高产率形成光学活性的D-色氨酸。

6. 发明授权

US4497957A Process for preparing optically active tryptophans 失效
标题翻译：光学活性色氨酸的制备方法
公开(公告)号：US4497957A
公开(公告)日：1985-02-05
申请号：US391997
申请日：1982-06-25
申请人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
发明人： Mamoru Nakai , Tokio Ohshima , Tomio Kimura , Tetsuo Omata , Noritada Iwamoto
IPC分类号： C12N9/80 , C12P13/04 , C12P13/22 , C12P41/00 , C12R1/025 , C12R1/05 , C12R1/06 , C12R1/07 , C12R1/13 , C12R1/145 , C12R1/20 , C12R1/225 , C12R1/265 , C12R1/32 , C12R1/365 , C12R1/38 , C12R1/46 , C12R1/465 , C12R1/645 , C12R1/65 , C12R1/66 , C12R1/72 , C12R1/77 , C12R1/78 , C12R1/80 , C12R1/84 , C12R1/845 , C12R1/85 , C12R1/88 , C12R1/885 , C07D209/20
CPC分类号： C12N9/80 , C12P13/04 , C12P13/227
摘要： Biochemical optical resolution of DL-tryptophans in which DL-tryptophan amides are interacted with the culture products, or their treated products, of a microorganism capable of producing amidase is described. L-Tryptophan amides in racemic DL-tryptophan amides are asymmetrically hydrolyzed to form optically active L-tryptophans at a high yield and almost all D-tryptophan amides remain without being subjected to hydrolysis. The resultant D-tryptophan amides are readily hydrolyzed, after separating L-tryptophans, to form optically active D-tryptophans at a high yield.

7. 发明授权

US3953514A Process for preparing cyclopentenone derivatives 失效
标题翻译：环戊烯酮衍生物的制备方法
公开(公告)号：US3953514A
公开(公告)日：1976-04-27
申请号：US496755
申请日：1974-08-12
申请人： Toshiharu Yamazaki , Mamoru Nakai , Yoshiaki Kuroki
发明人： Toshiharu Yamazaki , Mamoru Nakai , Yoshiaki Kuroki
IPC分类号： C07C49/597 , B01J21/00 , B01J23/00 , B01J27/00 , C07B61/00 , C07C45/00 , C07C45/45 , C07C45/57 , C07C45/59 , C07C45/60 , C07C67/00 , C07C45/18
CPC分类号： C07C45/60 , C07C45/45 , C07C45/455 , C07C45/57 , C07C45/59
摘要： A novel and industrial process for preparing cyclopentenone derivatives by heating C.sub.5 .about.C.sub.13 aliphatic acids having one substituent or intramolecular esters thereof in the presence of a solid acid catalyst in a good yield.
摘要翻译：通过在固体酸催化剂存在下以高收率加热C5 + L（具有一个取代基的18 C13脂肪酸或其分子内酯）来制备环戊烯酮衍生物的新颖和工业方法。

8. 发明授权

US4732051A Dust protective member for bicycle freewheel assembly 失效
标题翻译：用于自行车自由轮组装的防尘构件
公开(公告)号：US4732051A
公开(公告)日：1988-03-22
申请号：US832886
申请日：1986-02-26
申请人： Nobuo Ozaki , Mamoru Nakai
发明人： Nobuo Ozaki , Mamoru Nakai
IPC分类号： B62M9/10 , F16C33/80 , F16D41/24 , G05G1/08 , G05G1/14
CPC分类号： F16C33/80 , B62M9/10 , F16D41/24 , Y10T74/2164 , Y10T74/2168
摘要： A bicycle freewheel assembly comprising a hollow external body relatively rotatable with and radially spaced apart from a hollow internal body, a first dust protective member including a horizontal tubular body and an annular vertical flange and secured to the alternative of the internal body or the external body at one side of the the freewheel assembly, a second dust protective member including a horizontal tubular body and an annular vertical flange and secured to the alternative of the external body or a lock nut mounted on the internal body at the other side of the freewheel assembly, a first narrow clearance formed between the first dust protective member and the alternative of the internal body or the external body at the one side of the freewheel assembly, a second narrow clearance formed between the second dust protective member and the alternative of the external body or the lock nut at the other side of the freewheel assembly, and each of the first and the second clearances being L-shaped or hook-shaped to minimize undesirable intrusion of dust and/or rain into the inside of the freewheel assembly.
摘要翻译：一种自行车飞轮组件，包括与中空内部相对旋转并且与其径向隔开的中空外部主体，包括水平管状体和环形垂直凸缘的第一防尘构件，并固定到内部主体或外部主体的替代物在所述自由轮组件的一侧，包括水平管状体和环形垂直凸缘并固定到所述外部主体的替代物的第二防尘构件或在所述自由轮组件的另一侧安装在所述内部主体上的锁定螺母形成在第一灰尘保护构件和在该自由轮组件的一侧的内部主体或外部主体的替代物之间的第一窄间隙，形成在第二防尘构件和外部主体的替代物之间的第二窄间隙或在飞轮组件的另一侧的锁定螺母，以及第一和第二间隙中的每一个 L形或钩形，以最大限度地减少不必要的灰尘和/或雨侵入到飞轮组件的内部。

9. 发明授权

US4638094A Process for producing phenylacetones 失效
标题翻译：苯丙酮生产工艺
公开(公告)号：US4638094A
公开(公告)日：1987-01-20
申请号：US518691
申请日：1983-07-29
申请人： Mamoru Nakai , Takuji Enomiya
发明人： Mamoru Nakai , Takuji Enomiya
IPC分类号： C07C43/303 , C07C43/315 , C07C45/28 , C07C45/51 , C07C49/213 , C07C49/245 , C07C49/255 , C07C205/37 , C07D317/54 , C07C45/00
CPC分类号： C07D317/54 , C07C201/12 , C07C221/00 , C07C43/303 , C07C43/315 , C07C45/28 , C07C45/515 , C07C49/213 , C07C49/245 , C07C49/255
摘要： A phenylacetone or its derivative having the general formula (I): ##STR1## wherein X, Y, and Z are independently a hydrogen atom, a hydroxyl group, a halogen atom, a nitro group, an amino group, a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 6 carbon atoms, or a benzyloxy group and any two substituents of X, Y, and Z may form, together with the benzene ring, a heterocycling ring having 5 to 7 members including 1 or 2 oxygen atoms is produced at a high yield and a high selectivity by reacting a 3-phenylpropylene or its derivative having the general formula (II): ##STR2## wherein X, Y, and Z are as defined above, with an alkyl nitrite having the general formula (III):RONO (III)wherein R is an aliphatic, aromatic, or alicyclic saturated or unsaturated hydrocarbon group in the presence of (a) water, (b) an alcohol, (c) a palladium catalyst, and (d) an optional amine or copper compound, or by reacting the above-mentioned 3-phenylpropylene or its derivative with the above-mentioned alkyl nitrite in the presence of (a) an alcohol, (b) a palladium catalyst and (c) an optional amine or copper compound to form 1-phenyl-2,2-dialkoxypropane or it derivative having the general formula (IV): ##STR3## wherein X, Y, Z and R are as defined above, followed by hydrolyzing the reaction product.
摘要翻译：具有通式（I）的苯丙酮或其衍生物：其中X，Y和Z独立地为氢原子，羟基，卤素原子，硝基，氨基，低级具有1至6个碳原子的烷基，具有1至6个碳原子的低级烷氧基或苄氧基以及X，Y和Z的任意两个取代基可以与苯环一起形成具有5至通过使具有通式（II）的3-苯基丙烯或其衍生物：其中X，Y和Z作为（II），其中X，Y和Z如上所定义的3-苯基丙烯或其衍生物，以高产率和高选择性产生包含1或2个氧原子的7个成员具有通式（III）的亚硝酸烷基酯：RONO（III）其中R是脂族，芳族或脂环族饱和或不饱和烃基，在（a）水，（b）醇，（ c）钯催化剂，和（d）任选的胺或铜化合物，或通过使上述3-苯基丙烯或其衍生物在（a）醇，（b）钯催化剂和（c）任选的胺或铜化合物的存在下，使用上述烷基亚硝酸酯形成1-苯基-2,2-二烷氧基丙烷或其衍生物，其具有通式（IV）：其中X，Y，Z和R如上定义，然后水解反应产物。

10. 发明授权

US4269982A Process for preparing 5-amino-1,2,3-thiadiazoles 失效
标题翻译：制备5-氨基-1,2,3-噻二唑的方法
公开(公告)号：US4269982A
公开(公告)日：1981-05-26
申请号：US142718
申请日：1980-04-22
申请人： Mamoru Nakai , Katsumasa Harada , Yoshikatsu Mori
发明人： Mamoru Nakai , Katsumasa Harada , Yoshikatsu Mori
IPC分类号： C07D285/06
CPC分类号： C07D285/06
摘要： There is provided a process for preparing a 5-amino-1,2,3-thiadiazole represented by the formula ##STR1## wherein R represents a hydrogen atom, a lower alkyl group or an aryl group, which comprises bringing a diazoacetonitrile represented by the formula ##STR2## wherein R has the same meaning as defined above, into contact with hydrogen sulfide in the presence of a base or with a salt of hydrogen sulfide, in a solvent.
摘要翻译：提供一种制备式（Ⅰ）所示的5-氨基-1,2,3-噻二唑的方法，其中R代表氢原子，低级烷基或芳基，其中包括将由其中R具有与上述相同的含义，在碱的存在下或与硫化氢的盐在溶剂中与硫化氢接触。

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