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1. 发明申请

US20140363832A1 MOLECULAR MARKER FOR THE EARLY DETECTION OF MALIGNANT PLEURAL MESOTHELIOMA AND THE METHODS OF ITS EXPRESSION ANALYSIS USING BLOOD AND PLEURAL EFFUSION SAMPLES 审中-公开
标题翻译：用于早期检测恶性淋巴细胞的分子标记及其使用血液和稀释效应样品的表达分析方法
公开(公告)号：US20140363832A1
公开(公告)日：2014-12-11
申请号：US14344873
申请日：2012-09-14
申请人： Kiyoshi Yanagisawa , Takashi Takahashi , Kohei Yokoi , Yoshinori Hasegawa , Ken-ichiro Ono , Kasumi Yagi , Hitomi Masuda , Toshiyuki Takeuchi
发明人： Kiyoshi Yanagisawa , Takashi Takahashi , Kohei Yokoi , Yoshinori Hasegawa , Ken-ichiro Ono , Kasumi Yagi , Hitomi Masuda , Toshiyuki Takeuchi
IPC分类号： G01N33/574 , C07K16/18
CPC分类号： G01N33/57423 , C07K14/47 , C07K16/18 , G01N33/57407
摘要： The present invention provides a method for testing mesothelioma comprising a step of determining a concentration of a human periostin protein in at least one type of sample of blood or pleural fluid of a subject. In the step of determining the concentration of human periostin protein, an antibody directed against human periostin protein may be used. The present invention further provides a kit for diagnosing mesothelioma, said kit comprising an antibody directed against human periostin protein. In the kit for diagnosing mesothelioma, the antibody directed against a human periostin protein may be an antibody that binds to a polypeptide consisting of an amino acid sequence set out in SE ID NO: 2.
摘要翻译：本发明提供了一种用于测试间皮瘤的方法，包括测定受试者的至少一种类型的血液或胸膜液样品中人骨膜素蛋白浓度的步骤。在确定人骨膜素蛋白浓度的步骤中，可以使用针对人骨膜素蛋白的抗体。本发明还提供了用于诊断间皮瘤的试剂盒，所述试剂盒包含针对人骨膜素蛋白的抗体。在用于诊断间皮瘤的试剂盒中，针对人骨膜素蛋白的抗体可以是与由SE ID NO：2中列出的氨基酸序列组成的多肽结合的抗体。

2. 发明申请

US20110293618A1 ANTI-HUMAN CLCP1 ANTIBODY AND USE THEREOF 有权
标题翻译：抗人CLCP1抗体及其用途
公开(公告)号：US20110293618A1
公开(公告)日：2011-12-01
申请号：US13054554
申请日：2009-07-16
申请人： Ken-ichiro Ono , Takashi Takahashi
发明人： Ken-ichiro Ono , Takashi Takahashi
IPC分类号： A61K39/395 , C12P21/02 , C12N5/10 , C12N1/21 , A61P35/04 , G01N33/574 , C07K16/18 , C07H21/00 , A61P35/00 , C12N15/63 , C12N1/19
CPC分类号： G01N33/574 , A61K2039/505 , C07K16/3023 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , G01N33/5011
摘要： The present invention provides novel antibodies that recognize the extracellular domain of a human CLCP1 antigen; nucleic acids encoding the antibodies; vectors carrying the nucleic acids in an expressible manner; transformed cells containing the vectors; methods for producing the antibodies; diagnostic methods for cancer or prognosis of cancer, immunohistological or immunocytological assay methods, and kits for determining the expression level of CLCP1 in cells or tissues, all of which use the antibodies; pharmaceutical compositions comprising the antibodies; agents for treating or preventing CLCP1-expressing cancer; agents for inhibiting growth, migration, invasion, or metastasis of CLCP1-expressing cancer cells; immunostaining agents for staining CLCP1-expressing cancer cells; and agents for treating or preventing CLCP1-expressing tumor. The present invention also provides methods of screening for candidate substances that inhibit cancer cell growth, invasion, migration, or metastasis, or candidate substances having cytotoxicity against cancer cells.
摘要翻译：本发明提供识别人CLCP1抗原的细胞外结构域的新型抗体; 编码抗体的核酸; 以可表达的方式携带核酸的载体; 含有载体的转化细胞; 生产抗体的方法; 用于癌症或癌症预后的诊断方法，免疫组织化学或免疫细胞学测定方法以及用于测定细胞或组织中所有这些抗体的CLCP1表达水平的试剂盒; 包含抗体的药物组合物; 治疗或预防CLCP1表达癌症的药剂; 用于抑制表达CLCP1的癌细胞的生长，迁移，侵袭或转移的药剂; 用于染色表达CLCP1的癌细胞的免疫染色剂; 和用于治疗或预防表达CLCP1的肿瘤的药剂。本发明还提供筛选抑制癌细胞生长，侵袭，迁移或转移的候选物质或对癌细胞具有细胞毒性的候选物质的方法。

3. 发明授权

US08993728B2 Anti-human CLCP1 antibody and use thereof 有权
标题翻译：抗人CLCP1抗体及其用途
公开(公告)号：US08993728B2
公开(公告)日：2015-03-31
申请号：US13054554
申请日：2009-07-16
申请人： Ken-ichiro Ono , Takashi Takahashi
发明人： Ken-ichiro Ono , Takashi Takahashi
IPC分类号： A61K39/395 , G01N33/574 , C07K16/30 , G01N33/50 , A61K39/00
CPC分类号： G01N33/574 , A61K2039/505 , C07K16/3023 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/77 , C07K2317/92 , G01N33/5011
摘要： The present invention provides novel antibodies that recognize the extracellular domain of a human CLCP1 antigen; nucleic acids encoding the antibodies; vectors carrying the nucleic acids in an expressible manner; transformed cells containing the vectors; methods for producing the antibodies; diagnostic methods for cancer or prognosis of cancer, immunohistological or immunocytological assay methods, and kits for determining the expression level of CLCP1 in cells or tissues, all of which use the antibodies; pharmaceutical compositions comprising the antibodies; agents for treating or preventing CLCP1-expressing cancer; agents for inhibiting growth, migration, invasion, or metastasis of CLCP1-expressing cancer cells; immunostaining agents for staining CLCP1-expressing cancer cells; and agents for treating or preventing CLCP1-expressing tumor. The present invention also provides methods of screening for candidate substances that inhibit cancer cell growth, invasion, migration, or metastasis, or candidate substances having cytotoxicity against cancer cells.
摘要翻译：本发明提供识别人CLCP1抗原的细胞外结构域的新型抗体; 编码抗体的核酸; 以可表达的方式携带核酸的载体; 含有载体的转化细胞; 生产抗体的方法; 用于癌症或癌症预后的诊断方法，免疫组织化学或免疫细胞学测定方法以及用于测定细胞或组织中所有这些抗体的CLCP1表达水平的试剂盒; 包含抗体的药物组合物; 治疗或预防CLCP1表达癌症的药剂; 用于抑制表达CLCP1的癌细胞的生长，迁移，侵袭或转移的药剂; 用于染色表达CLCP1的癌细胞的免疫染色剂; 和用于治疗或预防表达CLCP1的肿瘤的药剂。本发明还提供筛选抑制癌细胞生长，侵袭，迁移或转移的候选物质或对癌细胞具有细胞毒性的候选物质的方法。

4. 发明授权

US07968362B2 Semiconductor light-emitting device, surface-emission laser diode, and production apparatus thereof, production method, optical module and optical telecommunication system 有权
标题翻译：半导体发光器件，表面发射激光二极管及其制造装置，制造方法，光模块和光通信系统
公开(公告)号：US07968362B2
公开(公告)日：2011-06-28
申请号：US12408362
申请日：2009-03-20
申请人： Takashi Takahashi , Morimasa Kaminishi , Shunichi Sato , Akihiro Itoh , Naoto Jikutani
发明人： Takashi Takahashi , Morimasa Kaminishi , Shunichi Sato , Akihiro Itoh , Naoto Jikutani
IPC分类号： H01L21/00
CPC分类号： H01L33/007 , B82Y20/00 , C23C16/301 , C23C16/54 , C30B25/02 , C30B29/40 , H01L21/02395 , H01L21/02458 , H01L21/02461 , H01L21/02463 , H01L21/02466 , H01L21/02507 , H01L21/0254 , H01L21/02543 , H01L21/02546 , H01L21/02549 , H01L21/02576 , H01L21/02579 , H01L21/02581 , H01L21/0262 , H01L33/025 , H01L33/10 , H01L33/32 , H01S5/0014 , H01S5/02284 , H01S5/18305 , H01S5/18308 , H01S5/18311 , H01S5/18341 , H01S5/18394 , H01S5/3211 , H01S5/32366 , H01S5/343 , H01S5/34306 , H01S5/34333 , H01S2304/04
摘要： A semiconductor light-emitting device has a semiconductor layer containing Al between a substrate and an active layer containing nitrogen, wherein Al and oxygen are removed from a growth chamber before growing said active layer and a concentration of oxygen incorporated into said active layer together with Al is set to a level such that said semiconductor light-emitting device can perform a continuous laser oscillation at room temperature.
摘要翻译：半导体发光器件具有在衬底和含有氮的有源层之间包含Al的半导体层，其中在生长所述有源层之前从生长室中除去Al和氧，并且与Al一起掺入所述有源层中的氧浓度被设定为使得所述半导体发光装置能够在室温下进行连续激光振荡的电平。

5. 发明授权

US07881357B2 Vertical cavity surface-emitting semiconductor laser device, optical transmission module, optical transmission device, and optical switching method 有权
标题翻译：垂直腔表面发射半导体激光器件，光传输模块，光传输器件和光开关方法
公开(公告)号：US07881357B2
公开(公告)日：2011-02-01
申请号：US12153152
申请日：2008-05-14
申请人： Takashi Takahashi
发明人： Takashi Takahashi
IPC分类号： H01S5/00
CPC分类号： H01S5/18311 , B82Y20/00 , H01S5/0425 , H01S5/06226 , H01S5/1021 , H01S5/18302 , H01S5/18308 , H01S5/1833 , H01S5/18358 , H01S5/2063 , H01S5/34306 , H01S5/3432
摘要： In a vertical cavity surface-emitting semiconductor laser device, first and second resonance wavelengths which are different are provided while a first resonator and a second resonator are coupled optically, and a gain of an active layer at the first resonance wavelength on the side of short wavelength is higher than that at the second resonance wavelength on the side of long wavelength. An absorption coefficient of an optical absorption layer when no electric field is applied is small for the first and second resonance wavelengths, and when an electric field is applied, an absorption coefficient of the optical absorption layer for the first resonance wavelength on the side of short wavelength is larger than that for the second resonance wavelength on the side of long wavelength.
摘要翻译：在垂直腔表面发射半导体激光器件中，在第一谐振器和第二谐振器被光耦合的同时提供不同的第一和第二谐振波长，并且在短边的第一谐振波长处的有源层的增益波长比在长波长侧的第二共振波长处高。当不施加电场时光吸收层的吸收系数对于第一和第二共振波长小，并且当施加电场时，第一共振波长的光吸收层的吸收系数在短边波长比在长波长侧的第二共振波长的波长大。

6. 发明申请

US20100195691A1 LASER DIODE AND SEMICONDUCTOR LIGHT-EMITTING DEVICE PRODUCING VISIBLE-WAVELENGTH RADIATION 有权
标题翻译：产生可见波长辐射的激光二极管和半导体发光器件
公开(公告)号：US20100195691A1
公开(公告)日：2010-08-05
申请号：US12696322
申请日：2010-01-29
申请人： Naoto Jikutani , Takashi Takahashi , Shunichi Sato
发明人： Naoto Jikutani , Takashi Takahashi , Shunichi Sato
IPC分类号： H01S5/187
CPC分类号： H01S5/2202 , B82Y20/00 , H01S5/22 , H01S5/2206 , H01S5/2209 , H01S5/221 , H01S5/2231 , H01S5/3201 , H01S5/3434
摘要： A laser diode includes a substrate having a lattice constant of GaAs or between GaAs and GaP, a first cladding layer of AlGaInP formed on the substrate, an active layer of GaInAsP formed on the first cladding layer, an etching stopper layer of GaInP formed on the active layer, a pair of current-blocking regions of AlGaInP formed on the etching stopper layer so as to define a strip region therebetween, an optical waveguide layer of AlGaInP formed on the pair of current-blocking regions so as to cover the etching stopper layer in the stripe region, and a second cladding layer of AlGaInP formed on the optical waveguide layer, wherein the current-blocking regions having an Al content substantially identical with an Al content of the second cladding layer.
摘要翻译：激光二极管包括具有GaAs晶格常数或GaAs和GaP之间的基板，在基板上形成的AlGaInP的第一包层，形成在第一包层上的GaInAsP的有源层，形成在第一包层上的GaInP的蚀刻停止层有源层，在蚀刻阻挡层上形成一对AlGaInP的电流阻挡区域，以便限定它们之间的条带区域，形成在一对电流阻挡区域上以覆盖蚀刻阻挡层的AlGaInP光波导层以及形成在光波导层上的AlGaInP的第二包覆层，其中，所述电流阻挡区域的Al含量基本上与第二包层的Al含量相同。

7. 发明申请

US20100048901A1 NOVEL CURCUMIN DERIVATIVE 有权
标题翻译：新的CURCUMIN DERIVATIVE
公开(公告)号：US20100048901A1
公开(公告)日：2010-02-25
申请号：US12516948
申请日：2007-11-30
申请人： Takashi Takahashi , Ichiro Hijikuro , Hachiro Sugimoto , Takeshi Kihara , Yoshiari Shimmyo , Tetsuhiro Niidome
发明人： Takashi Takahashi , Ichiro Hijikuro , Hachiro Sugimoto , Takeshi Kihara , Yoshiari Shimmyo , Tetsuhiro Niidome
IPC分类号： C07C49/203 , C07D211/82 , C07D241/40
CPC分类号： C07D209/08 , A61K31/404 , C07D209/12
摘要： The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.
摘要翻译：本发明提供了结构上类似于姜黄素并对A＆Bgr具有抑制作用的新型化合物; 聚集，对A＆Bgr的降解作用; 聚集体，对分泌酶的抑制作用，以及对神经元的保护作用。新化合物是由下列通式（Ia）表示的化合物或其盐：其中R1表示4-羟基-3-甲氧基苯基等，R2表示1H-吲哚-6-基或喜欢。

8. 发明授权

US07610355B2 Transferring web contents 失效
标题翻译：传送网页内容
公开(公告)号：US07610355B2
公开(公告)日：2009-10-27
申请号：US11832681
申请日：2007-08-02
申请人： Shigeo Azuma , Takashi Takahashi , Toshifumi Takahashi
发明人： Shigeo Azuma , Takashi Takahashi , Toshifumi Takahashi
IPC分类号： G06F15/16
CPC分类号： H04L67/06 , H04L67/02
摘要： To transfer web contents to a web server from a computer through a network, a plurality of files composing the web contents are stored in the computer. A processor of the computer then detects files to be transferred from the plurality of files to create a transfer file list table. A transfer priority of the files to be transferred is determined by the processor on the basis of reference relation data of the files to be transferred which are designated in the transfer file list table and file format data of the plurality of files to create a transfer priority list table for the files to be transferred. The files to be transferred are transferred to the web server from a communication controller of the computer through the network by the processor in order of the transfer priority set in the transfer priority list table.
摘要翻译：为了通过网络从计算机将web内容传送到web服务器，组成Web内容的多个文件被存储在计算机中。然后，计算机的处理器检测要从多个文件传送的文件以创建传送文件列表表。要传送的文件的传送优先级由处理器根据在传送文件列表表中指定的要传送的文件的参考关系数据和多个文件的文件格式数据来确定，以创建传送优先级列表要传输的文件。要传送的文件按照传输优先级列表表中设置的传送优先级的顺序，由处理器从计算机的通信控制器通过网络传输到Web服务器。

9. 发明申请

US20070242354A1 Optical head device with film wavelength plate incorporated therein 审中-公开
标题翻译：配有膜波长板的光头装置
公开(公告)号：US20070242354A1
公开(公告)日：2007-10-18
申请号：US11714913
申请日：2007-03-07
申请人： Takashi Takahashi , Nobuki Tanaka , Takaaki Saito , Tatsuya Nakata
发明人： Takashi Takahashi , Nobuki Tanaka , Takaaki Saito , Tatsuya Nakata
IPC分类号： G02B27/28
CPC分类号： G11B7/13922 , G11B7/1365
摘要： Members such as a laser diode (10) that is a light source, a diffraction grating (11), a polarizing beam splitter (12) and a collimator lens are arranged in a casing (20). An optical head device having such a casing (20) is improved, so that a film wavelength plate (14) is directly attached to the casing (20) in a form free from a support substrate. The film wavelength plate (14) consists of only one film and has a thickness of 0.2 to 1.0 mm. Particularly, the film wavelength plate is preferably constituted by fusing polycarbonate films in a three-layer structure.
摘要翻译：诸如作为光源的激光二极管（10），衍射光栅（11），偏振分束器（12）和准直透镜的构件被布置在壳体（20）中。具有这种壳体（20）的光学头装置被改进，使得膜波长板（14）以没有支撑基板的形式直接附接到壳体（20）。膜波长板（14）仅由一个膜构成，厚度为0.2至1.0mm。特别地，膜波长板优选通过将聚碳酸酯膜熔合成三层结构而构成。

10. 发明申请

US20070221908A1 Semiconductor light emitter 有权
公开(公告)号：US20070221908A1
公开(公告)日：2007-09-27
申请号：US11802391
申请日：2007-05-22
申请人： Takashi Takahashi , Shunichi Sato , Morimasa Kaminishi
发明人： Takashi Takahashi , Shunichi Sato , Morimasa Kaminishi
IPC分类号： H01L29/06
CPC分类号： H01L33/32 , B82Y20/00 , H01L33/06 , H01L33/105 , H01S5/18311 , H01S5/18358 , H01S5/22 , H01S5/3215 , H01S5/32366 , H01S5/3406 , H01S5/34306 , H01S5/34346 , H01S5/423 , H01S2304/04
摘要： A semiconductor light emitter includes a quantum well active layer which includes nitrogen and at least one other Group-V element, and barrier layers which are provided alongside the quantum well active layer, wherein the quantum well active layer and the barrier layers together constitute an active layer, wherein the barrier layers are formed of a Group-III-V mixed-crystal semiconductor that includes nitrogen and at least one other Group-V element, a nitrogen composition thereof being smaller than that of the quantum well active layer.

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