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2. 发明授权

US4638094A Process for producing phenylacetones 失效
标题翻译：苯丙酮生产工艺
公开(公告)号：US4638094A
公开(公告)日：1987-01-20
申请号：US518691
申请日：1983-07-29
申请人： Mamoru Nakai , Takuji Enomiya
发明人： Mamoru Nakai , Takuji Enomiya
IPC分类号： C07C43/303 , C07C43/315 , C07C45/28 , C07C45/51 , C07C49/213 , C07C49/245 , C07C49/255 , C07C205/37 , C07D317/54 , C07C45/00
CPC分类号： C07D317/54 , C07C201/12 , C07C221/00 , C07C43/303 , C07C43/315 , C07C45/28 , C07C45/515 , C07C49/213 , C07C49/245 , C07C49/255
摘要： A phenylacetone or its derivative having the general formula (I): ##STR1## wherein X, Y, and Z are independently a hydrogen atom, a hydroxyl group, a halogen atom, a nitro group, an amino group, a lower alkyl group having 1 to 6 carbon atoms, a lower alkoxy group having 1 to 6 carbon atoms, or a benzyloxy group and any two substituents of X, Y, and Z may form, together with the benzene ring, a heterocycling ring having 5 to 7 members including 1 or 2 oxygen atoms is produced at a high yield and a high selectivity by reacting a 3-phenylpropylene or its derivative having the general formula (II): ##STR2## wherein X, Y, and Z are as defined above, with an alkyl nitrite having the general formula (III):RONO (III)wherein R is an aliphatic, aromatic, or alicyclic saturated or unsaturated hydrocarbon group in the presence of (a) water, (b) an alcohol, (c) a palladium catalyst, and (d) an optional amine or copper compound, or by reacting the above-mentioned 3-phenylpropylene or its derivative with the above-mentioned alkyl nitrite in the presence of (a) an alcohol, (b) a palladium catalyst and (c) an optional amine or copper compound to form 1-phenyl-2,2-dialkoxypropane or it derivative having the general formula (IV): ##STR3## wherein X, Y, Z and R are as defined above, followed by hydrolyzing the reaction product.
摘要翻译：具有通式（I）的苯丙酮或其衍生物：其中X，Y和Z独立地为氢原子，羟基，卤素原子，硝基，氨基，低级具有1至6个碳原子的烷基，具有1至6个碳原子的低级烷氧基或苄氧基以及X，Y和Z的任意两个取代基可以与苯环一起形成具有5至通过使具有通式（II）的3-苯基丙烯或其衍生物：其中X，Y和Z作为（II），其中X，Y和Z如上所定义的3-苯基丙烯或其衍生物，以高产率和高选择性产生包含1或2个氧原子的7个成员具有通式（III）的亚硝酸烷基酯：RONO（III）其中R是脂族，芳族或脂环族饱和或不饱和烃基，在（a）水，（b）醇，（ c）钯催化剂，和（d）任选的胺或铜化合物，或通过使上述3-苯基丙烯或其衍生物在（a）醇，（b）钯催化剂和（c）任选的胺或铜化合物的存在下，使用上述烷基亚硝酸酯形成1-苯基-2,2-二烷氧基丙烷或其衍生物，其具有通式（IV）：其中X，Y，Z和R如上定义，然后水解反应产物。

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